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Annals of Dermatology 1995;7(2):144-149

BACKGROUND: Indomethacin is a potent inhibitor of prostaglandins biosysnthesis. Sunburn erythema is mainly mediated by prostaglandins. OBJECTIVE: Our purpose was to compare objectively the effectiveness of topical indomethacin with topical corticosteroid on the suppression of UVB erythema METHODS: Sixteen male medical students who had not exposed their back skin during the last year were included in this study. According to the individual´s MED, 1,2, and 3 MED of UVB were irradiated on each back in triplicate lines. Immediately after UVB irradiation, 2.5% indomethacin solution and 0.25% desoximethasone were applied to each row with one row left for control. 24 hours after the initial application the intensity of each erythema was measured by the naked eye and by colorimeter. RESULTS: The suppressive effectiveness of 2.5% indomethacin solution on UVB induced erythema was superior to that of 0.25% desoximethasone. The L* and a* value of colorimeter were significantly correlated to the differencies of UVB induced erythema among the experimental and control groups is a useful and rapid method to evaluate the UVB induced erythema, and can give a numerical expression to eye perception. CONCLUSION: Our data confirm that topical indomethacin has a stronger suggestive effect on UVB erythema than that of topical corticosteroid.. We suggest that the suppressive effect of indomethacin is mainly due to the inhibition of prostaglandins biosynthesis. The colorimeter CR-200(MINOLTA) is well correlated with the naked eye score and is a useful instrument for objective measurement of the degree of erythema.
Erythema* ; Humans ; Indomethacin* ; Male ; Methods ; Prostaglandins ; Skin ; Students, Medical ; Sunburn

5.Respiratory Gas Exchange and Ventilatory Functions at Maximal Exercise.

Yong Keun CHO ; Tae Hoon JUNG

Tuberculosis and Respiratory Diseases 1995;42(6):900-912

BACKGROUND: Although graded exercise stress tests are widely used for the evaluation of cardiorespiratory performance, normal standards on respiratory gas exchange and ventilatory functions at maximal exercise in Koreans have not been well established. The purpose of this study is to provide reference values on these by sex and age, along with derivation of some of their prediction equations. METHOD: Symptom-limited maximal exercise test was carried out by Bruce protocol in 1,000 healthy adults consisting of 603 males and 397 females, aged 20~66 years. Among them VC, FEV1 and MVV were also determined in 885 cases. All the subjects were members of a health center, excluding athletes. During the exercise, subjects were allowed to hold on to front hand rail of the treadmill for safety purpose. RESULTS: The VO2 max/m2, VCO2 max/m2 and VE max/m2 were greater in males than in females and decreased with age. The RR max in men and women was similar but decreased slightly with age. The VT max was markedly greater in men but showed no significant changes with age in either gender. The mean of VT max/VC, VE max/MVV and BR revealed that there were considerable ventilatory reserves at maximal exercise even in older females. The regression equations of the cardinal parameters obtained using exercise time(ET, min), age(A, yr), height(Ht, cm), weight(W, kg), sex(S, 0=male; l=female), VC(L), FEV1(L) and VE max(L) as variables are as follows: VO2 max/m2(L/min)=1.449+0.073 ET-0.007A+0.010W-0.006Ht-0.209S, VCO2 max/m2(L/min)= 1.672+0.063ET-0.008A + 0.010W -0.005Ht -0.319S, VE max/m2(L/min)=58.161 +1.503ET - 0.315A-9.871S or VE max/m2(L/min)=47.873+6.548 FEV1-5.715 S, and VT max(L)=1.497+ 0.223VC-0.493S. CONCLUSION: Respiratory gas exchange and ventilatory variables at maximal exercise were studied in 1,000 non-athletes by Bruce protocol. During exercise, the subjects were allowed to hold on to hand rail of the treadmill for safety purpose. We feel that our results would provide ideal target values for patients and healthy individuals to be achieved, since our study subjects were members of a health center whose physical fitness levels were presumably higher than ordinary population.
Adult ; Athletes ; Exercise Test ; Female ; Hand ; Humans ; Male ; Physical Fitness ; Reference Values

1.A study on the evaluation of stress in the alcoholic patients.

2.Epidemic Aseptic Meningitis in 1993.

3.A case of zosteriform cutaneous metastatic adenocarcinoma of cholangiocarcinoma.

4.The Effect of Topical Indomethacin and Topical Corticosteroid on UVB Induced Erythema.

5.Respiratory Gas Exchange and Ventilatory Functions at Maximal Exercise.

6.A case of Meigs' syndrome and elevated CA125 level.

7.3 cases of tsutsugamushi disease with meningitis in children.

8.A case of myelofibrosis.

9.Focal Dermal Hypoplasia Associated with Ichthyosis.

10.Focal Dermal Hypoplasia Associated with Ichthyosis.

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