No abstract available.
Child* ; Gastroenteritis* ; Humans* ; Infant*

Ticlopidine is a powerful inhibitor of platelet aggregation which is induced by adenosine diphosphate. Ticlopidine has been shown to be effective in reducing combined stroke, myocardial infarction, reocclusion of coronary stent. The principal side effects of ticlopidine are severe neutropenia, rash and gastrointestinal upset. Recently, we experienced two cases of severe neutropenia associated with ticlopidine. One was administered ticlopidine to prevent subacute thrombosis after intracoronary stent implantation in unstable angina pectoris. Thirty days of therapy, her absolute neutrophil count (ANC) had dropped to 14/mm3 . The other patient was presented with recurrent episodes of cerebral infarction, for which he had undergone right carotid angiogram. The carotid angiogram demonstrated tight stenosis of right internal carotid artery. Carotid artery stenting was performed at right internal carotid artery without any complications. Twenty seven days of ticlopidine therapy, his ANC had dropped to 111/mm3. The ticlopidine was stopped, and they were given granulocyte-colony stim-ulating factor 250 microgram/day subcutaneous injection until their ANC was up to 1000/mm3. They were discharged with normal neutrophil count and no other complications.
Adenosine Diphosphate ; Angina, Unstable ; Carotid Arteries ; Carotid Artery, Internal ; Cerebral Infarction ; Constriction, Pathologic ; Exanthema ; Granulocyte Colony-Stimulating Factor ; Humans ; Injections, Subcutaneous ; Myocardial Infarction ; Neutropenia* ; Neutrophils ; Platelet Aggregation ; Stents ; Stroke ; Thrombosis ; Ticlopidine*

BACKGROUND: Radiation therapy is widely employed in the treatment of head and neck cancer. Adverse effects of therapeutic irradiation include delayed bone healing after dental extraction or impaired bone regeneration at the irradiated bony defect. Development of a reliable experimental model may be beneficial to study tissue regeneration in the irradiated field. The current study aimed to develop a relevant animal model of post-radiation cranial bone defect. METHODS: A lead shielding block was designed for selective external irradiation of the mouse calvaria. Critical-size calvarial defect was created 2 weeks after the irradiation. The defect was filled with a collagen scaffold, with or without incorporation of bone morphogenetic protein 2 (BMP-2) (1 μg/ml). The non-irradiated mice treated with or without BMP-2-included scaffold served as control. Four weeks after the surgery, the specimens were harvested and the degree of bone formation was evaluated by histological and radiographical examinations. RESULTS: BMP-2-treated scaffold yielded significant bone regeneration in the mice calvarial defects. However, a single fraction of external irradiation was observed to eliminate the bone regeneration capacity of the BMP-2-incorporated scaffold without influencing the survival of the animals. CONCLUSION: The current study established an efficient model for post-radiation cranial bone regeneration and can be applied for evaluating the robust bone formation system using various chemokines or agents in unfavorable, demanding radiation-related bone defect models.
Animals ; Bone Morphogenetic Protein 2 ; Bone Regeneration ; Chemokines ; Collagen ; Head and Neck Neoplasms ; Mice ; Models, Animal ; Models, Theoretical ; Osteogenesis ; Regeneration ; Skull

No abstract available.
Brain Stem* ; Cysticercus* ; Granuloma*

No abstract available.
Eosinophils* ; Hypereosinophilic Syndrome*

The development of primary squamous cell carcinoma in the endometrium is extremely rare. In 1928 Fluhmann proposed three criteria to establish the diagnosis: (1) no coexisting endometrial adenocarcinoma, (2) no connection between the endometrial tumor and the squamous epithelium of the cervix and (3) no squamous cell carcinoma of the cervix present. More recently, the World Health Organization (WHO) updated Fluhmann's criteria by adding that the tumor must contain clear evidence of squamous differentiation, such as the presence of intercellular bridges and/or keratin. We have experienced a case of primary endometrial squamous cell carcinoma which fulfills Fluhmann's criteria and WHO's. In this report, we present the clinical and pathological findings of a case of a primary endometrial squamous cell carcinoma of a 62-year-old patient with a review of the concerned literatures.
Adenocarcinoma ; Carcinoma, Squamous Cell* ; Cervix Uteri ; Diagnosis ; Endometrium ; Epithelium ; Female ; Humans ; Middle Aged ; World Health Organization

