Objective Pancreatic neuroendocrine tumor( PNET) is a rare kind of tumor with slow growth for which surgery is the main treatment.The histological grading of PNET was closely related to the choice of operation mode and the comprehensive treat-ment after operation.Imaging examinations such as enhanced CT and MRI are of great value in the preoperative diagnosis of PNET. The aim of this study was to investigate the characteristic features of CT and MRI in the PNET. Methods Preoperative imaging data of 80 patients with PNET confirmed by pathology were reviewed, including CT and MRI, and the image features of each PNET were an-alyzed and the statistical analysis was performed. Results There were significant differences in the lesion morphology between the G1 and G2 levels of PNET.The majority of forms of the G1 stage PNET lesions presented round-like regular shape, but the G2 stage did not show regular shape.CT examination showed that regular morphological lesions accounted for 91.30%(21/23) in the G1 level, and 52.00%(13/25)in the G2 level,χ2 =8.857,P=0.003.MRI examination showed that regular morphological lesions accounted for 88.48%(22/27)in the G1 level, and 55%(11/20) in the G2 level, χ2 =3.862,P=0.050.The difference of scan density in PNET lesions was statistically significant.Low density lesions accounted for 73.91%(17/23)in the G1 level, and 32%(8/25)in the G2 level.Equidensity lesions accounted for 26.09%(6/23)in the G1 level, and 68.00%(17/25)in the G2 level,χ2 =8.842,P=0.004.The difference of bile pancreatic duct expansion in the G1 and G2 level lesions was statistically significant by MRI examination. Lesions with expanded pancreatic duct accounted for 7.41%(2/27)in the G1 level,and 40%(8/20) in the G2 level, χ2 =7.287, P =0.007.There was significant difference in the peak time after en-hanced scanning between the G1 and G2 levels.Lesion enhancement peak at the arterial phase by CT examination of accounted for 21.74%(5/23) in the G1 level,and 64%(16/25) in the G2 level,χ2 =8.694,P=0.003.Lesion enhancement peak at the arterial phase by MRI examination accounted for 29.63% (8/27) in the G1 level, and 70% (14/20) in the G2 level, χ2 =7.521,P=0.006. Conclusion The lesion morphology, density of CT plain scan, CT or MRI enhancement peak time, and expansion of the bile duct and pancreatic duct can provide reliable information to distinguish the G1 and G2 stage in PNET.

Burns ; complications ; therapy ; Cicatrix, Hypertrophic ; therapy ; Humans ; Keloid ; therapy

Circulating tumor cells (CTCs)are special kind of tumor cells in the peripheral blood of patient with tumor.Now CTCs detection has been used in the survival time prediction,post-operational recu-rrence detection,individualized treatment and other aspects in the patients with gastric cancer.As the research going,CTCs will provide new help for the comprehensive treatment of gastric cancer.

Objective To compare the curative effect of tension-free hernioplasty and transabdominal preperitoneal herniorrhaphy(TAPP)in adult patients with inguinal hernia.Methods A prospective randomized controlled study.A total of 240 patients with inguinal hernia were randomly divided into TAPP group and tension-free hernioplasty group(open group),120 patients in each.Results In both the groups,the surgical treatments were completed.The mean operation time in TAPP group was significantly longer than that in open group [(77?15)min vs(48?9)min,t=18.147,P=0.000],and the average cost for surgery in TAPP group was significant higher than that in open group [(7363?351)yuan vs(4635?242)yuan,t=72.663,P=0.000].However,the patients in TAPP group returned to activity and was discharged earlier than those in the open group [(6?1)h vs(10?2)h,t=-19.385,P=0.000;and(3?1)d vs(5?1)d,t=-15.300,P=0.000;respectively].No significant difference was detected in the severity of postoperative pain,complications,and recurrence rate between the two groups.Conclusion Both TAPP and tension-free hernioplasty are worth being wildly used.

Objective To explore the diagnosis and therapies of the lateral patellar compression syndrome.Methods This group included 21 cases(30 knees) of lateral patellar compression syndrome,with the average 45 years old(2 males and 19 females of 36～58 years old).All of the patients had obvious Clinical sings and symptoms,whose auxiliary examination was negative.It was almost as same as the Merchant classificasion of the lateral patellar compression syndrome.We adopt the lateral retinaculum release and debridement cartilage defects and drilling.Results All of the definitely diagnosised patients were reviewed with an average of 4 years follow-up visiting(range from 0.5 to 15 years) after operation.The rate of fineness is 96.7% in accordance with Ye Qibin's synthesis estimation for the ailing knee.Conclusion The lateral patellar compression syndrome is a common disease.The lateral retinaculum release and debridement cartilage defects and drilling is a good therapy with minor injury and significant effects for the severe or recurrent attacking lateral patellar compression syndrome.

Compressed oxygen in diaphragm-type compresesor currently used can easily cause fire,ex- plosion or damage.The reason for the causes was analysed and requirment for the oxygen was put forward. Proceed from the three aspect:selection of lubricating oil;replace of material quality and alarm for the di- aphragm broken;the problems of diaphragm-type compressor were finally settled.

