1.A Study for The Relationship between Steroid Receptor Expression and Histologic Findings in Breast Diseases.
Junghan YOON ; Youngjong JAEGAL ; Seungwhan LEE ; Woosuk YANG
Journal of Korean Breast Cancer Society 1998;1(1):61-68
The role of steroid receptor has been widely studied and well established in the field of breast cancer. In contrast of breast cancer, the clinicopathological roles of steroid receptors in benign breast diseases were not established clearly until now. Authors evaluated steroid receptor expressions of benign breast diseases using the immuno-histochemical staining and analyzed their relationship with pathologic types and the correlation between the positivity of steroid receptor expression and the proliferative activity of ductal epithelial cells. The results were follows; 1) The assayed tissue specimens were 93 cases which consisted with fibrocystic disease, 39 cases and fibroadenoma, 54 cases. 2) The positivity rate of steroid receptor expression in fibroadenoma (ER: 59.2%, PR: 75.9%) seemed to be more higher than in fibrecystic diseases (ER: 46.1%, PR: 55.5%) without a statistical significance. 3) The positivity rate of ER expression of fibrocystic diseases developed in premenopausal women (54.8%) was significantly higher than in postmenopausal women (2.5%). 4) Any significant correlation was not noted between the positivity of steroid receptor expression in the tissue and ductal epithelial proliferative activity. In conclusion, fibrocystic disease and fibroadenomas possessed a significant amount of steroid receptor positive cells in their tissues. However, the positivity of steroid receptor expression in the tissues seemed to have few correlation with the ductal epithelial cellular proliferation.
Breast Diseases*
;
Breast Neoplasms
;
Breast*
;
Cell Proliferation
;
Epithelial Cells
;
Female
;
Fibroadenoma
;
Humans
;
Receptors, Steroid*
2.Aspirin and Clopidogrel Resistance in Drug Eluting Stent Era.
Korean Circulation Journal 2007;37(4):135-147
Platelets play a central role in the pathogenesis of atherothrombosis. Dual antiplatelet therapy with clopidogrel plus aspirin has been shown to reduce ischemic events in patients undergoing percutaneous coronary intervention (PCI) and stenting. Although dual antiplatelet therapy reduces the risk of cardiovascular episodes after PCIs, a substantial number of incidents continue to occur. Many cardiologists have focused their attention to the relationships between the interindividual variability of platelet inhibition after aspirin or clopidogrel administration and major cardiac adverse events such as stent thrombosis. Recent evidence has suggested that "aspirin or clopidogrel resistance" is associated with poor health outcomes (recurrent atherothrombotic events and stent thrombosis) after drug eluting stent (DES) implantation. However, the current clinical guidelines do not support routine screenings for antiplatelet resistance because standardized objective screening has not yet been established. Thus, this review describes the antiplatelet therapy used in PCI and it outlines the mechanism, laboratory tests, clinical impact and treatment options for aspirin and clopidogrel resistance in the DES era.
Angioplasty
;
Aspirin*
;
Blood Platelets
;
Drug Resistance
;
Humans
;
Mass Screening
;
Percutaneous Coronary Intervention
;
Stents*
;
Thrombosis
3.Pulsed Wave and Color Doppler Echocardiography and Cardiac Catheterization Findings in Bilateral Pulmonary Vein Stenosis.
Namsik CHUNG ; Jong Won HA ; Junghan YOON ; Byung Ok KIM ; Yangsoo JANG ; Seung Yun CHO ; Bum Koo CHO
Korean Circulation Journal 1998;28(4):647-652
Pulmonary vein stenosis is a rare condition which is usually congenital in origin and is almost invariably fatal in its bilateral and severe forms. It is often overlooked, however, during clinical examination, routine echocardiography, and even at cardiac catheterization. This report describes pulsed Doppler, color flow echocardiography, and hemodynamic findings of bilateral pulmonary vein stenosis accompanying ventricular septal and atrial septal defects successfully corrected by surgery.
Cardiac Catheterization*
;
Cardiac Catheters*
;
Catheterization
;
Constriction, Pathologic*
;
Echocardiography
;
Echocardiography, Doppler, Color*
;
Heart Septal Defects, Atrial
;
Hemodynamics
;
Pulmonary Veins*
4.A Case of Stent Embolizations into the Left Renal and Right Common Iliac Artery during Primary PTCA.
