1.Relationship between interleukin-1β and silicosis development
Junjin LIAO ; Xueni YU ; Junpeng CHI ; Luocheng SHAO ; Shizi WANG ; Zhen LIU ; Zhuo CHEN ; Huihui TAO
Chinese Journal of Primary Medicine and Pharmacy 2023;30(2):316-320
Silicosis is a diffuse pulmonary fibrosis disease caused by occupational exposure to silica, which is one of the occupational diseases with high incidence in developing countries. Up to now, there is no definite drug to relieve or reverse the lung injury caused by silicosis, so it is very important to prevent, diagnose and treat pulmonary fibrosis as soon as possible. Studies have shown that a chronic inflammatory environment contributes to pulmonary fibrosis to a certain extent. Interleukin-1β is a cytokine that increases the number of inflammatory factors in the microenvironment in the immune response and plays a key role in inflammatory reaction. Therefore, the release of interleukin-1β is of great significance in the pathogenesis of silicosis. This paper aims to systematically expound the development course of silicosis, the signal pathway of interleukin-1β production, and the relationship between them.
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