1.Clinical Course of Endobrochial Tuberculosis Diagnosed by Flexible Bronchoscopy in Children.
Jungmin SUH ; Joongbum CHO ; Jung Hyun LEE ; Kangmo AHN
Pediatric Allergy and Respiratory Disease 2012;22(2):197-203
PURPOSE: The incidence of endobronchial tuberculosis in children is unknown, due to the inconsistent implementation of bronchoscopy in pediatric patients with pulmonary tuberculosis. In this study, our aim was to determine the incidence and clinical course of endobronchial tuberculosis in children. METHODS: We performed a retrospective chart review of patients less than 18 years of age, who was diagnosed with endobronchial tuberculosis via fiberoptic bronchoscopy. RESULTS: Out of the 101 patients with pulmonary tuberculosis, 16 patients had endobronchial tuberculosis. The median age at diagnosis was 11.2 years (range, 5 months to 16.1 years). Tuberculin skin test was positive in 9 cases (56.2%), and 6 patients (37.5%) had a history of household contact with tuberculosis. Consolidation lesion was common in the simple chest radiographs of patients with endobronchial tuberculosis. According to the bronchoscopic finding, actively caseating type was most common (43.8%). Nine of the 16 patients of endobronchial tuberculosis progressed to bronchial obstruction and 4 patients underwent pneumonectomy or lobectomy. Fibrostenotic and tumorous type tend to progress to endobronchial obstruction compared with actively caseating type. CONCLUSION: The incidence of endobronchial tuberculosis in pediatric pulmonary tuberculosis was 15.8%. Early detection and effective treatment of endobronchial tuberculosis are important to decrease the secondary complication, such as bronchial obstruction.
Bronchoscopy
;
Child
;
Family Characteristics
;
Humans
;
Incidence
;
Pneumonectomy
;
Retrospective Studies
;
Skin Tests
;
Thorax
;
Tuberculin
;
Tuberculosis
;
Tuberculosis, Pulmonary
2.Causes and Outcome of Tracheostomy in Children.
Jungmin SUH ; Jung Hyun LEE ; Man Ki CHUNG ; Han Sin JEONG ; Young Ik SON ; Kangmo AHN ; Sang Il LEE
Pediatric Allergy and Respiratory Disease 2012;22(2):188-196
PURPOSE: Tracheostomy is used to aid airway management in perdiatric respiratory care. This study was designed to review causes and outcomes of pediatric tracheostomy. METHODS: We performed a retrospective chart review of 153 patients, less than 18 years of age, who underwent tracheostomy between January 1995 and July 2010. Age at tracheostomy, indications, durations, complications and mortality were evaluated. RESULTS: Subglottic stenosis (19%) was the most common indication for tracheostomy. The median age at tracheostomy was 1.3 years (range, 22 days to 17.8 years). Seventy-three (47.7%) tracheostomies were performed in children under 1 year of age. Respiratory diseases were significantly more prevalent in patients under 1 year of age, while neuromuscular disease were more frequently found in patients older than 1 year (P=0.013). Stoma or tracheal granuloma formation (36.6%) was the most common complication of pediatric tracheostomy. Decannulation was accomplished in 61 (39.9%) patients with median cannulation time of 141 days (range, 1 to 2,529 days). Overall mortality rate was 10.5% (n=16), but only one patient (0.7%) died from tracheostomy-related complications. CONCLUSION: Respiratory diseases, such as subglottic stenosis and neuromuscular disease, are the main cause of pediatric tracheostomy. Although complications, like stoma or tracheal granuloma formation occur, tracheostomy in children is a safe way to aid airway management.
Airway Management
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Catheterization
;
Child
;
Constriction, Pathologic
;
Granuloma
;
Humans
;
Neuromuscular Diseases
;
Retrospective Studies
;
Tracheostomy
3.Comparison of the Effects of Breast Milk Feeding with Maternal Restriction and Hypoallergenic Milk Feeding on the Acquisition of Tolerance to Cow Milk.
