PURPOSE: TGF-beta is a key regulator of epithelial-mesenchymal transition. Among the TGF-beta responses, cell migration is closely associated with the expression of matrix metalloproteinases (MMPs). Therefore, we determined which MMPs are regulated by TGF-beta and examined the TGF-beta signaling involved in this event, focusing on Src family tyrosine kinases (SFKs) METHODS: First we examined the expression of MMPs in rat lens explant culture treated with TGF-beta and LECs attached to the anterior capsules of patients with nuclear (N), anterior polar (AP) cataracts using RT-PCR and immunofluorescence staining. It was examined whether the expression of MMPs is regulated by SFKs. RESULTS: The study using RT-PCR and immunofluorescence staining showed the expression of MMP-2 and -14 in explants and the expression of MMP-14 LECs of AP cataracts. The expression of MMP-2 and -14 was blocked by PP2 in explants. Furthermore, the activated form of SFKs was observed in LECs of AP cataracts by immunofluorescence staining. CONCLUSIONS: We suggest a novel role of SFKs signaling in the expression of MMP-14 induced by TGF-beta.
Animals ; Capsules ; Cataract ; Cell Movement ; Epithelial Cells* ; Epithelial-Mesenchymal Transition ; Fluorescent Antibody Technique ; Humans ; Matrix Metalloproteinases ; Rats ; src-Family Kinases ; Transforming Growth Factor beta*

No abstract available.
Intussusception* ; Ultrasonography*

No abstract available.
Humans ; Token Economy*

We present herein 3 cases of early secondary syphilis with simultaneous primary syphilitic lesions. These cases developed primary syphilitic lesions four to six weeks after sexual contact and lasted six to ten weeks thereafter until the secondary syphilitic lesions appeared. All three patients showed a strong positive for the STS. Spirochetes were seen under dark field examination of the primary syphilitic lesions, Histopathologically, numerous plasma cells around capillaries and endothelial hyperplasia were seen in the dermis.
Capillaries ; Dermis ; Humans ; Hyperplasia ; Plasma Cells ; Spirochaetales ; Syphilis*

No abstract available.
Bowen's Disease*

No abstract available.
Tibia*

No abstract available.
Lipomatosis* ; Neoplasm Metastasis* ; Small Cell Lung Carcinoma*

An intraosseous epidermal cyst is a rare benign cystic lesion. It is thought to result from congenital factors or trauma and can lead to bone destruction because the cyst develops at the soft tissue around the bone. Radiological findings of intraosseous epidermal cysts are a well-defined radiolucent lesion, with cortical expansion. It is important to differentiate an intraosseous epidermal cyst with other disease developed at distal phalanx because its clinical and radiological findings are similar. We report two rare cases of intraosseous epidermal cysts that developed at the distal phalanx.
Epidermal Cyst*

No abstract available.
Humans ; Liver Cirrhosis* ; Liver*

The present study has been undertaken, using 307 seemingly "normal" male rabbits sold in Korea, which were tested for sysphilis with two serologic tests, the RPR card test and the TPHA test. Among thc rabbits which were seropositive in these tests, 10 rabbits were selected for further tests, namely, the FTA test a.nd FTA-ABS test. The following results have been obtained. Nine rabbits(2.9%) were reactive in both the RPR card test and the TPHA test; 10(3.2%) were reactive in the RPR card test and non-reactive in the TPHA test; 8(2. 6%) were reactive in the TPHA test and non-reactive in the RPR card test, and 27(8.7%) were reactive in either tests. 2. The rabbits which were reactive in the TPHA test were also reactive in the FTA and FTA-ABS test. As can be seen in the results, 8.7% of the normal male rabbits sold in Korea are seropositive in the serologic tests for syphilis. Cnnsequently, all rabbit's undergoing syphilis experiments should be screened for possible reactive serologic tests and excluded from the experiments.
Dronabinol ; Fluorescent Treponemal Antibody-Absorption Test ; Humans ; Korea* ; Male* ; Rabbits* ; Serologic Tests* ; Syphilis*