Malignant histiocytosis(MH) is a rapidly progressive and usally fatal disorder characterized clinically fever, generalized weakness, lymphadeno athy, hepatosplenomegaly accompanied by jaundice, and purpura. The frequency of skin manifestations has been repoterd about 15% of MH patients. Papules, plaques and niidules are commonly met. Histopathologically MH shows infiltrations of atypical histiocyte; with uarious maturity in many organs including skin. We present a case of a 32-year-old female with MH involving not only lymph node, liver, spleen and bone marrow but also skin with vaorious features ; erythematous papules, annular purpuric patches, subcutaneous nodules and hemomagic nodules. Immunohist,ochemically the majority of patients atypical histiocytes in lesional skin shows a-1 antitrysin positive, but lysozyme negative. It may suggest that these are poorly differentiated atypical histiocytes rather than well differentiated ones.
Adult ; Bone Marrow ; Female ; Fever ; Histiocytes ; Histiocytic Sarcoma* ; Humans ; Jaundice ; Liver ; Lymph Nodes ; Muramidase ; Purpura ; Skin Manifestations* ; Skin* ; Spleen

On a total 233 sera from the VDRL reactive patients without a history of syphilitic symptoms or treatment for syphilis, TPHA and 19S(IgM)-FTA tests were performed, Also the reactivities of the 19 S (IgM)-FTA test in relation to the VDRL and the TPHA titers were observed. The results are summarized as follows: 1. Among 233 sera, 103 sera(44%) showed negative results in the 19S(IgM)- FTA test. 2. Reactivities of the 19 S(IgM)-FTA test were significantly increased in relation to the VDRL, titers arnong 233 sera reactive in the VDRL test: 47% in the VDRL titer 1: 1, 61% in 1: 2, 71% in 1: 4, 62% in 1: 8, 96% 1: 16 or more. 3. There was no relationship statistically (IgM)-FTA test and the TPHA titers. It can be derived from the above results that when a person with no history of treatment for syphilis and clear of any signs of syphilis shows a positive reaction in the VDRL test, he is less likey to be a syphilis patient when the VDRL titer is low.
Humans ; Immunoglobulin M* ; Syphilis

We report a case of angiocentric lymphoma in a 41-year-old female who complained chiefly of a genital ulcer and a bulging conjunctiva on the right eye. She had a history of a re-current oral ulcer over a 5 year period and a genital ulcer over 3 years. The above manifested clinical findings may suggest Behcet's disease. However, a biopsy from the upper vaginal wall and the inferior turbinate showed that atypical small and large lymphocytes with hyper-chromatic, elongated and convoluted nuclei had aggregated around the thickened blood vessels, which is consistent with angiocentric lymphoma. Immunophenotypically, the atypical cells were positive for pan T-cell markers not B-cells. Serologically, the patient showed a high titer of i?B virus viral capsid antigen(VCA) IgG.
Adult ; B-Lymphocytes ; Biopsy ; Blood Vessels ; Capsid ; Conjunctiva ; Female ; Humans ; Immunoglobulin G ; Lymphocytes ; Lymphoma* ; Oral Ulcer ; T-Lymphocytes ; Turbinates ; Ulcer

BACKGROUND: Melanocytes synthesize melanin pigment by the action of specific enzyme tyrosinase. Melanogenesis inhibitors such as ascorbic acid, kojic acid, arbutin, hydroquinone have been developed for use in cosmetic preparations for the skin hyperpigmentation,but they are still unsatisfactory to efficacy and tolerance. OBJECTIVES: In this study, the inhibitory effects of seaweed extract(SCH-T2)on tyrosinase activity and melanogenesis were investigated with B-16 melanoma cell line. METHODS: The patients were randomly assigned to one of three groups;control, diazepam, and ketorolac plus diazepam groups. Pain intensity was assessed 5 times at every ten minutes from the beginning of the peeling using visual analog scale(VAS). RESULTS: The seaweed was added with 21 organic solvents and extracted during 12 hours at 20-To evaluate the inhibitory effects of SCH-T2 on tyrosinase activity following to extraction time and temperature, this study was done at 4, 8, 12, 24, 72 hours and 4, 10, 20, 30, 40℃. Also, the effects of whitening agents (kojic acid, arbutin, licorice extracts,SCH-T2)on tyrosinase activity were compared by measuring the IC50,the concentration of the compound at which half of the original tyrosinase activity is inhibited. RESULTS: 1.The inhibitory effects of SCH-T2 on tyrosinase activity were high at 60-80% ethanol as an extraction organic solvent and showed increase in proportion to concentration following to extract concentration, but showed little differences following to extraction time and temperature. 2.SCH-T2 has relatively stronger inhibitory effects on tyrosinase activity than arbutin and licorice extracts. 3. The inhibitory effects of SCH-T2 on melanogenesis following to extract concentration were greatly increased at more than 20㎍/ml. CONCLUSION: This study showed that SCH-T2 seaweed extract has strong inhibitory effect on tyrosinase activity and melanogonesis. So, the results of this study suggest that SCH-T2 seaweed extract can be used as a new whitening agent.
Arbutin ; Ascorbic Acid ; Bleaching Agents ; Cell Line ; Diazepam ; Ethanol ; Glycyrrhiza ; Humans ; Ketorolac ; Melanins ; Melanocytes ; Melanoma ; Monophenol Monooxygenase ; Seaweed* ; Skin ; Solvents