Joongbum CHO ; Jungmin SUH ; Jung Hyun LEE ; Youngshin HAN ; Kangmo AHN ; Sang Il LEE
Pediatric Allergy and Respiratory Disease 2011;21(3):207-214
PURPOSE: The aim of this study was to compare the effects of breast milk (BM) feeding with those of maternal cow milk (CM) restriction and extensively hydrolyzed CM formula feeding on the duration of CM allergy as well as changes in specific immunoglobulin E (IgE) levels in infants with CM allergy. METHODS: Children diagnosed with CM allergy before 12 months age and BM fed were included retrospectively. CM allergy was diagnosed by CM specific IgE over 0.35 kU/L and 1) obvious clinical symptoms, 2) a suspicious history with positive provocation test, or 3) CM specific IgE over the 95% positive predictive value and subsequent documented report of clinical symptoms. The patients were classified into three groups by feeding regimen: BM group, extensively hydrolyzed formula (eHF) group, or mixed feeding (MF) group. Analysis of the groups regarding the duration of food allergy and changes in CM specific IgE was then performed. RESULTS: Forty-six children were included. Twenty-four children were in the BM group, 13 children were in the eHF group, and 9 children comprised the MF group. Thirteen patients reached tolerance. The means of the tolerance age were 69.7+/-5.4 months in the BM group, 36.6+/-4.6 months in the eHF group, and 38.2+/-7.9 months in the MF group. The survival curves of tolerance showed significant difference among the three groups (P=0.04). CM specific IgE levels measured at a second time period were 9.6 kU/L (interquartile range, 3.6-44.2) in the BM group, 2.0 kU/L (1.0-18.0) in the eHF group, and 4.8 kU/L (0.2-10.4) in the MF group (P=0.04). CONCLUSION: Feeding regimen influences the duration of CM allergy. Exclusively BM-fed children achieved tolerance later than eHF-fed children. Prospective and randomized controlled studies are required.
Breast
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Child
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Food Hypersensitivity
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Humans
;
Hypersensitivity
;
Immunoglobulin E
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Immunoglobulins
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Infant
;
Milk
;
Milk, Human
;
Retrospective Studies
4.Comparison of Prevalence and Risk Factors of Atopic Dermatitis by Physical Examination and Questionnaire Survey in Elementary School Children.
Jung Hyun LEE ; Eun Hye KIM ; Joongbum CHO ; Hye Young KIM ; Jungmin SUH ; Kangmo AHN ; Hae Kwan CHEONG ; Sang Il LEE
Pediatric Allergy and Respiratory Disease 2011;21(3):186-196
PURPOSE: The present study aimed to evaluate the accuracy of determining the prevalence of atopic dermatitis (AD) with a questionnaire by diagnosing AD with both a questionnaire and pediatricians' physical examinations and to determine the possible risk factors for AD. METHODS: A survey was conducted from December 2008 to February 2009 in four elementary schools. The Korean version of the International Study of Asthma and Allergies in Childhood written questionnaire (WQ) was used to identify AD ever and AD during the last 12 months. Current AD was diagnosed by well-trained pediatricians according to the Hanifin and Rajka's diagnostic criteria. A total of 2,729 children who completed the questionnaire and underwent a physical examination by pediatricians were included in this analysis. RESULTS: According to the WQ, the prevalence of AD in the entire life and in the last 12 months was 18.4% and 12.9%, respectively. The prevalence of clinically diagnosed AD by pediatricians was 8.8%. There was a significant positive relationship between the prevalence of AD diagnosed by physical examination and past history of allergic rhinitis (adjusted odds ratio [aOR], 1.45), allergy history of the mother (aOR, 2.48), and AD history of the mother (aOR, 1.61). According to the WQ, there was also a significant positive relationship between the prevalence of AD in the last 12 months and past history of asthma (aOR, 2.55) and AD history of the mother (aOR, 1.71). CONCLUSION: Prevalence and risk factors of AD were different according to the survey methods. When prevalence of AD is determined with a questionnaire in the future, more careful attention should be used, because the result can be overestimated compared to the actual prevalence.
Asthma
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Child
;
Dermatitis, Atopic
;
Humans
;
Hypersensitivity
;
Mothers
;
Odds Ratio
;
Physical Examination
;
Prevalence
;
Surveys and Questionnaires
;
Rhinitis
;
Rhinitis, Allergic, Perennial
;
Risk Factors
5.Natural Course of Cow's Milk Allergy in Children with Atopic Dermatitis.