PURPOSE: Laparoscopic appendectomy (LA) is currently more popular than an open appendectomy (OA), because of its advantages, such as a decrease in postoperative pain, short hospitalization and quick recovery. On the other hand, the efficacy and safety of a laparoscopic appendectomy for complicated appendicitis is controversial. Therefore, this study compared the efficacy and safety of LA and OA. METHODS: This study reviewed retrospectively 262 patients with perforated appendicitis who underwent ether open or laparoscoic appendectomy between January 2001 and December 2010. The medical record and video were used to collect data. The operative time, length of hospital stay, time to diet, time to remove drain and complications were assessed. RESULTS: There were 207 and 55 patients in the OA and LA group, respectively. The operation times were significantly longer in the LA group than the OA group (OA group 68.25+/-33.08 vs. LA group 90.80+/-47.64 min) (p<0.05). The length of hospital stay was longer in the OA group than the LA group (OA group 10.96+/-5.24 vs. LA group 8.86+/-5.18 days) (p<0.05). The time to diet and time to remove the drain was longer in the OA group than the LA group (p<0.05). The postoperative complication rate was similar in the two groups. CONCLUSION: The operative time was longer in the LA group but the length of hospital stay, time to diet, and time to remove drain was longer in the OA group. Such merits show that laparoscopic appendectomy is a good surgical option for perforated appendicitis.
Appendectomy ; Appendicitis ; Diet ; Ether, Ethyl ; Hand ; Hospitalization ; Humans ; Imidazoles ; Length of Stay ; Medical Records ; Nitro Compounds ; Operative Time ; Pain, Postoperative ; Postoperative Complications ; Retrospective Studies

PURPOSE: Rat arthritis was induced by bovine type II collagen. To present the remedial effects on type II collagen arthritis and clinical efficacy, a high dose of methotrexate, of a level similar to that used in cancer patients was given to rats. MATERIALS AND METHODS: Healthy male Brown Norway rats were used, of mean weight; 300 g. There were 7 subgroups: a control group, given collagen only, an orally methotrexate treated (2.5mg/week), high methotrexate dose groups; 10 mg/kg, 30 mg/kg, 50 mg/kg, 100 mg/kg and a low dose methotrexate group (0.375 mg/kg/week, 4 times) were included in the present study. Type II collagen was injected for arthritis induction and a single intraperitoneal injection of methotrexate was administered after 15 days. Orally treated group was administered 4 times (2.5 mg/week). Histopathologic findings were evaluated. RESULTS: 50 mg/kg methotrexate was effectively reduced the arthritis index and significantly decreased inflammatory cell number between 2nd and 6 weeks. CONCLUSION: A high dose of methotrexate may be clinically effective in the short period treatment of rheumatoid arthritis patients.
Animals ; Arthritis* ; Arthritis, Rheumatoid ; Cell Count ; Collagen ; Collagen Type II* ; Humans ; Injections, Intraperitoneal ; Male ; Methotrexate* ; Norway ; Rats*

Amyloidosis is characterized by deposition of homogenous, eosinophilic, hyaline material in various tissues. Presently, most cases occur in a generalized form as a manifestation of an underlying plasma cell neoplasm(myeloma) or plasmacytic dyscrasia. On the other hand, most cases of symptomatic amyloid disease in the urinary bladder has occurred as an apparently solitary, localized tumefactive process and mimicks invasive bladder tumor. We report a case of primary amyloidosis of the bladder which was diagnosed after transurethral resection in a 65-year-old man with chronic renal failure.
Aged ; Amyloid ; Amyloidosis* ; Eosinophils ; Hand ; Humans ; Hyalin ; Kidney Failure, Chronic ; Plasma Cells ; Urinary Bladder Neoplasms ; Urinary Bladder*

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the term applied to arginine vasopressin (AVP) excess associated with hyponatremia without edema in the absence of physiologic or pharmacologic stimuli to AVP secretion. SIADH is associated with various conditions such as malignant tumors, infection, central nervous system disorders, and different pharmacological agents. The patient was 73-year-old female. She was admitted to the hospital because of persistent cough, dizziness, general weakness and confusion. On admission, her serum osmolality was 253 mOsm/kg, urine osmolality was 416 mOm/kg, and urine Na concentration was 159 mEq/L. Her Chest X-ray and CT scan of lung showed about 4x3.5 cm sized mass at posterior basal segment of left lower lobe of the lung, and CT-guided percutaneous needle aspiration revealed small round cell with clusters of malignant squamous cells. She was treated by salt restriction, hypertonic saline infusion and demeclocycline. We planned chemotherapy for advanced combined lung cancer, but she was discharged because of poor general condition and associated pneumonia without cancer chemotherapy. We report a rare case of SIADH in small cell cancer of lung combined with squamous cell cancer of lung.
Aged ; Arginine Vasopressin ; Carcinoma, Small Cell ; Carcinoma, Squamous Cell ; Central Nervous System Diseases ; Cough ; Demeclocycline ; Dizziness ; Drug Therapy ; Edema ; Female ; Humans ; Hyponatremia ; Inappropriate ADH Syndrome ; Lung Neoplasms* ; Lung* ; Needles ; Neoplasms, Squamous Cell* ; Osmolar Concentration ; Pneumonia ; Thorax ; Tomography, X-Ray Computed