No abstract available.
Pancreaticoduodenectomy*

Cerebellar degeneration is a group of diseases that manifests as progressive ataxia, that finally led to death without specific treatment. We report here two patients with cerebellar degeneration, who had shown an improvement and less progressive course, which is associated with panax ginseng intake. Patient 1 was a 60-year-old woman with multisystem atrophy (MSA) type C with 5 year history of ginseng ingestion. Patient 2 was a 54-year-old woman with spinocerebellar ataxia (SCA) type 6, who had a history of ginseng intake for 30 months. Both the patients showed atrophic change in the cerebellum by brain magnetic resonance imaging. Cerebellar functions had been semi-quantified by International Cooperative Ataxia Rating Scale (ICARS) and monitored before and after the ginseng ingestion every 6 to 12 months. In Patient 1 with MSA type C, ICARS had improved from 21 to 17.5 ± 1.8 in the following 5 years. In Patient 2 with SCA, ICARS also showed an improvement from 22 to 6.0 ± 1.0 over 30 months. However, when she stopped taking ginseng, it progressed up to 13 points in two years. These observations provide a potential disease-modifying effect of ginseng on patients with cerebellar degeneration.
Cerebellar Ataxia ; Cerebellar Diseases

Nasal dermoids are congenital midline nasal lesions that occur along with encephaloceles and gliomas. They can cause both deformity of nasal structure and intracranial infection as they grow. Treatment for these lesions is be concerned with two aspects, the complete removal of the lesions and making the surgical scar cosmetically acceptable. To that goal, many surgical approaches such as vertical incision, transverse incision, lateral rhinotomy and open rhinoplasty have been introduced. A 12-month male child presented with palpable mass at nasal root. The mass was easily movable, non-compressible and did not present fistula. A well-defined cystic mass without intracranial extension was found on the computerized tomography scans. Open rhinoplasty approach was opted for according to the guardians’ preference to avoid visible facial scar, and the lesions were completely resected. The pathologic examination confirmed the lesion to be nasal dermoids. The columellar scar was negligible and there was no recurrence at 5 year-follow up after surgery.

Nasal dermoids are congenital midline nasal lesions that occur along with encephaloceles and gliomas. They can cause both deformity of nasal structure and intracranial infection as they grow. Treatment for these lesions is be concerned with two aspects, the complete removal of the lesions and making the surgical scar cosmetically acceptable. To that goal, many surgical approaches such as vertical incision, transverse incision, lateral rhinotomy and open rhinoplasty have been introduced. A 12-month male child presented with palpable mass at nasal root. The mass was easily movable, non-compressible and did not present fistula. A well-defined cystic mass without intracranial extension was found on the computerized tomography scans. Open rhinoplasty approach was opted for according to the guardians’ preference to avoid visible facial scar, and the lesions were completely resected. The pathologic examination confirmed the lesion to be nasal dermoids. The columellar scar was negligible and there was no recurrence at 5 year-follow up after surgery.

Nasal dermoids are congenital midline nasal lesions that occur along with encephaloceles and gliomas. They can cause both deformity of nasal structure and intracranial infection as they grow. Treatment for these lesions is be concerned with two aspects, the complete removal of the lesions and making the surgical scar cosmetically acceptable. To that goal, many surgical approaches such as vertical incision, transverse incision, lateral rhinotomy and open rhinoplasty have been introduced. A 12-month male child presented with palpable mass at nasal root. The mass was easily movable, non-compressible and did not present fistula. A well-defined cystic mass without intracranial extension was found on the computerized tomography scans. Open rhinoplasty approach was opted for according to the guardians’ preference to avoid visible facial scar, and the lesions were completely resected. The pathologic examination confirmed the lesion to be nasal dermoids. The columellar scar was negligible and there was no recurrence at 5 year-follow up after surgery.

Nasal dermoids are congenital midline nasal lesions that occur along with encephaloceles and gliomas. They can cause both deformity of nasal structure and intracranial infection as they grow. Treatment for these lesions is be concerned with two aspects, the complete removal of the lesions and making the surgical scar cosmetically acceptable. To that goal, many surgical approaches such as vertical incision, transverse incision, lateral rhinotomy and open rhinoplasty have been introduced. A 12-month male child presented with palpable mass at nasal root. The mass was easily movable, non-compressible and did not present fistula. A well-defined cystic mass without intracranial extension was found on the computerized tomography scans. Open rhinoplasty approach was opted for according to the guardians’ preference to avoid visible facial scar, and the lesions were completely resected. The pathologic examination confirmed the lesion to be nasal dermoids. The columellar scar was negligible and there was no recurrence at 5 year-follow up after surgery.

