1.Study on Characteristics of Pointing Movement Time for Targets with Different Position in Front of Human Body
Junmin DU ; Haiwen SHI ; Xiugan YUAN
Space Medicine & Medical Engineering 2006;0(04):-
Objective To study the characteristics of pointing movement time for targets with different position in front of human body,to detect the effects of targets location on pointing movement time.Methods A pointing movement experiment of human arm was designed and carried out.By the statistic analysis of the experimental data,the relationship between pointing movement time and target position was discussed.Results It was shown that the starting point position and target position extremely affected the pointing movement time.Conclusion When a right-handed person touches the different targets,both the direction to target and the starting point position(target-circle location) would affect the pointing movement time extremely.When the position of the starting point changed by horizontal or vertical,the pointing movement time is more changeful by horizontal than that by vertical.To compare the pointing movement time for each target on a target-circle,the pointing movement time for right-upper target is the shortest.When the starting point is located on the right side of human body,all pointing movement time of that target-circle is the shortest.
2.A Study of Pointing Movement Characteristics and Ergonomics on Front Board
Junmin DU ; Xiugan YUAN ; Haiwen SHI
Space Medicine & Medical Engineering 2006;0(01):-
Objective To study pointing movement characteristics and ergonomics when human upper limb touches different targets on the front board. Methods An experiment was designed, in which the data of motion duration, peak velocity, trajectory length and peak power at shoulder and elbow joint were collected. Results By analysis of the experimental results, the pointing movement characteristics among the different regions on the front board were disclosed preliminarily. Conclusion When a right-handed person touches a target on the front board, the pointing movement ergonomics on left-upper region is the best, while that on right-lower region is the worst.
3.Determination of 6,7-Dehydroroyleanone in Salvia Deserta Schang by UV
Junmin CHANG ; Niansheng DU ; Qing WANG ; Jianhong MA ;
Chinese Traditional Patent Medicine 1992;0(08):-
Objective: To determin the content of 6,7 Dehydroroyleanone in Salvia deserta Schang. Methods: The content of 6.7 Delydroroyleanone were identified with TLC by UV.Results: The content was 0.37% and RSD was 2.6%. The average recovery was 98.3%.Conclusion: The method is simple and accurate.
4. Analysis of correlation between plasma trough level and response of generic imatinib in the treatment of Chinese patients with chronic myeloid leukemia
Jianhua YOU ; Juan CHEN ; Li ZHOU ; Shenghong DU ; Hongying LU ; Shujun SUN ; Junmin LI ; Zhixiang SHEN
Chinese Journal of Hematology 2019;40(11):939-942
Objective:
To analyze the correlation between plasma trough level of generic imatinib and its metabolism and clinical outcomes in Chinese patients with chronic myeloid leukemia in chronic phase (CML-CP) .
Methods:
The 21 patients with CML-CP who enrolled in a clinical trial YMTN 1.0 from Oct 11th, 2012 to May 8th, 2013 and received generic imatinib were as study subjects. The correlation between steady plasma trough levels of imatinib and its metabolism with clinical response, age, weight and body surface area (BSA) were evaluated.
Results:
①The mean steady plasma trough level of generic imatinib and its metabolism was (1 185.07±417.91) μg/L and (251.53±76.50) μg/L, respectively. ②Age, weight and BSA has no significant effects on plasma trough level of generic imatinib and its metabolism (
5.Influencing factors analysis of microvascular invasion in patients with hepatocellular carcinoma
Peiyuan DU ; Jinghai SONG ; Jiangchun QIAO ; Xiuwen HE ; Jinsong ZHANG ; Jian CHEN ; Hua LYU ; Mingwei ZHU ; Junmin WEI
Chinese Journal of Hepatobiliary Surgery 2019;25(1):26-29
Objective To evaluate the correlation between microvascular invasion(MVI) and prognosis in patients with hepatocellular carcinoma (HCC),and to analyse the influencing factors of MVI in patients with HCC.Methods Total of 81 patients with hepatocellular carcinoma treated in Beijing Hospital from January 2014 to December 2016 were retrospectively studied.There were 65 males and 16 females.The mean age was 59.6± 12.7 years,and the age ranged from 21 to 87 years old.Pathological examination showed presence of MVI in 35 patients.Results Total of seventy-six patients with hepatocellular carcinoma were followed-up.The 1-,2-,3-and 4-year overall survival rates in the 35 patients with microvascular invasion of hepatocellular carcinoma were 78.6%,55.4%,38.3%,and 32.2%,respectively.The 1-,2-,3-,and 4-year overall survival rates of the 41 patients without microvascular invasion were 93.4%,76.5%,68.2% and 68.2%,respectively.The difference was significant (P<0.05).Cox multivariate regression analysis showed that microvascular invasion was an independent risk factor of overall survival after surgery (HR=3.071,95% CI:1.239~7.610,P<0.05).Sub-group analysis was done on patients with microvascular invasion based on pathological results which included the number of MVI lesions,the call number in the MVI lesion,the distance of the MVI to the primary liver cancer,and the gradings of MVI.There were no significant differences in the overall survival outcomes (P>0.05).Multivariate logistic regression analysis showed the maximum diameter of tumor > 5 cm (OR =6.340,95% CI:2.000 ~ 20.096),preoperative total bilirubin (TBil) > 17 μmol/L (OR =5.067,95%CI:1.386 ~ 18.525),and preoperative alpha-fetoprotein (AFP) >400 μg/L (OR =6.042,95% CI:1.435 ~ 25.444) were independent risk factors of microvascular invasion (P< 0.05).Conclusion Hepatocellular carcinoma patients with microvascular invasion had poor prognosis.Preoperative AFP,preoperative TBil,and diameter of tumor were independent risk factors of microvascular invasion in patients with hepatocellular carcinoma.