Byung Su YOO ; Junghan YOON ; Bong Ki LEE ; Ji Yean KO ; Seung Hwan LEE ; Sung Oh HWANG ; Kyung Hoon CHOE
Korean Circulation Journal 1999;29(11):1250-1254
Coronary stent embolization is a rare event but may result in clinically relevant cardiac ischemia or peripheral embolization during the procedure. We report a case of systemic embolizations of two coil stents during the primary PTCA in acute myocardial infarction, who were treated successfully with a double wire helix technique and a gooseneck snare. Although in our experience this rare complication did not produce any clinical complications, care should be taken to prevent this possibility, especially in patients with significant vessel tortuosity, calcification, total occlusion, or mild stenosis proximal to the target lesion.
Constriction, Pathologic
;
Humans
;
Iliac Artery*
;
Ischemia
;
Myocardial Infarction
;
SNARE Proteins
;
Stents*
5.Endovascular Stent Grafting via the Left Radial Artery for a Spontaneous Isolated Dissecting Rupture of the Superior Mesenteric Artery.
Ji Hyun LEE ; Sung Gyun AHN ; Junghan YOON
Korean Circulation Journal 2012;42(2):140-141
No abstract available.
Mesenteric Artery, Superior
;
Radial Artery
;
Rupture
;
Stents
;
Transplants
6.Diagnosis of Myocardial Injury in Blunt Chest Trauma.
Sung Oh HWANG ; Kang Hyun LEE ; Sun Man KIM ; Eun Seog HONG ; Junghan YOON ; Kyung Hoon CHOE ; Boo Soo LEE
Korean Circulation Journal 1997;27(3):326-332
PURPOSE: This study was designed to evaluate diagnostic accuracy of serial electrocardiograms(ECG), myocardial band of creatinine phosphokinase(CK)(CK-MB/CK ratio) and two dimensional echocardiography(ECHO) for myocardial injury in patients with blunt chest trauma. METHODS: We prospectively investigated 54 patients(male : 38, female : 16, mean age : 41) with severe blunt chest trauma. Presence of myocardial injury was determined by increase(>0.1ug/L) of peak serum troponin T(TnT) concentration from serial mesurements. RESULTS: Among 54 patients with blunt chest trauma, 23 patients(43%) had increased peak TnT level which suggested of myocardial injury. Among 23 patients with increased TnT, abnormal ECG findings were found in 18(78%) and echocardiographic abnormalities were observed in 17(74%). Cardiovascular events in 9(39%) of 23 patients with increase Tnt. There was no cardiovascular events in patients with normal TnT. CONCLUSION: Significant proprotion of patients with blunt chest trauma had elevated TnT value which suggested of myocardial injury. We recommend echocardiagraphy and serial tracing of ECG to verify the clinical significance of elevated TnT in patients with blunt chest trauma.
Creatinine
;
Diagnosis*
;
Echocardiography
;
Electrocardiography
;
Female
;
Humans
;
Prospective Studies
;
Thorax*
;
Trinitrotoluene
;
Troponin
;
Troponin T
7.A Case of Transradial Approach to Carotid Artery Angioplasty and Stenting in Left Internal Carotid Stenosis.
Byung Su YOO ; Seung Hwan LEE ; Junghan YOON ; Bong Ki LEE ; Ji Yean KO ; Kyung Hoon CHOE
Korean Circulation Journal 2000;30(3):359-364
Surgical endarterectomy has been shown to be superior to medical treatment in the management of severe carotid stenosis. Endarterectomy, although effective, does have limitations, and percutaneous transluminal angioplasty with stent may offer an alternative modality of treatment. We report on a patient with severe coronary disease that femoral arterial cannulation was not possible due to aorto-femoral shunt operation and absent pulse. The transradial approach was used for aortography, bilateral carotid angiography and successful elective stent deployment in the left internal carotid artery. The transradial approach might be useful alternative in case of problems with femoral approach.
Angiography
;
Angioplasty*
;
Aortography
;
Carotid Arteries*
;
Carotid Artery, Internal
;
Carotid Stenosis*
;
Catheterization
;
Coronary Disease
;
Endarterectomy
;
Humans
;
Stents*
8.Predictors of Left Atrial Thrombus in Mitral Stenosis A Transthoracic and Transesophageal Echocardiographic Study.
