The auther experienced 9 cases of congenital syphilis in infant at Chonnam National University Hospital during the period from January to July 1968. Diagnosis was reached by the definite X-ray finding of bony structure followed by family history and positive specific serologic test for parents. Clinical improvement with penicillin thereapy in those cases was constant and impressive.
Diagnosis ; Humans ; Infant ; Jeollanam-do ; Parents ; Penicillins ; Serologic Tests ; Syphilis, Congenital

No abstract available.
Bacteroides fragilis* ; Bacteroides*

To evaluate the relationship between spontancous diuresis and improvement of pulmonary function in respiratory distress syndrome, 15 premature neonates requiring mechanical ventilation for RDS, who admitted in NICU of Wonkwang University Hospital from January 1990 to June 1992, were studied. The results were as follows (results are mean+/-SEM) 1) Mean birth weight of study infants was 1.82+/-0.08Kg, and mean gestational age was 32.80+/-0.54 weeks. 2) The onset of diuresis occured at a mean age of 29.1+/-2.48 hours with maximum diuresis at a mean age of 41.9+/-1.8 hours 3) Mean urine output increased from 2.25+/-0.43ml/Kg/hr at the stage of pre 12 hours-onset of diuresis (p<0.001), then decreased 3.5+/-0.2ml/Kg/hr at the stage of after maximum diuresis (p<0.05). 4) After maximum diuresis, inspired oxygen gradient, peak inflating pressure, peak end expiratory pressure, mean airway pressure, and respiratory rate were decreased significantly (p<0.05), and alveolar-arterial oxygen gradient was decreased more significantly (p<0,01). So, We conclude that the pulmonary function was rapidly improving after maximum diuresis and these changes reflect the general principle used in ventilatory management of infants with RDS.
Birth Weight ; Diuresis* ; Gestational Age ; Humans ; Infant* ; Infant, Newborn ; Oxygen ; Respiration, Artificial ; Respiratory Rate

Uterine perforation is a serious complication in users of intrauterine devices for contraception. Authors encountered one case of displacement of Copper-T IVD into urinary blpossibly due to uterine perforation on insertion of the Copper-T IUD in a 28 year old 1-multipara, who experienced normal intrauterine pregnancy in the circumstances. This patient was in silent, asymptomatic condition and underwent cesarean section. And Copper-T IUD was removed under the cystotomy. So we report one case with brief review of literatures
Adult ; Asymptomatic Diseases ; Cesarean Section ; Contraception ; Copper* ; Cystotomy ; Female ; Humans ; Intrauterine Devices ; Pregnancy ; Urinary Bladder* ; Uterine Perforation

OBJECTIVES: MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To elucidate the role of p53 and MDM-2 protein in cervical neoplasia we investigated the expression rates of MDM-2 and p53 protein in surgically resected specimens. METHEDS: Immunohistochemical studies using anti-p53 and anti-MDM-2 protein in the paraffin embedded section of 62 cases including cervical intraepithelial neoplasm(CIN) and invasive cervical cancer were performed. RESULTS: Expression rates of p53 protein were 25% in CIN I& CINII, 20% in CINIII, and 44% in invasive carcinoma, respectively. The MDM-2 protein were 33% in CIN I & CIN II, 16% in CIN III, and 48% in invasive carcinoma, respectively. There was no evident correlation between p53 positivity and MDM-2 positivity(p>0.05). However, correlation between MDM-2 negativity and p53 negativity was statistically significant(p=0.002) CONCLUSION: These data suggest that the expression of p53 protein is presumed to be necessarily correlated with MDM-2 protein expression in cervical neoplasia.
Carcinogenesis ; Humans ; Paraffin ; Proto-Oncogene Proteins c-mdm2* ; Tumor Suppressor Protein p53 ; Uterine Cervical Neoplasms

BACKGROUND AND OBJECTIVES: Endoscopic paranasal sinus surgery is effective for the treatment of paranasal sinus lesion and reduction of invasiveness enabling the surgeon to perform precise procedures with minimal tissue traumatization. But, some studies showed that there was a risk of invasive management and major complications occurring in 0.5% to 1% of all procedures. The aim of this study was to assess the usefulness and effectiveness of image-guided endoscopic surgery in reducing the complication and treating the disease suitably. SUBJECTS AND METHOD: The image-guided paranasal sinus surgery was performed in 12 patients from 2000 to 2005 who had difficulty in endoscopic surgery for the diagnosis and treatment of the inaccessible location such as skull base, sphenoid and clivus, infratemporal fossa etc. and the uncertain lesion such as severe distorted lesion due to previous sinus operation, congenitally underdeveloped anatomic lesion, nearby vital organ-lesion and submucosal lesion in our experiences. We retrospectively reviewed radiologic evaluations and medical records in our patients. RESULTS: We included 6 oncogenic lesions such as craniopharyngioma, chordoma in clivus and sphenoid sinus, 5 infectious lesions such as invasive aspergillosis and 1 cystic lesion. The accuracy we could achieve varied between 0.9 and 2.0 mm. CSF rhinorrhea occurred in 2 cases after management. But, only one case was not only related to image-guided surgery but also resolved spontaneously. CONCLUSION: Image-guided endoscopic surgery is a safe and effective tool in paranasal sinus and skull base lesion for maximizing surgical results and limiting complications.
Aspergillosis ; Chordoma ; Cranial Fossa, Posterior ; Craniopharyngioma ; Diagnosis ; Endoscopy ; Humans ; Medical Records ; Paranasal Sinuses ; Retrospective Studies ; Skull Base* ; Skull* ; Sphenoid Sinus ; Surgery, Computer-Assisted*

