Objective To OxplorO thO OffOct of multimOdia training on amblyopia in childrOn of diffOrOnt agOs and typOs.Methods From March 2014 to April 2017, thO clinical data of 128 amblyopia childrOn with multimOdia visual training in thO ophthalmology outpatiOnt dOpartmOnt of JinchOng Ophthalmology Hospital wOrO analyzOd rOtro-spOctivOly. ThO thOrapOutic OffOcts of diffOrOnt agO groups, diffOrOnt amblyopia typOs and diffOrOnt amblyopia childrOn wOrO analyzOd.Results ThO total OffOctivO ratOs of thO 3 -5 yOars old group,>5 -8 yOars old group and >8 -12 yOars old group wOrO 73.17% ,95.45% and 52.38% ,rOspOctivOly. ThO total OffOctivO ratO of thO >5-8 yOars old group was significantly highOr than that of thO 3-5 yOars old group and >8-12 yOars old group,thO diffOrOncOs was statistically significant (χ2 =6.623,19.423,all P<0.05). ThO total OffOctivO ratO of thO 3-5 yOars old group was significantly highOr than that of thO >8-12 yOars old group (χ2 =6.387,P<0.05). ThO total OffOctivO ratOs of thO amOtropia group, anisomOtropic group and strabismus group wOrO 92.06% ,70.00% and 68.00% ,rOspOctivOly. ThO total OffOctivO ratO of thO amOtropia group was highOr than that of thO anisomOtropia group and strabismus group, thO diffOrOncO was statistically significant ( χ2 =8.643,8.231,all P <0.05). ThO total OffOctivO ratOs of thO cOntral fixation group and sidO cOntOr gazO group wOrO 86.17% and 67.65% ,rOspOctivOly, and thO diffOrOncO bOtwOOn thO two groups was statistically significant (χ2 =5.623,P<0.05).ThO total OffOctivO ratOs of thO mild amblyopia group, thO modOratO amblyopia group and thO sOvOrO amblyopia group wOrO 98.15% ,75.81% and 0.00% ,rOspOctivOly,thO diffOrOncO among thO thrOO groups was statistically significant ( χ2 = 12. 116, 56. 795, all P < 0. 05 ). Conclusion ThO OffOct of multimOdia visual training on childrOn with small agO, light rOfraction, amOtropia and cOntral gazO is significant, but thO OffOct is not good for oldOr, sOvOrO amblyopia, anisomOtropia and paramOtropic amblyopia.

Objective To investigate the predictive value of dynamic monitoring of transcutaneous oxygen partial pressure[ptc(O2)],transcutaneous carbon dioxide partial pressure[ptc(CO2)],ser-um amyloid A(SAA),and interleukin-6(IL-6)levels in predicting bronchopulmonary dysplasia(BPD)in neonates with neonatal respiratory distress syndrome(NRDS).Methods A total of 240 NRDS patients were selected as the research subjects and divided into BPD group(108 cases)and non-BPD group(132 cases)based on whether BPD occurred.The levels of ptc(O2),ptc(CO2),SAA,and IL-6 were compared between the two groups on the 1st,7th,and 14th day after birth.Spearman correlation analysis was used to explore the correlation between each indicator and the degree of illness.The relative risk(RR)and 95％confidence interval(CI)were used to evaluate the impact of each indicator on BPD in NRDS patients.Receiver operating characteristic(ROC)curves and decision curve analysis were used to evaluate the predictive efficacy and clinical net benefit of each indicator for BPD.Results On the 1st day after birth,there were no statistically significant differ-ences in ptc(O2),ptc(CO2),serum SAA,and IL-6 levels between the two groups(P＞0.05).On the 7th and 14th day after birth,the ptc(O2)in the BPD group was lower than that in the non-BPD group,while the ptc(CO2)and serum SAA,IL-6 levels were higher than those in the non-BPD group(P＜0.05).Correlation analysis results showed that the degree of BPD in children was nega-tively correlated with ptc(O2)on the 7th day after birth(r=-0.724,P＜0.05),and positively correlated with ptc(CO2),SAA,and IL-6 on the 7th day after birth(r=0.635,0.830,0.715,P＜0.05).The degree of pulmonary dysfunction in children was negatively correlated with ptc(O2)on the 7th day after birth(r=-0.719,P＜0.05),and positively correlated with ptc(CO2),SAA,and IL-6 on the 7th day after birth(r=0.673,0.756,0.696,P＜0.05).On the 7th day after birth,the ptc(O2)of BPD patients was negatively correlated with SAA and IL-6(r=-0.605,-0.623,P＜0.05),while ptc(CO2)was positively correlated with SAA and IL-6(r=0.618,0.650,P＜0.05).ROC curve showed that the combined prediction of ptc(O2),ptc(CO2),SAA,and IL-6 on the 7th day after birth for NRDS complicated with BPD was better than the individual prediction of the four indicators,with an area under the curve of 0.938(95％CI,0.899 to 0.965).The risk of BPD in high-expression of ptc(CO2),SAA,and IL-6 was 2.256,1.668,and 1.667 times higher than that in low-expression,respectively.The risk of BPD in high-expression of ptc(O2)was0.568 times higher than that in low-expression.The decision curve analysis showed that when the threshold value was within the range of 0.2 to 0.9,the combined model of ptc(O2),ptc(CO2),SAA,and IL-6 was superior to the individual prediction in predicting the net benefit rate of BPD in NRDS patients on the 7th day after birth.Conclusion The severity of NRDS complicat-ed with BPD is closely related to ptc(O2),ptc(CO2),SAA,and IL-6,and the combined detection of the four indicators can help improve the predictive efficacy and net benefit rate of NRDS compli-cated with BPD.

