1.A Case of Epidermolysis Bullosa Dystrophica Dominant.
Mi Jung JUNG ; Jong Seok LEE ; Young Keun KIM
Korean Journal of Dermatology 1994;32(3):518-522
Epidermolysis bullosa dystrophica is rare, chronic non-inflammtory mechanobullous disease of hereditary trait, which easily produces bullae by minor trauma or sponta neosly. A 1-day old male neonate presented wide spread vesicobullous minor, eruptions since birth. On examination, tense bullse were noted on the dorsa of the feet and right knei: area Which is usually serous but may be hemarrhagic tendeney. This was healed by the dropping of oxoline and wet betadine auze application along with the administration of vitamin E and phenytoin. We present a case of epidermolysis bullosa dystrophica that seems be a dominant type considering the presence of family history with histopathologic and electron microscopic findings.
Epidermolysis Bullosa Dystrophica*
;
Epidermolysis Bullosa*
;
Foot
;
Humans
;
Infant, Newborn
;
Male
;
Parturition
;
Phenytoin
;
Povidone-Iodine
;
Transcutaneous Electric Nerve Stimulation
;
Vitamin E
;
Vitamins
2.Protective Effect of Probucol against Adriamycin-Induced Apoptosis in Cultured Rat Cardiac Myocytes.
Sun Ju LEE ; Dong Seok LEE ; Yong Wook JUNG
Journal of the Korean Pediatric Society 2000;43(6):746-754
PURPOSE: In adriamycin(ADR)-induced cardiomyopathy, several different mechanisms are suggested. However, little information is available regarding the role of apoptosis. In the present study, we examined the induction of apoptosis on ADR treatment and anti-apoptotic effects of probucol, a lipid-lowering drug, and we also studied the changes of bcl-2 expression in order to see the molecular mechanisms underlying the effect of probucol. METHODS: Cardiac myocytes were isolated from 3-day-old rats, and cultured in low(1 pM) or high doses(10pM) of ADR for 24 hours. Probucol(50 pM) was added 30 minutes before ADR administration. Apoptosis was determined by TUNEL staining, and bcl-2 expression was estimated by immunocytochemistry. RESULTS: The number of TUNEL-positive cells significantly increased in both groups treated with ADR. However, anti-apoptotic effect of probucol was evident only in low dose. In addition, the expression of bcl-2 was significantly increased only in the low-dose ADR treatment group and its expression was inhibited by pretreatment of probucol. CONCLUSION: These results suggest that apoptosis might play an important role in ADR-induced cardiotoxicity, and ADR-induced apoptosis was partially prevented by pretreatment of probucol. And ADR-induced apoptosis was not related with depression of bcl-2. Additionally, inhibition of bcl-2 gene expression of low-dose ADR treatment group by probucol suggests that another cell survival mechanism could be implicated in the action of probucol. (J Korean Pediatr Soc 2000;43:746-754)
Animals
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Apoptosis*
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Cardiomyopathies
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Cell Survival
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Depression
;
Doxorubicin
;
Genes, bcl-2
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Immunohistochemistry
;
In Situ Nick-End Labeling
;
Myocytes, Cardiac*
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Probucol*
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Rats*
3.Relationship between clinical improvement and ego strength of hospitalized alcoholics.
Seok Hwan LEE ; Jae Hwan KIM ; Jung Kug LEE
Journal of Korean Neuropsychiatric Association 1991;30(2):333-343
No abstract available.
Alcoholics*
;
Ego*
;
Humans
4.Tendon transfer in radial nerve palsy.
Kwang Suk LEE ; In Jung CHAE ; Seok Woo LEE
The Journal of the Korean Orthopaedic Association 1993;28(5):1802-1807
No abstract available.
Paralysis*
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Radial Nerve*
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Tendon Transfer*
;
Tendons*
5.Clinical Course and Predictable Factors for Remission of Hashimoto' Thyroiditis in Children and Adolescents.
Keun Hye LEE ; Mi Jung KIM ; Heon Seok HAN
Journal of Korean Society of Pediatric Endocrinology 2004;9(1):34-41
PURPOSE:The natural course of Hashimoto' thyroiditis (HT) is so dynamic that the disease progresses to overt hypothyroid or spontaneous recovery. The authors reviewed the clinical course of this disease and analysed the possible predicting factors regarding remission. METHODS:Thirty nine patients with HT (38 girls and 1 boy) were studied retrospectively. Of these patients, 30 were followed for more than 2 years. The possible remission factors were analyzed at initial diagnosis and during follow-up period. RESULTS:The mean age at the diagnosis was 11.8+/-.1 years. Initial thyroid function was euthyroid in 38.5%, compensated hypothyroid in 35.9%, overt hypothyroid in 23.1%, and hyperthyroid in 2.6% of patients. Antithyroglobulin antibody (ATA) was positive in 94.7%, and antimicrosomal antibody (AMA) was positive in 74.4%. The overall remission rate was 53.3% during the follow-up period (51+/-7 months). Initial goiter size, thyroid function status, and autoantibody titer had no relation to the remission rate statistically. Follow-up autoantibody titers in remission group were marginally lower than those in nonremission group (P<0.1), and follow-up AMA titer was significantly higher than initial titers in nonremission group (P<0.05). CONCLUSION: We could not find any predictable remission factors from the initial clinical and autoantibody status. But, during follow-up period, patients with lower autoantibody titers showed slight higher remission, and those with increasing AMA titer showed less remission. Above results suggest that we should monitor antithyroid antibody titer as well as thyroid function regularly.
