No abstract available.
Drug Therapy* ; Humans ; Lung Neoplasms* ; Lung*

Between May 1982 and October 1983, arthroscopic meniscectomy had been performed in 54 knees between ages of 11 and 70 years. There were 32 male patients and 22 female patients in this series. The mean follow-up was 20 months, ranging from 15 months to 33 months. Postoperative complications developed were retropatellar tenderness and effusion. No infection, thrombophlebitis or instability occurred postoperatively. The aim of this study was to evaluate the effect of the various possible prognostic factors upon the developtnent of the above mentioned complications. The factors included were 1) shape of tear, 2) ligamentous injury, 3) degenerative arthritia, 4) discoid lateral meniscus, 5) quadriceps atrophy, 6) sites of meniscus(medial or lateral) & extent of excision, 7) preoperative retropatellar tenderness and 8) method of rehabilitation. The findings were statistically analyzed by the Chi-square test (df-1) & Fisher's direct probability method. The results obtained were as follows; 1. The rate of development of postoperative effusion was significantly high in cases of quadriceps atrophy (P<0.01) and preoperative retropatellar tenderness(P<0.01). 2. The rate of deveopment of postoperative retropatellar tenderness was significantly high in case of discoid lateral meniscus (P <0.01). 3. There was no significant correlation between complications and other factors including shape of tear, preoperative degerative arthritis, site of meniscus & extent of excision and methods of rehabilitation.
Arthritis ; Atrophy ; Female ; Follow-Up Studies ; Humans ; Knee ; Ligaments ; Male ; Menisci, Tibial ; Methods ; Postoperative Complications ; Prognosis ; Rehabilitation ; Tears ; Thrombophlebitis

No abstract available.

Hysterosalpingography and Hysteroscopy have been used for the detection of intraute-rine pathology such as polyps, submucous myomas, intrauterine adhesion and endometrial hyperplasia or cancer. Recently the ultrasound has also been utilized for the detection of uterine pathology. Therefore the purpose of this study was to evaluate the diagnostic efficacy of SonoHysterography in detection of intrauterine pathology compared with HSG and Hysteroscopy. 32 patients underwent Sono-Hysterography and Hysteroscopy for the evaluation of the uterine pathology from september 1995 to January 1996. Nine of 32 patients had infertility problem and HSG performed prior to Sono-Hysterography and Hysteroscopy. The results are as follows : 1. The patients' ages ranged from 20 to 50 years(median 37.9). 2. All 9 patients with infertility who had positive HSG findings in uterine cavity showed the intrauterine pathology in Sono-Hysterography as well as Hysteroscopy. The detail findings are as follows :septated uterus(n=2), intrauterine adhesion :IUA(n=3), endometrial polyp(n=3), and IUA combined endmetrial hyperplasia(n=1). 3. Twenty two of 23 patients with abnormal uterine bleeding showed the intrauterne pathology and one patient had negative finding in Sono-Hysterography. However, Hysteroscopy revealed positive intrauterine pathology in 22 patients who had abnormal uterine bleeding. One patients who had positive finding in Sono-Hysterograply showed negative by Hysterography. In contrast, one patient who had negative finding in Sono-Hysterography had positive uterine pathology with polyp in Hysteroscopy. The histologic pathology in all 23 patients reported endometrial polyp(n=12), placental polyp(n=2), submucous myoma(n=1), endometrial hyperplasia(n=5), endometrial cancer(n=1), normal endometrial finding(n=2). 4. Sono-Hysterography, therefore, has a sensitivity and positive predictive value of 96.6%, 93.5% respectively. Our study showed a positive Sono-Hysterography is very predictive of the intrauterine pathology. Sono-Hysterography is safe, quick and minimal invasive procedure. So it is an invaluable technique in the evaluation of uterine cavity.
Endometrial Hyperplasia ; Female ; Humans ; Hysterosalpingography ; Hysteroscopy* ; Infertility ; Myoma ; Pathology* ; Polyps ; Ultrasonography ; Uterine Hemorrhage

