1.Localization of Praziquantel Production and Clonorchiasis Control Program in Korea, 1970s~1980s
Korean Journal of Medical History 2021;30(2):317-354
The Korean parasite control program is regarded as one of the most successful examples of health care movement in Korea. This ‘Parasite Eradication Program’ which was conducted from 1969 to 1995, involved testing and treating of 300 million people. In cooperation with Japan, parasitologists and activists who participated in the parasite control program formed a common system called the ‘Mass Testing, Mass Treatment.’ This study focuses on the localization process of Praziquantel, Clonorchiasis treatment production and its application in Clonorchiasis control program. Parasitologists rapidly introduced newly developed Praziquantel, and Korean chemists quickly reverse engineered the compound to evade patent issues. This allowed for the mass production of Praziquantel at a lower price, which in turn enabled a nationwide Clonorchiasis control program. At the same time, low price and stable supply opened the private market for Praziquantel. However, acceptance and understanding of the Praziquantel differed significantly among the stakeholders. For the government, it was a means for policy propaganda, and for the health agencies, it was a means for mass scale control program, while for the public, it was a means for maintaining conventional eating habits without risk of infection. This study reveals how the material end of a disease control policy is accepted and interpreted by different actors.
2.Localization of Praziquantel Production and Clonorchiasis Control Program in Korea, 1970s~1980s
Korean Journal of Medical History 2021;30(2):317-354
The Korean parasite control program is regarded as one of the most successful examples of health care movement in Korea. This ‘Parasite Eradication Program’ which was conducted from 1969 to 1995, involved testing and treating of 300 million people. In cooperation with Japan, parasitologists and activists who participated in the parasite control program formed a common system called the ‘Mass Testing, Mass Treatment.’ This study focuses on the localization process of Praziquantel, Clonorchiasis treatment production and its application in Clonorchiasis control program. Parasitologists rapidly introduced newly developed Praziquantel, and Korean chemists quickly reverse engineered the compound to evade patent issues. This allowed for the mass production of Praziquantel at a lower price, which in turn enabled a nationwide Clonorchiasis control program. At the same time, low price and stable supply opened the private market for Praziquantel. However, acceptance and understanding of the Praziquantel differed significantly among the stakeholders. For the government, it was a means for policy propaganda, and for the health agencies, it was a means for mass scale control program, while for the public, it was a means for maintaining conventional eating habits without risk of infection. This study reveals how the material end of a disease control policy is accepted and interpreted by different actors.
3.Two Cases of Hungry Bone Syndrome after Huge Parathyroidectomy.
Hyeongjoo LEE ; Jinpyeong KIM ; Jungje PARK ; Seunghoon WOO
Journal of Korean Thyroid Association 2015;8(1):108-112
Hungry bone syndrome can occur after parathyroidectomy which is performed due to primary hyperparathyroidism. Hungry bone syndrome is characterized by showing postoperative hypocalcemia which is caused by the remineralization of various minerals, including calcium inside the bone. This syndrome requires a long term supplementation of calcium. Identifying the preoperative predictors of hypocalcemia is essential and important for postoperative management. From here on in, we report two cases of patients with parathyroid adenoma who have undergone parathyroidectomy. We would like to report and discuss the management of hungry bone syndrome experienced from the two cases that have been mentioned above. We report these two cases with a review of the literature.
Calcium
;
Humans
;
Hyperparathyroidism, Primary
;
Hypocalcemia
;
Minerals
;
Parathyroid Hormone
;
Parathyroid Neoplasms
;
Parathyroidectomy*
4.A Case of MELAS Syndrome Diagnosed in a Woman in Her 50s.
Yoonoo HWANG ; Jae Ho JEONG ; Yu Seok KIM ; Jungje CHO ; Woo Je LEE ; Joong Yeol PARK ; Ki Up LEE
Korean Journal of Medicine 2011;80(2):225-230
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, abbreviated to MELAS, syndrome is a common mitochondrial disease that can present with a wide range of clinical symptoms, including seizures, stroke-like episodes, neuropathy, myopathy, sensorineural hearing loss, and encephalopathy. Although more than 90% of patients present with stroke-like episodes before the age of 40 years, some reports have described patients presenting later in life. Here, we report MELAS syndrome diagnosed in a 52-year-old Korean woman admitted because of altered mentality. She had a history of diabetes, sensorineural hearing loss, and cardiomyopathy. The patient's mentality fluctuated and her lactic acid level was elevated in the hospital. Although she was in her 50s, her medical history, encephalopathy, and lactic acidosis made us strongly suspect MELAS syndrome. The diagnosis was confirmed when a test showed the A3243G mitochondrial DNA mutation.
Acidosis, Lactic
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Cardiomyopathies
;
Diabetes Mellitus
;
DNA, Mitochondrial
;
Female
;
Hearing Loss, Sensorineural
;
Humans
;
Lactic Acid
;
MELAS Syndrome
;
Middle Aged
;
Mitochondrial Diseases
;
Mitochondrial Encephalomyopathies
;
Muscular Diseases
;
Seizures