1.Survey on Secondary Research of Traditional Chinese Medicine Patent Literatures
Junwen WANG ; Hongjie GAO ; Yingkai ZHAO ; Hongguan JIAO ; Guofeng DONG
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(8):1780-1782
This survey included 59 secondary researches of traditional pharmaceutical patent literatures. The analysis was made on statistical indicator of the amount of annual papers, authors, institutions, published journals and re-search contents. The survey revealed that in the field of traditional Chinese medicine (TCM), the number of sec-ondary research of patent literature was on the increase, and the degree of concern of TCM patent was far more than others. This survey not only assisted the understanding of current condition of TCM patent literatures, but also held its development trend in order to apply it in the studies.
2.Effect of minimally invasive transpedicular bone grafting additional vertebral pedicle screw fixation in the treatment of thoracolumbar fracture
Xiaobin LI ; Junwen CHENG ; Zhikang ZHOU ; Bin DONG
Chinese Journal of Primary Medicine and Pharmacy 2015;(6):899-901
Objective To explore the effect of minimally invasive transpedicular bone grafting additional ver -tebral pedicle screw fixation in the treatment of thoracolumbar fracture .Methods 60 patients with thoracolumbar fracture were randomly divided into the observation group and the control group ,30 cases in each group .The control group received traditional open inter vertebral four nail pedicle screw fixation combined with posterolateral bone graft fusion for treatment while the observation group was treated by minimally invasive transpedicular bone grafting addi -tional vertebral pedicle screw fixation ,to analyze the clinical effects .Results The imaging parameters of postopera-tion[the sagittal index(1.9 ±7.1)°,Cobb's angle(4.2 ±3.5)°,change of vertebral body height (90.2 ±6.5)%]in the observation group were significantly better than those of the control group (t=6.78,6.80,7.02,all P<0.05). The imaging parameters 3 months after operation[the sagittal index(4.9 ±3.2)°,Cobb's angle(7.0 ±2.7)°,change of vertebral body height (87.6 ±4.1)%] in the observation group were significantly better than those of the control group(t=6.78,6.80,7.02,all P<0.05).The operation time,incision length,bleeding volume,postoperative drain-age,postoperative hospital stay of the observation group were (141.9 ±14.2)min,(10.8 ±1.7)cm,(105.7 ±12.3)mL, (5.6 ±4.1)mL,(6.6 ±1.1)d,respectively,which were significantly better than those of the control group (t=7.72,7.89,5.68,all P<0.05).Conclusion Minimally invasive transpedicular bone grafting additional vertebral pedicle screw fixation has a significant effect in the treatment of thoracolumbar fractures ,which is safe and reliable .
3.The Ebola-countering Operations in Sierra Leone Between UK and China and their implications:a comparative analysis
Shuangping YU ; Gang DONG ; Junwen MAO ; Jinsong MU ; Ningbo ZHAN ; Zhen HE
Military Medical Sciences 2016;40(3):190-194
The UK Ebola-countering Operation in Sierra Leone from September 2014 to November 2015 called Operation Gritrock and its countermeasures were briefly introduced , such as the national strategy , aero-maritime deployment , self medical support , base-oriented training and international cooperation .A comparative analysis was made of operations of the same type between the UK and China in terms of mission-orientation, command and control , deployment timeline , past experience, deployment routes, logistics and assistance effects.Four implications for China′s military function construction in future international disaster relief operations were also summarized at the strategic , operational and tactical levels .
4.Sequential flap of thigh perforator for closure of the anterolateral thigh free flap donor site
Yunsheng TENG ; Gaofeng LIANG ; Bo WEN ; Zonghai JIA ; Feng ZHI ; Meng WU ; Yongming GUO ; Chaopeng DUAN ; Manying ZHANG ; Ping'an XU ; Junwen DONG ; zhixiong MA
Chinese Journal of Microsurgery 2017;40(2):126-129
Objective To explore the clinical effects of sequential flap of thigh perforator for closure of the anterolateral thigh free flap donor site.Methods From March,2014 to May,2015,8 consecutive patients underwent elective anterolateral thigh free flap reconstruction for limb soft tissue defect.To design a sequential flap of thigh perforator to achieve primary closure of the anterolateral thigh free flap donor site.The area of anterolateral thigh free flap ranged from 9.0 cm×6.0 cm to 20.0 cm×1 1.0 cm,respectively.The area of thigh perforator flap ranged from 7.0 cm×3.0 cm to 12.0 cm×7.0 cm.Results All flaps healed uneventfully.Distal skin flap necrosis appeared in 1 flap which was healed after local transposition flap.All the patients were followed up for 1 to 6 months,with mean time of 4 months.The color,texture and appearance of flaps were satisfactory.Conclusion Sequential flap of thigh perforator,with reliable blood supply and constant position,represents an ideal model to close the anterolateral thigh free flap donor site of small defect.
