Mesalazine suppositories are widely used to treat ulcerative colitis and have a guaranteed safety profile, but although rare, they can cause pulmonary toxicity. A 35-year-old woman with ulcerative colitis was diagnosed to have acute eosinophilic pneumonia after 29 days of oral mesalazine use and improved after mesalazine and corticosteroid were withdrawn. Reintroduction of mesalazine suppositories resulted in acute eosinophilic pneumonia recurrence after 28 days. Mesalazine re-administration (even via a different route) in patients with a history of mesalazine-induced eosinophilic pneumonia should be undertaken cautiously, because eosinophilic pneumonia may recurrence.
Adult ; Colitis, Ulcerative ; Eosinophils ; Female ; Humans ; Mesalamine ; Pulmonary Eosinophilia ; Recurrence ; Suppositories ; Ulcer

BACKGROUND: Although both thyroid histology and serum concentrations of hormones are known to change with age, only a few reports exist on the relationship between the age-related structural and functional changes of the thyroid follicles in both mice and humans. Our objectives were to investigate age-related histological changes of the thyroid follicles and to determine whether these morphological changes were associated with the functional activity of the follicles. METHODS: The thyroid glands of mice at 18 weeks and at 6, 15, and 30 months of age were histologically examined, and the serum levels of thyroid hormones were measured in 11-week-old and 20-month-old mice. Samples of human thyroid tissue from 10 women over 70 years old and 10 women between 30 and 50 years of age were analyzed in conjunction with serum thyroid hormone level. RESULTS: The histological and functional changes observed in the thyroid follicles of aged mice and women were as follows: variable sizing and enlargement of the follicles; increased irregularity of follicles; Sanderson’s polsters in the wall of large follicles; a large thyroglobulin (Tg) globule or numerous small fragmented Tg globules in follicular lumens; oncocytic change in follicular cells; and markedly dilated follicles empty of colloid. Serum T3 levels in 20-month-old mice and humans were unremarkable. CONCLUSIONS: Thyroid follicles of aged mice and women show characteristic morphological changes, such as cystic atrophy, empty colloid, and Tg globules.
Aged ; Animals ; Atrophy ; Colloids ; Female ; Humans* ; Infant ; Mice ; Thyroglobulin ; Thyroid Gland* ; Thyroid Hormones

Malignant melanoma rarely develops in the paranasal sinuses, and generally has a poor prognosis. However, mucosal melanoma can masquerade both clinically and histopathologically as a benign lesion, rendering accurate early diagnosis difficult. On the other hand, angiofibroma, a benign tumor, is more easily diagnosed than a mucosal melanoma, because the former exhibits specific histopathological features. No cases of concurrent angiofibroma and mucosal melanoma have been reported to date. We describe such a case below.
Angiofibroma* ; Early Diagnosis ; Hand ; Melanoma* ; Nasal Cavity ; Nose* ; Paranasal Sinuses ; Prognosis

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the development of various tissues. However, its role in pancreas development has not yet been elucidated. METHODS: Pancreatic progenitor cell-specific Prmt1 knock-out (Prmt1 PKO) mice were generated and characterized for their metabolic and histological phenotypes and their levels of Neurog3 gene expression and neurogenin 3 (NGN3) protein expression. Protein degradation assays were performed in mPAC cells. RESULTS: Prmt1 PKO mice showed growth retardation and a severely diabetic phenotype. The pancreatic size and β-cell mass were significantly reduced in Prmt1 PKO mice. Proliferation of progenitor cells during the secondary transition was decreased and endocrine cell differentiation was impaired. These defects in pancreas development could be attributed to the sustained expression of NGN3 in progenitor cells. Protein degradation assays in mPAC cells revealed that PRMT1 was required for the rapid degradation of NGN3. CONCLUSION: PRMT1 critically contributes to pancreas development by destabilizing the NGN3 protein.
Animals ; Diabetes Mellitus ; Endocrine Cells ; Gene Expression ; Islets of Langerhans ; Mice ; Pancreas ; Phenotype ; Protein Stability ; Protein-Arginine N-Methyltransferases ; Proteolysis ; Stem Cells

Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers.
Carcinogenesis ; Carcinoma ; Disease Progression ; Energy Metabolism* ; Iodine ; Mitochondria ; Oncogenes ; Phenotype ; Thyroid Gland* ; Thyroid Neoplasms ; Biomarkers