OBJECTIVES: Cancer has attracted worldwide attention. The incidence and prevalence are increasing, and it is the main cause of death. The purpose of this study was to identify the characteristics of hospitalized cancer patients. METHODS: This study is a secondary data study using the Korean National Hospital Discharge In-depth Injury Survey Data conducted annually by the Korea Centers for Disease Control and Prevention. Using these data, we extracted inpatients who principal diagnosis is cancer for nine years from 2005 to 2013. RESULTS: According to the analysis, the annual trend of cancer inpatients is steadily increasing. In 2025, it is expected to increase to about 670,000 inpatients. A cancer diagnosis created a change in medical utilization depending on the characteristics of patients and hospital. Men are more at risk of cancer than women. The number of hospital beds and hospital days were inversely proportional to cancer inpatients. There was also a difference in the equity of medical utilization by region. Other cancer management policies should be based on sex. CONCLUSION: Populations between the ages of 45 and 64 years should be a priority in cancer policy. Because of the long-term hospitalization of patients with death as the outcome, a terminal cancer patient care facility is needed. These conclusions can provide a basis for various health policies.
Cause of Death ; Centers for Disease Control and Prevention (U.S.) ; Diagnosis ; Female ; Health Policy ; Hospitalization ; Humans ; Incidence ; Inpatients* ; Korea* ; Length of Stay ; Male ; Mortality ; Patient Care ; Prevalence

Objectives: This study investigated factors influencing intentional self-harm in Chungcheongbuk Province (hereinafter, Chungbuk) compared to Seoul in the Republic of Korea. Methods: Raw data from the Discharge In-depth Injury Survey conducted by the Korea Disease Control and Prevention Agency were utilized. From 2,329,149 cases recorded over 9 years (2013–2021), 911 were identified as intentional self-harm cases (248 from Chungbuk and 633 from Seoul). We analyzed the differences in and influencing factors of intentional self-harm in Chungbuk relative to Seoul using the independent sample t-test, chi-square test, and binomial logistic regression analysis. Results: Intentional self-harm was found to be 1.232 times more prevalent among females than males (p < 0.05); 2.327 times more prevalent among middle-aged and older adults, ages 50 to 64, compared to those under 50 years old (p < 0.01); 8.603 times more prevalent among those using hospitals with fewer than 500 beds compared to those with 500 beds or more (p < 0.001);2.412 times more prevalent among individuals using hospitals in different regions compared to those within the same region (p < 0.01); 2.217 times more prevalent among those attempting intentional self-harm during daily activities compared to other specified activities (p < 0.01);and 6.987 times more prevalent among those using pesticides or herbicides compared to other poisons (p < 0.001) in Chungbuk relative to Seoul. Conclusion In the Chungbuk region, intentional self-harm prevention programs should be implemented, specifically targeting women, particularly those aged 50 to 64. Additionally, due to the high incidence of intentional self-harm involving pesticides or herbicides in Chungbuk, these substances should be stringently monitored to restrict access.

Objectives: This study investigated factors influencing intentional self-harm in Chungcheongbuk Province (hereinafter, Chungbuk) compared to Seoul in the Republic of Korea. Methods: Raw data from the Discharge In-depth Injury Survey conducted by the Korea Disease Control and Prevention Agency were utilized. From 2,329,149 cases recorded over 9 years (2013–2021), 911 were identified as intentional self-harm cases (248 from Chungbuk and 633 from Seoul). We analyzed the differences in and influencing factors of intentional self-harm in Chungbuk relative to Seoul using the independent sample t-test, chi-square test, and binomial logistic regression analysis. Results: Intentional self-harm was found to be 1.232 times more prevalent among females than males (p < 0.05); 2.327 times more prevalent among middle-aged and older adults, ages 50 to 64, compared to those under 50 years old (p < 0.01); 8.603 times more prevalent among those using hospitals with fewer than 500 beds compared to those with 500 beds or more (p < 0.001);2.412 times more prevalent among individuals using hospitals in different regions compared to those within the same region (p < 0.01); 2.217 times more prevalent among those attempting intentional self-harm during daily activities compared to other specified activities (p < 0.01);and 6.987 times more prevalent among those using pesticides or herbicides compared to other poisons (p < 0.001) in Chungbuk relative to Seoul. Conclusion In the Chungbuk region, intentional self-harm prevention programs should be implemented, specifically targeting women, particularly those aged 50 to 64. Additionally, due to the high incidence of intentional self-harm involving pesticides or herbicides in Chungbuk, these substances should be stringently monitored to restrict access.

