We described here a case of hyperkeratosis of the nipple and areola. A 23-year- old woman had a verrucous thickening and brownish discoloration on her right nipple and areola that had been present for 4 yeare. The only symptom was an intermittent mild itching sensation. The patient had no other additioa.al hyperkeratotic conditians. She was not married and had never had a pregnancy. Riopsy spccimen showed papillomatous elongation of the epidermis and edema, of the underlying papillary eonnective tissue. The epidermis was parakeratotic and hyperpigmented, and showed focal intercellular and intracellular edema. The present case seems to be the nevoid form by the Levy-Franckel classification. The world literature was briefly reviewed.
Classification ; Edema ; Epidermis ; Female ; Humans ; Nipples* ; Pregnancy ; Pruritus ; Sensation

A characteristic dermatosis of infancy and childhood has recently been reported as many names, called juvenile plsntar dermatoais, recurrent juvenile eezema of hands and feet, and atopic winter feet in children. However, the clinicsl and epidemiological features of the published cases are strikingly the same The etiology of the diseaee remains unclear. The role of atopy appears to be highly controversial. We have observed 11 patients with juvenile plantar dermatosis and sumrnarized the results as followa: 1. The disease was found mainly in female children (3 boys, 8 girls) between 1 and 18 years old. Duration of the disease ranged from 1 month to 10 years. 2. The lesions occured or were exacerbated dunng the winter in 9 of them. 3. The disease affected symmetrically on the pressure areas of the feet, mainly the forefeet and toes, the lateral margins of the soles, and the heels. Five of our patients also showed the lesions on the hands simultaneously. 4. We have found a high incidence of atopy among the patients or close relative. Nine patients had a personal history of atopy and 5 gatients also had a history of atopy in the first degree relatives. 5. The serum IgE value increased in one of 6 patients determined. From the above clinical findinge, it is evident that juvenile plantar dermatosis is a true localized atopic dermatitis but also a primary irritant contact derrnatitis to which atopics are prone but which may occur in susceptible non-atopics.
Adolescent ; Child ; Dermatitis, Atopic ; Female ; Foot ; Hand ; Heel ; Humans ; Immunoglobulin E ; Incidence ; Skin Diseases* ; Toes

A case of hereditary papulotranslucent acrokeratoderma, a variant of familiaI punctate keratoderma, is presented. A 20-year-old female patient had a five-year history of persistent, asymptomatic, yellowish-white translucent papules and plaques on the thenar and hypothenar eminences and knuckles of both hands, and on the dorsa of proximal interphalangeal joints of both feet. She also had a vitiligo lesion on the left side of the face of 1.5 years duration. Her elder brother also had similar papular skin lesions on both hands and feet. Histologic section of a papule from the right thenar eminence showed marked hyperkeratosis, hypergranulosis, and acanthosis of the epidermis.
Female ; Humans

No abstract available.
Hemorrhage*

Highly specific and sensitive immunoassay method for soluble human recombinant interleukin-6 (hu rlL-6) was established by two different immunization methods. One is conventional method by Freund's adjuvant method and the other is special method which is directly injected to mouse spleen. Among seven established monoclonal antibodies (mAbs), two typical monoclonal antibodies, designated YB3 (IgG1) and NY2 (IgM), were further characterized. These mAbs highly bound to IL-6, however did not show cross reactivity with IL-1B and IL-2. As the results of ELISA inhibition assay and western blotting method, it was further identified that YB3 and NY2 had high binding specificity with IL-6. And the limiting detection amount of rlL-6 for YB3 was 5 ng/ml and for NY2 was 0.5 ng/ml. Furthermore, N-glycosylated human rlL-6 was also bound to YB3 on ELISA. On the other hand YB-3 furtherly recognized N-glycosylated human rlL-6 by sandwich ELISA method. These mAbs may be of use to diagnose the gynecopathy which contains abortion and preterm labor.
Animals ; Antibodies, Monoclonal* ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Female ; Freund's Adjuvant ; Hand ; Humans ; Immunization ; Immunoassay ; Interleukin-2 ; Interleukin-6 ; Mice ; Obstetric Labor, Premature ; Pregnancy ; Sensitivity and Specificity ; Spleen

Azithromycin* ; Doxycycline* ; Scrub Typhus*

We studied the association of nonspecific bronchial hyperresponsiveness with general characteristics, exposure concentration, respiratory symptoms, chest x-ray findings, past histories and pulmonary function. We determined bronchial hyperresponsiveness by methacholine challenge test. And we conducted a respiratory symptom questionnaire and performed spirometry on 111 workers occupationally exposed to isocyanates in various industries. About 21.6% of subjects had bronchial hyperresponsiveness. No significant differences were observed between the hyperresponsive and non-responsive group with respect to age, sex, employment period, height, and smoking histories cough and breathlessness were significantly associated with the bronchial hyperresponsiveness. The hyperresponsive group had more experience of bronchitis and asthma in the past than the non-responsive group. The lower FEV1 and FEV1 % were closely related with bronchial hyperresponsiveness. Bronchial hyperrespoosiveness seems to be associated with some of respiratory symptoms, past histories and pulmonary function parameters in workers exposed to isocyanates.
Asthma ; Bronchitis ; Cough ; Employment ; Isocyanates* ; Methacholine Chloride ; Occupations ; Surveys and Questionnaires ; Smoke ; Smoking ; Spirometry ; Thorax

No abstract available.
Child ; Child Development* ; Humans ; Infant* ; Mass Screening*

No abstract available.
Retinopathy of Prematurity* ; Risk Factors*

PURPOSE: This study was performed to examine the serial alteration of the optic nerve in chronic ischemia-induced brain injury of albino rat, which might be an experimental model of ischemia-induced optic nerve disease and vasogenic glaucoma in human. METHODS: We ligated bilateral common carotid arteries so that the brain and optic nerve had permanent ischemic injuries. Serial alteration of the optic nerve was studied on postoperative 1 day, 3 day, 5 day, 1 week, 2 week, 4 week and 9 week. After fixing the brain by perfusing formaline through the left ventiricle, we dissected the brain and optic nerve and then made specimen for Hematoxilin-Eosin (HE) stain to observe the histopathology of the optic nerve. Kluiver-Barrera (KB) stain was performed to qualify the myelin injury and optic nerve injury status. RESULTS: The HE stain specimen showed increased spaces in the nerve fiber layer and increased number of vacuoles three days after the operation. The optic neve injury became augmented with time. The KB stain showed better-defined configuration of HE stain. CONCLUSIONS: We were able to notice that optic nerve injury was induced by the bilateral common carotid ligation in this chronic ischemic experimental model, which might be an help to the studies of ischemic optic nerve disease, neurodefensive mechanism, and the hemodynamic mechanism of glaucoma in human.
Animals ; Brain ; Brain Injuries ; Carotid Arteries* ; Carotid Artery, Common ; Formaldehyde ; Glaucoma ; Hemodynamics ; Humans ; Ligation ; Models, Theoretical* ; Myelin Sheath ; Nerve Fibers ; Optic Nerve Diseases ; Optic Nerve Injuries ; Optic Nerve* ; Rats* ; Vacuoles