6.Advances in molecular biological studies of the mangrove Kandelia obovata Sheue, Liu & Yong.
Zhaokui DU ; He CHEN ; Junmin LI
Chinese Journal of Biotechnology 2017;33(2):196-204
Kandelia obovata Sheue, Liu & Yong, a mangrove species which distributed in tropical, subtropical coastal and estuarine intertidal, has important ecological functions in coastal ecosystems. Here, we reviewed several aspects of the recent research progress in molecular biological studies of K. obovata. We focused the phylogeography and genetic diversity of this species by several types of molecular markers, proteome analyses based on two-dimensional electrophoresis platform accomplished for this species, and functional genes isolated under non-biotic stress environment. Finally, based on the current research progress, we proposed some orientations for future molecular biological research on K. obovata.
7.Efficacy and safety of generic imatinib mesylate capsules produced in China for newly diagnosed chronic myeloid leukemia in chronic phase patients.
Juan CHEN ; Li ZHOU ; Shenghong DU ; Hongying LU ; Shujun SUN ; Junmin LI ; Weili ZHAO ; Zhixiang SHEN
Chinese Journal of Hematology 2015;36(3):235-237
8.BRICS report of 2016-2017: the distribution and antimicrobial resistance profile of clinical isolates from blood culture in China
Yunbo CHEN ; Jinru JI ; Chaoqun YING ; Peipei WANG ; Qing YANG ; Haishen KONG ; Yongyun LIU ; Ying HUANG ; Yuanyuan DAI ; Liping ZHANG ; Hui DING ; Liang GUO ; Baohua ZHANG ; Lisha ZHU ; Haifeng MAO ; Zhixiang LIAO ; Yanhong LI ; Lu WANG ; Shuyan HU ; Zhenghai YANG ; Beiqing GU ; Haixin DONG ; Fei DU ; Lin ZHENG ; Bo QUAN ; Wencheng ZHU ; Jianzhong WANG ; Lan MA ; Rong XU ; Li SUN ; Aiyun LI ; Junmin CAO ; Jinhua LIANG ; Hongyun XU ; Kunpeng LIANG ; Dengyan QIAO ; Xiaoyan QI ; Xiusan XIA ; Lanjuan LI ; Yonghong XIAO
Chinese Journal of Clinical Infectious Diseases 2020;13(1):42-54
Objective:To investigate the distribution and antimicrobial resistance profile of clinical bacteria isolated from blood culture in China.Methods:The clinical bacterial strains isolated from blood culture from member hospitals of Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected during January 2016 to December 2017. Antibiotic susceptibility tests were conducted by agar dilution or broth dilution methods recommended by US Clinical and Laboratory Standards Institute (CLSI) 2019. WHONET 5.6 was used to analyze data.Results:During the study period, 8 154 bacterial strains were collected from 33 hospitals, of which 2 325 (28.5%) were Gram-positive bacteria and 5 829 (71.5%) were Gram-negative bacteria. The top 10 bacterial species were Escherichia coli (34.7%), Klebsiella pneumoniae (15.8%), Staphylococcus aureus (11.3%), coagulase-negative Staphylococci (7.4%), Acinetobacter baumannii (4.6%), Pseudomonas aeruginosa (3.9%), Enterococcus faecium (3.8%), Streptococci (2.9%), Enterobacter cloacae (2.7%) and Enterococcus faecalis (2.5%). Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCNS) accounted for 34.2%(315/922) and 77.7%(470/605), respectively. No vancomycin-resistant Staphylococcus was detected. The resistance rate of Enterococcus faecium to vancomycin was 0.6%(2/312), and no vancomycin-resistant Enterococcus faecium was detected. The ESBLs-producing rates in Escherichia coli, Klebsiella pneumoniae and Proteus were 55.7%(1 576/2 831), 29.9%(386/1 289) and 38.5%(15/39), respectively. The incidences of carbapenem-resistance in Escherichia coli, Klebsiella pneumoniae were 1.2%(33/2 831), 17.5%(226/1 289), respectively. The resistance rates of Acinetobacter baumannii to polymyxin and tigecycline were 14.8%(55/372) and 5.9%(22/372) respectively, and those of Pseudomonas aeruginosa to polymyxin and carbapenem were 1.3%(4/315) and 18.7%(59/315), respectively. Conclusion:The surveillance results from 2016 to 2017 showed that the main pathogens of blood stream infection in China were gram-negative bacteria, while Escherichia coli was the most common pathogen; the MRSA incidence was lower than other surveillance data in the same period in China; carbapenem-resistant Escherichia coli was at a low level during this surveillance, while carbapenem-resistant Klebsiella pneumoniae is on the rise.