For the reconstruction of skin defects after remoral of cutanous tumors in the nasal area, local flaps or full-thickness skin grafts can be utilized depending on the size and site of the defectg. Burows graft, which is, variant of the full-thickness skin graft, makes use of the skin nearby as the donor site, minimizes deformity of the recipient site, maximizes ireservation of skin, easily aligns relaxed skin tension line, and is thus one of the methods with a good esultant color and texture match. A pigmented basal cell carcinoma on the nasal bridge in a 51-year old male was remaved by 4 serial sections of Mohs micrograplic surgery and was then successfully enstructed using a Burows graft.
Carcinoma, Basal Cell* ; Congenital Abnormalities ; Humans ; Male ; Middle Aged ; Mohs Surgery* ; Skin ; Tissue Donors ; Transplants*

Congenital self-healing reticulohistiocytosis (CSHRH) is a rare Langerhans cell disorder usually showing spontaneous resolution within 3-4 months. By electron microscopy, the identification of Birbeck granules and laminated dense bodies in the infiltrated cells is mandatory for the diagnosis of CSHRH. However, in some reported cases, Birbeck granules could not be demonstrated and only cytoplasmic dense bodies were seen. If the lesion is more advanced, Birbeck granules are transformed to lysosomes, i.e., 'unique phagosomes', in which they are degraded. A 2-month-old Korean girl presented with congenital, numerous red-brown pigmented papules on the left side of trunk and upper extremity without systemic symptoms. A biopsy specimen demonstrated papillary dermis containing epidermotropic infiltrates of histiocytes with abundant eosinophilic cytoplasm. Some had kidney-shaped nuclei and PAS-positive cytoplasmic inclusions. Immunohistochemically, infiltrating cells expressed S-100 protein and ultrastructurally, no Birbeck granules but many dense laminated bodies and unique phagosomes were found. It was ten months since the skin lesions developed that they have started resolving.
Biopsy ; Cytoplasm ; Dermis ; Diagnosis ; Eosinophils ; Female ; Histiocytes ; Humans ; Inclusion Bodies ; Infant ; Lysosomes ; Microscopy, Electron ; Phagosomes ; S100 Proteins ; Skin ; Upper Extremity

We report a case of Hunter' s syndrome with characteristic nodules on the upper back. The patient was a 7-year-old Korean boy who presented with ivory-colored papules and nodules on both sides of the scapula, pectoral regions and lateral aspects of the upper arms. These lesione are regarded as pathognomonic cutaneous markers for Hunter s syndrome. He also presented with truncal hypertrichosis, retarded growth, short neck, round face, claw like contractures of hands, multiple joint contractures, and a clear cornea. Severely elevated glycosaminoglycan levels were present in the patient s urine samples. The patient s 5-year-old brother had similar clinical features.
Animals ; Arm ; Child ; Child, Preschool ; Contracture ; Cornea ; Hand ; Hoof and Claw ; Humans ; Hypertrichosis ; Joints ; Male ; Mucopolysaccharidosis II* ; Neck ; Scapula ; Siblings

We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation

A 19 month old girl with trisomy 18 is described. She showed loose folds of skin about the neck, a prominent occiput, a simian crease on both palms, epicanthal folds, acrocephaly, micrognathia, and unusual dermatologic features including total alopecia and no finger prints on either hands. Because of the simian crease on both palms, dermatoglyphics of both hands and total alopecia, a skin biopsy from the scalp and a chromosomal study were established at age 19-months, and an absence of hair follicles was observed, while peripheral blood lymphocytes demonstrated 47, XX, 4-18. To our knowledge, this would be the first recorded report on the dermatoglyphic pattern of Edwards syndrome in a Korean journal of dermatology.
Alopecia ; Biopsy ; Craniosynostoses ; Dermatoglyphics* ; Dermatology ; Female ; Fingers ; Hair Follicle ; Hand ; Humans ; Lymphocytes ; Micrognathism ; Neck ; Scalp ; Skin ; Trisomy*

We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation