Objectives To describe the esthetic acceptance to dental fluorosis in the rural residents of eastern Guangdong Province and to explore whether the Dean's criteria is still suitable for modern society. Methods A survey was conducted in eastern areas of Guangdong Province in 1 237 cases of 9～17 and 35～44 years old rural residents who drank well water containing 0.1～2.5 mg/L of fluoride. Clinical examination and questionnaire investigation were performed to record dental fluorosis and the severity of perceived appearance of their teeth. Results While the study subjects perceived the appearance of their teeth as " no problem", the community fluorosis index (CFI) was 0.5 and prevalence rate of dental fluorosis was 10.1 %. While perceived "a little bit bad" and "bad" and "very bad", the CFI and prevalence rate would be 0.9 and 33.7 %, 1.3 and 75.8 % and 1.7 and 98.2 % respectively. Conclusion The acceptance to the severity was basically in accordance with Dean's criteria. The Dean's criteria about dental fluorosis is still suitable for rural areas of eastern Guangdong Province and therefore it can be used in setting criteria of fluoride concentration in drinking water in these areas.

Objective To evaluate the safety of intracoronary Doppler flow measurement using Doppler FloWire  Methods and Results A total of 906 patients were examined with intracoronary Doppler using a 0 014″ or a 0 018″ Doppler FloWire  For coronary flow reserve measurement, intracoronary injection of adenosine or papaverine was used Of the patients studied, 77 were cardiac transplant recipients, 829 were nontransplant patients, of whom 617 patients underwent diagnostic coronary procedures and 212 had coronary interventions In 27 (2 98%) of 906 patients adverse cardiac events were observed Fifteen (1 66%) of 906 patients developed severe transient bradycardia (asystole or Ⅱ? to Ⅲ? atrioventricular block) after intracoronary administration of adenosine Of which, 14 occurred in RCA and 1 in LAD Nine (0 99%) of 906 patients experienced coronary spasm during the passage of the Doppler wire (5 in RCA, 4 in LAD) Two (0 22%) of 906 patients developed ventricular fibrillation during the procedure Hypotension with bradycardia and ventricular extrasystole each occurred in one (0 11%) of 906 patients The incidence of complication was significantly higher in transplant recipients than in nontransplant patients underwent either diagnostic or interventional procedures (12 99% vs 2 43% vs 0 94%, P

Objective To observe the effect of Gongxuening for the women placing the IUDafter cesarean section, and to analyze the effect and value of Gongxuening on intrauterine device placement after cesarean section. Methods 156 women who received voluntary intrauterine device after cesarean sectionin theShengzhou Maternal and Child Health Hospital of Shaoxing, Zhejiang were as the observation object. According to whether the application of Gongxuening, they were divided into two groupsafter treatment, the Gongxuening group of 75 cases (using Gongxuening + Nifloxacin) and the control group of 81 cases (using norfloxacin). The changes of serum inflammatory indexes were compared between the two groups before and after operation, and the uterine bleeding was compared between the two groups. Results After operation, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) were with a significantfluctuation, and at the same time, Gongxuening group TNF-α, IL-6, IL-10, 24hours after surgery, postoperative 7d was significantly lower than the control group, the difference was statistically significant (P< 0.05). After treatment, the WBC of Gongxuening group 24hours after surgery, postoperative 7d was significantly lower than the control group, but the Hb 24 hours after surgey was significantly higher than the control group, the difference was statistically significant (P<0.05). The bleeding volume2h, 24h, bleeding stop time and puerperium duration in the Gongxuening group were significantlylower than the control group, the difference was statistically significant (P<0.05). Conclusion After cesarean section maternal IUD use Gongxuening capsule treatment, not only can effectively inhibit the expression of serum inflammatory markers, and can shorten the time of uterine bleeding, reduce bleeding, prevent postoperative anemia. It is suggested to pay more attention to clinical treatment.

