1.Comparison of Plasma Concentration of Norvancomycin by HPLC and Microbiological Method
Kaili ZHANG ; Cheng LI ; Yuzhen LI ; Chunzhi YANG
China Pharmacy 2015;(26):3655-3657
OBJECTIVE:To explore the differences of plasma concentration of norvancomycin by HPLC and microbiological method. METHODS:Microbiological method and HPLC were used to detect the plasma concentration of norvancomycin,and clinical test result of both techniques was retrospectively analyzed. RESULTS:There were no significant differences in the plasma concentra-tion of norvancomycin by microbiological method and HPLC(y=0.992 7x+0.155 8,r=0.997 6)(P>0.05). CONCLUSIONS:Both microbiological method and HPLC are more effective and reliable for the plasma concentration detection of norvancomycin. The hospi-tals can choose corresponding method according to their condition when determining plasma concentration of norvancomycin.
2.Influencing factors of the recovery of psychosocial functioning with depressed patients
Kaili DIAO ; Haitao QU ; Hui MA ; Changjun TENG ; Cheng YIN ; Hua YANG ; Ning ZHANG
Chinese Journal of Behavioral Medicine and Brain Science 2017;26(5):476-480
Major depressive disorder (MDD) is a mental disorder with high prevalence,morbidity and recurrence rate.The treatment goal of acute stage is to achieve remission,which means asymptomatic.However,clinical treatments and studies found impairment of psychosocial functioning still exists even after remission,which means incomplete recovery.As is known,the normalization of psychosocial functioning is essential to the recovery and the recurrence prevention of MDD.In order to provide reference and guidance for the clinical treatments and studies,we reviewed the related studies and found many kinds of factors influencing the restoration of psychosocial functioning,including demographic factors,diseases related factors,psychological factors,social factors and therapeutic approaches.However,few interior studies focused on the recovery of MDD,and the results of foreign studies were inconsistent,while the understanding of how those factors influence the recovery of MDD is not clear enough.In order to make the characteristics of psychosocial functioning recovery and mechanisms of the influencing factors clear,more in-depth studies should be done in the future.
3.Advances in diagnosis of gastrointestinal stromal tumor
Kaili CHEN ; Nan ZHANG ; Qing ZHANG ; Hongju CHENG
Chinese Journal of Primary Medicine and Pharmacy 2020;27(16):2045-2048
Gastrointestinal stromal tumor(GIST) is the most common mesenchymal tumor in the digestive system, with potential malignant tendency.With the change of living habits and the update of instruments and equipments, the morbidity and detection rate of GIST have been increased year by year, attracting much attention.However, its clinical manifestations are not characteristic.At present, primary diagnosis is mainly made by imaging techniques such as CT and MRI, and pathological diagnosis is the gold index.In recent years, with the development of immunohistochemical technology and gene technology, immune markers and gene detection play an increasingly important role in the diagnosis of GIST.This paper reviews the progress of GIST diagnostic techniques.
4.Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion
Shuyin MA ; Meijuan ZHANG ; Huiyang QU ; Yuxuan CHENG ; Shuang DU ; Jiaxin FAN ; Qingling YAO ; Xiaodong ZHANG ; Mengying CHEN ; Nan ZHANG ; Kaili SHI ; Yizhou HUANG ; Shuqin ZHAN
Journal of Clinical Neurology 2022;18(1):14-23
Background:
and Purpose Collateral circulation is considered an important factor affecting the risk of stroke, but the factors that affect collateral circulation remain unclear. This study was performed to identify the factors associated with collateral circulation, especially blood lipids.
Methods:
The study involved patients who had undergone digital subtraction angiography and were confirmed as having severe unilateral stenosis or occlusion of the internal carotid artery (ICA). We classified the collateral circulation status of each patient as good (Grade 3 or 4) or poor (Grade 0, 1, or 2) according to the grading system of the American Society of Interventional and Therapeutic Neuroradiology/American Society of Interventional Radiology. We collected data on patients’ characteristics and identified the factors that affect collateral circulation.
