Objective To investigate the hypoglycemic effects of the ethanol extracts of Plantago asiatica in different diabetes animal models.Methods The different diabetes animal models (adrenaline -induced hyperglyce-mic models,glucose -induced hyperglycemic models,alloxan -induced hyperglycemic models)have been applied. Results Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(10.26 ±1.76)mmol/L] possessed obviously hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =2.558,P <0.01)and the middle dose[(11.74 ±2.35)mmol/L]possessed hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =1.524,P <0.05 );Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(11.38 ±1.76)mmol/L]possessed obviously hypoglycemic effects on glucose -induced hyperglycemic mice[(16.15 ±2.49)mmol/L](t =2.710,P <0.01 )and the middle dose [(13.01 ±3.23)mmol/L]possessed hypoglycemic effects on glucose -induced hyperglycemic mice(t =1.334,P <0.05);In addition,the ethanol extracts of Plantago asiatica could significantly inhibit the rise of blood glucose level and had certain hypoglycemic effect on halloxan -induced diabetic mice.Conclusion The ethanol extracts of Planta-go asiatica have a significant role in lowering blood glucose at a certain extent.

Objective To analyze the effect of non -xanthine adenosine receptor antagonist (SLV320)on the ventricular remodeling and renin -angiotensin -aldosterone system (RAAS)in animal experimental models of chronic heart failure (CHF).Methods The 40 healthy male New Zealand rabbits were received adriamycin by intra-venous injection to establishing the experimental animal models and were randomly divided into 4 groups,which were high -dosage group (injected with SLV320,10.0μg·kg -1 ·d -1 ),medium -dosage group (injected with SLV320, 5.0μg·kg -1 ·d -1 ),low -dosage group (injected with SLV320,2.5μg·kg -1 ·d -1 )and furosemide group (fed with furosemide,2.0mg·kg -1 ·d -1 ).Each group had 10 rabbits and continuous treated for one week.The indexes of plasma renin activity (PRA),angiotensinⅡ (AngⅡ),aldosterone (ALD)and beta ntriuretic peptide (BNP)were detected at pre -and post -treatment,and compared among 4 groups.The indexes of left ventricular end -systolic dimension (LVESD),left ventricular end -diastolic dimension (LVEDD),left ventricular posterior wall (LVPW), left ventricle ejection fraction (LVEF),left ventricular fractional shortening (LVFS)and E /A at pre -and post -treatment were detected by echocardiography and compared among 4 groups.The wet weigh of the left and right ventri-cle were weigh accurately.And the indexes of left ventricle weight index (LVWI)and the body weight index (BWI) were calculated and compared among 4 groups.Results The plasma levels of PRA,AngⅡ,ALD and BNP were no different among 4 groups before study (all P >0.05).The sequence of 4 groups on the plasma levels of RAAS indexes was high -dosage group 0.05).The sequence of 4 groups on the levels of LVEF and LVFS was high -dosage group >medium -dosage group >low -dosage group >furosemide group,and the sequences of LVESD,LVEDD,LVPW and E /A were high -dosage group

Objective To study the clinical effect of Fufangqiaoruisu granule in the treatment of children with bronchial asthma.Methods 152 children with bronchial asthma were randomly divided into treatment group and control group.All the patients were treated with based therapy,and the patients in the control group were treated with montelukast,the patients in the treatment group received montelukast/Fufangqiaoruisu granule.The clinical symptoms such as cough,asthma were compared,and also the total effective rate.Results The disappear time of clinical symp-toms of cough,ashma,moist rale in the treatment group were (3.8 ±1.0) days,(3.5 ±0.8) days,and (2.1 ± 0.6)days,which were much shorter than (5.2 ±0.7)days,(4.7 ±0.9)days,(3.0 ±0.5)days in the control group, the differences were statistically significant(t =4.56,5.12,4.89,all P <0.05).After treatment,the FVC,FEV1 and PEF in the treatment group were (4.9 ±1.7)L,(3.8 ±0.6)L and (3.9 ±0.5)L/min,which in the control group were (3.2 ±1.2)L,(2.1 ±0.8)L and (2.8 ±0.5)L/min,(t =5.12,4.87,5.32,all P <0.05).The total effective rate of the observation group was 92.1%,which of the control group was 73.7%,the difference was statistically significant(χ2 =1.62,P =0.027).Conclusion Fufangqiaoruisu granule shows satisfactory clinical efficacy in the treatment of bronchial asthma,and it is worthy of clinical use.

