1.The Regulation of MMP-2 and -14 Expressions by TGF-beta in Lens Epithelial Cells.
Min Jung SON ; Jong Tak KIM ; Choun Ki JOO
Journal of the Korean Ophthalmological Society 2006;47(7):1110-1116
PURPOSE: TGF-beta is a key regulator of epithelial-mesenchymal transition. Among the TGF-beta responses, cell migration is closely associated with the expression of matrix metalloproteinases (MMPs). Therefore, we determined which MMPs are regulated by TGF-beta and examined the TGF-beta signaling involved in this event, focusing on Src family tyrosine kinases (SFKs) METHODS: First we examined the expression of MMPs in rat lens explant culture treated with TGF-beta and LECs attached to the anterior capsules of patients with nuclear (N), anterior polar (AP) cataracts using RT-PCR and immunofluorescence staining. It was examined whether the expression of MMPs is regulated by SFKs. RESULTS: The study using RT-PCR and immunofluorescence staining showed the expression of MMP-2 and -14 in explants and the expression of MMP-14 LECs of AP cataracts. The expression of MMP-2 and -14 was blocked by PP2 in explants. Furthermore, the activated form of SFKs was observed in LECs of AP cataracts by immunofluorescence staining. CONCLUSIONS: We suggest a novel role of SFKs signaling in the expression of MMP-14 induced by TGF-beta.
Animals
;
Capsules
;
Cataract
;
Cell Movement
;
Epithelial Cells*
;
Epithelial-Mesenchymal Transition
;
Fluorescent Antibody Technique
;
Humans
;
Matrix Metalloproteinases
;
Rats
;
src-Family Kinases
;
Transforming Growth Factor beta*
2.Meaurement of the Muscle Fatigue Patterns using Electromyography Technique.
Jae Yong AHN ; Jung Soo HAN ; Ki Sik MIN
The Journal of the Korean Orthopaedic Association 1998;33(4):1184-1192
Injuries and pains of musculoskeletal joint in human body is common onset in industrialized world. However, muscle fatigue plays a very significant role in contributing causes of many pains associated with musculoskeletal joints. Based on this hypothesis, degree of muscle fatigue was investigated using electromyography measurement technique during isometric and concentric/eccentric muscle contractions. Different response of the muscle fatigue between two different muscle contractions (isometric and concentric/eccentric contractions) was examined by comparison of parameters which were median frequency, median power and RMS value. Healthy 16 young persons without previous musculoskeletal diesease history were tested with Noraxon Myosystem 2000 EMG measurement system. In this study, two different exercises were performed. First exercise was concentric/eccentric exercise. Second exercise was isometric muscle contraction. In the case of the isometric exercise, median frequency was decreased, but median power and RMS were increased. However, during the concentric/eccentric exercse, median frequency was increased, but median power and RMS were decreased. Both of those revealed that the pattern of the median frequency was W type, but median power and RMS were M type as time passed. In this study, the patterns of the muscle fatigue during concentric/eccentric exercise as well as isometric exercise were identified. It will be helpful to prevent musculoskeletal injury from over-working andexercising.
Electromyography*
;
Exercise
;
Human Body
;
Humans
;
Joints
;
Muscle Contraction
;
Muscle Fatigue*
3.Measurement in the proximal part of the tibia in Korean..
Min Suk CHUNG ; Jung Ki SHIN ; Hee Jung CHO ; Kang JOO ; In Hyuk CHUNG
Korean Journal of Physical Anthropology 1992;5(2):201-209
No abstract available.
Tibia*
4.A Case of Actinic Reticuloid.
Ki Ho KIM ; Sung Moon JUNG ; Min Soo LEE ; Jung Ho YOON ; Jai Il YOUN
Annals of Dermatology 1999;11(4):240-243
Actinic reticuloid as a manifestation of chronic actinic dermatitis (CAD) is a rare dermatosis whose clinical and histologic features resemble other types of pseudolymphomas including mycosis fungoides and Jessner's lymphocytic infiltration, and it is regarded as an eventual stage of various photodermatoses like photosensitive eczema or persistent light reaction or chronic photoallergic contact dermatitis and so on. Phototests in the patients with actinic reticuloid usually reveal hypersensitivity to UVB, UVA, and sometimes to visible light. We present a case of actinic reticuloid in a 65-year-old male, whose skin lesions developed as erythematous lichenified infiltrating plaques on the face at first, and then spread themselves onto the upper trunk later. Histologically those skin lesions showed the aggregation of atypical lymphocytes and photobiologically the results of phototests revealed photosensitivity to UVB and UVA.