Results:
This study included 212 patients. The multivariate logistic regression analysis showed that the high-density lipoprotein cholesterol (HDL-C) concentration and a complete anterior half of the circle of Willis were independent protective factors for good collateral circulation, whereas elevated lipoprotein(a) [Lp(a)] and serum creatinine concentrations were independent risk factors for good collateral circulation. The area under the receiver operating characteristics curve (AUC) was 0.68 (95% confidence interval [CI], 0.61–0.76) for HDL-C and 0.69 (95% CI, 0.62–0.76) for Lp(a). A binary logistic regression model analysis of the joint factor of HDL-C and Lp(a) yielded an AUC of 0.77 (95% CI, 0.71–0.84).
Conclusions
In patients with severe unilateral ICA stenosis or occlusion, the combination of HDL-C and Lp(a) is a useful predictor of collateral circulation.
5.The application research of analogical thinking combined with situational teaching method to create a happy learning situation in ophthalmic nursing teaching
Ajuan CHEN ; Jie BAI ; Kaili GOU ; Yang LI ; Lina CHENG
Chinese Journal of Medical Education Research 2023;22(5):776-779
Objective:To explore the application of analogical thinking combined with situational teaching method to create a happy learning situation in ophthalmic nursing practice teaching.Methods:A total of 90 nursing students who had practice in Department of Ophthalmology, Xijing Hospital, Air Force Medical University, from October 2020 to January 2022 were selected as the research objects. According to different teaching methods, they were divided into control group and observation group. The control group ( n=45) adopted conventional teaching, while the observation group ( n=45) adopted analogical thinking combined with situational teaching method. The two groups of nursing students were evaluated by comprehensive examination results, teaching effect questionnaire and students' overall satisfaction with their teachers. SPSS 22.0 was used for t-test and Chi-square test. Results:The test scores of theoretical knowledge [(85.39±1.57) vs. (84.41±1.34)] and nursing skills [(87.52±0.04) vs. (82.64±0.05)] of observation group were both higher than those of control group. In the observation group, the students' awareness of medication safety, professional interest and independent learning, cooperation and organization ability, independent thinking and independent learning ability, the purpose of multi-disciplinary knowledge integration, information and knowledge range improvement, clinical thinking communication ability enhancement, flexible application of theoretical knowledge, practical operation ability enhancement, and the cultivation of innovation consciousness were all improved. And all the scores were better than those of the control group. The satisfaction of teachers in the observation group on students' learning attitude, language expression, calling communication ability and independent problem-solving ability was higher than that in the control group ( P < 0.05). Conclusion:The combination of analogical thinking and the situational teaching method to create a happy learning situation can improve the average scores of nursing students and nursing skills, and significantly improve the satisfaction of students to the teachers.
6.Mediating effect of self-evaluation of depressive symptoms on automatic thinking and psychosocial function of patients with depression in remission
Hui WANG ; Hui MA ; Kaili DIAO ; Haitao QU ; Changjun TENG ; Cheng YIN ; Hua YANG ; Ning ZHANG
Chinese Journal of Behavioral Medicine and Brain Science 2018;27(12):1091-1095
Objective To investigate the mediating effects of self-evaluation of depressive symptoms between psychosocial function and negative automatic thinking in patients with depression in remission.Methods The Hamilton depression scale (HAMD-17),generic quality of life inventory(GQOLI),Beck depression inventory(BDI) and automatic thoughts questionnaire (ATQ) were applied to 122 subjects who were patients with depression in remission.Results (1) There was significantly negative correlation between self-evaluation of depressive symptoms and physical function and psychological function and social function(r=-0.559,r=-0.435,r=-0.388,all P<0.01),and negative correlation between negative automatic thinking and physical function,psychological function and social function(r=-0.563,r=-0.449,r=-0.468,all P<0.01).(2)The score of physical function,psychological function and social function in the group with low self-evaluation of depressive symptoms was higher than those in the group with high self-evaluation of depressive symptoms (low group:70.27±11.33,69.54±11.53,69.09±10.41;high group:53.33±9.32,57.24±13.80,57.69± 12.77),and the differences were statistically significant (t=7.40,4.82,4.48,P<0.01).(3) Negative automatic thinking had a significant negative effect on physical function (B =-0.17,P<0.01),which was affected by self-evaluation of depressive symptoms.The relationship between negative automatic thinking and psychological function was affected by self-evaluation of depressive symptoms.Conclusion Self-evaluation of depressive symptom plays a mediating role between negative automatic thinking and physical function,which also was a mediator in the relationship between negative automatic thinking and mental function.
