"Belt and Road" is not only a concept of space and international economic cooperation strategy,but also a China oriented culture framework in the area of globalization.The implementation of "Belt and Road Initiative" strategy needs to put culture first,while traditional Chinese medicine (TCM) culture is an important starting point to boost the "Belt and Road" construction.TCM culture communication with countries along "Belt and Road" should take strategies of overall communication,local communication and differentiation communication.And it also needs to promote the construction of TCM communication platform,to enrich TCM culture connotation,to build TCM culture brand and develop cultural and creative industries in TCM.