Objective: The objectives were to explore the optimal concentration of drinking water in Eastern Guangdong and to provide information for the health administrative department to set up the criteria for fluoride concentration. Methods: Totally 1237 9～ 17 and 35～44 years old residents in Eastern Guangdong who drinking water containing 0.1～2.5mg/L fluoride were recruited to investigate the occurrences of dental caries and dental fluorosis. Their background information and perceived appearances of teeth were also recorded. Results: The major factor influencing dental fluorosis was fluoride concentration in drinking water. Dental caries decreased when the fluoride concentration increased but dental fluorosis also increased at the same time. It was showed by calculation that the Dental Fluorosis Index would be 0.4 and 0.6 when the fluoride concentration was 0.57 mg/L and 0.7 mg/L respectively. The acceptation to the severity of dental fluorosis among the study subjects was in accordance with the Dean's criteria. Conclusion: It suggests that the optimal fluoride concentration in Eastern Guangdong is 0.57 mg/L and should not exceed the upper limit of 0.7 mg/L.

Objective To investigate the characteristics of the objective sleep disturbances in Parkinson' s disease (PD) and the factors related to it.Methods One hundred and one PD patients and 90 age- and sex- matched controls underwent a video-polysomnography.The sleep parameters and its related factors in two groups were analyzed.Results Sleep latency was not statistically different in comparing two groups.PD patients had a higher percentage of non-rapid eye movement( non-REM ) sleep stage 1 and a lower percentage of non-REM sleep stage 2 compared with controls ( 27.9 ± 1 7.8 vs 21.2 ± 11.7,t =3.034,P =0.003 ;47.8 ± 17.4 vs 54.7 + 12.9,t =- 3.043,P =0.003 ).Reduced sleep efficiency,decreased the proportion of slow wave sleep and REM sleep,increased awake time and longer REM sleep latency occurred in PD patients.There were no significant differences of these above parameters.Some sleep parameters in PD patients were correlated with advancing age,the severity of PD,and the degree of depression.The index of periodic leg movements in sleep (PLMSI) of 41 PD patients (40.6％ ) was more than 15.These PD patients didn' t complain corresponding symptoms about their legs.The PLMSI in PD patients were significantly higher than the controls.PLMSI increased with aging in the PD group( r =0.261,P ＜0.01 ).PD patients didn' t suffer significantly lower apnea- hypopnea index and oxygen desaturation index.The lowest SPO2 ( L-SPO2 ) increased in the PD group.REM sleep without atonia occurred in 83 patients (82.2％) with PD.Thirty-eight patients (37.6％) were diagnosed with REM sleep behavior disorder (RBD).The incidences of REM without atonia and RBD in the PD group were significantly higher than in the control s(0 and 8 patients (8.9％),x2 =42.271,102.480; both P ＜ 0.01 ).Conclusions The sleep parameters in PD patients are changed.For PD patients,there is no difficulty in falling asleep.The PD patients also have sleep structure disorder and difficulty in maintaining sleep.The sleep parameters are correlated with advancing age,the severity of PD,and the degree of depression in PD.PLMS don' t lead to sleep disturbances in PD patients.The blood oxygen saturation don' t decrease severely when PD patients suffer apnea or hypopnea.RBD occur more frequently in PD patients.

Objective:To explore the differences in intravascular ultrasound results in elderly coronary heart disease(CHD)patients with different uric acid levels.Methods:A total of 145 elderly patients diagnosed with CHD in our hospital from December 2017 to May 2020 were included as study subjects.Uric acid levels were measured and intravascular ultrasound examination was conducted in all patients.They were divided into different groups based on uric acid levels: Group A(uric acid≤199 μmol/L), Group B(uric acid 200~399 μmol/L)and Group C(uric acid≥400 μmol/L). Data from intravascular ultrasound-derived indexes were analyzed and compared between the three groups.Results:There was no significant difference in the degree of left main stenosis between Group A and Group B, but it was less severe in both groups than in Group C( F=5.625, P=0.039). Plaque fibrous cap thickness showed no significant difference between Group B and Group C, but it was smaller than in Group A( F=7.825, P=0.020). Group C had the largest plaque area and maximum thickness among the three groups, followed by Group B[(11.12±1.73)mm 2 and(1.76±0.24)mm]and Group A[(8.29±3.14)mm 2 and(1.38±0.09)mm]( F=6.384 and 6.827, P=0.028 and 0.015). Conclusions:Elevated uric acid levels in elderly CHD patients can increase the area and thickness of plaques, and reduce plaque fibrous cap thickness, leading to an increased risk of formation of unstable plaques, which can be life-threatening for these patients.Thus, monitoring and managing uric acid levels should be stressed in elderly CHD patients.

