1.Monoclonal Antibodies Specific for Treponema Pallidum , Nichols Strain.
Min Geol LEE ; Kyu Kwang HWANG ; Jung Bock LEE
Korean Journal of Dermatology 1990;28(6):686-701
No abstract available.
Antibodies, Monoclonal*
;
Treponema pallidum*
;
Treponema*
2.The Etiology of Optic Neuropathy.
Jeong Min HWANG ; Yeon Chul JUNG
Journal of the Korean Ophthalmological Society 1999;40(4):1078-1083
In order to investigate causative mechanisms of optic neuropathy, retrospective clinical studies including ophthalmologic examination, imaging study, and molecular biologic analyses were performed on 322 patients with optic neuropathy. The causes include hereditary optic neuropathy(71 patients, 22.1%), optic neuritis(66 patients, 20.5%), traumatic optic neuropathy(40 patients, 12.5%), ischemic optic neuropathy(35 patients, 10.9%), compressive optic neuropathy(31 patients, 9.6%), toxic optic neuropathy(23 patients, 7.1%), etc. In 29 patients of bilateral optic atrophy and 18 patients of unilateral optic atrophy, the causative mechanism was not clear. In conclusion, hereditary optic neuropathy was the most common causative mechanism of optic neuropathy in this study. The importance of meticulous history taking and molecular biologic test should be stressed in differential diagnosis of optic neuropathy.
Diagnosis, Differential
;
Humans
;
Optic Atrophy
;
Optic Nerve Diseases*
;
Optic Nerve Injuries
;
Optic Neuritis
;
Retrospective Studies
3.The Etiology of Optic Neuropathy.
Jeong Min HWANG ; Yeon Chul JUNG
Journal of the Korean Ophthalmological Society 1999;40(4):1078-1083
In order to investigate causative mechanisms of optic neuropathy, retrospective clinical studies including ophthalmologic examination, imaging study, and molecular biologic analyses were performed on 322 patients with optic neuropathy. The causes include hereditary optic neuropathy(71 patients, 22.1%), optic neuritis(66 patients, 20.5%), traumatic optic neuropathy(40 patients, 12.5%), ischemic optic neuropathy(35 patients, 10.9%), compressive optic neuropathy(31 patients, 9.6%), toxic optic neuropathy(23 patients, 7.1%), etc. In 29 patients of bilateral optic atrophy and 18 patients of unilateral optic atrophy, the causative mechanism was not clear. In conclusion, hereditary optic neuropathy was the most common causative mechanism of optic neuropathy in this study. The importance of meticulous history taking and molecular biologic test should be stressed in differential diagnosis of optic neuropathy.
Diagnosis, Differential
;
Humans
;
Optic Atrophy
;
Optic Nerve Diseases*
;
Optic Nerve Injuries
;
Optic Neuritis
;
Retrospective Studies
4.Expression and Characterization of Chimeric Antigens of Hepatitis B and D Viruses : Implications for the Development of Divalent Vaccine.
Dong Hwa CHOI ; Jung Min PARK ; Kyu Jin PARK ; Soon Bong HWANG ; Soo Ho CHOI
Journal of Bacteriology and Virology 2001;31(4):361-367
No abstract available.
Hepatitis B*
;
Hepatitis*
5.Expression of Neuron Specific Enolase, Chromogranin, and Synaptophysin in Peripheral Neuroblastic Tumors.
Hyung Seok KIM ; Jae Ha HWANG ; Jong Jae JUNG ; Min Cheol LEE
Korean Journal of Pathology 2000;34(8):588-596
The presence and distribution of pan-neuroendocrine markers such as neuron-specific enolase (NSE), chromogranin (CG), and synaptophysin (SYP) were investigated by immunohistochemistry in 15 cases of neuroblastic tumors, including four cases of neuroblastomas, six cases of ganglioneuroblastomas, and five cases of ganglioneuromas. Three cases of normal sympathetic ganglion were used for the normal control group. NSE was observed in all cases and both in ganglion cells and in neuropils. NSE was detected not only in the majority of the neuroblasts showing signs of differentiation, but also in some poorly differentiated neuroblasts. All cases of neuroblastic tumors were positive for CG, however, some variability of staining intensity and distribution patterns were noted. CG was found mainly in differentiated neuroblasts with enlarged cytoplasm and nuclei along the periphery of the perikaria, and was also found in the perinuclear regions of some undifferentiated cells. SYP was positive in 9 of 11 cases. In all of the 9 cases, SYP was detected in some differentiating neuroblasts and differentiated neuroblasts, as well as the mature ganglion cells. However, it has scarcely stained in dot or granular pattern. Two CG-negative tumors were also negative for SYP. Our data indicate that antibodies against NSE and CG are helpful as a diagnostic aid for neuroblastic tumors.