Jungmin SUH ; Hyeonyoung LEE ; Jung Hyun LEE ; Joongbum CHO ; Jung Seok YU ; Jihyun KIM ; Youngshin HAN ; Kangmo AHN ; Sang Il LEE
Journal of Korean Medical Science 2011;26(9):1152-1158
Cow's milk is one of the most common food allergens in children with atopic dermatitis (AD). This study was conducted to describe the natural course of cow's milk allergy in children with AD, and to identify factors predictive of outcome. To accomplish this, we reviewed the medical records of 115 children who were diagnosed with AD and cow's milk allergy before 24 months of age to evaluate their clinical characteristics and prognostic factors. During a follow-up period of 24 to114 months, the median age for tolerance to cow's milk was found to be 67 months. Multivariate analysis using the Cox proportional hazard model revealed that the peak cow's milk-specific IgE level within 24 months after birth was the most important factor for prediction of the outcome of cow's milk allergy. In conclusion, half of the children younger than 24 months of age with AD and cow's milk allergy could tolerate cow's milk at 67 months of age. The peak cow's milk-specific IgE level within the first 24 months of birth is useful to predict the prognosis of cow's milk allergy in children with AD.
Animals
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Cattle
;
Child
;
Child, Preschool
;
Dermatitis, Atopic/complications/*diagnosis
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Female
;
Follow-Up Studies
;
Humans
;
Immune Tolerance
;
Immunoglobulin E/blood
;
Infant
;
Male
;
Milk/immunology
;
Milk Hypersensitivity/complications/*diagnosis
;
Odds Ratio
;
Prognosis
;
Time Factors
6.A case of Hyper-IgE syndrome with a mutation of the STAT3 gene.
Ji man KANG ; Jungmin SUH ; Jihyun KIM ; Hee Jin KIM ; Yae jean KIM ; Hun Seok LEE ; Young Kee SHIN ; Kangmo AHN ; Sang Il LEE
Korean Journal of Pediatrics 2010;53(4):592-597
Hyperimmunoglobulin E syndrome (HIES) is a rare immunodeficiency disease which is characterized by high serum IgE levels, eczema, and recurrent infections. Herein we present the case of a patient with HIES associated with STAT3 gene (stat3) mutation. A 16 year-old girl was admitted to our hospital due to hemoptysis caused by pneumonia with bronchiectasis. She had a history of recurrent skin and respiratory tract infections, such as pneumonia caused by MRSA (methicillin-resistant Staphylococcus aureus) and Pseudomonas aeruginosa. On physical examination, a broad round shaped nose, oral thrush, and chronic eczematous skin rash over her whole body were found. Laboratory data showed an elevated eosinophil count (750/microliter) and total IgE level (5,001 U/mL). The patient's National Institutes of Health (NIH) score for HIES was 44. Direct sequencing of the STAT3 gene revealed that the patient was heterozygous for a missense mutation in the DNA binding domain of the STAT3 protein (c.1144C>T, p. Arg382Trp). HIES should be suspected in patients with recurrent infections and can be confirmed by clinical scoring and genetic analysis.
Bronchiectasis
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Candidiasis, Oral
;
DNA
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Eczema
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Eosinophils
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Exanthema
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Hemoptysis
;
Humans
;
Immunoglobulin E
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Job's Syndrome
;
Methicillin-Resistant Staphylococcus aureus
;
Mutation, Missense
;
National Institutes of Health (U.S.)
;
Nose
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Physical Examination
;
Pneumonia
;
Pseudomonas aeruginosa
;
Respiratory Tract Infections
;
Skin
;
Staphylococcus
;
STAT3 Transcription Factor
7.Prevalence and Risk Factors of Asthma and Allergic Rhinitis in Elementary School Children in Jinan-Gun.