9. The effect of standardized lymphectomy and sampling of resected lymph nodes on TNM staging of resectable pancreatic head cancer
Jingyong XU ; Zhe LI ; Hongyuan CUI ; Jun DU ; Jian CHEN ; Jiangchun QIAO ; Xiuwen HE ; Jinghai SONG ; Junmin WEI ; Yinmo YANG
Chinese Journal of Surgery 2019;57(8):572-577
Objective:
To examine the effect of standardized lymphectomy and sampling of resected lymph nodes (LN) on TNM staging of resectable pancreatic head cancer.
Methods:
Consecutive patients with resectable pancreatic head cancer who received standard pancreatoduodenctomy at Department of General Surgery in Beijing Hospital from December 2017 to November 2018 were recruited as study group. After operation, the surgeon sampled lymph nodes from the fresh specimen following the Japanese Gastric Cancer Guidelines.Thirty-three cases were recruited in the study group and the mean age was (59.8±15.2) years.Pathologic reports from December 2015 to November 2016 were taken as control group, containing 29 cases with age of (57.0±13.0) years. Number of lymph nodes, standard-reaching ratio and positive nodes ratio were compared between two groups. According to the seventh edition and eighth edition of TNM staging, the changes of N staging and TNM staging were analysed. The quantitative data conforming to normal distribution were tested by independent sample
10.Prognostic significance of Ph-positive acute lymphoblastic leukemia.
Li ZHOU ; Jiong HU ; Juan CHEN ; Shenghong DU ; Aihua WANG ; Jianhua YOU ; Wen WU ; Zhixiang SHEN ; Junmin LI
Chinese Journal of Hematology 2014;35(2):109-113
OBJECTIVETo explore the prognostic significance of Ph-positive and/or BCR-ABL positive acute lymphoblastic leukemia (Ph⁺ ALL).
METHODSA retrospective analysis of 72 patients with Ph⁺ ALL to probe prognostic factors including sex, age, high white cell counts at diagnosis, additional chromosome abnormality, BCR-ABL transcripts type, imatinib based therapy, allo-HSCT and complete remission (CR) after one-course induction on the outcomes of Ph⁺ALL patients.
RESULTSOf 72 patients with median age 40.5 (13-68) years, 38 patients received imatinib plus chemotherapy. With median follow-up of 11 (0.2-96) months, total CR rate in patients receiving imatinib plus chemotherapy was higher than of patients receiving chemotherapy only (97.4% vs 62.3%, P=0.019). High white blood counts at diagnosis or additional chromosome abnormality had no effects on CR rate. 2-year overall survival (OS) and disease free survival (DFS) in imatinib plus chemotherapy group were (28.9±7.4) % and (25±7.4) %, respectively, which were higher than those in chemotherapy group (P<0.001). OS rate in HSCT group was significantly higher than that in non-HSCT group[ (61.1±11.5) % vs (5.6±3.1) %, P<0.001]. Multivariate prognostic analysis for OS showed that imatinib-based therapy [RR=0.413 (95% CI 0.237-0.721), P=0.002], allo-HSCT [RR=0.175 (95% CI 0.075-0.389), P=0.000] and CR after one-course induction [RR=0.429 (95% CI 0.245-0.750), P=0.003] were of importance for survival.
CONCLUSIONallo-HSCT was an optimal choice for Ph⁺ALL patients. Imatinib-based therapy could increase CR rate, maintain CR duration and decrease relapse, resulting in more chance of HSCT. Imatinib improved the outcomes of Ph⁺ALL patients who were not eligible for HSCT.
Adolescent ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Benzamides ; therapeutic use ; Disease-Free Survival ; Female ; Fusion Proteins, bcr-abl ; antagonists & inhibitors ; Hematopoietic Stem Cell Transplantation ; Humans ; Imatinib Mesylate ; Male ; Middle Aged ; Philadelphia Chromosome ; Piperazines ; therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; diagnosis ; genetics ; therapy ; Prognosis ; Protein Kinase Inhibitors ; therapeutic use ; Pyrimidines ; therapeutic use ; Retrospective Studies ; Young Adult