1.Clinical application of quantitative computed tomography in osteogenesis imperfecta-suspected cat.
Sungjun WON ; Woo jo CHUNG ; Junghee YOON
Journal of Veterinary Science 2017;18(3):415-417
One-year-old male Persian cat presented with multiple fractures and no known traumatic history. Marked decrease of bone radiopacity and thin cortices of all long bones were identified on radiography. Tentative diagnosis was osteogenesis imperfecta, a congenital disorder characterized by fragile bone. To determine bone mineral density (BMD), quantitative computed tomography (QCT) was performed. The QCT results revealed a mean trabecular BMD of vertebral bodies of 149.9 ± 86.5 mg/cm³. After bisphosphonate therapy, BMD of the same site increased significantly (218.5 ± 117.1 mg/cm³, p < 0.05). QCT was a useful diagnostic tool to diagnose osteopenia and quantify response to medical treatment.
Animals
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Bone Density
;
Bone Diseases, Metabolic
;
Cats*
;
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
;
Diagnosis
;
Fractures, Multiple
;
Humans
;
Male
;
Osteogenesis Imperfecta
;
Osteogenesis*
;
Radiography
2.Application of pulsed Doppler ultrasound for the evaluation of small intestinal motility in dogs.
Yong Joo AN ; Heechun LEE ; Dongwoo CHANG ; Youngwon LEE ; Jai Ki SUNG ; Mincheol CHOI ; Junghee YOON
Journal of Veterinary Science 2001;2(1):71-74
The purpose of this study was to verify whether small intestinal peristalsis could be observed and quantitatively assessed using pulsed-Doppler ultrasound. Pulsed-Doppler ultrasound was used to evaluate small intestinal peristalsis after a meal in ten normal dogs and ten sedated dogs. The small intestinal peristalses were measured 0, 1, 3, 6, 9, 12, and 24 hours after a 24-hour fast and after feeding. The number of small intestinal peristalsis were 0.133/min, 0.100/min, 0.033/min, 0.167/min, 0.070/min, 0.067/min, and 0.100/min in the fasted dogs, and 1.667/ min, 0.933/min, 1.133/min, 1.234/min, 1.933/min, 1.533/ min, and 0.533/min in fed dogs, respectively. In the dogs sedated with xylazine HCl, the number of small intestinal peristalsis was significantly reduced (p<0.01). However, in the dogs treated with ketamine HCl and acepromazine, the number of small intestinal peristalsis remained unchanged. Therefore, it can be concluded that pulsed-Doppler ultrasound allows graphic visualization of the intestinal movements, which can be subjected to qualitative and quantitative analysis, and may be suitable for a non-invasive study of small intestinal motility.
Acepromazine/pharmacology
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Animals
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Dogs
;
Dopamine Antagonists/pharmacology
;
Excitatory Amino Acid Antagonists/pharmacology
;
*Gastrointestinal Motility/drug effects
;
Intestine, Small/drug effects/*physiology/ultrasonography
;
Ketamine/pharmacology
;
Peristalsis/drug effects/*physiology
;
Ultrasonography, Doppler, Pulsed/methods/*veterinary
3.Pulsed tissue Doppler imaging of the left ventricular septal mitral annulus in healthy dogs.
Jihye CHOI ; Hyunwook KIM ; Junghee YOON
Journal of Veterinary Science 2013;14(1):85-90
This study evaluated pulsed TDI variables including the isovolumic time interval and duration of the major wave in a population of large healthy dogs. Longitudinal myocardial motion at the septal mitral annulus was evaluated with pulsed TDI in 45 healthy adult dogs. Maximal myocardial velocities, isovolumic time intervals, and duration of the myocardial waves were measured. The correlation between time intervals and velocity variables was also investigated. The mean maximal systolic velocity was 6.92 +/- 1.78 cm/sec, the mean early diastolic velocity (Em) was 6.58 +/- 1.81 cm/sec, the mean late diastolic velocity (Am) was 5.10 +/- 2.00 cm/sec, the mean isovolumic contraction time (IVCT) was 53.61 +/- 95.13 msec, and the mean isovolumic relaxation time (IVRT) was 26.74 +/- 57.24 msec. The early diastolic mitral inflow velocity (E)/Em ratio was 10.94 +/- 3.27 while the Em/Am ratio was 1.40 +/- 0.40. There was a negative correlation between Am duration and Am amplitude, and a positive correlation between the IVRT and Em/Am ratio (p < 0.05). The normal LV parameter using pulsed TDI method could be used as the reference range for identifying myocardial dysfunction in dogs.
