1.A Case of Giant Fibrous Histiocytoma.
Yoon Kee PARK ; Min Geol LEE ; Dong Sik BANG ; Tae Jung KWON ; Jung Sook KIM
Korean Journal of Dermatology 1984;22(1):83-88
Fibrous histiocytomas are characterized by a variable combination of cells with fibroblastic and histiocytic features. They exhibit a distinctive but inconstant cellular arrangement referred to as a storiform or cartwheel pattern. Considerable corfusion has enveloped these tumors as a result of their various terminology-fibrous histiocytoma, dermatofibroma, sclerosing hemangioma, fibroxanthoma, subepidermal nodular fibrosis, xanthogranuloma, giant cell tumor of tendon sheath. A histologically benign but locally infiltrating, 15 * 20cm sized, fibrous histiocytoma was found in the posterior aspect of left thigh of a 17-year-old man. The tumor was incompletely excised due to adhesion of the tumor mass to sciatic nerve and then radiation therpy was combined, Histogenesis and prognostic aspects of the tumor are discussed.
Adolescent
;
Fibroblasts
;
Fibrosis
;
Giant Cell Tumors
;
Histiocytoma
;
Histiocytoma, Benign Fibrous*
;
Humans
;
Sciatic Nerve
;
Tendons
;
Thigh
2.Primitive Neuroectodermal Tumor of the Ovary: A case report .
Chan Kwon JUNG ; Eun Sun JUNG ; Youn Soo LEE ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1999;33(8):631-635
Primitive neuroectodermal tumors (PNET) of the ovary are rare tumors with an exclusive or almost exclusive malignant neuroectodermal composition, and are generally regarded as a monodermal expression of an ovarian teratoma. The tumors are basically identical with the lesions of the same name occuring typically in the central nervous system of children. These tumors consist chiefly of undifferentiated small cells resembling neuroblasts. There are also mature, well- differentiated neuroectodermal cells, such as astrocytes and ependymal cells. We report a case of ovarian PNET with glial and neuroblastic differentiation and focal teratomatous foci of non-neural tissue in a 17-year-old female.
Adolescent
;
Astrocytes
;
Central Nervous System
;
Child
;
Female
;
Humans
;
Neural Plate
;
Neuroectodermal Tumors, Primitive*
;
Ovary*
;
Teratoma
3.Electronmicroscopic Study of Familial Benign Chronic Pemphigus.
Mi Jin Hee TAK ; Yoon Kee PARK ; Sung Nack LEE ; Tae Jung KWON ; Chung Sook KIM
Korean Journal of Dermatology 1982;20(5):777-781
Familial benign chronic pemphigua is a rare disease characterized by a localized recurrent eruption of grouped vesicles and exudative lesions involving the neck, groin, axillae and intertriginous areas. There are no systemic manifestations but chronicity and pruritic lesions creates a significant social and psychological handicap to those afflicted. We presented a case of familial benign chronic pemphigus in a 39 years old man He has had recurrent vesicles, fissures and crust formation in inguinal area for 10 years. Light microscopic findings showed suprabasal vesiculation with acantholysis and villi formation. And electron-microscopic findings showed as follows: Bizzare microvilli changes with widened intercellular spaces, followed by loss of desmosome and complete acantholysis. Tonofilament-desmosome complex is disrupted. Many of acantholytic cells are associated with abnormal keratinization which is repreaented by perinuclear thickened bundles of tonofilament arranged in whorls or lumps. Authors diagnosed with clinical symptoms, light and electron-microscopic findings as Hailey-Hailey disease. The lesions were improved by systemic antibiotics and steroid with cold soaking.
Acantholysis
;
Adult
;
Anti-Bacterial Agents
;
Axilla
;
Desmosomes
;
Extracellular Space
;
Groin
;
Humans
;
Intermediate Filaments
;
Microvilli
;
Neck
;
Pemphigus, Benign Familial*
;
Rare Diseases
4.Dendriform Pulmonary Ossification: A case report.
Chan Kwon JUNG ; Kyo Young LEE ; Chang Suk KANG ; Sang In SHIM ; Byung Kee KIM
Korean Journal of Pathology 2000;34(11):950-952
The dendriform pulmonary ossification (DPO) is a rare condition of unknown origin in which branching mature bony spicules, usually containing marrow, are found within the alveolar septa. DPO manifests slow progression over many years or may remain unchanged; spontaneous regression has not been recorded. Most patients have no symptoms directly attributed to the ossification, although they may have symptoms due to the underlying fibrotic process. We experienced a case of DPO in 38 year-old-man who presented with cough and sputum for a month. The chest X-ray showed marked coarsened interstitial lung markings in both lungs, especially in the lower lobes. Open lung biopsy was done. Grossly, there were significant dendriform osseous structures. Histologically, branching arrays of mature bone were found in the interstitium and occasionally in alveolar spaces. Some bony trabeculae contained fatty or cellular marrow. The alveolar septa showed fibrous thickening with chronic inflammation. The transition between fibrosis and bone tissue was observed. Our case suggests that dendriform pulmonary ossification may be a rare special manifestation of chronic fibrosing interstitial inflammation of the lung. Osseous structures seem to derive from metaplastic bone formation in the vicinity of undergoing fibrous process.
Biopsy
;
Bone and Bones
;
Bone Marrow
;
Cough
;
Fibrosis
;
Humans
;
Inflammation
;
Lung
;
Lung Diseases, Interstitial
;
Osteogenesis
;
Sputum
;
Thorax
5.Effect of obstructive jaundice on rat liver regeneration.