Gastric adenocarcinoma is the most common cancer of the gastrointestinal tract in Korea, and its prognosis is related to several factors, such as depth of invasion, lymph node metastasis, and differentiation. Heat-shock proteins (HSPs) are present constitutively in normal cells, where they play an important role in normal cell metabolism. In mammarian cells, they are induced by a variety of physical and chemical stimuli. Among them, HSP70 is found at a higher level in growing cells than in resting cells. The p53 gene is located on the short arm of the chromosome 17 and acts as a cancer suppressor gene. A mutant p53 gene induces a malignant transformation. The mutant p53 protein binds with HSP70 and the p53-HSP70 complex has functional significance in the transforming capacity of the mutant p53. We evaluated the correlation between the HSP70 scores and the p53 protein expression by immunohistochemical methods and compared it with well-known prognostic factors, such as depth of invasion, size, histologic type, and DNA ploidy pattern, in 37 gastric adenocarcinomas. The HSP70 expression was scored according to the staining intensity and extent. An immunoreactivity of over 1% in tumor cell nuclei was considered as positive for p53 protein. The results are summarized as follows: The p53 protein expression rate did not significantly differ based on depth of invasion, histologic type, lymph node metastasis, or DNA ploidy. The HSP70 scores was higher in group II (AGC with TNM stage III) than in group I (EGC & AGC with TNM stage II) and in p53-positive carcinomas than in p53- negative carcinomas(P<0.05). In conclusion, the p53 protein and HSP70 were closely correlated to each other in our immunohistochemical study for gastric adenocarcinomas and the HSP70 scores may play a role in the progression of a gastric adenocarcinoma. However, further studies are needed for determining their prognostic values in gastric adenocarcinomas. HSP70 and p53 expression are factors, just like depth of invasion. The question is their value.
Adenocarcinoma ; Arm ; Cell Nucleus ; Chromosomes, Human, Pair 17 ; DNA ; Gastrointestinal Neoplasms ; Genes, p53 ; Genes, Tumor Suppressor ; Heat-Shock Proteins* ; HSP70 Heat-Shock Proteins* ; Korea ; Lymph Nodes ; Metabolism ; Neoplasm Metastasis ; Ploidies ; Prognosis ; Stomach

Gastric adenocarcinoma is the most common cancer of the gastrointestinal tract in Korea, and its prognosis is related to several factors, such as depth of invasion, lymph node metastasis, and differentiation. Heat-shock proteins (HSPs) are present constitutively in normal cells, where they play an important role in normal cell metabolism. In mammarian cells, they are induced by a variety of physical and chemical stimuli. Among them, HSP70 is found at a higher level in growing cells than in resting cells. The p53 gene is located on the short arm of the chromosome 17 and acts as a cancer suppressor gene. A mutant p53 gene induces a malignant transformation. The mutant p53 protein binds with HSP70 and the p53-HSP70 complex has functional significance in the transforming capacity of the mutant p53. We evaluated the correlation between the HSP70 scores and the p53 protein expression by immunohistochemical methods and compared it with well-known prognostic factors, such as depth of invasion, size, histologic type, and DNA ploidy pattern, in 37 gastric adenocarcinomas. The HSP70 expression was scored according to the staining intensity and extent. An immunoreactivity of over 1% in tumor cell nuclei was considered as positive for p53 protein. The results are summarized as follows: The p53 protein expression rate did not significantly differ based on depth of invasion, histologic type, lymph node metastasis, or DNA ploidy. The HSP70 scores was higher in group II (AGC with TNM stage III) than in group I (EGC & AGC with TNM stage II) and in p53-positive carcinomas than in p53- negative carcinomas(P<0.05). In conclusion, the p53 protein and HSP70 were closely correlated to each other in our immunohistochemical study for gastric adenocarcinomas and the HSP70 scores may play a role in the progression of a gastric adenocarcinoma. However, further studies are needed for determining their prognostic values in gastric adenocarcinomas. HSP70 and p53 expression are factors, just like depth of invasion. The question is their value.
Adenocarcinoma ; Arm ; Cell Nucleus ; Chromosomes, Human, Pair 17 ; DNA ; Gastrointestinal Neoplasms ; Genes, p53 ; Genes, Tumor Suppressor ; Heat-Shock Proteins* ; HSP70 Heat-Shock Proteins* ; Korea ; Lymph Nodes ; Metabolism ; Neoplasm Metastasis ; Ploidies ; Prognosis ; Stomach

