1.Mismatched bone marrow transplantation for severe aplastic anaemia after liver transplantation for associated acute liver failure.
Vidyadhar P MALI ; Poh Lin TAN ; Marion AW ; Lincoln D S K LOH ; Seng Hock QUAK ; Krishnakumar MADHAVAN ; Prabhakaran KRISHNAN
Annals of the Academy of Medicine, Singapore 2011;40(9):420-421
2.MARS liver dialysis in children with acute liver failure.
M Da COSTA ; M K H LEE ; H L LEE ; M AW ; K H LEE ; K B PHUA ; K PRABHAKARAN ; S H QUAK
Annals of the Academy of Medicine, Singapore 2004;33(5 Suppl):S73-4
3.Expanding the donor pool for liver transplantation in the setting of an "opt-out" scheme: 3 years after new legislation.
Victor T W LEE ; Chan Chung YIP ; Iyer Shridhar GANPATHI ; Stephen CHANG ; Kenneth S W MAK ; K PRABHAKARAN ; Krishnakumar MADHAVAN
Annals of the Academy of Medicine, Singapore 2009;38(4):315-317
INTRODUCTIONThe revised Human Organ Transplant Act (HOTA) was implemented in Singapore in July 2004. We aim to evaluate expanding the potential donor pool for liver transplant in Singapore with the inclusion of marginal donors.
MATERIALS AND METHODSAll donor referrals between July 2004 and June 2007 were studied. All potential deceased liver donors were heart-beating. After being reviewed by the transplant coordinator, potential donors were assessed by a transplant hepatologist and a transplant surgeon for suitability of organ donation strictly based on the programme's donor assessment protocol. Reasons for rejection as potential donors were documented. The clinical characteristics of all donor referrals were retrospectively reviewed, and an independent decision was made as to whether liver retrieval in each rejected case might have been possible.
RESULTSAmong the 128 potential donor referrals, 20 donors (15.6%) underwent liver retrieval. Of the 20 livers retrieved, 16 were implanted and 4 were not implanted (3 unfit recipients, and 1 donor liver with 40% steatosis). Another 10 donor livers were assessed intraoperatively and were rejected because of varying levels of steatosis. Of these livers assessed, 5 donor livers had steatosis <40% and 5 had steatosis >40%. Of the remaining potential donors, 45 were deemed not possible because of prolonged hypotension (9), on-going or unresolved sepsis (13), high-risk behaviour (4), non-actualisation (8), or pre-existing medical conditions (11). Another 53 donors may potentially have been suitable donors but were rejected because of possible sepsis (13), no suitable recipients (12), transient hypotension (10), transient abnormal liver function test (6), history of alcohol ingestion (5), non-actualisation because of consent (4) and other reasons (3). Overall, it was deemed that 61 donors (47.7%) might potentially have been suitable liver donors.
CONCLUSIONSDespite new legislation (HOTA) in Singapore, the utilisation of cadaveric donor livers showed no increase in the last 3 years. By expanding our donor criteria to include marginal donors, we could potentially increase the availability of deceased donor livers to meet our waiting list demands.
Adult ; Female ; Humans ; Liver Transplantation ; Living Donors ; legislation & jurisprudence ; supply & distribution ; Male ; Middle Aged ; Referral and Consultation ; organization & administration ; Retrospective Studies ; Singapore ; Tissue and Organ Procurement ; legislation & jurisprudence ; Waiting Lists
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