1.Hypocalcemic Convulsion in Formula Feeding Young Infants.
Cheol Woo KO ; Ja Hoon KOO ; Mi Jung KIM
Journal of the Korean Society of Pediatric Nephrology 1998;2(1):14-19
Adenoid cystic carcinoma arising from the submucosal glands of the trachea and bronchial tree is rare. The histopathology and natural history of bronchial adenoid cystic carcinoma have been well documented, but detailed descriptions of its cytomorphology are few. We report a case of primary bronchial adenoid cystic carcinoma in a 20-year-old female, diagnosed by bronchial brushing cytology. The cytologic specimens showed large clusters of small cells arranged around cystlike spaces containing globular basophilic material.
Basophils
;
Bronchi
;
Carcinoma, Adenoid Cystic
;
Ependymoma
;
Female
;
Humans
;
Infant*
;
Natural History
;
Seizures*
;
Spinal Cord
;
Trachea
;
Young Adult
2.Asymptomatic Primary Hematuria in Children.
Jung Mi LEE ; Woo Saeng PARK ; Cheol Woo KO ; Ja Hoon KOO ; Jung Sik KWAK
Journal of the Korean Society of Pediatric Nephrology 2000;4(1):25-32
Localized or solitary fibrous tumor (SFT) of the pleura has been classified as a type of mesothelioma, arising from the submesothelial connective tissue cells. The preoperative diagnosis of the tumor at the cytologic or histologic level is very important for the proper handling of the lesion. This preoperative diagnosis is now possible by means of the advance in the transthoracic fine needle aspiration biopsy (FNA) techniques and in the very experience of the cytopathologists. We describe FNA cytologic feature of two cases of SFT arising from the pleura. Cytologic, histologic, immunohistochemical, and electron microscopic characteristics of pleural SFT are discussed. The tumor cells of SFT are spindle or oval in shape with a variable amount of cytoplasm. They are arranged in irregular trabeculae intimately ass- ociated with capillaries. A unique cytologic feature observed in this tumor is that thick, eosinophilic, amorphous collagen bundles are scattered between tumor cells
Biopsy
;
Biopsy, Fine-Needle
;
Capillaries
;
Child*
;
Collagen
;
Connective Tissue Cells
;
Cytoplasm
;
Diagnosis
;
Eosinophils
;
Hematuria*
;
Humans
;
Mesothelioma
;
Pleura
;
Rhabdomyosarcoma
;
Solitary Fibrous Tumors
3.Gram-negative Septicemia after Infliximab Treatment in an Infant with Refractory Kawasaki Disease.
Jin Hwan LEE ; Jung Min YOON ; Jae Woo LIM ; Kyong Og KO ; Eun Jung CHEON
Korean Journal of Pediatric Infectious Diseases 2014;21(3):225-230
Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.
Bacterial Infections
;
Cardiovascular Diseases
;
Developed Countries
;
Humans
;
Immunoglobulins
;
Infant*
;
Male
;
Mucocutaneous Lymph Node Syndrome*
;
Opportunistic Infections
;
Sepsis*
;
Tumor Necrosis Factor-alpha
;
Infliximab
4.Effect of cyclosporin, indomethacin and methylprednisolone on puromycin-aminonucleoside induced nephrosis in rats.
Hong Bae KIM ; Hae Lee CHUNG ; Cheol Woo KO ; Ja Hoon KOO ; Jung Sik GWAK
Journal of the Korean Pediatric Society 1993;36(4):495-505
This experimental study was conducted to evaluate the effect of indomethacin and methylprednisolone on PAN-induced nephrosis in rats. Sprague-Dawley rats weighing 150~200gm were used and divided into controls, group I (PAN intraperitoneally), group II(PAN intraperitoneally, followed by indomethacin peritoneally for 12 days), group III (PAN intraperitoneally, followed by methylprednisolone peritoneally for 12 days) and group IV (PAN intraperitoneally, followed by cyclosporin subcutaneously for 12 days). Twenty four-hour urinary protein excretion was measured on day 0, 5, 10 and 17. On the 17th day, rats were sacrificed for the determination of total serum protein, albumin and cholesterol levels. Foot process widths of glomerular epithelial cells were measured, and anionic sites of lamina rara externa were determined by using PEI as cationic probes. The following results were obtained. Twenty four-hour urinary protein excretion (mg/day) of group I was significantly increased to 455.7+/-188.8 on the 5th day compared to 15.2+/-3.7 on day 0 (p<0.01), and increased gradulally to 525.6+/-203.5 on the 10th day, then decreased to 280.6+/-25.2 on the 17th day. In group III, 24 hr urinary protein excretion on 17 th day (180.7+/-64.5) was significantly lower than that of group I (280.6+/-25.2). Total serum protein of group III was significantly lower than that of group I, and serum albumin and cholesterol did not show any significant difference among Group I, II, III and IV. Foot process widths (nm) of glomerular epithelial cells in group I, II, III and IV were 409.5+/-15.2, 387.8+/-49.2, 279.9+/-36.9 and 398.3+/-38.3, respectively. And the value of group of group III was significantly lower than that of group I (p<0.01). The number of anionic sites per 1micrometer length of glomerular basement membrane in Group I, II, III and IV were 10.3+/-1.3, 10.1+/-1.6, 12.5+/-1.5and 10.2+/-1.5, respectively. And the value of group III was significantly lower than that of group I (P<0.01). In conclusion, cyclosporin and indomethacin did not show any significant effect on PAN nephrosis in rat. However, methylprednisolone reduced the urinary protein excretion and showed significant recovery of foot process widths and number of anionic sites of glomerular basement membrane.