PURPOSE: To examine the fate of muscle-derived stem cells (MDSC) after injection into different host conditions and provide an insight for their mechanism of action. MATERIALS AND METHODS: MDSCs differentiated in vitro towards the endothelial lineage and transfected with lentivirus tagged with green fluorescent protein (GFP) were injected into two animal models mimicking vascular diseases: hindlimb ischemia and carotid injury models. Injected cells were tracked at the site of injection and in remote organs by harvesting the respective tissues at different time intervals and performing immunofluorescent histological analyses. Stem cell survival was quantified at the site of injection for up to 4 weeks. RESULTS: MDSCs were successfully tagged with fluorescent material GFP and showed successful implantation into the respective injection sites. These cells showed a higher affinity to implant in blood vessel walls as shown by double fluorescent co-stain with CD31. Quantification of stem cell survival showed a time-dependent decrease from day 3 to 4 weeks (survival rate normalized against day 3 was 72.0% at 1 week, 26.8% at 2 weeks and 2.4% at 4 weeks). Stem cells were also fo und in distant organs, especially the kidneys and liver, which survived up to 4 weeks. CONCLUSION: MDSCs were successfully tracked in different vascular disease models, and their fate was assessed in terms of cell survival and distribution. Better understanding of the donor cell properties, including their interaction with the host conditions and their mechanism of action, are needed to enhance cell survival and achieve improved outcomes.
Adult Stem Cells ; Animals ; Blood Vessels ; Cell Survival ; Hindlimb ; Humans ; Ischemia ; Kidney ; Lentivirus ; Liver ; Models, Animal ; Stem Cell Niche ; Stem Cells* ; Tissue Donors ; Vascular Diseases

No abstract available.
Asthma* ; Humans ; Prednisolone* ; Theophylline*

OBJECTIVE: This study aimed at identifying the etiological background, symptomatic expressions, defense styles and coping strategies related to hahn. METHOD: The subjects were given a questionnaire for demographic data, life experiences and psychological and physical symptoms, Bond's questionnaire of defense style, and Weisman's scale for coping strategies and scales for severity of hahn and hwabyung. The subjects were 110 normal healthy adults and 151 patients with neurotic disorders, diagnosed with ICD-9. RESULTS: More vivid hahn was found in the married women, the less educated, and those from a low socio-economic state. In the area of etiological life experiences, hahn is significantly related with an unhappy and frustrated marital life, unsatisfactory filial Piety, Poor family background, poverty, little education, a hard life since childhood, betrayal, failure in business, personality problems, injustice in society and resignation to fate. Hahn, unresolved and accumulated, was believed to cause various psychological and physical illnesses. In many cases hahn was corhad been dealt with by simple suppression and being dependent on religious faith or sharing and communicating with people. More people considered hahn as one of the etiologies of hwabyung, a chronic anger syndrome. Hahn of patients with hwabyung was more serious than that of those without hwabyung. Symptoms of hahn were - in addition to various symptoms of depression, anxiety and other neurotic conditions or somatization - a mass in the epigastrium, sighing, something pushing-up in the chest, paranoid ideas and hyprochondria sis nor hygochondriacal ideas. On the other hand, hypersensitivity and irritability were less significant. Defense styles and coping strategies related with hahn were somatization, splitting-projection, passive-aggressiveness, incorporation, primitive idealization, stimulus reduction, self-pity and shared-concerns and dependency. CONCLUSION: These results suggest that hahn is an unique emotional condition which is characterized by culture-related somatization symptoms, paranoid ideas and hypochondriasis, in addition to general neurotic symptoms such as depression and anxiety and related somatic symptoms.
Adult ; Anger ; Anxiety ; Commerce ; Depression ; Education ; Female ; Hand ; Humans ; Hypersensitivity ; Hypochondriasis ; International Classification of Diseases ; Life Change Events ; Neurotic Disorders ; Poverty ; Surveys and Questionnaires ; Thorax ; Weights and Measures

Osteoporosis in gastric cancer patients is often overlooked or even neglected despite its high prevalence in these patients. Considering that old age, malnutrition, chronic disease, chemotherapy, decreased body mass index and gastrectomy are independent risk factors for osteoporosis, it is reasonable that the prevalence of osteoporosis in gastric cancer patients would be high. Many surviving patients suffer from back pain and pathological fractures, which are related to osteoporosis. Fractures have obvious associated morbidities, negative impact on quality of life, and impose both direct and indirect costs. In the era of a >55.6% 5-year survival rate of gastric cancer and increased longevity in gastric cancer patients, it is very important to eliminate common sequelae such as osteoporosis. Fortunately, the diagnosis of osteoporosis is well established and many therapeutic agents have been shown to be effective and safe not only in postmenopausal females but also in elderly males. Recently, effective treatments of gastric cancer patients with osteoporosis using bisphosphonates, which are commonly used in postmenopausal woman, were reported.
Aged ; Back Pain ; Body Mass Index ; Chronic Disease ; Diphosphonates ; Female ; Fractures, Spontaneous ; Gastrectomy ; Humans ; Longevity ; Male ; Malnutrition ; Mass Screening ; Osteoporosis ; Prevalence ; Quality of Life ; Risk Factors ; Stomach Neoplasms ; Survival Rate