Background and purpose:Aberrant expressions of microRNAs (miRNA, miR)are reported in various cancers and may associate with cancer occurrence, development, invasion and metastasis, thereby functioning as either tumor suppressors or oncogenes. This study attempted to observe the expression of miR-214 in pancreatic cancer and to explore its clinical signiifcance.Methods:Real-time PCR was used to detect the miR-214 expressions between pancreatic cancer tissues and matched adjacent tissues. The correlations of miR-214 expression with clinic-pathological features and clinical prognosis were analyzed.Results:MiR-214 expression was up-regulated in 69.4%(25/36) of tumor tissue specimens. The relative expression level of miR-214 was signiifcantly higher in tumor tissues than in matched adjacent tissues (3.45vs 1.52,P<0.01). Higher miR-214 level was strongly associated with T3-T4 stage (P=0.018). The Kaplan-Meier analysis revealed that patients with higher expression of miR-214 had a shorter survival time (P=0.032).Conclusion:The expression of miR-214 is associated with clinic-pathological features and patient’s clinical prognosis, so it may be used as a potential diagnostic biomarker and a prognostic predictor in patients with pancreatic cancer.

Objective To know the prevalence rates of diabetes and its risk factors among residents in Haizhu district,Guangzhou.Methods With multiple stages stratified and systematic-random sampling,8 403 residents(aged 18 yrs old and over)were selected and investigated by cross-sectional study,items including:general conditions,risk factors of diabetes,physical examination and knowledge about diabetes,and 2 017 cases were assayed on their blood glucose and lipids.Data were analyzed with SPSS software.Results The general prevalence rate of diabetes was 9.0%(182/2017),the standardized prevalence rate of diabetes was5.5%;the rate of impaired fasting blood glucose(IFG)was 5.1%(103/2017),the standardized rate of IFG was 3.8%.The prevalence rate of diabetes was positively correlated with age(r=0.98,P