Animals
;
Cholesterol
;
Cyclosporine*
;
Epithelial Cells
;
Foot
;
Glomerular Basement Membrane
;
Indomethacin*
;
Methylprednisolone*
;
Nephrosis*
;
Nephrotic Syndrome
;
Rats*
;
Rats, Sprague-Dawley
;
Serum Albumin
5.Clinical Course of IgA Nephropathy in Children.
Ihn Hee HONG ; Jun Hwa LEE ; Cheol Woo KO ; Ja Hoon KOO ; Jung Sik KWAK
Journal of the Korean Society of Pediatric Nephrology 1999;3(2):153-160
A statistical analysis of the diagnostic value for 244 aspiration biopsy cytology(ABC) among a total 1,043 cases from various sites was performed. ABC, using diagnostic terminology similar to that of a surgical pathology reports, was compared to the final tissue diagnosis. For the entire series, a sensitivity of 91.8%, a specificity of 99.3%, a positive predictive value of 98.9%, a negative predictive value of 94.8%, and an efficacy of the test of 96.3% were shown. There were 8 false negative and 1 false positive diagnosis. The diagnostic accuracy was 89.8%. Those results indicate that the ABC is a considerably highly accurate procedure that should be routinely employed.
Biopsy, Needle
;
Child*
;
Diagnosis
;
Glomerulonephritis, IGA*
;
Humans
;
Immunoglobulin A*
;
Intranuclear Inclusion Bodies
;
Meningioma
;
Pathology, Surgical
;
Sensitivity and Specificity
6.Cystosarcoma Phyllodes of the Breast.
Jong Gun KO ; Woo Jung KWEON ; Eil Sung CHANG
Journal of the Korean Surgical Society 1999;57(5):653-658
BACKGROUND: Cystosarcoma phyllodes are relativly rare neoplasms of the breast and have an unpredictable clinical behavior. This study is to determine whether histological features correlate with clinical behavior, and which operation method affect recurrence. METHODS: This study reviewed the histological features and clinical outcomes in 12 patients with phyllode tumors of the breast diagnosed at Chungnam University Hospital from 1989 to 1998. RESULTS: The pathological results revealed benign forms were in 8 cases and malignant forms in 4 casese. As to the nature of the growth, the tumors in 10 cases grew rapidly 10 cases were rapid in nature, but two malignant tumors not. One of the 4 malignant tumors was high grade, the others were borderline. Eight (8) patients were had been treated conservatively (7 cases, wide tumor excision; 1 case, excisional biopsy), and 4 cases patients underwent radical operation (2 cases, modified radical mastectomy; other 2 cases, simple mastectomy). Only one patient with borderline malignancy, who underwent modified radical mastectomy, experienced recurrence. CONCLUSIONS: Tumor growth & histological features do not correlate with recurrence, and wide resection should to be primary treatement and axillary dissection is not worthwhile.
Breast*
;
Chungcheongnam-do
;
Humans
;
Mastectomy, Modified Radical
;
Phyllodes Tumor*
;
Recurrence
7.IL - 5 and IL - 10 production of peripheral blood mononuclear cells by stimulation of D. farinae antigen in atopic asthmatics.
