No abstract available.
Headache*

With aging, several progressive changes occur on the midface including descent of attenuated lower eyelid skin which creates a skeleton-like appearance with infraorbital hollowness, and descent of the malar fat pad with exaggeration of the nasolabial fold. Most of the procedures for midfacial rejuvenation require extensive peripheral-to-central dissection in the subcutaneous, sub-SMAS or subperiosteal plane. The author's procedure entails direct access to the midface through a subciliary incision, elevation of the orbicularis oculi muscle and ptotic malar soft tissue. It has been performed through subcutaneous dissection on 67 patient and subperiosteal dissection on 4 patients. Subcutaneous dissection on the midface was made laterally to the zygomaticus maior, medially to the levator labii superioris under the oricularis muscle and inferiorly beyond the nasolabial fold. The range of subperiosteal dissection was similar to subcutaneous dissection, except on the dissection plane. Suspension sutures made at the malar retaining ligament and infero-lateral portion of the orbicularis oculi were fixed to periosteum of the lateral canthal area. In some patients, this procedure was combined with forehead lift(4), temporal lift(2), upper blepharoplasty(28), cervicoplasty(2), and lateral canthoplasty(12). In 23 patients who had a particularly prominent tear trough, a fat sliding technique was combined. The author has followed up 62 patients from a minimum 2 months to a maximum 27 months. Complications included urdercorrection(3), longstanding malar fullness(2), ectropion(1), transient numbness(2), and cheek dimpling(1). In conclusion, this centrofacial can be applied to patients who have limited ptosis of the midface with mild nasolabial fold.
Adipose Tissue ; Aging ; Cheek ; Eyelids ; Forehead ; Humans ; Ligaments ; Nasolabial Fold ; Periosteum ; Rejuvenation ; Skin ; Sutures

No abstract available.
Complementary Therapies*

Cyclosporine A (CSA), a lipophilic cyclic undecapeptide, is not accumulated evently in all tissues and has a high affinity to several tissues such as lymphoid organs, liver, and kidneys. From this point of view, it is reasonable to assume that the amount of CSA uptake would be correlated with the extent of cell injury. On the other hand, verapamil, a Ca2+ channel blocker, bas been shown to ameliorate CSA nephrotoxicity. Since proximal tubule is the major site of drug transport and CSA uptake and its interaction with verapamil in isolated human renal proximal tubular cells. The CSA uptake rapidly increased over the first 5 min and then achieved almost steady-state after 10 min at all concentrations (0.5-10 uM). Kinetic analysis yielded that the Km and Vmax values of CSA were 5.6 uM and 86.2 p mol/mg cell protein/min, respectively. And Ca2+ depletion in media enhanced CSA uptake significantly but verapamil reduced it. These results suggest that the Ca2+ channels and CSA transporting sites on cell membrane are closely associated and that Ca2+ and CSA might be taken up competitively by proximal tubular cells.
Humans

Nephrotoxicity is the most common dose-limiting factor of cyclosporine A (CSA) in clinical usage. But the mechanism of CSA-induced nephrotoxicity still remains unresolved. Many authors insisted that CSA induced renal proximal tubular cell injury is due to the secondary effects following hemodynamic changes or endothelial cell damage, instead of direct toxicity by CSA. To find out that CSA has a direct toxicity to the proximal tubular cells, the author used primary cultures of human proximal tubular cells to eliminate the hemodynamic or endothelial influences that could be produced in in vivo model. In the present study, the viability against CSA was tested by the neutral red assay method with modulation of Ca2+ amount in incubating media and observed electron microscopically. The viability test showed direct toxic effect of CSA on human proximal tubular cells and this was enhanced by Ca2+ depletion in incubating media. Morphologically noted are accumulation of lipid droplets and polyribosomal dispersion, which may be association with inhibition of cellular synthetic activity. These results suggest the toxixity is a direct effect of cyclosporine and that toxic mechanism may be due to inhibition of cellular synthetic activity. And this experiment also showed that primary cultures of human renal proximal tubular cells can be a good in in vivo model for investigating CSA nephrotoxicity.
Humans

No abstract available.
Humans ; Korea*

The purpose of this article was to determine the discriminant function analysis of the Korean Wechsler Intelligence Scale (KWIS) for 110 normal controls and 98 schizophrenics. Of special interest was to verify the clinical discriminant power of two subtests of the KWIS (Vocabulary and Digit Symbols) and Zung's Self-rating Anxiety Scale (SAS). Four major hypotheses were postulated. The normal control group would show higher scores then the schizophrenics; mean scores on both Vocabulary and Digit Symbol. The mean difference in Digit Symbol between the two groups would be greater than that in the Vocabulary. There would be no significant relation among Digit Symbol, Vocabulary, and Anxiety. The most powerful discriminant power would be expected from subtest of Digit Symbol. The mean discriminant scores were 1.34425 for the control subjects, 1.34425 for the schizophrenics. The correctly discriminated percentage was 89.1% for the control subjects, 90.8% for the schizophrenics. From the findings it was concluded that both Digit Symbol and Vocabulary scales had strong diagnostic value but the former was more powerful than the latter. However, the Anxiety scales had less diagnostic value.
Anxiety ; Humans ; Intelligence ; Vocabulary ; Weights and Measures

No abstract available.

No abstract available.
Motor Vehicles*

This study was carried out to develop a Korean language version of Zung's self-rating depression scale (SDS). The subjects consisted of 173 males and 161 females drawn from various groups of the general population by a cluster of sampling methods. In order to analyze the data on depression scores, Pearson's product moment correlation coefficient method was carried .out, as well as reliability and factor analysis, by the SPSS/PC+ program. The results obtained were as follows: The mean average of the total depression scores were 40.60. 8.66 for the subjects. Thirty-seven subjects (11.1%) showed high depression scores of 50 or over. Test-retest reliability(coefficient r=0.82, p <0.001), internal consistency(coefficient r=0.84, p <0.001) were satisfactory. Factor analysis using oblique technique rotation yielded five factors. The items of confusion, indecisiveness, decreased libido, diurnal variation, and psychomotor retardation were scored higher by the subjects. The items of suicidal rumination, psychomotor agitation, constipation, irritability, and weight loss were scored lower.
Constipation ; Depression* ; Female ; Humans ; Libido ; Male ; Psychomotor Agitation ; Weight Loss