Nowadays, for gait instability phenomenon, many researches have been carried out at home and abroad. However, the relationship between plantar pressure and gait parameters in the process of balance adjustment is still unclear. This study describes the human body adaptive balance reaction during slip events on slippery level walk by plantar pressure and gait analysis. Ten healthy male subjects walked on a level path wearing shoes with two contrastive contaminants (dry, oil). The study collected and analyzed the change rule of spatiotemporal parameters, plantar pressure parameters, vertical ground reaction force (VGRF), etc. The results showed that the human body adaptive balance reaction during slip events on slippery level walk mainly included lighter touch at the heel strikes, tighter grip at the toe offs, a lower velocity, a shorter stride length and longer support time. These changes are used to maintain or recover body balance. These results would be able to explore new ideas and provide reference value for slip injury prevention, walking rehabilitation training design, research and development of walking assistive equipments, etc.
Adaptation, Physiological ; Foot ; Gait ; Humans ; Male ; Postural Balance ; physiology ; Pressure ; Reference Values ; Walking

Objective To investigate the relationship between insulin level and mild cognitive impairment(MCI) of type 2 diabetes and analyze the risk factors for MCI. Methods We collected 101 type 2 diabetes subjects who were divided into two groups:MCI and normal cognition(NC).All subjects were evaluated with cognition scores of MMSE,GDS,CMS,ADL.Insulin,glycosylated hemoglobin,blood routine test,blood pressure,ECG,brain CT were detected.Independent t-test,correlation and multiple regression analysis were performed. Results 1. The diabetic patients with MCI showed the higher levels of insulin at fasting, 2hr and 3hr after meal than did NC(P

The first metatarsophalangeal joint bending plays an important role in the foot movement. However, the existing researches mainly focused on the movement scope of the joint and the clinical treatments of related foot diseases. In order to investigate the effects of the first metatarsophalangeal joint bending on human walking gait stability, the present researchers recruited 6 healthy young men to perform the first metatarsophalangeal joint constraint (FMJC) and barefoot (BF) walking tests. Data of the temporal and spatial parameters, the joint angles of lower limbs, the ground reaction forces (GRF) and utilized coefficients of friction (UCOF) were collected and analyzed. The results showed that, since hip and knee could produce compensation motions, the FMJC had no significant effects on waking gait, but the slip and fall probability increased significantly.
Friction ; Gait ; Humans ; Male ; Metatarsophalangeal Joint ; physiology ; Walking

Objective To explore the influence of MiniQuest teaching model on improving critical thinking ability of nurses in Department of Orthopedics. Methods From January to May 2017, 76 nurses in Orthopedics Department from 4 Class Ⅲ hospitals of one province were selected as the research objects. The nurses of 2 hospitals were set up as the observation group by drawing method of head nurse, and the nurses of the other 2 hospitals were set as the control group, with 36 cases in the observation group and 40 in the control group. The nurses in the control group were taught by routine department work. The observation group was trained with MiniQuest teaching method, and the Critical Thinking Ability Scale was used to compare the critical thinking of 2 groups of nurses. Results The fact finding, open thinking, analytical ability, systematic ability, critical thinking self-confidence, cognitive maturity and total score of the Critical Thinking Ability Scale of the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). There was no significant difference in the score of dimension of thirst for knowledge between the two groups of nurses (P>0.05). Conclusions MiniQuest teaching model can improve the critical thinking ability of nurses in department of orthopedics, and it is worthy of popularizing.

Objective To investigate the influence of Wechat follow-up on the treatment compliance and quality of life for young adult patients with type 2 diabetes mellitus.Methods A total of 120 cases, who were able to use Wechat independently,were selected as the research objects from patients with type 2 diabetes mellitus during February 2015 to December 2015. They were randomly divided into control group (60 cases) and intervention group (60 cases). Patients in control group received routine nursing and health education,while patients in intervention group received knowledge about type 2 diabetes mellitus and nursing care through Wechat. Data of the patients in these two groups were obtained after 6 months. And the parameters including treatment compliance,blood glucose control,the incidence of complications,sleeping quality (PSQI), depression (SDS),and anxiety (SAS) of these patients were analyzed.Results After intervention,the score of treatment compliance in intervention group (12.7±1.5) was higher than (8.7±1.7) of control group (t=-3.056, P<0.05). The compliance of reasonable diet,standardized medication,moderate exercise,benign psychology and regular blood glucose monitoring for intervention group were significantly improved than that of control group (P<0.05). The infection,glycopenia,diabetic eye diseases,acute complications in the intervention group were lower than that of control group (P<0.05),but neuropathy and rate of nephropathy in intervention group were better than that of control group,but there were no statistical significance (P>0.05). Before intervention, there were no statistical significance between two groups in the levels of fasting blood glucose,postprandial 2 h plasma glucose and glycosylated hemoglobin,as well as PSQI,SDS and SAS (P>0.05). However,the levels of fasting blood glucose,postprandial 2h plasma glucose and glycosylated hemoglobin,as well as PSQI,SDS and SAS were significantly decreased compared with the control group with statistical significance (P<0.05). Conclusions Follow-up by Wechat can effectively improve the treatment compliance of young adult patients with type 2 diabetes mellitus,and improve the quality of life and patients' satisfaction.

Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies. Although gemcitabine (GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C (Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect (80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-l-cysteine (NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum (ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation (ERAD) ubiquitinates and downregulates YAP to enhance ER stress via destruction complex (YAP-Axin-GSK-βTrCP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate.