Pigmented Bowen's disease (PBD) is a rare variant of Bowen's disease(BD). Most of the reported cases showed pigmented patches or thin plaques. Thus its clinical manifestations may simulated other various pigmented skin lesions. We experienced 2 cases of PBD in patients with multiple BD developed after taking Korean proprietary pills (KPP, "Hwan-Yak"), which were suspected to contain certain amount of arsenics. Both patients also showed arsenical keratosis on their palms and soles. The darker pigmentation of the PBL led us to differentiated them from melanoma.
Bowen's Disease* ; Humans ; Keratosis ; Melanoma ; Pigmentation ; Skin

We observed a family with 12 members in four consecutive generations affected by hereditary epidermolytic palmoplantar keratoderma(HEPPK). The affected family members demonstrated not only autosomal dominant inheritance, but also a high penetrance and constant expression. The lesion of all affected person had developed at birth or within the first few weeks of life. The lesions of three members(the proband, her sister and mother) were biopsed, and all of them showed the characteristic features of epidermolytic hyperkeratosis. Two of family members(the proband, her nephew-not affected by HEPPK) had vitiligo, but we concluded that this coexistance was accidental.
Family Characteristics* ; Humans ; Hyperkeratosis, Epidermolytic ; Keratoderma, Palmoplantar, Epidermolytic* ; Parturition ; Penetrance ; Siblings ; Vitiligo ; Wills

We observed 2 cases of occupational radiodermatitis which occurred during the radioisotope transpierce test. Patient 1, a 40-year-old man, noticed swelling, erythema, and stiffness on his left 2nd, 3rd, 4th, and 5th fingers 5 days after the exposure to about 2700 rem. Patient 2, a 32-year-old man, noticed painful swelling, erythema, bullae and necrosis on his right palm and thumb 1 week after the exposure to about 5500 rem. Clinicopathologically, patient 1 and 2 came under 2 and 3 burns respectively. The symptoms have been improving after treatment with systemic and topical corticosteroids and antibiotics.
Adrenal Cortex Hormones ; Adult ; Anti-Bacterial Agents ; Burns ; Erythema ; Fingers ; Humans ; Necrosis ; Radiodermatitis* ; Thumb

Deep skin and soft tissue defects with exposed bone and tendon is difficult to treat, because skin graft rarely survives and flap surgery is sacrifice of donor site. Since "Stage I" membrane was developed by Yannas and Bruke in 1980, numerous kinds of artificial skin have been developed. The adaptability of "Terudermis", developed by the Terumo Co., as an artificial skin composed of sponge made of a fibrillar atelocollagen and a heat-denatured atelocollagen, was clinically evaluated on application to 13 cases presenting deep skin and soft tissue defect with exposed bones and tendons from October 1997 to march 1998. Terudermis has the advantage of allowing early incorporation of fibroblasts and capillaries into its collagen sponge due to very weak dehydrothermal cross-linking. Before Terudermis graft, several days of wet dressing and debridement were required to prepare healthy well-vascularized bed because Terudermis was weak on unsanitary wounds. After bed preparation, Terudermis was grafted like usual skin graft. Tie-over bolster dressing or compressive dressing was used case by case. The dressing was opened 2~3 days after Terudermis grafting. Wet dressing was done daily until the skin graft was done. Autologous skin graft was done 2-3 weeks after Terudermis graft. Our clinical results indicated that Terudermis was beneficial in treating 77% of our patients. Through the use of this new method, treatment of severe skin and soft tissue defects that are usually treated by musculocutaneous or other conventional skin flaps can be replaced by Terudermis as an new artificial dermis.
Bandages ; Capillaries ; Collagen ; Debridement ; Dermis ; Fibroblasts ; Humans ; Membranes ; Porifera ; Skin ; Skin, Artificial ; Tendons ; Tissue Donors ; Transplants ; Wounds and Injuries*