Actins*
;
Aged
;
Dermatitis, Photoallergic
;
Eczema
;
Humans
;
Hypersensitivity
;
Light
;
Lymphocytes
;
Male
;
Mycosis Fungoides
;
Photosensitivity Disorders
;
Pseudolymphoma
;
Skin
;
Skin Diseases
5.Yersinia enterocolitica typing by restriction enzyme analysis of plasmid DNA.
Chang Min KIM ; Ho Jung OH ; Chul Soon CHOI ; Hong Ki MIN
Journal of the Korean Society for Microbiology 1993;28(4):269-277
No abstract available.
DNA*
;
Plasmids*
;
Restriction Mapping*
;
Yersinia enterocolitica*
;
Yersinia*
6.The significance of sepsis severity score in multiple organ failure due to sepsis.
Ki Hoon JUNG ; Seng Kwan OH ; Yun Sik HONG ; Sae Min KIM
Journal of the Korean Surgical Society 1991;41(1):85-92
No abstract available.
Multiple Organ Failure*
;
Sepsis*
7.The significance of sepsis severity score in multiple organ failure due to sepsis.
Ki Hoon JUNG ; Seung Kwon OH ; Yun Sik HONG ; Sae Min KIM
Journal of the Korean Surgical Society 1991;40(6):758-764
No abstract available.
Multiple Organ Failure*
;
Sepsis*
8.Clinical Manifestation of Human Metapneumovirus Infection in Korean Children.
Jung Min AHN ; Seong Yeol CHOI ; Dong Soo KIM ; Ki Hwan KIM
Korean Journal of Pediatric Infectious Diseases 2013;20(1):28-35
PURPOSE: The aim of this study was to determine the frequency, epidemiology and the clinical manifestation of human metapneumovirus (hMPV) infection in Korean children. METHODS: From February 2010 to January 2012, we collected nasopharyngeal aspiration from 1,554 children who were hospitalized for acute lower respiratory tract infections at the Department of Pediatrics, Severance Children's Hospital. hMPV was detected by performing reverse transcriptase-polymerase chain reaction (RT-PCR). The medical records of the patients with positive results were retrospectively reviewed. RESULTS: We detected hMPV in 99 of the 1,554 hospitalized children. The mean age of the hMPV infected children was 25 months, and 87% of the illnesses occurred between April and June. The most common diagnoses were pneumonia (73%) and bronchiolitis (16%). The clinical manifestations included cough, fever, respiratory distress, hoarseness, tachypnea, and wheezing. Coinfection with other respiratory viruses was found in 43 children (43%). CONCLUSION: hMPV is one of the major virus causing acute respiratory tract infection in the age between 13 months and 48 months old with peaks during April to June. Reports of hMPV in Korea has been increasing but additional studies are required to define the epidemiology and the extent of disease caused by hMPV to determine future development of this illness in Korean children.
Bronchiolitis
;
Child
;
Child, Hospitalized
;
Coinfection
;
Cough
;
Fever
;
Hoarseness
;
Humans
;
Korea
;
Medical Records
;
Metapneumovirus
;
Pediatrics
;
Pneumonia
;
Respiratory Sounds
;
Respiratory Tract Infections
;
Retrospective Studies
;
Tachypnea
;
Viruses
9.The effect of the cytotoxicity on cultured fibroblast to various type of miniplate.
Book Jung KIM ; In Woong UM ; Dong Keun LEE ; Seung Ki MIN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1992;18(1):42-52
No abstract available.
Fibroblasts*
10.Surgical Treatment of the Low Lumbar (L3 - L5) Spinal Fractures.
Ki Soo KIM ; Yong Soo CHOI ; Chai In LIM ; Yang Min CHUNG ; Heun Gyun JUNG
Journal of Korean Society of Spine Surgery 1997;4(1):74-80
No abstract available.
Spinal Fractures*