Animals
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Dogs/*anatomy & histology
;
Female
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Heart Ventricles/*ultrasonography
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Male
;
Mitral Valve/*ultrasonography
;
Ultrasonography, Doppler, Pulsed/methods/*veterinary
4.Diagnostic imaging features of hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia in a cat
Namsoon LEE ; Jihye CHOI ; Junghee YOON
Journal of Veterinary Science 2022;23(3):e42-
A 1-year-old male Persian cat was presented for castration. Liver incarcerated in a peritoneopericardial diaphragmatic hernia (PPDH) was diagnosed through pre-anesthetic tests. Multiple homogeneous hyperechoic nodules in the hepatic parenchyma were identified using ultrasound. The nodules showed decreased attenuation compared with normal hepatic parenchyma, and the herniated hepatic parenchyma showed increased arterial and decreased portal enhancement on computed tomography. From the histopathology, we diagnosed hydropic degeneration with portal fibrosis and myelolipoma. This report presents diagnostic imaging features of hepatic myelolipoma incarcerated in a PPDH in a cat. When perfusion of the hepatic parenchyma is altered, surgical treatment should be considered.
5.Semi-quantitative strain elastography may facilitate pre-surgical prediction of mandibular lymph nodes malignancy in dogs
Mihyun CHOI ; Junghee YOON ; Mincheol CHOI
Journal of Veterinary Science 2019;20(6):e62-
Evaluation of mandibular lymph nodes in a patient with head and neck cancer is important for stage determination and prognosis development, and, in human medicine, the use of sonoelastography for differentiating between non-metastatic and metastatic lymph nodes has been reported. Our prospective, cross-sectional study aimed to evaluate the diagnostic performance of strain elastography and to determine elastographic cut-off values for predicting malignancy. Sixty-six mandibular lymph nodes were included (clinical healthy, n = 45; non-metastatic, n = 8; and metastatic, n = 13). Elastographic images were evaluated qualitatively (elastographic pattern) and semi-quantitatively (mean hue histogram and stiffness area ratios). Elastographic patterns were classified as grades 1 to 4, according to the percentage of high elasticity determined by visualization. The mean hue histogram was defined based on as the mean pixel color values within the lymph node. Stiffness area ratios were determined by computer program analysis of the stiff area. Among the criteria, receiver operating characteristic curve analyses revealed cut-off values for the prediction of malignancy of 92.26 for mean hue histogram (sensitivity: 100%, specificity: 92%), and 0.17 for stiffness area ratios (sensitivity: 86%, specificity of 100%). Reproducibility and repeatability were excellent. In conclusion, semi-quantitative evaluation via strain elastography holds potential for predicting lymph node malignancy.
Animals
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Cross-Sectional Studies
;
Dogs
;
Elasticity
;
Elasticity Imaging Techniques
;
Head and Neck Neoplasms
;
Humans
;
Lymph Nodes
;
Prognosis
;
Prospective Studies
;
ROC Curve
;
Sensitivity and Specificity
6.Oral contrast media for computed tomography of canine pancreas.
Jihye CHOI ; Jinhwa CHANG ; Sunkyoung OH ; Junghee YOON
Korean Journal of Veterinary Research 2011;51(2):165-169
Barium suspension, oral iodine contrast medium and water were applied in eight dogs to evaluate (1) distension of gastrointestinal tract, (2) the effect of the oral contrast media on the identification of the pancreas from surrounding organs, and (3) image quality and the presence of artifacts in canine pancreas computed tomography (CT) images. Oral iodine contrast medium, gastrografin, produced significant artifacts that deteriorated the CT images of the pancreas. The use of water did not provide the fullness of the gastrointestinal lumens. Barium suspension was effective for the identification of the pancreas from the surrounding gastrointestinal tract, without significantly increasing image noise. Barium suspension can be used as an optimal contrast medium that will not cause an adverse effect on the pancreatic density and image quality.
Animals
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Artifacts
;
Barium
;
Contrast Media
;
Diatrizoate Meglumine
;
Dogs
;
Gastrointestinal Tract
;
Iodine
;
Noise
;
Pancreas
;
Water
7.Blood Transcriptome Profiling in Myasthenia Gravis Patients to Assess Disease Activity: A Pilot RNA-seq Study.
Kee Hong PARK ; Junghee JUNG ; Jung Hee LEE ; Yoon Ho HONG
Experimental Neurobiology 2016;25(1):40-47
Myasthenia gravis (MG) is an antibody-mediated autoimmune disease characterized by exertional weakness. There is no biomarker to reflect disease activity and guide treatment decision. Here, we reported a pilot blood transcriptome study using RNA sequencing (RNA-seq) that identified differences of 5 samples in active status and 5 in remission from 8 different patients and 2 patients provided samples for both active and remission phase. We found a total of 28 differentially expressed genes (DEGs) possibly related to disease activity (23 up-regulated and 5 down-regulated). The DEGs were enriched for the cell motion and cell migration processes in which included were ICAM1, CCL3, S100P and GAB2. The apoptosis and cell death pathway was also significantly enriched, which includes NFKBIA, ZC3H12A, TNFAIP3, and PPP1R15A. Our result suggests that transcript abundance profiles of the genes involved in cell trafficking and apoptosis may be a molecular signature of the disease activity in MG patients.
