Biomedical Research ; organization & administration ; trends ; Singapore

A case of osteosarcoma in a 14 month old girl is reported. The child presented with a history of difficulty in standing for 2 months and x-rays revealed an osteolytic lesion in the upper third of the femur associated with widening of bone and periosteal reaction. Osteosarcoma was diagnosed by biopsy. Treatment was refused and the child died 13 weeks later. Only one other case of osteosarcoma in a child as young as 14 months has been reported. A review of literature showed 22 cases of osteosarcoma in children aged 5 years or younger.
Age Factors ; Child, Preschool ; Female ; Femoral Neoplasms ; pathology ; Humans ; Infant ; Male ; Osteosarcoma ; pathology

Humans ; Singapore ; Sports Medicine

Female ; Gynecologic Surgical Procedures ; methods ; Humans ; Laparoscopy ; Pregnancy ; Pregnancy Complications ; Pregnancy, Ectopic ; diagnostic imaging ; physiopathology ; surgery ; Pregnancy, Tubal ; surgery ; Radiography ; Treatment Outcome ; Uterus ; abnormalities ; Young Adult

Cognition ; Diagnostic Errors ; psychology ; Humans ; Physicians ; psychology ; Thinking

Epilepsy ; drug therapy ; Humans ; Public Opinion ; Quality of Health Care ; Quality of Life

Stricture, NOS ; MALAYSIAN

INTRODUCTIONWe report a case of successful rehabilitation of hearing with a cochlear implant in a patient with nasopharyngeal carcinoma who developed post-irradiation hearing loss following treatment.

CLINICAL PICTUREA 55-year-old Chinese lady suffered from radiation-induced sensorineural hearing loss due to treatment for nasopharyngeal carcinoma. Audiological tests and imaging studies showed an intact retrocochlear pathway.

TREATMENTCochlear implantation.

OUTCOMECochlear implant was done with successful rehabilitation of hearing until the time of this report.

CONCLUSIONSIf functionally active auditory fibres survive with no recurrent tumour, successful rehabilitation of post-irradiation induced sensorineural hearing loss is possible with a cochlear implant in a patient with nasopharyngeal carcinoma.

Audiometry, Evoked Response ; Cochlear Implants ; Female ; Hearing Loss ; etiology ; rehabilitation ; Hearing Loss, Sensorineural ; etiology ; rehabilitation ; Humans ; Middle Aged ; Nasopharyngeal Neoplasms ; radiotherapy

While there is an ethical obligation to improve clinical outcomes by developing better therapies, surgical innovation has largely progressed without the strict regulations required of novel pharmaceutical products. We explore the reasons why new surgical techniques are frequently introduced without the benefit of randomised controlled trials, and present an approach to the ethical evaluation of novel surgical procedures.
Biomedical Research ; ethics ; Clinical Competence ; Diffusion of Innovation ; Ethics, Medical ; General Surgery ; ethics ; methods ; standards ; Humans ; Informed Consent ; Medical Audit ; Medicine ; Singapore ; Specialty Boards

Antirheumatic Agents ; therapeutic use ; Arthritis, Rheumatoid ; complications ; drug therapy ; Atlanto-Axial Joint ; injuries ; Humans ; Joint Dislocations ; etiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Syringomyelia ; diagnosis ; etiology ; physiopathology