Objective To explore the clinical significance of changes of serum cfDNA and CRP in patients with hand -foot -and -muoth disease.Methods Serum levels of cfDNA,CPP were measured with fluorescent quan-titation PCR and immunoturbidime,respectively in 108 cases of children patients with hand -foot -and -muoth and 108 healthy subjects children as control group.Results Serum cfDNA and CPP levels with hand -foot -and -muoth group(523.45 ±42.31)mg/L,(22.57 ±5.52)mg/L were significantly higher than those of control group detection results(260.18 ±20.56)mg/L,(2.88 ±0.82)mg/L(t =58.16,36.85,all P <0.05).And we observed the serum cfDNA and CPP levels in different severity extent of pneumonia,the results show that the serum increased gradually with the increase of the severity(t =29.80,13.68,all P <0.05).and the serum level of cfDNA was positive correla-tion with CRP(r =0.730,P <0.01 ).Conclusion The serum.cfDNA and CRP reflect situation of patients and extent of hand -foot -and -muoth disease,which have a close relationship between the clinical process of hand -foot-and -muoth disease and have significance value to evaluate the pathogenetic condition and prognosis.

Objective To assess the efficacy,safety,and tolerability of Topiramate(TPM) and Sodium Valproate(SV) as prophylactic therapy for migraine.Methods Prospectively,total of 146 patients with episodic migraine were randomly divided into two groups:TPM group(74 cases) and SV group(72 cases).TPM was titrated by 25 mg per week for 2～4 weeks and the highest dose was 100 mg/d.SV was given at 200 mg twice daily during initial titration of therapy and the highest dose was 600 mg/d.The therapies lasted for 13 weeks,meanwhile the migrain frequency,days and the severity of headache were recorded in headache diaries.The severity of headache was rated on a 0～10 rating scale.Results Mean frequency of headache attack decreased from 7.01 to 1.89 times per month(P