Apoptosis
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Autoimmune Diseases
;
Cell Death
;
Cell Movement
;
Gene Expression Profiling*
;
Humans
;
Myasthenia Gravis*
;
Sequence Analysis, RNA
;
Transcriptome*
8.Development and validation of the Health Literacy Index for the Community for the Korean National Health and Nutrition and Examination Survey
Junghee YOON ; Soo Jin KANG ; Mangyeong LEE ; Juhee CHO
Epidemiology and Health 2024;46(1):e2024061-
OBJECTIVES:
We developed and validated the Health Literacy Index for the Community (HLIC) to assess the health literacy of the Korean population within the framework of the Korean National Health and Nutrition and Examination Survey.
METHODS:
The HLIC was developed through (1) defining the conceptual framework and generating the item pool and (2) finalizing the items and identifying the cut-off value. Interviews were conducted to examine items’ face validity, and a cross-sectional survey was performed to analyze the item-response theory and Rasch models to investigate the instrument’s psychometric properties.
RESULTS:
In this study of 1,041 participants, most had no difficulty understanding health information; however, 67.9% struggled to assess the reliability of health information from the Internet or media. A 4-factor structure was identified through factor analysis, leading to the exclusion of some items. This resulted in 10 items across 4 domains: (1) disease prevention, (2) health promotion, (3) health care, and (4) technology and resources. The HLIC demonstrated good internal consistency, with a Cronbach’s α of 0.87. It also showed high test-retest reliability and correlations with other health literacy instruments. A socio-demographic analysis of the HLIC revealed disparities in health literacy across various age groups, education levels, and income brackets.
CONCLUSIONS
The HLIC was developed to systematically measure health literacy in Korea’s general population. Its simplicity and conciseness ensure reliability and validity and improve its accessibility, making it particularly suitable for the broader Korean population, including those with lower literacy levels.
9.Development and validation of the Health Literacy Index for the Community for the Korean National Health and Nutrition and Examination Survey
Junghee YOON ; Soo Jin KANG ; Mangyeong LEE ; Juhee CHO
Epidemiology and Health 2024;46(1):e2024061-
OBJECTIVES:
We developed and validated the Health Literacy Index for the Community (HLIC) to assess the health literacy of the Korean population within the framework of the Korean National Health and Nutrition and Examination Survey.
METHODS:
The HLIC was developed through (1) defining the conceptual framework and generating the item pool and (2) finalizing the items and identifying the cut-off value. Interviews were conducted to examine items’ face validity, and a cross-sectional survey was performed to analyze the item-response theory and Rasch models to investigate the instrument’s psychometric properties.
RESULTS:
In this study of 1,041 participants, most had no difficulty understanding health information; however, 67.9% struggled to assess the reliability of health information from the Internet or media. A 4-factor structure was identified through factor analysis, leading to the exclusion of some items. This resulted in 10 items across 4 domains: (1) disease prevention, (2) health promotion, (3) health care, and (4) technology and resources. The HLIC demonstrated good internal consistency, with a Cronbach’s α of 0.87. It also showed high test-retest reliability and correlations with other health literacy instruments. A socio-demographic analysis of the HLIC revealed disparities in health literacy across various age groups, education levels, and income brackets.
CONCLUSIONS
The HLIC was developed to systematically measure health literacy in Korea’s general population. Its simplicity and conciseness ensure reliability and validity and improve its accessibility, making it particularly suitable for the broader Korean population, including those with lower literacy levels.
10.Development and validation of the Health Literacy Index for the Community for the Korean National Health and Nutrition and Examination Survey
Junghee YOON ; Soo Jin KANG ; Mangyeong LEE ; Juhee CHO
Epidemiology and Health 2024;46(1):e2024061-
OBJECTIVES:
We developed and validated the Health Literacy Index for the Community (HLIC) to assess the health literacy of the Korean population within the framework of the Korean National Health and Nutrition and Examination Survey.
METHODS:
The HLIC was developed through (1) defining the conceptual framework and generating the item pool and (2) finalizing the items and identifying the cut-off value. Interviews were conducted to examine items’ face validity, and a cross-sectional survey was performed to analyze the item-response theory and Rasch models to investigate the instrument’s psychometric properties.
RESULTS:
In this study of 1,041 participants, most had no difficulty understanding health information; however, 67.9% struggled to assess the reliability of health information from the Internet or media. A 4-factor structure was identified through factor analysis, leading to the exclusion of some items. This resulted in 10 items across 4 domains: (1) disease prevention, (2) health promotion, (3) health care, and (4) technology and resources. The HLIC demonstrated good internal consistency, with a Cronbach’s α of 0.87. It also showed high test-retest reliability and correlations with other health literacy instruments. A socio-demographic analysis of the HLIC revealed disparities in health literacy across various age groups, education levels, and income brackets.
CONCLUSIONS
The HLIC was developed to systematically measure health literacy in Korea’s general population. Its simplicity and conciseness ensure reliability and validity and improve its accessibility, making it particularly suitable for the broader Korean population, including those with lower literacy levels.