5. Study on the transfer mechanism and destructive law of the bacterial antibiotic resistance genes disinfected by chlorination
Zhongwei YANG ; Hanji JIANG ; Zhiqiang CHEN ; Dong YANG ; Zhigang QIU ; Lu LIU ; Jing YIN ; Huaran WANG ; Junwen LI ; Min JIN
Chinese Journal of Preventive Medicine 2018;52(9):892-897
Objective:
To study the response of Escherichia coli (
6.Repair of complex defects in right upper extremity with microsurgery: A case report
Zonghai JIA ; Gaofeng LIANG ; Chaopeng DUAN ; Manying ZHANG ; Junwen DONG ; Wei ZHANG ; Zhongyu JIA ; Yunsheng TENG ; Yongming GUO
Chinese Journal of Microsurgery 2022;45(6):702-704
This is a report of a complex defects in the right upper extremity treated in the Department of Hand and Microsurgery, 521 Hospital of Norinco Group, in October 2016. The patient received multi-transfers of flaps for one-stage reconstruction, including a double-paddled ALTPF and a compound flap of the great toe and the second toe. Vascular compromises occurred in flaps on the 2nd day after surgery. All the flaps were rescued and survived completely after surgical exploration. Followed-up at 3 year after surgery showed that the appearance and function of the affected limb recovered well. The flexion and extension of elbow and wrist were normal. The pinch function of the reconstructed thumb and index finger recovered well.
7.Major Diseases of Panax notoginseng And Their Control Strategies
Lianjuan ZHANG ; Yue GAO ; Linlin DONG ; Guangfei WEI ; Juan YANG ; Junwen CHEN ; Bencai SHA
World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(10):1635-1640
The occurrence of Panax notoginseng diseases seriously constrains its economic yield,which has becoming one of the main factors that hinders the development of P.notoginseng.For the sustainable development of P.notoginseng industry,this study summarized the pathogens,incidence conditions,transmissions and control methods of main P.notoginseng diseases.This paper elaborated that the prevention of major P.notoginseng diseases should be a comprehensive strategy based on agricultural,chemical and biological control.The disease prevention-control system of focusing on prevention and comprehensive management should be established.The breeding of new varieties should be strengthened to improve the disease resistance and to promote the sustainable development of P.notoginseng industry.