Antibodies
;
Cytoplasm
;
Ganglia, Sympathetic
;
Ganglion Cysts
;
Ganglioneuroblastoma
;
Ganglioneuroma
;
Immunohistochemistry
;
Neuroblastoma
;
Neurons*
;
Neuropil
;
Phosphopyruvate Hydratase*
;
Synaptophysin*
6.Factors affecting Final Adult Height in Turner Syndrome.
Min Ho JUNG ; Jin Soon HWANG ; Eun Young KIM ; Sei Won YANG
Journal of Korean Society of Pediatric Endocrinology 1999;4(1):64-70
Purpose : Shortness is the most frequent and quite disturbing characteristics of patients with Turner syndrome. The aim of this study was to evaluate the factors affecting final adult height(FAH) in these patients. METHODS : The study group was comprised of 19 patients who were diagnosed as Turner syndrome and attained FAH. We analyzed the influences of various factors on FAH in GH treated group with those in GH untreated group. Results : Nineteen patients were enrolled; thirteen received GH treatment and six did not. The mean duration of GH treatment was 24.3 months(range : 9 to 50 months), and the mean dosage of GH was 0.98+/-0.35IU/kg/wk in GH treated group. The mean growth velocity during GH treatment was 5.6+/-1.8 cm/yr, which was significantly higher than that during pretreatment period(P<0.05). In GH treated group, the mean chronological age, bone age, mean height, and height SD score at GH therapy were 13.7+/-1.7yr, 11.3+/-1.9yr, 129.7+/-7.9cm, and -4.1+/-1.1, respectively, which were not statistically different from those at diagnosis of GH untreated group. In GH treated group, the mean FAH and FAH SD score were 144.8+/-5.0cm, and -3.2+/-0.9, respectively, which showed no significant difference compared with those of GH untreated group. Analyzing the factor affecting FAH in all Turner girls of both groups together, parental height, chronological age, bone age, and bone age delay at diagnosis(or at the initiation of GH therapy) were not related to FAH. Height and height SD score at diagnosis(or at the initiation of therapy) were positively related to FAH(P<0.05, r=0.72). CONCLUSION : The results suggest that GH treatment dose not improve FAH in patients with Turner syndrome, despite increased growth velocity during GH treatment, which might come from intermittern GH therapy. This should be remained to be clarified with more Turner patients who attained FAH.
Adult*
;
Diagnosis
;
Female
;
Growth Hormone
;
Humans
;
Parents
;
Turner Syndrome*
7.Application of BMS(TM) Avoids a Defunctioning Colostomy in the Treatment of Fournier's Gangrene.
Dae Ho SHON ; Sang Hun JUNG ; Min Chul SHIM ; Jae Hwang KIM
Journal of the Korean Society of Coloproctology 2008;24(2):137-143
PURPOSE: Recently developed BMS(TM) (Zassi Bowel Management System(TM): Hollister Inc., Illinois, USA) can provide effective nonsurgical fecal diversion without the risks associated with colostomy creation and subsequent closure. Our aim is to evaluate the effectiveness of the BMS in diverting feces from the perianal wide surgical wound in patients with Fournier's gangrene. METHODS: BMS(TM) was applied in five patients (male: 2, median age; 44) with Fournier's gangrene from January 2000 to September 2001. The treatments consist of three times a day wound dressing after wide surgical debridement and intravenous antibiotic therapy. For evacuation of feces, twice daily warm saline irrigation was administered via BMS(TM) or low daily doses of polyethylene glycol solutions were orally taken in. An endoscopic and anorectal manometric study was done to evaluate possible mucosal complications and anorectal functional changes. RESULTS: The average duration of the BMS application was 41 (range, 22~63) days. The result of a manometric study after immediate removal of the BMS(TM) showed a decreased mean resting pressure (range: 22~36 mmHg) and a decreased mean squeezing pressure (range: 32~39 mmHg). After 3 days, the sphincter pressure had improved markedly: mean resting pressures of 38, 45, 60, and 63 mmHg and mean squeezing pressure of 78, 89, 91, and 101 mmHg respectively. Fecal incontience was not noted in any patient. Other possible mucosal complications were not noted. There were no mortalit. CONCLUSIONS: BMS(TM) application in Fournier's gangrene patients after surgery successfully avoids a defunctioning colostomy. Furthermore, no significant complications were noted over a prolonged period up to 63 days.
