1.Clinical significance of minimal residual disease in patients with Ph-negative precursor B-acute lymphoblastic leukemia.
Kai Qq LIU ; Hui WEI ; Dong LIN ; Ying WANG ; Chun Lin ZHOU ; Bing Cheng LIU ; Xing Li ZHAO ; Yan LI ; Hui Jun WANG ; Cheng Wen LI ; Qing Hua LI ; Ben Fa GONG ; Yun Tao LIU ; Xiao Yuan GONG ; Ying Chang MI ; Jian Xiang MI ; Jianxiang WANG
Chinese Journal of Hematology 2018;39(9):724-728
Objective: To explore the predictive value of minimal residual disease (MRD) level in Ph-negative precursor B-acute lymphoblastic leukemia (ALL) patients. Methods: De novo 193 Ph-negative B-ALL patients from Sep 2010 to Nov 2017 were involved in the study. The patients' MRD evaluation which can be performed by multiparametric flow cytometry (MFC) after 1 month, 3-month, 6-month treatment. Relapse free survival (RFS) and overall survival (OS) were compared in patients with different MRD level. Results: The median follow-up was 22 months. All patients was evaluated at 497 MRD level. Patients who reach the good MRD level at 1 month (<0.1% or ≥0.1%), 3-month (negative or positive), 6-month (negative or positive) had a significantly higher probability of estimated RFS (74.5% vs 29.9%; 75.6% vs 29.7%; 74.6% vs 11.6%) and of estimated OS (67.5% vs 30.3%; 71.6% vs 27.8%; 74.0% vs 15.7%). Patients who reach the MRD negative at all 3 times had a significantly higher probability of estimated RFS (80.5% vs 30.5%) and better estimated OS (77.1% vs 29.4%) compared to patients with at least MRD failure in one time (P<0.001). Multivariable analysis showed MRD level at 3-month was an independent prognostic factor for DFS and OS. Conclusion: MRD is an important prognosis factor for Ph-negative B- ALL patients.
Flow Cytometry
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Humans
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Neoplasm, Residual
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Prognosis
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Recurrence
Result Analysis
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