Nasal dermoids are congenital midline nasal lesions that occur along with encephaloceles and gliomas. They can cause both deformity of nasal structure and intracranial infection as they grow. Treatment for these lesions is be concerned with two aspects, the complete removal of the lesions and making the surgical scar cosmetically acceptable. To that goal, many surgical approaches such as vertical incision, transverse incision, lateral rhinotomy and open rhinoplasty have been introduced. A 12-month male child presented with palpable mass at nasal root. The mass was easily movable, non-compressible and did not present fistula. A well-defined cystic mass without intracranial extension was found on the computerized tomography scans. Open rhinoplasty approach was opted for according to the guardians’ preference to avoid visible facial scar, and the lesions were completely resected. The pathologic examination confirmed the lesion to be nasal dermoids. The columellar scar was negligible and there was no recurrence at 5 year-follow up after surgery.

BACKGROUND: Purified major allergens of house dust mite are essential for evaluation of the allergic mechanism in molecular basis and development of new modalities of immunemodulation. OBJECTIVE: In this study, we aimed to purif group 1 and group 2 allergens from Dermatophagoides pteronyssinus (Dp). In addition, cDNAs corresponding to Der pI and II in Korean Dp were isolated and recombinant Der p1 and Der pII were synthesized. MATERIALS AND and METHOD: Der pI allergen was purified by ammonium sulfate precipitation, anion -exchange column chromatography, and gel filtrat,ion chromatography. Der pII allergen was purified by anion exchange chromatography, gel filtration chromatography, and a preparative isoelectric focusing method. RESULTS: Eight hundred ug of Der pI and 50 ug of Der pII were obtained from 100 g of culture medium and 1 g of mite bodies, respectively. The purities of these allergens were confirmed by SDS PAGE and the strong reactivity to the patient sera was identified. In order to produce a recombinant allergens, poly(A) RNA from house dust mites were isolated and used for cDNA synthesis by RT PCR. The cDNA was inserted into prokaryotic expression vector and the vectors were transformed into E. coli. A little amount of recombinant Der pI protein was produced due to the low solubility, and 1.2 mg of recombinant Der pII was produced from 1 L of E. coli culture medium. The antigenicity of Der pI was relatively weak, however, Der pII showed a strong antigenicity. Amino acid sequence of the amplified cDNA deduced from DNA sequences of Der pII showed 6 different variants. The variation of amino acid sequences suggests the possibility of high incidence of mutation of Der pII protein. CONCLUSION: A simplified method for the purification of Der pI and Der pII was developed. Recombinant allergens will be useful for the diagnosis and treatment of allergy with lower costs.
Allergens* ; Amino Acid Sequence ; Ammonium Sulfate ; Base Sequence ; Chromatography ; Chromatography, Gel ; Dermatophagoides pteronyssinus* ; Diagnosis ; DNA, Complementary ; Electrophoresis, Polyacrylamide Gel ; Humans ; Hypersensitivity ; Incidence ; Isoelectric Focusing ; Mites ; Polymerase Chain Reaction ; Pyroglyphidae* ; RNA, Messenger ; Solubility

PURPOSE: The purpose of this study was to evaluate the effects of theophylline in preterm infants with apnea on glucose homeostasis and insulin values. METHOD: In this prospective study, level of glucose and insulin were measured from peripheral blood of 8 neonates(1,450+/-114gm, 31+/-2.1week), who were admitted from April 1, 1997 to July 30, 1997 in Neonatal Intensive Care Unit of Wonkwang University Hospital, for apnea of prematurity(> 20 sec with bradycardia and/or cyanosis) were given aminophylline intravenously. Blood samples were collected at pretreatment, posttreatment 2hours, 1-2days, 3-4days, 5-7days and posttreatment 48hours, and compare to those of the 8 control neonates(1,711+/-232gm, 32+/-1.7week). RESULTS: The results were as follows: 1) Plasma glucose values were significantly higher in the treatment group than those of the control group at 1-2days(104.67+/-20.39mg/dL vs 83.43+/-15.86mg/dL) and 3-4days(111.0+/-32.39mg/dL vs 79.25+/-14.03mg/dL)(p<0.05). 2) Plasma glucose values which were increased at 1-2days(104.67+/-20.39mg/dL)and 3-4days(111.0+-32.39mg/dL), were significantly higher than pretreatment values(66.33+/-31.19mg/ dL)(p<0.02), but were not increased to the level of hyperglycemia(> 125mg/dL). 3) The mean posttreatment glucose levels drawn at 48hours after discontinuation of theophylline was significantly decreased to the values of pretreatment values compared to those of the 1-2days and 3-4days(p<0.01). 4) Insulin concentrations were also increased insignificantly when blood glucose were increased in the treatment group compared with control group. CONCLUSION: In conclusion, intravenous administration of theophylline produces hyperglycemia significantly, including an increase in a serum insulin. But, clinically significant hyperglycemia(> 125mg/dL) was not noted. So, plasma glucose may not need to be monitored in preterm apneic infants receiving theophylline. But, further studies are need to elucidate the effect of theophylline considering the serum toxic level of theophylline.
Administration, Intravenous ; Aminophylline ; Apnea* ; Blood Glucose* ; Bradycardia ; Glucose ; Homeostasis ; Humans ; Hyperglycemia ; Infant ; Infant, Newborn ; Infant, Premature* ; Insulin* ; Intensive Care, Neonatal ; Plasma* ; Prospective Studies ; Theophylline

No abstract available.