Objectives: This study investigated factors influencing intentional self-harm in Chungcheongbuk Province (hereinafter, Chungbuk) compared to Seoul in the Republic of Korea. Methods: Raw data from the Discharge In-depth Injury Survey conducted by the Korea Disease Control and Prevention Agency were utilized. From 2,329,149 cases recorded over 9 years (2013–2021), 911 were identified as intentional self-harm cases (248 from Chungbuk and 633 from Seoul). We analyzed the differences in and influencing factors of intentional self-harm in Chungbuk relative to Seoul using the independent sample t-test, chi-square test, and binomial logistic regression analysis. Results: Intentional self-harm was found to be 1.232 times more prevalent among females than males (p < 0.05); 2.327 times more prevalent among middle-aged and older adults, ages 50 to 64, compared to those under 50 years old (p < 0.01); 8.603 times more prevalent among those using hospitals with fewer than 500 beds compared to those with 500 beds or more (p < 0.001);2.412 times more prevalent among individuals using hospitals in different regions compared to those within the same region (p < 0.01); 2.217 times more prevalent among those attempting intentional self-harm during daily activities compared to other specified activities (p < 0.01);and 6.987 times more prevalent among those using pesticides or herbicides compared to other poisons (p < 0.001) in Chungbuk relative to Seoul. Conclusion In the Chungbuk region, intentional self-harm prevention programs should be implemented, specifically targeting women, particularly those aged 50 to 64. Additionally, due to the high incidence of intentional self-harm involving pesticides or herbicides in Chungbuk, these substances should be stringently monitored to restrict access.

Objectives: This study investigated factors influencing intentional self-harm in Chungcheongbuk Province (hereinafter, Chungbuk) compared to Seoul in the Republic of Korea. Methods: Raw data from the Discharge In-depth Injury Survey conducted by the Korea Disease Control and Prevention Agency were utilized. From 2,329,149 cases recorded over 9 years (2013–2021), 911 were identified as intentional self-harm cases (248 from Chungbuk and 633 from Seoul). We analyzed the differences in and influencing factors of intentional self-harm in Chungbuk relative to Seoul using the independent sample t-test, chi-square test, and binomial logistic regression analysis. Results: Intentional self-harm was found to be 1.232 times more prevalent among females than males (p < 0.05); 2.327 times more prevalent among middle-aged and older adults, ages 50 to 64, compared to those under 50 years old (p < 0.01); 8.603 times more prevalent among those using hospitals with fewer than 500 beds compared to those with 500 beds or more (p < 0.001);2.412 times more prevalent among individuals using hospitals in different regions compared to those within the same region (p < 0.01); 2.217 times more prevalent among those attempting intentional self-harm during daily activities compared to other specified activities (p < 0.01);and 6.987 times more prevalent among those using pesticides or herbicides compared to other poisons (p < 0.001) in Chungbuk relative to Seoul. Conclusion In the Chungbuk region, intentional self-harm prevention programs should be implemented, specifically targeting women, particularly those aged 50 to 64. Additionally, due to the high incidence of intentional self-harm involving pesticides or herbicides in Chungbuk, these substances should be stringently monitored to restrict access.

Objectives: This study investigated factors influencing intentional self-harm in Chungcheongbuk Province (hereinafter, Chungbuk) compared to Seoul in the Republic of Korea. Methods: Raw data from the Discharge In-depth Injury Survey conducted by the Korea Disease Control and Prevention Agency were utilized. From 2,329,149 cases recorded over 9 years (2013–2021), 911 were identified as intentional self-harm cases (248 from Chungbuk and 633 from Seoul). We analyzed the differences in and influencing factors of intentional self-harm in Chungbuk relative to Seoul using the independent sample t-test, chi-square test, and binomial logistic regression analysis. Results: Intentional self-harm was found to be 1.232 times more prevalent among females than males (p < 0.05); 2.327 times more prevalent among middle-aged and older adults, ages 50 to 64, compared to those under 50 years old (p < 0.01); 8.603 times more prevalent among those using hospitals with fewer than 500 beds compared to those with 500 beds or more (p < 0.001);2.412 times more prevalent among individuals using hospitals in different regions compared to those within the same region (p < 0.01); 2.217 times more prevalent among those attempting intentional self-harm during daily activities compared to other specified activities (p < 0.01);and 6.987 times more prevalent among those using pesticides or herbicides compared to other poisons (p < 0.001) in Chungbuk relative to Seoul. Conclusion In the Chungbuk region, intentional self-harm prevention programs should be implemented, specifically targeting women, particularly those aged 50 to 64. Additionally, due to the high incidence of intentional self-harm involving pesticides or herbicides in Chungbuk, these substances should be stringently monitored to restrict access.

OBJECTIVES : We aimed to define the effects of antioxidant vitamins and oxidative stress in the intrauterine period on childhood neurobehavioral development. METHODS : The behavioral status of 100 children (aged four) at Ewha Womans University Mokdong Hospital in Korea was examined using the K-CBCL. Their maternal vitamin and oxidative stress status were analyzed at midterm as intrauterine circumstance indices. The relationship between intrauterine condition and childhood behavioral development was analyzed using a general linear model. RESULTS : K-CBCL scores were lower in the group which took high levels of maternal vitamins B6 and B12 than scores in the group which too low levels of these vitamin. In contrast, the group with high maternal oxidative stress exhibited higher scores in behavioral problem scales. After adjusting for inborn and childhood environmental covariates, K-CBCL differences were statistically significant in the B2 group comparison (high group vs. low group;total problem : 47.0+/-1.0 vs. 53.0+/-1.8, internalizing problem 46.5+/-1.0 vs. 51.2+/-1.8). In addition, significant highest means of K-CBCL were in low vitamin and high oxidative stress group than other combined groups. CONCLUSION : We have established a relationship between maternal vitamins and oxidative stress during pregnancy, and a 4 year-old child's behavioral development. This suggests that preventive efforts during pregnancy are influential on early childhood behavioral problems.
Child ; Female ; Humans ; Korea ; Oxidative Stress ; Pregnancy ; Vitamins ; Weights and Measures