Objective The aims of this study were to determine the expression of Ki-67 and PTEN in oral adenoid cystic carcinoma( OACC) and its relationship with clinicopathological features,and to explore the re-lationship between the expression of Ki-67 and PTEN. Methods Forty cases of oral adenoid cystic carcinoma were collected from the pathological laboratory in our hospital. Another 15 cases of normal gland in patients with oral adenoid cystic carcinoma were selected as the control group. The expression of Ki-67 protein and PTEN in adenoid cystic carcinoma was detected by immunohistochemistry. Results The positive rate of Ki-67 protein in oral adenoid cystic carcinoma was 70%(28/40),which was significantly higher than that in the control group(2/15)(P<0. 05). The positive rate of PTEN in oral adenoid cystic carcinoma was 63%(25/40),which was signif-icantly higher than that in the control group 20%(3/15)(P <0. 05). They were associated with histological types,metastasis,lymph node metastasis and neural invasion,and not correlated with age,gender and tumor loca-tion. The expression of Ki-67 and PTEN in oral adenoid cystic carcinoma may have a significant correlation. Conclusion The expression of Ki-67 and PTEN in adenoid cystic carcinoma is high,and their occurrence and development in adenoid cystic carcinoma play an important role in the process of evolution and metastasis. Ki-67 and PTEN proteins may be markers of oral adenoid cystic carcinoma.

Objective To explore the effects of network platform health education in the patients with cervical cancer after the operation of cervical cancer patients. Methods We selected 54 cases of cervical cancer surgery patients from June 2014 to February 2015 in our hospital for treatment according to the voluntary principle. The patients were divided into observation group and control group by random numbers, and the patients of observation group accepted continue nursing health education network platform while the patients of control group accepted routine care. The complication rate, re-hospitalization rate and treatment satisfaction of the two groups were compared. Results The complications rate and re-hospitalization rates of observe group were 0. 00%, and these of the control group were 14. 81% and 18. 52% (P<0. 05). Observation group′s satisfaction was 96. 30%, while that of the control group was only 59. 26% (P<0. 05). Conclusions Health education network platform for nursing care to a certain extent can reduce cervical cancer patient the incidence of postoperative complications,re-hospitalization rates, and increase the patients health knowledge, the effects of treatment and treatment satisfaction.

Objective To explore the application effects of targeted health education for gastroscopy patients. Methods A total of 300 gastroscopy patients treated in Gastroenterology Department were selected as objects and were randomly divided into control group ( 150 cases ) and observation group ( 150 cases ) . The patients of control group were treated with conventional health education programs, while the patients of observation group were treated with targeted health education programs on the basis of convention. Degree of discomfort during inspection, fear, nausea, vomiting, success rate of first intubation, and patient satisfaction were compared between the two groups. Results Degree of discomfort in the observation group was significantly lower than that in the control group, and patients with fear of the inspection, nausea, or vomiting in the observation group were significantly less than those in the control group ( P <0. 05 ); success rate of first intubation in the observation group was 100. 0%, significantly higher than in the control group (82. 7%) (χ2 =9. 764, P<0. 05);patient′s satisfaction in the observation group was 95. 3%, significantly higher than 76. 7%in the control group (χ2 =9. 263,P<0. 05). Conclusions Targeted health education can improve patients′discomfort level during gastroscopy, reduce fear, nausea, vomiting and other reactions, and enhance success rate of first intubation and patient satisfaction.

Objective To study the effects of quality control circle (QCC) activities on nursing quality of children with hand foot mouth disease. Methods A total of 104 children with hand foot and mouth disease in the pediatric emergency department of Zhoushan Maternal and Child Health Care Hospital from May 2015 to December 2017, when QCC activities have been were carried out, selected as observation group. At the same time, 104 cases of hand foot mouth disease children from January 2014 to April 2015, before QCC carried out, were selected as control group. The comprehensive evaluation of nurses, nursing quality, mistake rate of medical record and evaluation and the ability of quality control management of the nurses were compared between the two groups. Results The comprehensive evaluation, nursing quality and the ability of quality control of the observation group were all higher than those of the control group, and the mistake rate of medical record and card was lower than the control group. All the differences were statistically significant (P＜ 0.01). Conclusions Quality control circle activities can improve the quality of care for children with hand, foot and mouth disease, improve the comprehensive evaluation and quality management ability of nurses, which is worthy of clinical application.