Objective To investigate the immunomodulatory effects of lyophilized royal jelly ( LRJ) on immunoglobulin IgG,IgA,IgM and complement C3 and C4 in patients with low immunity ,and to evaluate the clinical efficacy of LRJ.Methods A self-controlled clinical study of immunomodulatory efficacy of LRJ was performed in 32 patients with low immunity.Every patient took orally LRJ,two times a day.The hepatic function AST,ALT,and immunoglobulin IgG,IgA,IgM and complement C3,C4 were assayed after treatment for 28 days,and then the efficacy and safety of LRJ were evaluated.Results After took orally LRJ,the levels of IgG,IgA,and IgM [(10.31 ±2.03)g/L, (1.69 ±0.55)g/L,(1.51 ±0.55)g/L] were significantly higher than those before treatment [(8.52 ±1.94)g/L, (1.38 ±0.57)g/L,(1.36 ±0.55)g/L](t=5.21,2.25,1.56,all P<0.05),and the levels of C3 and C4 after treatment were significantly higher than before treatment [(0.93 ±0.15) g/L,(0.30 ±0.07) g/L vs (0.83 ± 0.12)g/L,(0.26 ±0.08)g/L] (t=1.94,1.78,all P<0.05).However,there were no significant differences in the levels of AST and ALT before[(38.17 ±12.84)U/L,(32.63 ±12.81)U/L] and after [(36.13 ±11.47)U/L, (31.83 ±12.36)U/L] treatment (t=0.82,0.44,all P>0.05).Conclusion LRJ can increase the levels of immu-noglobulin IgG,IgA and IgM,thus to improve the symptoms of patients with low immunity .

Objective To investigate the effect of Astragalus Polysaccharide on peripheral circulation myeloid derived suppressor cells (MDSC) in lung cancer and its clinical effect. Methods 100 patients with advanced non small cell lung cancer were selected and divided into 2 groups, 50 cases in the control group treated with chemotherapy aalone, 50 cases in the experiment group received injection of Astragalus Polysaccharide on the basis of the control group, peripheral blood MDSC levels, peripheral blood T lymphocyte subsets levels, serum ARG I activity, TNF-α, IL-6 levels, the clinical effect and incidence of adverse reactions were compared after the treatment. Results Compared with the control group, peripheral blood levels of MDSC (Lin-HLA DR-\CD33+\CD11b+) was lower after treatment in the experiment group , peripheral blood levels of CD3+, CD4+T lymphocytes and CD4+/CD8+ were higher, and CD8+T lymphocytes level was lower after treatment, serum levels of ARG I activity, TNF-α, IL-6 levels were lower after treatment, (P<0.05) , the total effective rate in the control group(42.0%)was lower than the experiment group(64.0%), (P<0.05), the incidence of gastrointestinal reaction(40/24), 3 ~ 4 degree of leukocyte reduction(26/12), liver function damage(19/9), renal damage(17/7) in the control group were higher than the experiment group (P<0.05). Conclusion Astragalus Polysaccharide can significantly reduce the peripheral circulation MDSC (Lin-HLA DR-\CD33+\CD11b+) level in patients with lung cancer, improve T lymphocyte immune function, inhibit the activity of serum ARG I, reduce the level of TNF-αand IL-6, effectively improve the clinical efficacy, and reduce the toxic and side effects of chemotherapy.

