Objective To investigate the anti-proliferation effect of triptolide-eluting stent, as well as its effectiveress, dose-effect relationship and safety. Methods Experimental stents were divided into 4 groups with 10 stents each, namely bare stent group, sirolimus-coated stent group, 5.6 ?g triptolide-coated stent group and 56 ?g triptolide-coated stent group. By morphometric and histopathologic analysis,we compared 5.6 ?g and 56 ?g triptolide-eluting stents with bare metal stents and sirolimus-eluting stents 28 days after stenting in rabbit iliac models of restenosis. Results The neointimal area of 5.6 ?g triptolide-eluting stents was similar to that of bare metal stents, but larger than that of sirolimus-eluting stents. The neointimal area of 56 ?g triptolide-eluting stents was smaller than that of bare metal stents and 5.6 ?g triptolide-eluting stents, but was similar to that of sirolimus-eluting stents. In all the groups, proliferation on both edges of the stents was insignificant. No toxic effect had been found in the experimental animals related to triptolide-eluting stent. Conclusion Triptolide-eluting stents may inhibit neointimal proliferation. The effect of inhibiting neointimal proliferation is dose dependent and with no adverse effect. These results suggest that triptolide-eluting stent can prevent restenosis within four weeks.

OBJECTIVE:To explore the automated intelligent construction and effect of pharmacy intravenous admixture servic-es(PIVAS)in our hospital. METHODS:The main situation of automated intelligent construction and effect of PIVAS in our hospi-tal was introduced,the time and error rate of related links before(Jul.-Sept. 2016)and after(Oct.-Dec. 2016)the automated intelli-gent construction of PIVAS in our hospital were collected,and its effects were evaluated. RESULTS:Our hospital conducted auto-mated intelligent construction in selecting,labeling,sorting and delivering medicines in PIVAS and established related system and process construction. After automated intelligent construction,time for selecting medicines per medical order was shortened from (6.78±0.87)s to(2.65±0.71)s;time for labeling was shortened from(3.24±0.71)s to(1.41±0.55)s;time for sorting a bag of finished infusion was shortened from (13.37 ± 2.84) s to (5.33 ± 1.72) s;and time for delivering the same amount of infusion shortened from (35.64 ± 4.33) min to (18.12 ± 3.57) min (P<0.05). The error rate of selecting medicines was decreased from (2.35 ± 0.59)‰ to (0.26 ± 0.21)‰;error rate of labeling was decreased from (1.51 ± 0.45)‰ to (0.22 ± 0.10)‰;error rate of misclassifying in a wrong ward was decreased from(3.47±1.02)‰ to(0.17±0.10)‰;and error rate of delivering was decreased from(1.33±0.55)‰ to(0.13±0.11)‰(P<0.05). CONCLUSIONS:The automated intelligent construction in PIVAS of our hos-pital has improved work efficiency,reduced error rate and potential medication risk and improved management level in PIVAS.

Recently, malaria incidence has sharply resurgence in the border area of northern Myanmar, with the parasite incidence rate in 2023 being 21.47 times (95% CI: 18.84-24.48) that of 2019 in Kachin State's Razan and nearby areas. This resurgence caused the number of imported malaria cases to increase from 188 in 2019 to 398 in 2023 in Yunnan Province. In addition to the impact of military conflict, the border malaria joint prevention and control cooperation mechanism and malaria control measures established between China and Myanmar have failed to be implemented effectively due to the impact of the international COVID-19 epidemic. Hence, it is recommended that relevant departments evaluate the quality and effectiveness of the current cross-border transmission measures for malaria in the China-Myanmar border area from a technical perspective, and provide a large demand for primaquine, which can block the spread of malaria and cure vivax malaria, in response to the current prevalent characteristics of vivax malaria predominating in northern Myanmar. Moreover, to effectively reduce the mortality of imported malaria patients and prevent re-importation and transmission, it is necessary to enhance clinical physicians' knowledge, awareness, and vigilance regarding malaria diagnosis and treatment in the Yunnan border region, as well as China's ability and quality of appropriate response to imported malaria.

Amino Acid Sequence ; Genes, Bacterial ; Hydrogen Peroxide ; pharmacology ; Molecular Sequence Data ; Mutation ; genetics ; Mycobacterium ; drug effects ; genetics ; growth & development ; Peptides ; chemistry ; metabolism ; Stress, Physiological ; drug effects