Han Soo KIM ; Namsik CHUNG ; Si Hoon PARK ; Junghan YOON ; Won Heum SHIM ; Seung Yun CHO ; Woong Ku LEE
Korean Circulation Journal 1992;22(5):791-797
BACKGROUND: Left atrial thrombus(LAT) has long been recognized as a complication of mitral stenosis(MS).The transesophageal echocardiographic approach readily visualize LAT. We evaluated the risk factors for left atrial thrombus in patients with MS using transthoracic(TTE) and transesophageal echocardiography(TEE). METHODS AND RESULTS: One hundred and forty-three(patients) who had moderate to severe MS were consecutively studied with TTE and TEE. They were 43 males(30%) and 100 females(70%).The mean age was 44+/-11 years(range 21-70). Twenty-five patients had at least one episode of embolic events. Ninety-six patients were in atrial fibrillation(AF). LAT was detected in 30 pts(21%) : 16 had thrombus confined to the LA appenge(LAA), 14 to true LA cavity and/or LAA. TTE variables were compared between LAT group and non-LAT group. Univariate predictors of LAT were mitral valve area(MVA)(0.78+/-0.22cm2 vs 1.05+/-0.32cm2, p=0.001), pressure half time(353+/-88ms vs 258+/-118ms, p=0.002). LV ejection fraction(EF)(55+/-11% vs 62+/-8%,p=0.008), LA size (58+/-11mm vs 52+/-7mm, p=0.033) and AF(p=0.001). Stepwise logistic regression analysis revealed significant independent predictors of LAT to be AF(p=0.02), MVA(p=0.02) and EF(p=0.03). CONCLUSION: Left atrial thrombus was not uncommon in patients with rheumatic mitral stenosis. Small mitral valve area and reduced ejection fraction of left ventricle appear to be significant predictors of LAT in mitral stenosis with atrial fibrillation.
Atrial Fibrillation
;
Echocardiography*
;
Heart Ventricles
;
Humans
;
Logistic Models
;
Mitral Valve
;
Mitral Valve Stenosis*
;
Risk Factors
;
Thrombosis*
9.The Effect of Lovastatin(Mevacor(R)) on Serum Lipids of Patients with Hypercholesterolemia.
Woong Ku LEE ; Junghan YOON ; Yang Soo JANG ; Seung Yun CHO ; Won Heum SHIM ; Sung Soon KIM ; Namsik CHUNG
Korean Circulation Journal 1991;21(3):567-572
We evaluated the hypolipidemic effect and adverse reaction of Lovastatin, HMG-CoA reductase inhibitor 20 to 40mg once-daily in the evening, in 20 patients with primary hypercholesterolemia for 12 weeks and the following results were obtained. 1) Lovastatin significantly reduced the total cholesterol(from 264.8+/-12.9mg/dl to 195.3+/-31.3mg/dl) by 26.3%, TG(from 191.1+/-41.5mg/dl to 156.2+/-52.9mg/dl) by 18.3%, LDL-C(from 177.0+/-12.4mg/dl to 121.3+/-19.6mg/dl) by 31.5% and increased th HDL-C (from 39.8+/-4.2mg/dl to 41.6+/-5.0mg/dl) by 4.5% at the end of 12th week. 2) The adverse reaction during the period of study were limited to diarrhea and nausea in one patient, dryness of skin and itching in one patient, and no patients was withdrawn form therapy. In this study, Lovastatin was well toterated and effective agent for the treatment of hypercholesterolemia without serious side effects.
Diarrhea
;
Humans
;
Hypercholesterolemia*
;
Lovastatin
;
Nausea
;
Oxidoreductases
;
Pruritus
;
Skin
10.4 Cases of Spontaneous Coronary Dissection in Ischemic Heart Disease.
Won Sik LEE ; Byung Su YOO ; Seung Chan AHN ; Byoung Ki SEO ; Junghan YOON ; Keum Soo PARK ; Kyung Hoon CHOE
Korean Circulation Journal 1995;25(6):1241-1246
Spontaneous coronary artery dissection is a rarely identified entity whose exact incidence, etiology, pathogenesis, medium-term evolution and optimal treatment have not yet been firmly estabilished. The cause of spontaneous disection remains unclear but theories of etiology include a medial eosinophilic angiitis, pregnancy induced degeneration of collagen and rupture of the vasovasoum. Most paients die suddenly, but a clinical spectrum is seen including and unstable angina, myocardial infarction and cardiogenic shock. We experienced 4 cases with spontaneous coronary artery dissection found angiographically which caused myocardial infarction and unstable angina. Our patients were treated medically.
Angina, Unstable
;
Collagen
;
Coronary Vessels
;
Eosinophils
;
Humans
;
Incidence
;
Myocardial Infarction
;
Myocardial Ischemia*
;
Pregnancy
;
Rupture
;
Shock, Cardiogenic
;
Vasculitis