7.Characterization of influenza epidemic in Changzhou City, Jiangsu Province from 2019 to 2023
Kaili CHENG ; Jingjing CAO ; Xianzhi ZHENG ; Qian ZHEN ; Gan CAO ; Xia JIANG ; Xufeng LYU
Shanghai Journal of Preventive Medicine 2023;35(11):1063-1067
ObjectiveTo analyze the epidemic intensity and characteristics of influenza in Changzhou City, Jiangsu Province from 2019 to 2023, and to provide scientific evidence for the formulation of influenza prevention and control strategies. MethodsThe surveillance data of influenza surveillance sentinel hospitals in Changzhou City from April 2019 to March 2023 were collected through the China influenza surveillance information system. Influenza-like illness (ILI) cases before and after the pandemic of COVID-19 in Changzhou City were analyzed, and the differences among qualitative data were compared by using χ² test. ResultsFrom April 2019 to March 2023 the percentages of ILI cases’ medical visits in the four-influenza surveillance year were 2.57%, 1.84%, 5.38%, and 3.66%, respectively, and the positive detection rates of influenza virus were 25.71%, 0.44%, 22.78%, and 24.32%, respectively. The number of influenza outbreaks was 61, 1, 23, and 128, respectively. ILI cases were mainly among adolescent children aged 5‒14 years. The percentage of ILI cases in 2020‒2021 after the pandemic of COVID-19 was significantly lower than that in 2019‒2020 (χ2=737.342, P<0.001), and the percentage of ILI cases in 2021‒2023 was higher than that in 2019‒2020. Influenza viruses in 2019‒2021 were dominated by type B Victoria, and influenza A virus was the dominant strain in positive influenza virus detections in 2022‒2023. The number of influenza outbreaks in 2021‒2023 was significantly lower than that in 2019‒2020 (χ2=185.662, P<0.001). ConclusionThe epidemiological characteristics of influenza are different in different stages of COVID-19 prevention and control during 2019‒2023. In the dynamic clearance phase of COVID-19, ILI case’s medical visits showed low-level fluctuations without obvious seasonal fluctuations, and influenza virus was dominated by type B. In the high-intensity phase of the pandemic, the level of ILI case’s medical visits has reached the peak of the calendar year, and the positive detection of influenza virus was dominated by type A H3N2. In the "Category B B control" phase, the level of ILI case’s medical visits increased after a rapid decline, and the positive detection of influenza virus was dominated by type A H1N1. It is necessary to further strengthen the monitoring of influenza cases, pay close attention to the changes in influenza strains, actively promote influenza vaccination for key population group, and promote health behavior changes for the whole population.