Adolescent*
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Child*
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Diagnosis
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Female
;
Follow-Up Studies
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Goiter
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Humans
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Retrospective Studies
;
Thyroid Gland*
;
Thyroiditis*
6.Enterocele confirmed by preoperative defecography: 3 case reports.
Bong Bae KIM ; Jung Moo LEE ; Hong SEOK
Journal of the Korean Surgical Society 1993;45(1):133-136
No abstract available.
Defecography*
;
Hernia*
7.Susceptibility to Antivirals of a Human HBV Strain with Mutations Conferring Resistance to Both Lamivudine and Adefovi.
Yun Jung CHANG ; Myung Seok LEE
The Korean Journal of Gastroenterology 2005;46(4):316-317
No abstract availble
8.Quantitative Evaluation of Dysphagia Using Scintigraphy.
Seok Gun PARK ; Jung Keun HYUN ; Seong Jae LEE
Korean Journal of Nuclear Medicine 1998;32(3):276-289
PURPOSE: To evaluate dysphagia objectively and quantitatively, and ta clarify the effect of neck position and viscosity changes in patients with aspiration and laryngeal penetration. MATERIALS AND METHODS: We studied 35 patients with dysphagia and 21 normal controls using videofluoroscopy and scintigraphy. Videofluoroscopy was performed with barium with three different viscosity, and scintigraphy was done, with water, yogurt, and steamed egg mixed with Tc-99m tin colloid. 1f aspiration was found during videofluoroscopic examination, patients neck position was changed and study repeated. Videofluoroscopy was analyzed qualitatively. We calculated 7 quantitative parameters from scintigraphy. According to the videofluoroscopic findings, we divided patients into 3 subgroups; aspiration, laryngeal penetration, and no-aspiration group. RESULTS: The result of videofluoroscopy revealed that the most cornmon finding was the delay in triggering pharyngeal swallow. Pharyrigeal transit time (PTT) and pharyngeal swallowing efficiency(PSE) in patients with aspiration were significantly different from other groups. After neck position change, aspiration could be reduced in all of 7 patients, and laryngeal penetration reduced hy about 82%. PTT ancl PSE were also improved after position change. Aspiration and laryngeal penetration occurred more frequently in thin liquid swallowing than in thick liquid and solid swallowing. CONCLUSION: PTT and PSE were useful for the evaluation of dysphagia. Aspiration and laryngeal penetration could be reduced when appropriate position assumed, We could decrease the chance of aspiration by changing the patient diet consisIency. Scintigraphy might be useful tool to quantitate and follow up these changes.
Barium
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Colloids
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Deglutition
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Deglutition Disorders*
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Diet
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Evaluation Studies as Topic*
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Follow-Up Studies
;
Humans
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Neck
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Ovum
;
Radionuclide Imaging*
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Steam
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Tin
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Viscosity
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Water
;
Yogurt
9.The in vitro distribution of 99mTc-phytate IL-2 complex on selective splenic arterial injection.
Seok Kil SEON ; Hee Jung LEE ; Soo Sang SOHN
Korean Journal of Nuclear Medicine 1992;26(1):124-126
No abstract available.
Interleukin-2*
10.Changes of hematological references depends on storage period and temperature conditions in rats and dogs.
Laboratory Animal Research 2016;32(4):241-248
Because changes in rat and dog hematological parameters according to storage conditions have been poorly documented, we sought to examine such changes. Blood analysis was performed using two hematology analyzers (ADVIA 2120i and Sysmex XN-V) after storage at room temperature and in cold storage for 5, 24, and 48 h, respectively. Interassay coefficients of variation for hematological parameters analyzed with the ADVIA 2120i and the XN-V showed similar. The levels of hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and platelet (PLT) showed significant variations with time in blood samples of rats and dogs. The leukocyte subpopulation showed high variation with storage conditions. The data for leukocyte differential counts obtained using the ADVIA 2120i, XN-V, and a manual differential counting procedure showed good agreement for neutrophils and lymphocyte counts, but monocytes, eosinophils, and basophils showed differences between the procedures. In conclusions, most rat and dog hematological parameters showed minimal changes; however, some showed high variation with storage time and temperature, especially PLT and leukocyte subpopulations. In conclusion, when performing hematological analysis in dogs and rats, it will be exactitude to analyze blood samples in fresh condition and at least within 24 h in the cold storage.
Animals
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Basophils
;
Blood Platelets
;
Dogs*
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Eosinophils
;
Erythrocyte Indices
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Hematocrit
;
Hematology
;
Leukocytes
;
Lymphocyte Count
;
Monocytes
;
Neutrophils
;
Rats*