No abstract available.
Nasal Polyps*

No abstract available.

No abstract available.
Choristoma* ; Ear, Middle* ; Salivary Glands*

No abstract available.

The present study was carried out in order to observe the changes in the expression of the sialoglycoconjugates of the rabbit sinus mucosa after inoculation of influenza A virus utilizing a biotin labeled lectins for light microscopy with four different lectins; Maackia amurensis(MAA), Wheat germ agglutinin(WGA), Sambucus nigra(SNA), and Peanut(PNA). A comparison of the affinity of these lectins demonstrated the different distribution of sialoglycoconjugates in the ciliary layer and goblet cells. The normal sinus mucosa stained with four types of lectins showed that the sialoglycoconjugates were mainly distributed in the ciliary layer and goblet cells. Moreover, the main sugar residues of the sialoglycoconjugates were figured out to be consisted of Neu5Ac(alpha2,3)Gal, GlcNAc and Neu5Ac. Influenza A virus infection decreased the staining intensity of the mucosa with MAA, but not with WGA. The staining intensity of PNA, however, was highly increased in the viral infected mucosa. These results suggest that Neu5Ac(alpha2,3)Gal sugar residues may be required as protecting factor or modulator for Influenza A virus infectivity.
Biotin ; Goblet Cells ; Influenza A virus* ; Influenza, Human* ; Lectins ; Maackia ; Maxillary Sinus* ; Microscopy ; Mucous Membrane* ; Sambucus ; Triticum

BACKGROUND AND OBJECTIVES: Oxygen free radicals are generated markedly in various infected condition, and these molecular species were identified as potent pathologic agents. The activities of various antioxidant enzymes have close relationships to genereration and metabolism of oxygen free radicals. The purpose of this study was to investigate the changes in the generation of superoxide radicals and activities of antioxidant enzymes and to compare histopathological changes in influenza A virus-induced maxillary sinusitis. MATERIALS AND METHODS: The experimental viral infection was induced in New Zealand white rabbits by inoculating 0.3 ml of influenza A virus. Maxillary sinus mucosa were examined with a light microscope and the generation of superoxide radicals and activity of antioxidant enzymes were measured at the intervals up to 28 days after inoculation. RESULTS: The mucosal changes deteriorated and reached maximum at seven days after inoculation. The first day of inoculation, mononuclear phagocytes and neutrophils began to be found in subepithelial layer. We also found that capacity of oxygen generation increased about one and a half fold compared with the non-infected control group. The activity of SOD, GSH-Px and CAT, which are specific scavengers of oxygen radicals, peaked at three, five, and seven days after viral inoculation, respectively. CONCLUSIONS: These results suggest that oxygen free radicals play an improtant role in the histopathologic damage in the early stage of influenza A viral infection, and the activities of antioxidant enzymes are enhanced by the generation of superoxide radicals. It is also indicated that antioxidant enzymes may have a therapeutic potential for this viral infection and other conditions associated with free radicals.
Animals ; Catalase ; Cats ; Free Radicals ; Glutathione Peroxidase ; Influenza A virus ; Influenza, Human* ; Maxillary Sinus ; Maxillary Sinusitis ; Metabolism ; Mucous Membrane ; Neutrophils ; Oxygen ; Phagocytes ; Rabbits* ; Reactive Oxygen Species ; Sinusitis* ; Superoxide Dismutase ; Superoxides*

No abstract available.
Cervical Ripening* ; Female ; Pregnancy

BACKGROUND AND OBJECTIVES: Postnasal drip is a common presentation to the medical practitioner. It is a result of disturbance to the normal drainage or an increase in secretion of the paranasal sinuses. However, sometimes no underlying cause can be found and the patient has to be reassured, and that they may just have to live with it. The aim of this study is to evaluate the clinical manifestations of patients with postnasal drip. MATERIAL AND METHOD: There were 90 patients complaining with postnasal drip. We performed a prospective study about accompanying symptoms and physical and psychiatric evaluation. CONCLUSION: Postnasal drip is more common in females over 30 years and the duration of symptoms is usually long. Anatomical nasal abnormality and sinusitis are common. There is no correlation with postnasal drip and psychiatric problems. But several items are concerned with postnasal drip. So we need detailed history taking and physical examination on patients who complained of postnasal drip.
Drainage ; Female ; Humans ; Paranasal Sinuses ; Physical Examination ; Prospective Studies ; Sinusitis

No abstract available.
Statistics as Topic*

Rhinocerebral mucormycosis, a rare opportunistic invasive fungal infection, is known to be fatal and aggressive. It is characterized by an aggressive necrotizing infection spreading from the nose to the paranasal sinuses, orbit, and the brain. This disease is most often associated with diabetic ketosis but can be seen with uremic acidisis, leukemia, malnutrition, AIDS, steroid, antimetabolic or antibiotic therapy, severe burn, septicemia, and treatment with immunosuppressive medications. Early clinical recognition of this potentially fatal disease is essential before irreversible changes occur. We report in this study about a 40-year-old man with poorly controlled diabetes mellitus who developed mucormycosis which involved unilateral paranasal sinus, orbit, and selective cranial nerves (especially, hypoglossal nerve). Despite of treatment he died from an abruptly developed acute respiratory distress syndrome that might be caused by mucormycotic hematogenous dissemination 33 days after admission.
Adult ; Brain ; Burns ; Cranial Nerve Diseases* ; Cranial Nerves* ; Diabetes Mellitus ; Diabetic Ketoacidosis ; Humans ; Hypoglossal Nerve ; Leukemia ; Malnutrition ; Mucormycosis* ; Nose ; Orbit ; Paranasal Sinuses ; Respiratory Distress Syndrome, Adult ; Sepsis