ObjectiveTo summarize the pathological features, methods of diagnosis and treatment of Mirizzi Syndrome to improve the outcomes of diagnosis and treatment.Methods Pre-operative and intraoperative data from 37 patients with Mirizzi Syndrome were retrospectively analyzed.ResultsFifteen of the 37 patients were diagnosed with Mirizze Syndrome definitely before operation, among whom 10 were given cholecystectomy.Another 11 patients were treated with cholecystectomy + common bile duct exploration + T tube drainage,9 with cholecystectomy + bile duct exploration and repair + T tube drainage.3 with hepatic ductjejunum Roux-en-Y anastomosis; 4 with cholecystectomy under laparoscope among whom 1 patients received routine abdominal surgical after failure of microscopical cholecystectomy for severe adhesion.One patients experienced complication of biliary fistula.All the patients were cured and left hospital.Conclusion Type-B ultrasound, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography are major measures which can be comprehensively used for the diagnosis of Mirizzi Syndrome.Mirizzi Syndrome is heterogenous in the pathological features on which the surgical procedures should be based on.