2.Wilms's Tumor: Three Cases.
Ro Jung PARK ; Jung Chul YOON ; Ung Joon AHN
Korean Journal of Urology 1970;11(2):93-100
Three cases of Wilms's tumor observed during the period from January, 1969 to October, 1969 are presented and related literature reviewed.
Wilms Tumor
3.Cardiac Effect of Pulse Dexamethasone Therapy in Infants with Bronchopulmonary Dysplasia.
Jeong Nyun KIM ; Chul Young JUNG ; Eun Soo PARK ; Dong Chul PARK
Korean Journal of Perinatology 1999;10(1):10-16
PURPOSE: To examine the cardiac function, incidence and natural history of cardiac hypertrophy (CH) and the association of side effects with CH after pulse dexamethasone therapy in infants with bronchopulmonary dysplasia. METHODS: Twelve infants, gestational age 28.6+/-1.6(26-31)weeks, birth weight 1243+/-186 (1010- 1620)g, received a pulse course of dexamethasone, starting at 0.5mg/kg/d for three days and readministered ten days thereafter at a median of 19 days of age. Serial echocardiographic measurement of septal thickness(ST), left ventricular(LV) posterior wall thickness(PWT), LV diameter(LVD), LV length(LVL), LV mass, ejection fraction(EF) and acceleration time to right ventricular ejection time ratio(AT/RVET) were taken before, and 4, 11 days after starting dexamethasone. For infants diagnosed as CH, echocardiography was performed weekly until the parameters were normalized. Side effects of dexamethasone such as leukocytosis, hypertension, hyperglycemia and insulin therapy were recorded and compared. RESULTS: CH occurred in 5 of 12 infants(47%). ST, PWD, and AT/RVET increased significantly at 4 days and 11 days after starting dexamethasone than baseline. LVD decreased significantly at 4 days and 11 days after the administration of dexamethasone than before. Other parameter such as LVL, LV mass and EF were not changed and the evidence of left ventricular outflow obstruction was not observed. The incidence of hyperglycemia and insulin therapy were higher in CH group than in no CH group(p<0.05). Five infants with CH recovered until five weeks after starting dexamethasone on serial echocardiography, CONCLUSION: Infants receiving a pulse course of dexamethasone developed evidence of septal hypertrophy, thickened left ventricular wall and impaired filling of left ventricle immediately after starting dexamethasone but always resolved within five weeks Serial echocardiography is not probably routinely required in preterm infants with bronchopulmonary dysplasia receiving pulse dexamethasone therapy.
Acceleration
;
Birth Weight
;
Bronchopulmonary Dysplasia*
;
Cardiomegaly
;
Dexamethasone*
;
Echocardiography
;
Gestational Age
;
Heart Ventricles
;
Humans
;
Hyperglycemia
;
Hypertension
;
Hypertrophy
;
Incidence
;
Infant*
;
Infant, Newborn
;
Infant, Premature
;
Insulin
;
Leukocytosis
;
Natural History
;
Ventricular Outflow Obstruction
4.A Study on HBV Precore Mutant in Liver Tissues of Chronic Hepatitis B Patiets.
