Myxofibrosarcomas (MFSs), which consist of multiple nodules with a variable cellular population in a myxoid matrix, are primarily located in subcutaneous tissue. Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare soft-tissue tumors characterized by a proliferation of highly pleomorphic spindle or polygonal cells and abundant ectatic blood vessels in cellular or myxoid stroma. We present here an unusual case of a high-grade MFS with a PHAT-like appearance. A 67-year-old man presented with an asymptomatic subcutaneous mass in the right forearm. The tumor had myxoid, hypo-, and hypercellular areas with highly pleomorphic spindle or polygonal tumor cells that showed frequent mitoses and nuclear pseudoinclusions. Foci of punctuate necrosis and inflammatory infiltration were present throughout the tumor, and abundant ectatic, thick-walled vessels containing blood clots were noted. The tumor cells were immunohistochemically positive for vimentin but negative for CD34, S-100 protein, smooth muscle actin, desmin, and bcl-2.
Actins ; Aged ; Blood Vessels ; Desmin ; Forearm ; Humans ; Hyalin ; Mitosis ; Muscle, Smooth ; Necrosis ; S100 Proteins ; Sarcoma ; Subcutaneous Tissue ; Vimentin

No abstract available.
Autopsy* ; Statistics as Topic*

Many of early findings regarding intestinal stem cells (ISCs) and their niche in the human intestine have relied on colorectal cancer cell lines and labor-intensive and time-consuming mouse models. However, these models cannot accurately recapitulate the physiologically relevant aspects of human ISCs. In this study, we demonstrate a reliable and robust culture method for 3D expanding intestinal spheroids (InSexp ) mainly comprising ISCs and progenitors, which can be derived from 3D human intestinal organoids (HIOs). We did functional chararcterization of InSexp derived from 3D HIOs, differentiated from human pluripotent stem cells, and optimization culture methods. Our results indicate that InSexp can be rapidly expanded and easily passaged, and show enhanced growth rates via WNT pathway activation. InSexp are capable of exponential cell expansion and cryopreservation. Furthermore, in vitro-matured HIO-derived InSexp proliferate faster than immature HIO-derived InSexp with preservation of the parental HIO characteristics. These findings may facilitate the development of scalable culture systems for the long-term maintenance of human ISCs and provide an alternative platform for studying ISC biology.

OBJECTIVE: This study aimed to explore the readability and comprehensibility of the drug information on a patient leaflet for the senior by employing performance-based user-testing. METHODS: We included 36 elderly (65 years old or older) as the senior group (intervention group) and 36 adults (40~59 years old) as the adult group (control). We developed a questionnaire to test if participants could access to drug information. After completing a questionnaire, the participant was interviewed about their understanding over the patient leaflet. We performed t-test, χ2-test or Fisher's exact test to examine differences between two groups in primary outcomes. RESULTS: The senior were less likely able to find information (78%) than the adult (91%); they were much less likely able to understand information (42%) than the adult (69%). While we found differences between the ability of finding and understanding drug information in both groups, the senior group had greater difficulties in understanding all kinds of drug information. They had significant difficulties to remember information after reading the patient leaflet and frequently failed to find proper information even though they were allowed to access freely to the leaflet during interviewing. CONCLUSION: To secure safe and effective use of drugs for the senior, it is necessary to develop drug leaflets for the senior.
Adult ; Aged* ; Comprehension ; Health Literacy ; Humans

PURPOSE: Effective transitional care is needed to improve the quality of life in older adult patients with chronic illness and avoid discontinuity of care and adverse events. The aim of this article is to provide an overview of the key features, broader implications, and the utility of Meleis' transition theory intended for the transitional care of older adults with chronic illnesses. We present the role of nurse in the context of transitional care and propose future directions to increase the quality of nursing care. METHODS: The online databases Cumulative Index of Nursing and Allied Health Literature, MEDLINE, and Science Direct were searched for relevant literature published since 1970 along with textbooks regarding nursing theory. RESULTS: An evaluation of the usefulness of transition theory based on transitional care in older adult patients with chronic illnesses is provided. Healthy transition should be the expected standard of nursing care for older adults across all healthcare settings. CONCLUSION: Nurses need to contribute to the development of transitional care for vulnerable populations; however, transition theory needs to be enhanced through additional theoretical work and repeated evaluations of the applicability in areas of transitional care.
Aged ; Chronic Disease ; Databases, Factual ; Education, Nursing ; Humans ; Models, Theoretical ; Nurse's Role ; *Quality of Life ; *Transitional Care

PURPOSE: The purpose of this study was to identify factors related to level of satisfaction among mothers of preschoolers. METHODS: Participants were 359 mothers of firstborn healthy preschoolers. The questionnaires were collected from August 1 to November 21, 2012. Data were analyzed using SPSS 20.0. RESULTS: The mean score for degree of mothers' parenting satisfaction was 5.94 out of 7. There were significant differences in the level of parenting satisfaction according to mother's job (t=2.48, p=.014), planned pregnancy (t=3.07, p=.002), number of children (t=2.22, p=.027), and parenting education (F=4.33, p=.005). The environmental variables of age of spouse (F=3.06, p=.048) and monthly income of the household (F=2.87, p=.036) also seemed to have an influence. Analysis of predictors such as the mother's job, planned pregnancy, parenting education, overall health problems, parenting stress, perception of emotional status and behaviors in children, age of spouse, and spouse's support explained 31.5% of the variance in mother's parenting satisfaction. CONCLUSION: The results suggest a need to develop nursing intervention programs for parenting stress reduction, and health programs for fathers to support mothers' child rearing.
Child ; Child Rearing ; Education, Nonprofessional ; Family Characteristics ; Family Planning Services ; Fathers ; Humans ; Mothers* ; Nursing ; Parenting* ; Parents* ; Spouses