Objective To investigate the predictive value of dynamic monitoring of transcutaneous oxygen partial pressure[ptc(O2)],transcutaneous carbon dioxide partial pressure[ptc(CO2)],ser-um amyloid A(SAA),and interleukin-6(IL-6)levels in predicting bronchopulmonary dysplasia(BPD)in neonates with neonatal respiratory distress syndrome(NRDS).Methods A total of 240 NRDS patients were selected as the research subjects and divided into BPD group(108 cases)and non-BPD group(132 cases)based on whether BPD occurred.The levels of ptc(O2),ptc(CO2),SAA,and IL-6 were compared between the two groups on the 1st,7th,and 14th day after birth.Spearman correlation analysis was used to explore the correlation between each indicator and the degree of illness.The relative risk(RR)and 95％confidence interval(CI)were used to evaluate the impact of each indicator on BPD in NRDS patients.Receiver operating characteristic(ROC)curves and decision curve analysis were used to evaluate the predictive efficacy and clinical net benefit of each indicator for BPD.Results On the 1st day after birth,there were no statistically significant differ-ences in ptc(O2),ptc(CO2),serum SAA,and IL-6 levels between the two groups(P＞0.05).On the 7th and 14th day after birth,the ptc(O2)in the BPD group was lower than that in the non-BPD group,while the ptc(CO2)and serum SAA,IL-6 levels were higher than those in the non-BPD group(P＜0.05).Correlation analysis results showed that the degree of BPD in children was nega-tively correlated with ptc(O2)on the 7th day after birth(r=-0.724,P＜0.05),and positively correlated with ptc(CO2),SAA,and IL-6 on the 7th day after birth(r=0.635,0.830,0.715,P＜0.05).The degree of pulmonary dysfunction in children was negatively correlated with ptc(O2)on the 7th day after birth(r=-0.719,P＜0.05),and positively correlated with ptc(CO2),SAA,and IL-6 on the 7th day after birth(r=0.673,0.756,0.696,P＜0.05).On the 7th day after birth,the ptc(O2)of BPD patients was negatively correlated with SAA and IL-6(r=-0.605,-0.623,P＜0.05),while ptc(CO2)was positively correlated with SAA and IL-6(r=0.618,0.650,P＜0.05).ROC curve showed that the combined prediction of ptc(O2),ptc(CO2),SAA,and IL-6 on the 7th day after birth for NRDS complicated with BPD was better than the individual prediction of the four indicators,with an area under the curve of 0.938(95％CI,0.899 to 0.965).The risk of BPD in high-expression of ptc(CO2),SAA,and IL-6 was 2.256,1.668,and 1.667 times higher than that in low-expression,respectively.The risk of BPD in high-expression of ptc(O2)was0.568 times higher than that in low-expression.The decision curve analysis showed that when the threshold value was within the range of 0.2 to 0.9,the combined model of ptc(O2),ptc(CO2),SAA,and IL-6 was superior to the individual prediction in predicting the net benefit rate of BPD in NRDS patients on the 7th day after birth.Conclusion The severity of NRDS complicat-ed with BPD is closely related to ptc(O2),ptc(CO2),SAA,and IL-6,and the combined detection of the four indicators can help improve the predictive efficacy and net benefit rate of NRDS compli-cated with BPD.