PURPOSE: 'Programming' describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and neonatal blood pressure(BP). METHODS: We studied 127 neonates who were born at Ewha Womans' Hospital and their mothers enrolled our cohort study during pregnancy. Data on the mothers and details of the birth records were tracked and collected from medical charts. Neonatal BP was measured within 24 hours after birth. RESULTS: Neonatal SBP was positively correlated to intrauterine growth indices; birth weight(BW)(r= 0.4), head circumference(HC)(r=0.4), and birth height(r=0.3). However, an inverse relationship existed, between HC/BW ratio and neonatal SBP(r=-0.4). After adjusting for the baby's sex, maternal BP, and gestational age, neonatal SBP still associated with intrauterine growth indices. SBP was 7 mmHg higher in the highest BW group(> or =90 percentiles) compared to the lowest group(<10 percentiles). On the other hand, SBP was 17 mmHg lower in the highest HC/BW group(> or =90 percentiles) compared in the lowest group(<10 percentiles). CONCLUSION: This study could not find the evidence that intrauterine growth retardation affect on elevated neonatal BP. It suggests that the initiating events of BP programming may occur during postnatal growth period. To identify the critical starting period that intrauterine growth retardation leads to elevated BP, a study tracking BP changes from birth to childhood is required.
Adult ; Birth Certificates ; Blood Pressure* ; Cohort Studies ; Critical Period (Psychology) ; Fetal Growth Retardation ; Gestational Age ; Hand ; Head ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Mothers ; Parturition ; Pregnancy

Canine adenovirus type 2 (CAV-2) is a common causative agent of respiratory disease in canines. There have been no reports of CAV-2 variants isolated from raccoon dogs. This study aims to investigate the biological and genetic characteristics of a novel Korean CAV-2 variant. Madin-Darby canine kidney cells were used to isolate the CAV-2 variant from 45 fecal swab samples. Diagnostic tools such as the cytopathic effect (CPE) assay, electron microscopy, polymerase chain reaction, and immunofluorescence and hemagglutination assays were used to confirm the presence of the CAV-2 isolate. A cross-virus neutralization assay was performed to verify the novelty of this CAV variant. Genetic analysis was performed using nucleotide sequences obtained through next-generation sequencing. The isolate was confirmed to be a CAV-2 variant based on the aforementioned methods and designated CAV2232. The number of bases in the fiber and E3 genes of CAV2232 were 1,626 and 414, respectively. Phylogenetic analysis of the fiber and E3 genes confirmed that CAV2232 was classified into a different clade from the known CAV-1 and CAV-2 strains. Mice inoculated with the CAV2232 vaccine developed high virus neutralization antibody titers of 1,024 (210) against CAV2232, while mice inoculated with CAV-1 and CAV-2 vaccines had low virus neutralization antibody titers of 12.9 (23.7) and 6.5 (22.7), respectively, against CAV2232. CAV2232 isolated from wild raccoon dog feces was classified as a novel CAV-2 variant. CAV2232 may therefore be used as an antigen for new vaccine development and serological investigations.

Canine adenovirus type 2 (CAV-2) is a common causative agent of respiratory disease in canines. There have been no reports of CAV-2 variants isolated from raccoon dogs. This study aims to investigate the biological and genetic characteristics of a novel Korean CAV-2 variant. Madin-Darby canine kidney cells were used to isolate the CAV-2 variant from 45 fecal swab samples. Diagnostic tools such as the cytopathic effect (CPE) assay, electron microscopy, polymerase chain reaction, and immunofluorescence and hemagglutination assays were used to confirm the presence of the CAV-2 isolate. A cross-virus neutralization assay was performed to verify the novelty of this CAV variant. Genetic analysis was performed using nucleotide sequences obtained through next-generation sequencing. The isolate was confirmed to be a CAV-2 variant based on the aforementioned methods and designated CAV2232. The number of bases in the fiber and E3 genes of CAV2232 were 1,626 and 414, respectively. Phylogenetic analysis of the fiber and E3 genes confirmed that CAV2232 was classified into a different clade from the known CAV-1 and CAV-2 strains. Mice inoculated with the CAV2232 vaccine developed high virus neutralization antibody titers of 1,024 (210) against CAV2232, while mice inoculated with CAV-1 and CAV-2 vaccines had low virus neutralization antibody titers of 12.9 (23.7) and 6.5 (22.7), respectively, against CAV2232. CAV2232 isolated from wild raccoon dog feces was classified as a novel CAV-2 variant. CAV2232 may therefore be used as an antigen for new vaccine development and serological investigations.