PURPOSE: The purpose was to identify the risk of drug use by adolescents. METHOD: The participants were 933 male students in the first grade of a high school in D city. The data were collected from Aug. 5th to Oct. 30th, 2004. The instrument was the High Risk Group Adolescent Drug User Screening Test (HIRIGADUST) developed by the Korea Adolescent Society (1996). The data were analyzed using SPSS. RESULTS: For substance use, 64.5% of the students answered that they had drunk, 40.3% that they had smoked, and 2.0% that they had tried drug use. For scores on HIRIGADUST regarding socio-demographic characteristics, there were significant differences depending on school type, personality, academic performance, economic status, and ability to talk with parents. For scores on HIRIGADUST regarding drug using-related characteristics, there were significant differences depending on drinking experience, frequency of drinking, amount of alcohol intake, smoking experience and number of cigarettes smoked. Of the students 27.2% students were in the high risk group. CONCLUSION: In schools, systematic and intensive assessment of drug use should be done, and if needed, a service system connected to clinics specializing in drug addiction should be established. Prevention education should be carried out continuously.
Adolescent* ; Drinking ; Drug Users ; Education ; Humans ; Korea ; Male* ; Mass Screening ; Parents ; Smoke ; Smoking ; Substance-Related Disorders ; Tobacco Products

PURPOSE: The purposes of the study were to determine the effects of AIDS education which includes discussion on knowledge, prejudice, social interaction, and intention for AIDS prevention in college students. METHOD: A convenience sampling method was used to collect data, and 136 university students participated in the study. One group pretest-post test design was used and questionnaire for measuring knowledge about AIDS and attitude to AIDS were administered before and after 100 minutes of AIDS education, The education program consisted of a 50-minute lecture with video aids and 50 minutes of small group discussion. Means, SD, and paired t-test with the SPSS program were used to analyze the data. RESULTS: There were significant increases in knowledge (p= .000) and social interaction (p= .002) after the education, but no significant changes in prejudice (p= .832) nor in intention for AIDS prevention (p= .074). CONCLUSION: AIDS education including discussion was found to be an effective method for improving knowledge and social interaction of college students. The results suggest that education which includes discussion sessions should be used with college students to improve social interaction with people who are HIV positive and enhance knowledge about AIDS.
Education* ; HIV ; Humans ; Intention* ; Interpersonal Relations* ; Prejudice* ; Surveys and Questionnaires

PURPOSE: The purpose of this study was to examine the relationship between work-family conflict, social support, job satisfaction, and organizational commitment which are closely linked to staff turnover from the perspective of married hospital nurses. METHOD: A survey was conducted using self-report structured questionnaire from 220 married nurses. Data analysis included descriptive statistics, t-test, one-way ANOVA, correlation and multiple linear regression with SPSS Win 17.0 program. RESULTS: Job satisfaction, social support, work-family conflict and age were strong predictors of organizational commitment. These variables explained 46.5% of the variance of the organizational commitment. Higher levels of organizational commitment were associated with greater job satisfaction and social support. Nurse with lower levels of work-family conflict and older age reported a high level of organizational commitment. CONCLUSION: These results show that improving job satisfaction has the best effect on enhancing nurses' organizational commitment. Also supportive relationships, reduction of work-family conflict and older age were significantly correlated with organizational commitment. Organizations should design more family- friendly policies and provide opportunities for career development to health professionals to induce organizational commitment.
Health Occupations ; Job Satisfaction ; Linear Models ; Surveys and Questionnaires ; Statistics as Topic

PURPOSE: The purpose of this study was to investigate the influencing factors on externalized and internalized problem behaviors among high school students. METHODS: The subjects for this study were 707 students in two high schools in K province. The data were collected during the period from October to November, 2014 by use of questionnaires. The instruments used were the Korean Youth Self-report, Daily Hassles Questionnaire, State-Trait Anger Expression Inventory, and Ego Resiliency Scale. The data were analyzed using SPSS. RESULTS: Significant predictors to explain externalized problem behaviors comprised anger-out, anger-in, anger-control, relation with parents, daily stress, and religion. It was found that these factors explained 46% of externalized problem behavior. Ego resiliency, anger-in, daily stress, gender, relation with parent, and anger-out were significant predictors to explain internalized problem behaviors. It was found that these factors explained 45% of internalized problem behaviors. CONCLUSION: This study suggests that the influencing factors on problem behaviors differ from externalized and internalized problem behaviors. So these findings will provide the basic data to develop a program that is differentiated by problem behavior type.
Adolescent* ; Anger ; Ego ; Humans ; Parents ; Problem Behavior* ; Stress, Psychological