Objective:To investigate the effectiveness and safety of docetaxel combined with cisplatin in the second-line treatment of advanced non-small cell lung cancer in older adult patients.Methods:120 older adult patients with advanced non-small cell lung cancer who received second-line treatment in Jiaozhou People's Hospital from January 2017 to December 2019 were included in this study. They were randomly assigned to undergo treatment with docetaxel (control group, n = 60) or docetaxel + cisplatin (observation group, n = 60). Clinical efficacy and complications were compared between the two groups. Results:After chemotherapy, short-term total response rate was significantly higher in the observation group than in the control group [70.00% (42/60) vs. 33.33% (20/60), χ2 = 16.15, P < 0.05]. Serum levels of carcinoembryonic antigen, carbohydrate antigen 125, cytokeratin 19-fragment CYFRA21-1 were (22.57 ± 3.22) μg/L, (48.61 ± 5.42) U/mL, (10.61 ± 1.64) μg/L, respectively in the observation group, which were significantly lower than those in the control group [(35.52 ± 4.46) μg/L, (69.64 ± 7.75) U/mL, (14.26 ± 1.95) μg/L, t = 18.23, 17.22, 11.09, all P < 0.001]. The percentages of CD 3+ and CD 4+ cells were (78.31 ± 8.09)% and (48.63 ± 5.74)%, respectively in the observation group, which were significantly higher than those in the control group [(69.58 ± 7.26)%, (39.82 ± 4.25)%, t = -6.22, -9.55, both P < 0.001]. The percentage of CD 8+ was significantly lower in the observation group than in the control group [(22.64 ± 3.82)% vs. (26.77 ± 4.01)%, t = 5.77, P < 0.001). The 1-year survival was significantly higher in the observation group than in the control group ( χ2 = 4.05, P < 0.05). There was no significant difference in the incidence of adverse reactions during chemotherapy between the two groups ( P > 0.05). Conclusion:Docetaxel combined with cisplatin is highly effective on advanced non-small cell lung cancer in older adult patients. The combined therapy can decrease serum tumor marker levels, improve immune function, and increase 1-year survival rate. It is safe and provides reliable efficacy and thereby is worthy of clinical promotion.

Objective:To investigate the clinical efficacy of Ginkgo biloba diterpenoid lactone glucosamine combined with edaravone dextrogenol in the treatment of acute ischemic stroke in patients as well as its effect on neurological function and levels of inflammatory factors.Methods:A retrospective case-control study was conducted on the clinical data of 86 patients with acute ischemic stroke who received treatment at Jiulong Hospital of Jiaozhou from December 2021 to October 2023. The patients were divided into two groups based on their treatment regimens, with 43 patients in each group. Both groups received standardized conventional treatment. The control group received additional treatment with edaravone dextrogenol, while the observation group was given Ginkgo biloba diterpenoid lactone glucosamine in addition to the treatments provided to the control group. All patients were treated for 14 days. The clinical efficacy of both groups was assessed. The National Institutes of Health Stroke Scale score, serum C-reactive protein level, and lipoprotein-associated phospholipase A2 level were compared before and after treatment. The incidence of adverse reactions during the whole treatment period was compared between the two groups.Results:After 14 days of treatment, the National Institutes of Health Stroke Scale score in the observation group was (7.09 ± 2.15) points, which was significantly lower than that of the control group [(8.23 ± 2.97) points, t = -2.04, P = 0.045]. The clinical efficacy of the observation group was significantly superior to that of the control group ( Z = 1.62, P = 0.011). The serum levels of C-reactive protein and lipoprotein-associated phospholipase A2 in the observation group were (14.53 ± 5.05) mg/L and (169.95 ± 17.62) μg/L, respectively, which were significantly lower than those in the control group [(16.88 ± 5.46) mg/L, (178.53 ± 20.34) μg/L, t = -2.07, -2.09, P = 0.047, 0.040]. There was no significant difference in the incidence of adverse reactions between the two groups (χ2 = 0.09, P = 0.763). Conclusion:The combination of Ginkgo biloba diterpenoid lactone glucosamine and edaravone dextrogenol for the treatment of acute ischemic stroke in patients is effective and reliable. This combined therapy exhibits a good neuroprotective effect, helps improve neurological function, reduces inflammatory responses, and does not increase the incidence of adverse reactions.

