Objective To observe the effects of vitamin C (VC) and E (VE) on the uhrastrueture of liver, kidney and brain tissue of fluorosis rats. Methods One hundred and twenty Wistar rats were chosen as the experimental animals and were divided into 9 groups randomly. The control group were given distilled water and the fluoride exposed group were given distilled water containing sodium fluoride 150 mg/L. The throe VC-fluoride exposed groups were given VC orally in a dose of 50,100,150 mg·kg-1.d-1, respectively, and the three VE-fluoride exposed groups were given VE of 25,50,75 mg·kg-1·d-1, respectively. The VC-VE-fluoride exposed group were given VC of 100 mg·kg-1·d-1and VE of 50 mg·kg-1·d-1at the same time of high fluoride water intake. The rats were sacrificed after 9 months and the ultrastructure changes on liver, kidney and brain tissues of each group were observed under transmission electron microscope(TEM). Results The uhrastrueture of liver, kidney and brain showed pathologic changes in the rats that drank water containing high eoneentrations of sodium fluoride. ①Edema of hepatocytes, smeared mitochontria and nuclear matrix, lipid droplet in eytoplasm of hepatocytes, margination of nueleohs as well as obvious swelling of liver sinusoidal endothelial were observed in fluoride exposed group. ② There were marginafion of heterochromatin, expansion of cell space and endoplasmic reticulum in the kidney after the exposure to excess fluoride.③Signifieant changes were found on glial eells on the brain, including cell swelling, increase and marginafion of heterochromatin in the fluoride exposure group. There were no significant uhrastrueture changes in the VC or VE intervention group, while the VC-VE-fluoride exposure group was almost the same as the control group. Conclusions Fluoresis may cause damage on liver, kidney and brain in rats. VC and VE, alone or combined, have protective effects, and the combined supplementation was stronger than single supplementations.

Objective: To compare the differences of dietary behavior between autistic children and normal children, and to explore the dietary behavior problems and their influencing factors in autistic children, so as to provide theoretical basis for improving dietary behavior problems and guiding scientific feeding of autistic children. Methods: 113 autistic children aged 2-7 from a hospital and an autism rehabilitation training institution in Urumqi were selected as the case group and 223 children aged 2-7 from a hospital in Urumqi as the control group. Results: The results showed that there were significant differences between the two groups in the main type of care, caregiver education, caregiver occupation and monthly per capita economic income(P<0.05). The scores of picking food, food response, unhealthy eating habits, overeating response and emotional eating were significantly higher in the case group than in the control group, while the scores of extrinsic eating and active eating ability were significantly lower in the case group than in the control group(P<0.05). Conclusion The main dietary problems of autistic children include severe picky eating, food response to different degrees, over fullness response, bad eating behavior, emotional eating and so on.

Objective: To understand the dietary nutritional status of AIDS orphans aged 7-12 in Urumqi, and to provide a scientific basis for promoting growth, development and health. Methods: Using a random sampling method, a total of 309 children aged 7-12, from Urumqi were selected. The sample included 98 orphans with AIDS, 66 orphaned children not affected by AIDS, and 145 cases of non orphaned children. A 24 hour diet review method was used to record the diet of all three groups of children who received three meals per day, energy levels and the nutrient intake of AIDS orphans and their attainment were analyzed according to the daily recommended nutrient intake (RNI) of Chinese residents. Results: The detection rate of wasting in the AIDS orphans group was 44.9%, which was higher than that in the orphans without AIDS group (40.9%) and the non orphaned group ( 28.2 %); the overweight rates of AIDS orphans and orphans without AIDS were 3.1% and 3.0%, respectively, which were both lower than those of non orphaned children (8.3%); the average daily intake of energy and dietary nutrients in the AIDS orphans group was lower than that in the other two groups, and the intake of vitamin A, vitamin B 2, vitamin B 6, vitamin C,vitamin D, folic acid, calcium, zinc, and iron was seriously insufficient, the intake of food grains, vegetables, fruit, eggs, milk and dairy products, and the average daily intake of oil was lower among AIDS orphans than orphans without AIDS and non orphaned children, additionally,except for food grains,eggs, there were significant differences between the three groups ( F =3.02，5.23，27.86，16.59， P <0.05), and the daily intake of vegetables, aquatic products, eggs and milk in AIDS orphans and orphans was lower than the recommeded intake. Conclusion A higher rate of wasting, unbalanced nutrient intake, and poor nutritional status was found among AIDS orphans aged 7-12 in Urumqi. Therefore, there is a need to improve the dietary structure of AIDS orphans with the aim of promoting healthy development.