8.Effect of ultrasound-guided serratus anterior plane block on postoperative analgesia in patients undergoing laparoscopic radical gastrectomy
Zhongping CHENG ; Kaili YU ; Ruo WANG ; Xiaokun WANG ; Weihao LUO ; Yiqing YIN
Chinese Journal of Clinical Oncology 2024;51(1):23-26
Objective:To evaluate the effect of ultrasound-guided subserratus anterior plane block on postoperative analgesia in patients un-dergoing laparoscopic radical gastrectomy.Methods:Sixty patients who underwent elective laparoscopic radical gastrectomy were enrolled between May 2022 and October 2023 at Tianjin Medical University Cancer Institute&Hospital.Patients were assigned into two groups us-ing a random number table method:the control(group C)and the ultrasound-guided serratus anterior plane block(SAPB)(group S).Patient-controlled intravenous analgesia(PCIA)was administered at the end of the surgery.After surgery,visual analogue scale(VAS)of static pain scores was evaluated at 1,6,12,24,and 48 hours.PCIA pump was started at the VAS pain score≥4 after surgery,and sufentanil 0.1μg/kg was intravenously injected when the efficacy was inadequate.The requirement for PCIA use,time to first postoperative anal exhaust,first postoperative out-of-bed activity,first oral intake,and the duration of hospitalization stay were recorded for the two groups.Results:VAS scores were significantly lower at postoperative 1,6,and 12 h in group S than in group C(P<0.05).Additionally,the number of effective uses of PCIA,and rescue analgesia were significantly lower in group S[(6.1±0.4)(2)]than in group C[(18.6±1.4)(17)](P<0.001).The time to first postoperative anal exhaust,first postoperative out-of-bed activity,first oral intake,and duration of hospital stay were shortened in group S than in group C(P<0.05).There were no significant differences in other parameters between these two groups.Conclusion:Ultrasound-guided SAPB can reduce postoperative pain and facilitate fast recovery in laparoscopic radical gastrectomy patients.
9.Effect of ultrasound-guided internal branch of superior laryngeal nerve block on quality of anesthesia recovery in patients undergoing intracranial tumor surgery: a retrospective study
Zhongping CHENG ; Kaili YU ; Xin HE ; Ruo WANG ; Yajing YUAN ; Yiqing YIN
Chinese Journal of Anesthesiology 2024;44(3):282-285
Objective:To evaluate the effect of ultrasound-guided internal branch of superior laryngeal nerve(ibSLN) block on the quality of anesthesia recovery in the patients undergoing intracranial tumor surgery.Methods:The data from patients of either gender, aged 18-65 yr, with a body mass index of 18-28 kg/m 2, who underwent intracranial tumor surgery from December 2022 to October 2023, were retrospectively collected. Patients were divided into control group (group C) and ultrasound-guided ibSLN block group (group U). Bilateral ibSLN block was performed with 0.375% ropivacaine hydrochloride 2 ml.The tracheal extubation time, emergence time, development of cardiovascular events within 15 min after extubation, emergence agitation, Ramsay sedation score, Steward recovery score, visual analogue scale scores at 10 min after extubation and development of postoperative sore throat and hoarseness in postanesthesia care unit were recorded. Results:Compared with group C, the incidence of emergence agitation, Ramsay sedation score, visual analogue scale scores and sore throat were significantly decreased, the incidence of hoarseness was increased ( P<0.05), and no significant change was found in the extubation time, emergence time and Steward recovery score in group U( P>0.05). No hypertension, hypotension, tachachycardia and bradycardia were found in two groups. Conclusions:Ultrasound-guided ibSLN block can improve the quality of anesthesia recovery in the patients undergoing intracranial tumor surgery.
10.Multicenter Randomized Controlled Clinical Trial of Longmu Zhuanggu Granule in Treatment of Children Recurrent Respiratory Infection with Lung-Spleen Qi Deficiency Syndrome
Xin-lu ZHU ; Si-yuan HU ; Cheng-liang ZHONG ; Hong-fang LUO ; Yun-feng ZHANG ; Yue-xia ZHANG ; Mo-li GAO ; Hai-jun FENG ; Juan WU ; Ying DING ; Niu-an MENG ; Yu-hua BAI ; Wen-long YI
Chinese Journal of Experimental Traditional Medical Formulae 2021;27(23):111-117
Objective:To evaluate the clinical efficacy and safety of Longmu Zhuanggu granule for the treatment of children recurrent respiratory infection due to lung-spleen Qi deficiency. Method:This multicenter stratified, block-randomized, double-blind, double-dummy, positive drug (pidotimod granule) parallel controlled, and non-inferiority trail intended to included 240 children patients and divided them into the experimental group (