Do Soo KIM ; Mi Ran PARK ; Jung Seok YU ; Ho Suk LEE ; Jung Hyun LEE ; Jungmin SUH ; Jihyun KIM ; Youngshin HAN ; Sang Il LEE ; Kangmo AHN
Pediatric Allergy and Respiratory Disease 2012;22(4):374-382
PURPOSE: The aim of this study was to evaluate the prevalence and risk factors associated with asthma and allergic rhinitis in rural elementary school children. METHODS: Children in 12 elementary schools in Jinan-gun, Jeollabuk-do, a typical rural area in Korea, were enrolled. We conducted cross-sectional survey using a Korean version of International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. RESULTS: A total of 947 questionnaires out of 1,062 were completed and the response rate was 89.1%. The symptom prevalence of asthma and allergic rhinitis (AR) in the last 12 months was 7.4% and 28.1%. The prevalence of physician-diagnosed asthma and AR was 7.2% and 22.2%. Male, passive smoking, visible mold at home, and use of antibiotics during infancy more than 3 times were associated with higher prevalence of asthma diagnosis (adjusted odds ratio [aOR] 2.35, 95% confidence interval [CI] 1.30 to 4.26; aOR 2.49, 95% CI 1.38 to 4.48; aOR 2.19, 95% CI 1.23 to 3.89; and aOR 8.45, 95% CI 4.23 to 16.59). Parental history of allergic diseases, children without siblings, use of antibiotics during infancy more than 3 times were associated with higher prevalence of AR (aOR 4.89, 95% CI 3.37 to 7.10; aOR 5.20, 95% CI 2.38 to 11.35; and aOR 2.39, 95% CI 1.36 to 4.19). CONCLUSION: In Jinan-gun, the symptom prevalence of asthma and AR in the last 12 months was 7.4% and 28.1%. The environmental factors such as passive smoking, visible mold at home, use of antibiotics during infancy and number of siblings are associated with asthma and allergic rhinitis.
Anti-Bacterial Agents
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Asthma
;
Child
;
Cross-Sectional Studies
;
Fungi
;
Humans
;
Hypersensitivity
;
Korea
;
Male
;
Odds Ratio
;
Parents
;
Prevalence
;
Surveys and Questionnaires
;
Rhinitis
;
Rhinitis, Allergic, Perennial
;
Risk Factors
;
Siblings
;
Tobacco Smoke Pollution
8.Change in Quality of Life according to the Change in Atopic Dermatitis Severity.
Joongbum CHO ; Jung Hyun LEE ; Jungmin SUH ; Jung Seok YU ; Hoseok LEE ; Eunah PARK ; Hyunmi KIM ; Eun Young CHANG ; Jihyun KIM ; Youngshin HAN ; Kangmo AHN
Pediatric Allergy and Respiratory Disease 2012;22(1):86-99
PURPOSE: The aim of this study was to longitudinally examine the correlation between the change of atopic dermatitis (AD) severity and the change of quality of life (QOL). METHODS: We assessed AD severity and QOL of patients and their families, by a prospective followed up for at least 12 months. AD severity was assessed, using the scoring of atopic dermatitis (SCORAD) index. A questionnaire based on dermatitis family impact (DFI), infants' dermatologic quality of life (IDQoL) and children's dermatology life quality index (CDLQI) were used to determine QOL. RESULTS: Seventy-nine AD patients were assessed for total and objective SCORAD and DFI. Among them, 45 patients that were less than 36 months old completed IDQoL and 13 patients that were equal to or more than 36 months old completed CDLQI. Objective SCORAD (oSCORAD) were correlated with DFI (r=0.235), IDQoL (r=0.602) and CDLQI (r=0.589) (P<0.05). At the 2nd interview, median oSCORAD (from 17.4 to 7.8), DFI (from 23.0 to 18.0) and IDQoL (from 9.0 to 6.0) were significantly decreased (P<0.01). The changes of oSCORAD were linearly related with the change of IDQoL (P<0.01), but neither with DFI (P=0.356) nor with CDLQI (P=0.267). Of the 64 patients with decreased oSCORAD, food allergy was accompanied more frequently in those with an increased DFI than those with a decreased DFI (60.7% vs. 27.8%, P<0.01). CONCLUSION: In this longitudinal study, the improvement of AD severity is correlated with the improvement of the patient's QOL, under the age of 3. To improve the family's QOL, we need to find out accompanying factors, such as food allergy, and to support the family accordingly.