Objective To investigate the effects of Hedan tablet on serum adipocytokines and inflammatory factors in rats with metabolic syndrome.Methods The 24-rat model of metabolic syndrome were randomly divided into three groups(n=8,each):normal group were given normal diet,model group were given high-lipid and high-salt diet and intervention group were given high lipid and high salt dict plus Hedan tablet 6.0 g · kg-1 · d-1 by intragastric administration for 3 weeks.Body weight,blood pressure,blood levels of glucose,lipid,leptin,visfatin,adiponectin and CRP were measured in all rats at the beginning and the end of the study.Results Compared with normal group,model group (model versus normal) showed significantly increased serum levels (P ＜ 0.05) of weight,total cholesterol(TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),glucose,leptin(5.5±0.1 vs.5.2±0.0 mmol/L),visfatin(17.5±0.5 vs.16.6±0.0 mmol/L and CRP(1 676.6 ± 74.8 vs.1 642.3 ± 52.2 mmol/L),and showed significantly decreased (P ＜ 0.05) serum level of adiponectin(74.6±2.4 vs.81.3±2.1 mmol/L).Compared with 20 weeks of age group,the 23 weeks of age group(23 weeks versus 20 weeks)showed significantly decreased levels of weight,TC,TG,LDL-C,serum leptin(5.4±0.1 mmol/L vs.5.9±0.2 mmol/L),visfatin(16.7±0.4 mmol/L vs.17.7±0.6 mmol/L)and CRP(1 498.8±51.0 mmol/L vs.1 682.1±76.6 mmol/L(all P＜0.05),and showed significantly increased serum adiponectin level(81.2±3.0 mmol/L vs.73.9±3.1 mmol/L)(P＜0.05).But there was no significant change in model group between 20 weeks and 23 weeks of age.Conclusions Hedan tablet reduces the body weight and ameliorates blood lipid level in rats with metabolic syndrome.These effects may be related to regulation of Hedan tablet on adipocytokines and inflammatory factors.

Objective To explore the effects of erythropoietin (EPO) on the expression of signal transducer and activator of transcription (STAT) 1,phosphorylated STAT1 (P-STAT1),STAT3,P-STAT3 and cell apoptosis in rat models of focal cerebral ischemia-reperfusion.Methods Eighty male SpragueDawley rats were randomly and evenly divided into four groups by completely random design method: shamoperation (group A),cerebral ischemia-reperfusion (group B),cerebral ischemia-reperfusion ± saline (group C) and cerebral ischemia-reperfusion ± EPO (group D).The model of focal cerebral ischemiareperfusion injury was established by blocking the left middle cerebral artery.All rats underwent MRI for the detection of the changes of infarct area between 2 h post ischemia and 24 h of reperfusion.Western blot was used to observe the expression of STAT1,P-STAT1,STAT3,P-STAT3.Terminal oxynucleotidyl transferase mediated dUTP biotin nick end labeling (TUNEL) was used to evaluate the cell apoptosis including the relative area (ROI area/whole brain area of the same layer × 100％) of abnormal signal region,relative optical density (rOD) and apoptotic index.One-way analysis of variance and q test were used to analyze the data.Results On T2WI imaging,rats in group B and group C presented large hyperintense areas in the cortex and subcortex of left hemispheric ((28.00±4.60)％ and (29.70±4.80)％ respectively).Group D presented less hyperintense areas in the cortex and subcortex of left hemispheric compared with group B and group C ((21.10±2.40) ％; F=11.285,P＜0.01).The expression of STAT1 and STAT3 proteins was not significantly affected by ischemia-reperfusion and EPO intervention compared with normal brain tissue (F=0.806,1.558,both P＞0.05).However,the level of P-STAT1 was low in group A (rOD =0.75±0.13) but increased after cerebral ischemia-reperfusion.Compared with group B and group C,P-STAT1 expression was lower in group D (B-D: 2.08±0.15,2.05±0.16,1.92±0.05; F=3.274,P＞0.05).The level of P-STAT3was also low in group A (rOD=1.02±0.09).Compared with group B and group C,P-STAT3 expression in group D was significandy higher (B-D: 2.22±0.13,2.04±0.14,4.21±0.21 ; F=40.719,P＜0.01).The apoptotic index of group B and group C was (42.00±1.30)％ and (41.20±2.50)％,respectively,which was significantly higher than that of group D ((20.90± 1.46) ％ ; F=378.704,P＜0.01).Conclusion Intraperitoneal injection of EPO can reduce the cerebral ischemic area and the number of apoptotic cells in the ischemic penumbra in rat ischemia-reperfusion models through increasing P-STAT3 and decreasing P-STAT1 levels.

Objective To evaluated the feasibility and accuracy of obtaining the myocardial perfusion image and coronary artery image of pig models of acute myocardial infarction by the second generation dual-source CT dual-energy myocardial perfusion one-stop scanning. Methods The pig models of acute myocardial infarction was established by using the interventional gelatin sponge embolism method on 5 pigs. The myocardial perfusion scanning and coronary angiography were respectively used 20 min before and 24-48 h after modeling. The heart were taken out immediately after the inspection for multiple punch biopsy and HE staining, then the heart was sliced for triphenyltetrazolium chloride (TTC) staining. According to the gold standard of coronary angiography and pathological staining, the sensibility and speciifcity of the coronary artery image of acute myocardial infarction of pig reconstructed by myocardial perfusion scanning and the myocardial perfusion image were respectively evaluated, and the consistency of the results was veriifed by Kappa test. Results Compared with the pathologic gold standard, the sensitivity, speciifcity, of myocardial perfusion iodine image obtained by myocardial perfusion scanning were 93%, 91%; and Kappa value was 0.68. Compared with the coronary angiography gold standard, the sensitivity and speciifcity of coronary artery image obtained by myocardial perfusion scanning were 93%, 81%, and Kappa value was 0.71. Conclusions The second generation dual-source CT dual-energy myocardial perfusionone-stopscanning can accurately get the coronary artery and myocardial perfusion images of the pig models of acute myocardial infarction.