Objective:To explore the effects of intensive nursing intervention on patients with dilated cardiomyopathy and ventricular arrhythmia treated with amiodarone.Methods:Totally 100 patients with dilated cardiomyopathy and ventricular arrhythmia treated with amiodarone who were hospitalized in China-Japan Union Hospital of JiLin University from January 2017 to March 2019 were selected by convenient sampling. Patients hospitalized from January 2017 to February 2018 were divided into the control group, while patients hospitalized from March 2018 to March 2019 were divided into the experimental group. Patients in the control group received routine nursing care, while patients in the experimental group received intensive nursing intervention. The Profile of Mood States-Short Form (POMS-SF) and the World Health Organization Quality of Life (WHOQOL-BREF) were used to evaluate the intervention effects.Results:The POMS-SF scores of the two groups after intervention were lower than those before intervention, and the POMS-SF score of the experimental group was lower than that of the control group, and the differences were statistically significant ( P<0.05) . The WHOQOL-BREF scores of the two groups after intervention were higher than those before intervention, and the WHOQOL-BREF score of the experimental group was higher than that of the control group, and the differences were statistically significant ( P<0.05) . Conclusions:Intensive nursing intervention can mitigate the negative emotion of patients with dilated cardiomyopathy and ventricular arrhythmia treated with amiodarone, and improve their quality of life.