8.Protective effects of cinnamaldehyde on benzene-induced immune and oxidative stress injury in mice
Mengyang LI ; Gui WANG ; Yamei QIAO ; Pingyu WANG ; Min JIN ; Dong YANG ; Junwen LI
Military Medical Sciences 2024;48(1):44-51
Objective To investigate the effects of cinnamaldehyde,the main active component of cinnamon,on benzene-induced immune injury in mice and the related mechanism.Methods Forty male BALB/c mice were randomly divided into the control group,model group(benzene 500 mg/kg),cinnamaldehyde low,medium and high dose groups(5,25,50 mg/kg),with 8 mice in each group.Except the control group,mice in each group were treated with benzene by intragastric administration daily to induce immune and oxidative stress damage,but the intervention group was treated with cinnamaldehyde 5 times/week for 3 weeks.After medication,peripheral blood was collected 24 h after the last gavage for blood cell count,and the changes in body weight of mice in each group were observed.The pathological structure of the spleen and thymus was observed via hematoxylin-eosin(HE)staining.Peripheral blood mononuclear cells(PBMCs)of mice were extracted and the amounts of reactive oxygen species(ROS)and ATP in mitochondria were measured.Plasma levels of malondialdehyde(MDA)were measured using the barbituric acid method,the activity of glutathione peroxidase(GSH-PX)in plasmawith the dithiodinitrobenzoic acid methodand the activity of total superoxide dismutase(SOD)in plasma using the hydroxylamine method.Results After exposure to benzene,the body weight of the model group became lower(P<0.05).The spleen and thymus were damaged,and the indexes of the spleen and thymus were decreased(P<0.05).Counts of peripheral white blood cells and lymphocyteswere decreased(P<0.05).The activities of GSH and SOD in plasma were decreased(P<0.05),but the content of MDA was increased(P<0.05).The amount of mitochondrial ROS in PBMC was increased,while the ATP content was decreased(P<0.05).The weight of mice increased after treatment with cinnamaldehyde.The spleen and thymus tissues recovered well,and the indexes of the spleen and thymus were increased(P<0.05).Counts of peripheral white blood cells and lymphocytesin the high dose cinnamaldehyde group were increased(P<0.05).The activities of GSH and SOD in plasma were increased,while the content of MDA was decreased(P<0.05).The amount of mitochondrial ROS in PBMC was decreased,but the ATP content was increased(P<0.05).Treatment with cinnamaldehyde could alleviate the damage to the mitochondrial function of PBMC induced by benzene in mice,and 50 mg/kg was the best dose(P<0.05).The therapeutic effect of cinnamaldehyde had a dose-response relationship.Conclusion Cinnamaldehyde can inhibit benzene-induced immune injury and oxidative stress injury in mice by delivering an antioxidant effect and improving mitochondrial enhancement of PBMC.
9.Masquelet technique with transfer of free iliac inguinal flap in reconstruction of infectious bone and soft tissue defect after metacarpal fracture surgery: a report of 16 cases
Junwen DONG ; Gaofeng LIANG ; Chao ZHANG ; Feng ZHI ; Xiaobo QUAN ; Zonghai JIA ; Yongtao CHENG ; Chaopeng DUAN ; Yunsheng TENG ; Yongming GUO
Chinese Journal of Microsurgery 2023;46(4):383-390
Objective:To investigate the clinical effects of Masquelet technique with the transfer of free iliac inguinal flap in reconstruction of infectious bone and soft tissue defect after metacarpal fracture surgery.Methods:From January 2014 to January 2020, 16 patients suffered from infectious bone and soft tissue defect after surgery of metacarpal fracture were treated in Department of Hand Surgery, Institute for Hygiene of Ordnance Industry (Weapon Industry 521 Hospital). Debridement and vacuume sealing drainage (VSD) coverage of wound were carried out in emergency surgery, and Masquelet technique combined with free iliac inguinal flap for reconstruction of infected metacarpal bone defect were performed in sub-emergency surgery. The patients were 14 males and 2 females with an average age of 38 (20-50) years old. Plates were removed in 10 patients and retained in 6 patients. Defects of metacarpal bone ranged from 0.8 cm×0.8 cm×2.0 cm to 1.5 cm×2.0 cm× 5.1 cm in size. Soft tissue defects ranged from 3.6 cm×6.8 cm to 7.8 cm×11.6 cm. Tendon defects were found in all 16 patients. After the primary procedure of Masquelet technique combined with free iliac inguinal flap, routine anti-infection, anticoagulant, antispasmodic and other treatments were offered to all patients. Then all patients were observed by fortnightly reviews. After infection was cleared, the second phase of Masquelet treatment began. The defects of metacarpal bone were reconstructed with autologous cancellous bone grafts, and measures to prevent from infection together with other therapies were offered after the surgery. Follow-up of the second phase surgery was carried out once per 1-2 weeks and then per 2-4 months after bone union. The follow-up review items included: wound infection and necrosis, appearance, shape, texture and sensory recovery of flap. Bone union of infectious metacarpal defect was evaluated, recurrence of infection was closely observed as well as the resorption or nonunion of bone by X-rays. Hand function was assessed according to the Evaluation Trial Standards of Upper Limb Partial Functional of Hand Surgery of Chinese Medical Association. Donor sites healing and functional recovery were also included in the postoperative observation.Results:The follow-up time ranged from 1.5-3.0 (average 2.4) years. There was no necrosis of iliac inguinal flap, no recurrence of infection, and the flaps all healed well. The appearance, shape and texture of flaps were found close to the adjacent skin in all patients. Two-point discriminations (TPD) of the transferred iliac inguinal flaps were at 8-10 mm. X-ray reviews showed that bone union achieved in all patients. The time of bone union were 2.1-3.4 months (2.9 months in average) after bone grafting. There was no bone resorption, infection or nonunion. According to the Evaluation Standard of Upper Limb Partial Functional of Hand Surgery of Chinese Medical Association, 13 patients were excellent and 3 patients were good. All donor sites had primary healing with the motion of donor hips unaffected.Conclusion:Masquelet technique combined with free iliac inguinal flap is an effective, safe and feasible surgical procedure in reconstruction of infectious bone and soft tissue defect after metacarpal fracture surgery. It offers a satisfactory outcome with relatively less damage to the donor site.