PURPOSE: To evaluate the efficacy of vitrectomy in patients with diabetic macular edema. METHODS: The results of pars plana vitrectomy in 10 eyes were analyzed. Major outcome measurements were preoperative and postoperative best corrected visual acuity, fundus findings of macula, and postoperative complications. All eyes had at least 4 months of follow- up after surgery. RESULTS: The improvement of visual acuity up to 2 lines on the chart was found in 5 eyes (50%) after the surgery and six eyes (60%) showed improvement in macular edema. The complications after surgery were vitreous hemorrhage in 1 eye and submacular exuadates in 1 eye. CONCLUSIONS: Vitrectomy may be beneficial for patients with diabetic macular edema.
Humans ; Macular Edema* ; Postoperative Complications ; Visual Acuity ; Vitrectomy* ; Vitreous Hemorrhage

A case of iridocyclitis due to cysticercus cyst in the anterior chamber and exophthalmos due to in the orbit. A case of iridocycleitis due to cysticercus cyst in the anterior chamber of the left eye, bilateral exophthalmos due to in the orbit and generalized multiple cysticercus cyst in the subcutaneous tissue, brain and the internal organs is reported in a twenty one year old Korean male. To watch characteristic heaving and undulatory movements of the live cysticercus cyst in the anterior chamber of the eye is fascinating. Iridocyclitis was improved fairly after subconjunctival injection of hydrocortisone acetate 5mg and with general treatment for iridocyclitis. Regarding to literature, ocular cysticercosis is known as a very rare case in Korea. A brief review of the related literatures is presented.
Anterior Chamber ; Brain ; Cysticercosis ; Cysticercus* ; Exophthalmos ; Humans ; Hydrocortisone ; Iridocyclitis ; Korea ; Male ; Orbit ; Subcutaneous Tissue

No abstract available.
Hand*

A 20 year old woman with noninsulin-dependent diabetes mellitus (NIDDM) developed an extensive warty and focally cauliflower like mass located at anogenital area. Its histopathologic study and in situ DNA hybridization revealed this lesion an ordinary condyloma acuminatum without large bulbous downward proliferation of which HPV type was 6 and/or 11. The mass lesion was successfully treated by excision and electrodesiccation under spinal anesthesia. Intermittent recurrence of several papular condylomata acuminata was observed during a follow up period of 6 months, which were easily cured by podophylline application on each occasion.
Anesthesia, Spinal ; Brassica ; Condylomata Acuminata ; Diabetes Mellitus, Type 2* ; DNA ; Female ; Follow-Up Studies ; Humans ; Podophyllin ; Recurrence ; Young Adult

Pseudoxanthoma elasticum is a rare, heritable disorder of elastic fibers characterized by yellowish, coalescing papules on the loose and wrinkled flexural skin. An 18-year-old man presented cutis laxa-like marked wrinkling on the axillae, trunk and thighs for about 10 years. There was no similar skin lesion on his family members and no other systemic involvement was found. Histopathological examination of the abdomen revealed fragmentation and calcification of elastic fibers in the middle and lower dermis. Von Kossa staining showed calcium deposition along the altered elastic fibers. Herein, we report a rare case of autosomal recessive pseudoxanthoma elasticum presenting generalized cutaneous laxity.
Abdomen ; Adolescent ; Axilla ; Calcium ; Dermis ; Elastic Tissue ; Humans ; Pseudoxanthoma Elasticum* ; Skin ; Thigh

A 28-year-old woman presented with multiple, asymptomatic, erythematous to bluish papules located on the chest. Histopathologically, three round, well defined cystic structures were seen on the upper and lower dermis. The first cyst was milia, the second was apocrine hidrocystoma and the other, largest cyst was an eruptive vellus hair cyst (EVHC). A diagnosis of multiple pilosebaceous cysts combined with apocrine hidrocystoma was made. Since the milia and EVHC originate from the pilosebaceous unit, and the apocrine duct opens to the pilosebaceous orifice, we suggest that they can occur simultaneously in the same unit.
Adult ; Biopsy ; Dermis ; Female ; Hair ; Hidrocystoma ; Humans ; Thorax