Asthma
;
Dermatitis
;
Dermatitis, Atopic
;
Dermatology
;
Food Hypersensitivity
;
Humans
;
Immunoglobulin E
;
Longitudinal Studies
;
Prospective Studies
;
Quality of Life
;
Surveys and Questionnaires
;
Rhinitis, Allergic, Perennial
9.Abbreviated chemotherapy for limited-stage diffuse large B-cell lymphoma after complete resection.
Jungmin JO ; Dok Hyun YOON ; Sang Wook LEE ; Chan Sik PARK ; Jooryung HUH ; Kyoungmin LEE ; Eun Hee KANG ; Shin KIM ; Cheolwon SUH
Blood Research 2014;49(2):115-119
BACKGROUND: Abbreviated chemotherapy followed by radiotherapy or full cycles of chemotherapy is recommended as a standard treatment for limited-stage (LS) diffuse large B-cell lymphoma (DLBCL). After complete resection of tumors, however, Burkitt and childhood B-cell Non-Hodgkin lymphoma show favorable outcomes, even after abbreviated chemotherapy of only 2 or 3 cycles. We investigated the effectiveness of abbreviated chemotherapy in patients with LS DLBCL after complete tumor resection. METHODS: We retrospectively reviewed 18 patients with LS DLBCL who underwent complete tumor resection followed by either 3 or 4 cycles of chemotherapy between March 2002 and May 2010. RESULTS: With a median follow-up period of 57.9 months (range, 31.8-130.2 months), no patients experienced disease relapse or progression; however, 1 patient experienced secondary acute myeloid leukemia during follow-up. The 5-year progression-free survival rate and overall survival rate were 93.3% and 94.1%, respectively. CONCLUSION: These results warrant further investigation into abbreviated chemotherapy as an alternative treatment for patients who have undergone complete resection of LS DLBCL.
B-Lymphocytes
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Disease-Free Survival
;
Drug Therapy*
;
Follow-Up Studies
;
Humans
;
Leukemia, Myeloid, Acute
;
Lymphoma, B-Cell*
;
Lymphoma, Non-Hodgkin
;
Radiotherapy
;
Recurrence
;
Retrospective Studies
;
Survival Rate
10.Surveillance of home environment in children with atopic dermatitis: a questionnaire survey
Jung Hyun LEE ; Jungmin SUH ; Eun Hye KIM ; Joong Bum CHO ; Hwa Young PARK ; Jihyun KIM ; Kangmo AHN ; Hae Kwan CHEONG ; Sang IL LEE
Asia Pacific Allergy 2012;2(1):59-66
BACKGROUND: The increasing prevalence of atopic dermatitis (AD) suggests a role for environmental factors in triggering a genetic predisposition in sufferers. OBJECTIVE: The purpose of this study was to investigate home environmental factors related to AD severity. METHODS: We conducted a questionnaire survey about the home environmental factors in 380 children from two daycare centers and the Samsung Medical Center outpatient clinic. AD was diagnosed by Hanifin and Rajka's criteria and its severity was assessed by the Severity Scoring of Atopic Dermatitis index. Children were divided into normal control group, mild AD group and severe AD group. Home environmental factors were compared among the three groups and were statistically analyzed using analysis of variance, Chi-square test, Fisher's exact test, and multiple logistic analysis. RESULTS: Indoor remodeling activities, such as painting (p = 0.004), floor covering (p = 0.001) and wallpaper changing (p = 0.002) were associated with severity of AD. Those in the severe AD group were more likely to live in an apartment (p < 0.001). Severe AD was observed more frequently when the monthly income of household (p = 0.027) and final educational status of mother (p = 0.001) were higher. CONCLUSION: Some home environmental factors were associated with AD severity, but its causal relationship is not clear. Further research is needed to confirm these associations and to clarify whether they are causative.
Ambulatory Care Facilities
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Child
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Dermatitis, Atopic
;
Educational Status
;
Family Characteristics
;
Genetic Predisposition to Disease
;
Humans
;
Mothers
;
Paint
;
Paintings
;
Prevalence
;
Risk Factors