Objective: To observe and compare the clinical effects of different electroacupuncture waveforms on primary dysmenorrhea. Methods: This was a prospective, randomized, three-group, parallel-controlled trial. Participants with primary dysmenorrhea were randomly divided into dense-sparse wave, continuous wave, and discontinuous wave groups in a 1:1:1 ratio. Two lateral Ciliao (BL 32) points were used. All three groups started treatment 3–5 days before menstruation, once a day for six sessions per course of treatment, one course of treatment per menstrual cycle, and three menstrual cycles. The primary outcome measure was the proportion with an average visual analog scale (VAS) score reduction of ≥50% from baseline for dysmenorrhea in the third menstrual cycle during treatment. The secondary outcome measures included changes in dysmenorrhea VAS scores, Cox Menstrual Symptom Scale scores and the proportion of patients taking analgesic drugs. Results: The proportion of cases where the average VAS score for dysmenorrhea decreased by ≥50% from baseline in the third menstrual cycle was not statistically significant (P > .05). Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea, there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle (P < .05). Additionally, there was a statistically significant difference between the dense-sparse wave and discontinuous wave groups 24 h after acupuncture (P < .05). Conclusions Waveform electroacupuncture can alleviate primary dysmenorrhea and its related symptoms in patients. The three groups showed similar results in terms of short- and long-term analgesic efficacy and a reduction in the number of patients taking analgesic drugs. Regarding achieving immediate analgesia, the dense-sparse wave group was slightly better than the other two groups.

OBJECTIVETo explore the relationship between the lymph node metastasis and clinicopathological features in patients with clinical stage T1a non-small cell lung cancer (NSCLC).

METHODSClinicopathological data of a total of 418 patients who underwent lobectomy and systematic lymph node dissection were retrospectively analyzed. Logistic regression was used to analyze the relationship between lymph node metastasis and clinicopathological features.

RESULTSLymph node metastasis was observed in 25 patients. There were 122 patients who were diagnosed as ground glass opacity with no lymph node metastasis. 399 patients had subcarinal dissection, among them 7 patients were found to have lymph node metastasis. Univariate analysis showed that gender, smoking history, diameter of lymph node, ground glass opacity (GGO), differentiation of the tumor and tumor site were the factors affecting lymph node metastasis (all P < 0.05). Logistic regression analysis showed that diameter of lymph node, differentiation of the tumor and the site of lesion were independent risk factors for lymph node metastasis of NSCLC.

CONCLUSIONSTumor in the left lung, poor differentiation, and diameter of lymph nodes ≥ 1 cm on the preoperative CT image are independent risk factors for lymph node metastasis of NSCLC, hence we should pay attention before surgery and systematic lymph node dissection should be done. For patients with poor differentiation and lymph nodes ≥ 1 cm, subcarinal lymph nodes dissection is recommended for the sake of higher possibility of lymph node metastasis. For patients with ground glass opacity ≤ 2 cm, the lymph node metastasis is extremely rare, therefore, selective lymph node dissection is reconmmended.

Analysis of Variance ; Carcinoma, Non-Small-Cell Lung ; pathology ; secondary ; surgery ; Cell Differentiation ; Humans ; Logistic Models ; Lung Neoplasms ; pathology ; surgery ; Lymph Node Excision ; Lymph Nodes ; pathology ; Lymphatic Metastasis ; Neoplasm Staging ; Retrospective Studies ; Risk Factors ; Sex Factors ; Smoking

Objective To explore the relationship between the lymph node metastasis and clinicopathological features in patients with clinical stage T1a non-small cell lung cancer ( NSCLC ) . Methods Clinicopathological data of a total of 418 patients who underwent lobectomy and systematic lymph node dissection were retrospectively analyzed.Logistic regression was used to analyze the relationship between lymph node metastasis and clinicopathological features.Resulst Lymph node metastasis was observed in 25 patients.There were 122 patients who were diagnosed as ground glass opacity with no lymph node metastasis.399 patients had subcarinal dissection, among them 7 patients were found to have lymph node metastasis.Univariate analysis showed that gender, smoking history, diameter of lymph node, ground glass opacity ( GGO ) , differentiation of the tumor and tumor site were the factors affecting lymph node metastasis ( all P<0.05) .Logistic regression analysis showed that diameter of lymph node, differentiation of the tumor and the site of lesion were independent risk factors for lymph node metastasis of NSCLC. Conclusions Tumor in the left lung, poor differentiation, and diameter of lymph nodes ≥1 cm on the preoperative CT image are independent risk factors for lymph node metastasis of NSCLC, hence we should pay attention before surgery and systematic lymph node dissection should be done.For patients with poor differentiation and lymph nodes≥1 cm, subcarinal lymph nodes dissection is recommended for the sake of higher possibility of lymph node metastasis.For patients with ground glass opacity≤2 cm, the lymph node metastasis is extremely rare, therefore, selective lymph node dissection is reconmmended.