10.Repair the donor site of ipsilateral fibular hallux flap with transverse V-Y advancement flap of the great toe
Gaofeng LIANG ; Junwen DONG ; Xiaobo QUAN ; Yunsheng TENG ; Zonghai JIA ; Hu YU ; Hong LIANG ; Manying ZHANG ; Chao ZHANG ; Yongming GUO
Chinese Journal of Microsurgery 2022;45(5):493-497
Objective:To explore the clinical application and effect of repairing the donor site of ipsilateral fibular hallux flap with the transverse V-Y advancement flap of the great toe.Methods:Form January 2017 to January 2020, the donor sites of the ipsilateral fibular hallux flap were repaired by the transverse V-Y advancement flap of the great toe in the Department of Hand Surgery, 521 Hospital of Weapon Industry on 20 patients, including 16 males and 4 females with an average age of 33 (18-52) years old. First, the donor site of the fibular hallux flap was sutured to reduce the size of wound. The width of the remaining wound was 0.4 to 1.6 cm, and the area of the remaining wound was 0.5 cm×0.8 cm-1.6 cm×1.8 cm. Then the remaining wound was repaired with the transverse V-Y advancement flap of the ipsilateral great toe. The distance for transfer of transverse advancement V-Y flap was 0.2-0.8 cm, and the area of the transverse V-Y advancement flap was 1.0 cm×1.4 cm-1.8 cm×2.4 cm. The end of postoperative follow-up was scheduled in July 2021. The follow-up items included: survival of the transverse V-Y advancement flap, wound infection, appearance, shape, texture and sensation of the V-Y advancement flap, pain on the V-Y advancement flap and the great toe, cold tolerance and the scar condition at the donor site of the ipsilateral fibular hallux flap and the V-Y advancement flap, the appearance, sensation and flexion and extension of the great toe at the donor site, other discomforts in the donor site of great toe, walking and other functions affected by the discomforts.Results:The postoperative follow-up lasted from 12 to 18(average of 14) months. All the V-Y advancement flaps survived without infection at the donor sites of the great toe, and donor sites healed primarily. The appearance, shape and texture of the advancement V-Y flap were close to the skin of the same area of the contralateral great toe. The TPD of the V-Y advancement flap and the ipsilateral great toe ranged from 4 to 7 mm. The average score of the Visual analog scale(VAS) was 0.3 and 0.6 respectively in the evaluation of cold tolerance of the advancement V-Y flap and the ipsilateral great toe. The average score of the Vancouver scar scale(VSS) was 0.2 and 1.2 respectively in the scar evaluation of the V-Y advancement flap and the ipsilateral great toe. There was no visual difference between the appearance of the great toe at the donor site and the contralateral toe. There was no pain and other discomfort on the V-Y advancement flap and the ipsilateral great toe. The functions of the donor foot were not affected in walking, running, jumping and tiptoeing in all cases.Conclusion:It is a simple, safe and effective method to repair the donor site of the small-area ipsilateral fibular hallux flap by the transverse V-Y advancement flap of the great toe. It only causes a small wound but the appearance and function of the ipsilateral great toe can be repaired with a transverse V-Y advancement flap of the great toe.