PURPOSE: The purpose of this study was to evaluate compartmental changes using combined single-photon emission computerized tomography and conventional computerized tomography (SPECT/CT) after open wedge high tibial osteotomy (OWHTO) for providing clinical guidance for proper correction. MATERIALS AND METHODS: Analysis was performed using SPECT/CT from around 1 year after surgery on 22 patients who underwent OWHTO. Postoperative mechanical axis was measured and classified into 3 groups: group I (varus), group II (0°–3° valgus), and group III (>3° valgus). Patella location was evaluated using Blackburne-Peel (BP) ratio. On SPECT/CT, the knee joint was divided into medial, lateral, and patellofemoral compartments and the brighter signal was marked as a positive signal. RESULTS: Increased signal activity in the medial compartment was observed in 12 cases. No correlation was observed between postoperative mechanical axis and medial signal increase. Lateral increased signal activity was observed in 3 cases, and as valgus degree increased, lateral compartment’s signal activity increased. Increased signal activity of the patellofemoral joint was observed in 7 cases, and significant correlation was observed between changes in BP ratio and increased signal activity. CONCLUSIONS: For the treatment of medial osteoarthritis, OWHTO requires overcorrection that does not exceed 3 valgus. In addition, the possibility of a patellofemoral joint problem after OWHTO should be kept in mind.
Humans ; Knee ; Knee Joint ; Osteoarthritis ; Osteotomy ; Patella ; Patellofemoral Joint ; Tomography, Emission-Computed, Single-Photon

PURPOSE: The purpose of this study is to compare the clinical and radiological results between posteromedial portal technique and posterior transseptal portal technique in making a tibial tunnel in single bundle posterior cruciate ligament (PCL) reconstruction with remnant preservation. MATERIALS AND METHODS: Thirty-three cases of posteromedial portal technique and 35 cases of posterior transseptal portal technique in making a tibial tunnel in single bundle PCL reconstruction with remnant preservation were evaluated retrospectively. The clinical evaluation, including function and stability, was assessed. The tibial tunnel placement was measured using computed tomography. RESULTS: At final follow-up, the clinical results showed significant improvement compared to preoperation in both groups. There were no significant differences in clinical results including function and stability in both groups. The centers of tibial tunnels by posteromedial portal technique were placed more medially and proximally than those of the posterior transseptal portal technique. CONCLUSION: Remnant preserved single bundle PCL reconstructions by posteromedial portal technique and posterior transseptal portal technique were good methods for restoring function and stability compared to preoperation. There were no significant differences in clinical results in both groups. However, the tibial tunnels by posteromedial portal technique tended to be more medial and proximal placements than those of the posterior transseptal portal technique.
Follow-Up Studies ; Posterior Cruciate Ligament* ; Retrospective Studies

Candidal infection is recently reported to increase in certain predisposing condition, although isolated candidiasis from larynx is infrequently recognized and reported. Iisolated whitish lesions of vocal cord may be confused with precancerous lesions, squamous cell carcinoma, or verrucous carcinoma. A 62-year-old male visited our department for continuous hoarseness. Flexible laryngoscopy disclosed a whitish irregular exophytic mucosal lesion in right true vocal cord, which extended to anterior commissure and subglottis. Laryngeal microscopic surgery was done because of a concern regarding the possibility of glottic cancer. A pathologic biopsy revealed distorted and septated hypae and yeasts, scattered in moderate dysplasia. The patient was treated with itraconazole for 4 weeks, and followed up without any recurrence of candidiasis or dysplasia.
Biopsy ; Candidiasis* ; Carcinoma, Squamous Cell ; Carcinoma, Verrucous ; Hoarseness ; Humans ; Itraconazole ; Laryngoscopy ; Larynx ; Male ; Middle Aged ; Recurrence ; Vocal Cords* ; Yeasts

Retropharyngeal hematomas are relatively rare. But, they are clinically important because of the close proximity of the retropharyngeal space to the upper airway. The authors experienced four cases of the retropharyngeal hematoma following cervical trauma, esophageal foreign body, stellate ganglion block, and discuss the diagnosis and treatment of individual condition.
Airway Obstruction ; Diagnosis ; Foreign Bodies ; Hematoma* ; Stellate Ganglion