Bandages
;
Colostomy
;
Debridement
;
Fasciitis, Necrotizing
;
Feces
;
Fournier Gangrene
;
Humans
;
Illinois
;
Polyethylene Glycols
8.Clinical Outcome after Pancreatectomy in Patients with Persistent Hyperinsulinemic Hypoglycemia of Infancy.
Min Ho JUNG ; Jin Soon HWANG ; Choong Ho SHIN ; Sei Won YANG ; Je G CHI
Journal of Korean Society of Pediatric Endocrinology 2000;5(2):171-181
PURPOSE: The purpose of this study was to describe the clinical outcome after pancreatcetmy and its relationship with pathological appearances and clinical features in patients with persistent hyperinsulinemic hypoglycemia of infancy(PHHI). METHODS: Medical records of 10 patients(9 males and 1 female, mean age:40.4+/-1.5 months) who were diagnosed as PHHI and underwent pancreatectomy from 1988 to 2000 were reviewed. Clincal and biochemical data were recorded. Subjects were classified arbitrarily into early-onset or late-onset group according to age of onset. Pathologic appearance of pancreas was divided into 2 forms:diffuse or focal. The former had a focal pancreatic adenomatous hyperplasia and the latter was characterized by increased number of betacells with similar distribution seen in normal neonates. RESULTS: One patient had focal, and nine had diffuse lesions. After near-total pancreatectomy, 4 patients(40.0%) showed complete response, 4(40.0%) had persistent hypoglycemia, and 2(20.0%) developed diabetes mellitus. As neurological sequelae, 6 patients(60.0%) had persistent seizures, and 6(60.0%) had delayed motor and speech development. No clinical or biochemical factors related to postoperative outcome were found. CONCLUSION: This data indicate that early diagnosis of patients who present with hypoglycemic symptoms in infancy, especially early in life, and development of more effective therapy are warranted, because there is no clinical or biochemical factor predicting final outcome after near-total pancreatectomy and only 40% of patients with PHHI remained euglycemic after surgery with possible severe neurological sequelae.
Age of Onset
;
Congenital Hyperinsulinism*
;
Diabetes Mellitus
;
Early Diagnosis
;
Female
;
Humans
;
Hyperplasia
;
Hypoglycemia
;
Infant, Newborn
;
Male
;
Medical Records
;
Pancreas
;
Pancreatectomy*
;
Seizures
9.Fetus in fetu of the retroperitoneal cavity.
Soo Young YOO ; Hwang Min KIM ; Soon Hee JUNG ; Eung Jo KIM
Journal of the Korean Surgical Society 1992;43(3):459-465
No abstract available.
Fetus*
10.Arthroscopic Decompression of an Inferior Paralabral Cyst of the Shoulder in an Elderly Patient: A Case Report.
Ju Oh KIM ; Ki Yong AN ; Hwang Se BONG ; Kyu Jung LEE ; Woong Bae MIN
Clinics in Shoulder and Elbow 2015;18(4):266-268
The widespread use of diagnostic radiography, especially using magnetic resonance imaging, has helped to increase the diagnosis of paralabral cysts in patients with chronic shoulder pain. These paralabral cysts are frequent in the anterior, the superior, and the posterior compartment of the shoulder joint but are rare in the inferior compartment. Paralabral cysts in the shoulder appear particularly in men in their third and fourth decades but rarely in elderly patients. We report a case of an inferior paralabral cyst in an elderly patient whom we treated through arthroscopic decompression.
Aged*
;
Arthroscopy
;
Decompression*
;
Diagnosis
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Radiography
;
Shoulder Joint
;
Shoulder Pain
;
Shoulder*