ObjectiveTo investigate the prevalence of high-risk HPV infection among women in Kashgar area， analyze related risk factors， conduct follow-up and health education interventions for positive cases in the past three years， and assess intervention outcomes to improve HPV screening awareness and reduce cervical cancer incidence. MethodsThis study randomly selected 571 women from Kashgar who underwent HPV screening as part of a health check-up in the First People’s Hospital of Kashgar between January 2021 and June 2023. High-risk HPV-DNA was detected using the PCR-RDB method. Based on the test results， participants were divided into HPV-negative and HPV-positive groups， and the infection rates and associated risk factors were analyzed. Additionally， follow-up was conducted for women who tested positive for high-risk HPV during the screening to assess the effectiveness of health management interventions. ResultsFrom 2021 to 2023， the high-risk HPV positive rate among women in Kashgar showed a year-on-year decline， recorded at 19.15%， 16.43%， and 11.30%， respectively （P<0.001）， with a total of 3，921 cases （16.13%） testing positive for high-risk HPV during this period. Uyghur women had a significantly higher infection rate compared with those of Han nationality and other ethnic minorities （P<0.05）. Risk factors included age， age at first sexual activity， number of sexual partners， contraceptive methods， and a history of vaginal inflammation （P<0.05）. Health management interventions significantly improved participants’ awareness scores regarding cervical cancer prevention and the proportion of women voluntarily receiving HPV vaccination （P<0.05）. ConclusionsHigh-risk HPV infection among Uyghur women in Kashgar area is relatively high， with single infection of HPV-16 and HPV-52 and mixed infections of HPV-16 +HPV-52 and HPV-16 +HPV-58 being predominant. Risk factors include age at first sexual activity， number of sexual partners， contraceptive methods， and history of vaginal inflammation. Through triple-education interventions， the incidence of cervical cancer in Kashgar has been effectively reduced， and standards for primary-level diagnosis， treatment， and health supervision have been improved.

ObjectiveTo investigate the incidence and influencing factors of postpartum depression and anxiety in Urumqi during the coronavirus disease （COVID-19） epidemic period in 2020. MethodsResearch subjects were the parturients who underwent postpartum health checkups in a third class hospital in Urumqi from January 2020 to December 2020. The maternal socio demographic and obstetric information were collected， and PHQ-9 and GAD-7 scales were used for screening of PPD and PPA. Calcaneal bone mineral density of the parturients was measured by French Pegasus ultrasonic bone densitometer. After univariate analysis of the related influencing factors of PPD and PPA， multivariate binary logistic regression analysis was used to explore the relationship between mental disorders and various influencing factors. ResultsA total of 2 490 puerpera participated in the survey. The incidences of PPD and PPA in 2020 were 13.4 % and 10.8 %， respectively. Six factors with statistical differences after univariate analysis were included in multivariate binary logistic regression analysis. The final results suggested that age over 35 （OR=1.707，95%CI：1.142‒2.551）， unemployment （OR=1.478，95%CI：1.003‒2.205）， multipara（OR=1.340，95%CI：1.037‒1.733）， bone loss and osteoporosis （OR=1.434，95%CI： 1.076‒1.910） were the risk factors of PPD， while breastfeeding （OR=0.466，95%CI： 0.301‒0.721） was a protective factor. Ages between 18‒24 （OR=1.559，95%CI：1.282‒3.097） and cesarean section （OR=1.433，95%CI： 1.105‒1.859） were the risk factors of PPA， while ages between 30‒34 years old （OR=0.524，95%CI： 0.332‒0.827）， occupation as medical staff （OR=0.282，95%CI： 0.807‒0.919）， breastfeeding （OR=0.530，95%CI： 0.330‒0.850） were protective factors. ConclusionIncidences of PPD and PPA are in middle-low levels during COVID-19 epidemic period. Age， occupation， delivery mode， delivery times， feeding pattern and bone mineral density are the influencing factors. Screen coverage of PPD and PPA in special period should be strengthened， and measures should be taken to reduce the risk.