Hae Chul CHUNG ; Yeong Hong PARK ; Jung Myung CHUNG
The Korean Journal of Hepatology 1996;2(2):145-159
BACKGROUND/AIMS: In order to determine the relationship between the HBV precore mutant and the severity of liver disease in Korea, we performed liver biopsies in patients with HBV related chronic liver disease and compared the types of mutations and histologic findings in the same liver tissue simultaneously. METHODS: HBV DNA in liver tissues was amplified by polymerase chain reaction (PCR). The precore mutants were detected by PCR-SSCP(single strand conformation polymorphism), cloning the amplified PCR products and direct sequencing for them. RESULTS: 1. HBV DNA was detected in liver tissues of 28 cases among 30 patients with PCR. And with SSCP, the most cases were mixed type infections. 2. The HBV precore mutants were found in 12 cases among the total number of 28 cases(42.9%) and all mutations were G to A change at nucleotide 1896, creating a stop codon at codon 28. However, 10 cases among 12 mutants were associated with simultaneous another mutation at different positions or regions;9 cases at core gene region, 2 cases at nucleotide 1856(C to T change at codon 15), one case at core promoter, and one case with double mutations at nucleotide 1837 and 1846 respectively. Also, all HBV precore mutants were combined with wild type HBV sequence. 3. The relationship between HBV precore mutants and HBeAg status revealed that 4 cases from 13 HBeAg positive(30.8%) and 8 from 15 HBeAg negative or Anti-Hbe positive(53.3 %) were mutants. 4. In analysis of the types of mutants and histopathological findings of liver diseases, 6 among 15 chronic active hepatitis(40.0%), all 3 cases with hepatocellular carcinoma(100,0 %), 2 among 4 asymptomatic carriers with minimal histopathologic changes(50.0%) and a case with chronic lobular heaptitis(100.0%) showed precore region mutation. CONCLUSION: The patterns of HBV precore mutants in Korea could be summarized as followings. Firstly, most of the mutations are composed of G to A change at nucleotide 1896. Secondly, the most of the mutants at nuclmtide 1896 have been associated with simultaneous mutations at core promoter, core gene, and rarely at other positions, and manifested usua'ly mixed type viremic conditions. Thirdly, although precore mutation could be occurred in asymptomatic carrier, this type of mutation might be closely related with chronic or severe liver disease. However, it needs further investigations hereafter.
Biopsy
;
Clone Cells
;
Cloning, Organism
;
Codon
;
Codon, Terminator
;
DNA
;
Hepatitis B e Antigens
;
Hepatitis B, Chronic*
;
Hepatitis, Chronic*
;
Humans
;
Korea
;
Liver Diseases
;
Liver*
;
Polymerase Chain Reaction
;
Polymorphism, Single-Stranded Conformational
5.Clinical analysis of the inhalation injury of the facial burn patients.
Yark Sung JUNG ; Song KIM ; Hee Chul PARK
Journal of the Korean Surgical Society 1991;40(3):391-396
No abstract available.
Burns*
;
Humans
;
Inhalation*
6.Anal incontinence due to anal sphincter injury.
Je Been CHUNG ; Jae Jung LEE ; Chul Jae PARK
Journal of the Korean Surgical Society 1992;43(2):266-272
No abstract available.
Anal Canal*
7.A Case of Hidradenoma Papilliferum of the Nipple.
Chul Hyun AHN ; Eun Jung CHYUNG ; See Ryong PARK
Korean Journal of Dermatology 1989;27(6):720-723
We report a case of hidradenoma papilliferum of the left nipple in a 23-year-old female patient. Hidradenoma papilliferum occurs only in women, usually on the labia majora or in the perineal or perineal region and represents an adenoma with apocrine dif ferentiation. Histologic examination of the lesion revealed findings consistent with hidradenoma papilliferurn. She had been performed surgical excision
Acrospiroma*
;
Adenoma
;
Female
;
Humans
;
Nipples*
;
Young Adult
8.Clinical observation of civilian colorectal injuries.
Tae Gyun KIM ; Jae Jung LEE ; Chul Jae PARK
Journal of the Korean Surgical Society 1993;44(3):406-413
No abstract available.
9.Comparisons of the Ratio of Pulmonary to Systemic Blood Flow(Qp/Qs) Determined by Non-invasive Doppler Echocardiography and Radionuclide-Angiocardiography in Congenital Heart Diseases.
Jung Suk LEE ; Chul Wo PARK ; Hyang Suk YOON
Journal of the Korean Pediatric Society 1989;32(7):943-950
No abstract available.
Echocardiography, Doppler*
;
Heart Diseases*
;
Heart*
10.A study on the physical growth and development of Korean based on the '92 national anthropometric survey.
Soo Chan PARK ; Jin Ho KIM ; Chul Jung KIM
Korean Journal of Physical Anthropology 1993;6(2):177-189
No abstract available.
Growth and Development*