Jung Won PARK ; Chein Soo HONG ; Si Hwan KO ; Cheol Woo KIM
Journal of Asthma, Allergy and Clinical Immunology 1999;19(4):557-565
BACKGROUND: IL - 5 has been recognized as a potent proeosinophilic cytokine and IL-10 has been reported as an important anti - inflammatory cytokine in allergic inflammation. But the clinical roles of these cytokines in allergic asthma are still unclear. Objectives : We studied the clinical implications of IL - 5 and IL - 10 secretions from stimulated peripheral blood mononuclear cells ( PBMC ) in Dermatophagoides farinae ( DF ) atopic asthmatics ( BA ). METHODS: Thirty - six DF sensitized BA and 9 non - atopic BA were enrolled for this study. Twenty - seven out of 36 subjects were challenged by inhalation of DF crude allergen. The isolated PBMCs were cultured for 6 days with DF antigen and the stimulatory index ( SI ) and secretions of IL - 5, IFN - y and IL - 10 from PBMC were measured. We analyzed these parameters with clinical parameters. RESULTS: SI (4.2 +/- 1.0 vs. 1.3 +/- 0.3, p<0.05) and secretions of IL - 5 ( 19.9 vs. 1.7 g/L, p< 0.001 ) and IL-10 ( 185.5 vs. 34.3 g/L, p(0.05 ) from the atopic BA were significantly higher than those of non-atopic BA, but the secretion of IFN - r was not different between the two groups ( 56.6 vs. 47.3 ug/L ). No significant difference in secretions of IL - 5, IL - 10, IFN - r and SI of PBMC was found between responder and non - responder of DF inhalation challenge test. Among responders to antigen challenge test ( n = 17 ), the production of IL - 5 correlated with the productions of IL - 10 (r = 0.773, p< 0.01 ) and methacholine PC20 ( r = 0.503, p< 0.05 ). Production of IL - 5 from the PBMC of atopic mild intermittent BA ( n = 10 ) was higher than that of atopic per'sistent BA ( n = 27 ) ( p< 0.01 ), but no difference in IL - 10, IFN - r and SI was found between the two groups. Conclusions : Allergen specific productions of IL - 5 and IL - 10 from the PBMC may be specific for atopic subjects and secretion of IL - 5 from the stimulated PBMC may contribute to the pathogenesis of atopic BA. The severity of BA may be more influenced by other factors.
Asthma
;
Cytokines
;
Dermatophagoides farinae
;
Inflammation
;
Inhalation
;
Interleukin-10
;
Methacholine Chloride
8.Treatment of intertrochanteric fracture with captured hip screw.
Sang Wook BAE ; Woo Ku JUNG ; Tae Hong KO ; Young Shin SHIN
The Journal of the Korean Orthopaedic Association 1993;28(6):2074-2082
No abstract available.
Hip*
9.Therapeutic effects of self-administrating portable TENS for posttherapeutic neuralgia.
Sae Yoon KANG ; Young Jin KO ; Jung SUH ; Sung Woo CHOI
Journal of the Korean Academy of Rehabilitation Medicine 1991;15(4):522-526
No abstract available.
Neuralgia*
;
Transcutaneous Electric Nerve Stimulation*
10.A Case of Dilated Cardiomyopathy Associated with Pheochromocytoma.
Min Cheul KIM ; Gi Beum CHO ; Cheul Woo NAM ; Yong Ho KO ; In Kwon JUNG ; Jae Woo LEE
Korean Circulation Journal 1992;22(1):182-187
The diagnosis of dilated cardiomyopathy associated with pheochromocytoma was made in a 24 year old male on the basis of symptoms and signs, measurements of metabolites of catecholamine,echocardiography and radionuclide ventriculography were preformed and demonstrated. The presence of a tumor on both adrenal glands without definite distant metastasis was demonstrated by abdominal ultrasonography, CT scanning and 131I-MIBC scintigraphy. Surgical removal was performed after proper preoperative preparation with a-adrenergic blocker. During the surgery, neither significant arrhythmia nor severe change of blood pressure was observed. After surgery, cardiac function of the patient improved slowly and progressively.
Adrenal Glands
;
Arrhythmias, Cardiac
;
Blood Pressure
;
Cardiomyopathy, Dilated*
;
Diagnosis
;
Humans
;
Male
;
Neoplasm Metastasis
;
Pheochromocytoma*
;
Radionuclide Imaging
;
Radionuclide Ventriculography
;
Thoracic Surgery
;
Tomography, X-Ray Computed
;
Ultrasonography
;
Young Adult