Benefiting from various DNA technologies, DNA markers have now become a popular means for the identification of Chinese medicinal materials. Facing the huge amount of valuable data that has been produced, researchers need to understand the bioinformatics tools for analyzing the obtained DNA information. This paper summarizes the applications of bioinformatics in molecular authentication of Chinese medicinal materials, including checking phylogenetic information of the samples, searching and retrieving DNA sequence data, matching of similarity between the sequences and performing multiple sequence alignment.
Base Sequence ; Computational Biology ; methods ; Drugs, Chinese Herbal ; chemistry ; Plants, Medicinal ; chemistry ; genetics

Sickle cell disease (SCD) in pregnancy is uncommon in Malaysia. We present a case of sickle cell disease in pregnancy with maternal and fetal complications. The patient presented with acute pain crisis and hemolysis in the third trimester. Despite thromboprophylaxis, she developed deep vein thrombosis. The pregnancy was further complicated by severe pre-eclampsia and intrauterine growth restriction which require preterm caesarean section. The baby was admitted to Neonatal Intensive Care Unit due to prematurity and low birth weight. Multidisciplinary approach in managing pregnant patient with SCD is essential in achieving good obstetrics outcome.