Jung Kee CHUNG ; Oh Joong KWON ; In Kyu HONG ; Kun Wook LEE ; Soo Tae KIM
Journal of the Korean Surgical Society 1991;40(3):275-281
No abstract available.
Animals
;
Jaundice, Obstructive*
;
Liver Regeneration*
;
Liver*
;
Rats*
6.Myofibrosarcoma of the Breast: A case report .
Chan Kwon JUNG ; Kyo Young LEE ; Chang Suk KANG ; Sang In SHIM ; Byung Kee KIM
Korean Journal of Pathology 2000;34(1):96-98
Myofibrosarcoma of the breast is a rare malignant mesenchymal tumor that has been reported in only four well documented cases so far. We report a case of myofibrosarcoma of the breast in an 88-year-old man who complained of a palpable mass for 1 year. Microscopically, the tumor consisted mainly of spindled cells, arranged in irregular fascicles and embedded in broad bands of dense hyalinized collagen. It showed ill-defined border infiltrating the adjacent adipose tissue, moderate cellular pleomorphism, and high mitotic rate (8~9/10 HPF). Immunohistochemical study confirmed myofibroblastic differentiation of the tumor cells with diffuse strong reaction for vimentin, smooth muscle actin, and fibronectin.
Actins
;
Adipose Tissue
;
Aged, 80 and over
;
Breast*
;
Collagen
;
Fibronectins
;
Humans
;
Hyalin
;
Muscle, Smooth
;
Myofibroblasts
;
Vimentin
7.Subperiosteal Cortical Defect: Case Analysis
Kwon Ick HA ; Han Koo LEE ; Myung Sang MOON ; Jung Ihl KEE ; Sae Il SUK
The Journal of the Korean Orthopaedic Association 1969;4(3):55-59
Subperiosteal Cortical Defect is a symptomless rarefaction of cortical bone which begins most often on the external surface of the medial and posterior cortical walls of the lower end of the femur in children between the ages of 3 and 6 years. The name of Subperiosteal Cortical Defect was first used by Aegerter who differentiated it from non-osteogenic fibroma. The authors found out 5 positive cases of incidental findings among 62 cases of both knee joint X-ray of which 3 was male and 2 was female. Also we experienced 3 cases which necessiat d a correct diagnosis and differential diagnosis. Because this is a common lesion, it frequently accompanies more serious bone conditions, and because this is self-limited disease, treatment is not necessary. It was emphasized that its nature should be understood by all those dealing with bone disease lest it be overdiagnosed and overtreated.
Bone Diseases
;
Child
;
Diagnosis
;
Diagnosis, Differential
;
Female
;
Femur
;
Fibroma
;
Humans
;
Incidental Findings
;
Knee Joint
;
Male
8.Rhabdomyosarcoma (Report of Five Cases)
Kwon Ick HA ; Jung Ihl KEE ; Se Il SUK ; Moon Sik HAHN
The Journal of the Korean Orthopaedic Association 1970;5(2):83-87
Rhabdomyosarcoma which was first described by Weber has generally been considered an uncommon tumor. Recently it was classified as four types such as pleomorphic, embryonal, botryoid and alveolar type by Stout, Stobbe et al, Horn et al. and Riopelle et al. Five cases of rhabdomyosarcoma treated recently in Seoul National University Hospital were repored in this paper. 1. There were three pleomorphic types, one alveolar type and one undifferentiated malignant mesenchymal tumor. 2. Four cases were between 18-23 years old and one was 37 years old. 3. Three were male and two were female. 4. Time to be consulted to us was average 8 months. 5. Three were in lower extremity (two in thigh, one in calf) and two were in upper extremity (one in elbow, the other in forearm). 6. Follow-up study was done for three cases. One was exoired at,three months after hindquarter amputation, the other was expired at two years after supracondylar amputation and no recurrence and metastases were developed one year after local resection in another one case.
Amputation
;
Animals
;
Elbow
;
Female
;
Follow-Up Studies
;
Horns
;
Humans
;
Lower Extremity
;
Male
;
Neoplasm Metastasis
;
Recurrence
;
Rhabdomyosarcoma
;
Seoul
;
Thigh
;
Upper Extremity
9.The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
Young Bae KWON ; Young Chan JEONG ; Jung Kee KWON ; Ji Seon SON ; Kee Won KIM
The Korean Journal of Physiology and Pharmacology 2009;13(6):425-429
Intracranial headaches, including migraines, are mediated by nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. We previously demonstrated that selective blockage of spinal sigma-1 receptors (Sig-1R) produces a prominent antinociceptive effect in several types of pain models. This study evaluates whether the Sig-1R antagonist (BD1047) has an antinociceptive effect on capsaicin (a potent C-fiber activator) induced headache models in rats. Intracisternal infusion of capsaicin evoked pain behavior (face grooming), which was significantly attenuated by BD1047 pretreatment. BD1047 consistently reduced capsaicin-induced Fos-like immunoreactivity (Fos-LI), a neuronal activator, in the TNC in a dose-dependent manner. Moreover, capsaicin-induced phosphorylation of N-methyl-D-aspartate receptor subunit 1 was reversed by BD1047 pretreatment in the TNC. These results indicate that the Sig-1R antagonist has an inhibitory effect on nociceptive activation of the TNC in the capsaicin-induced headache animal model.
Animals
;
Capsaicin
;
Headache
;
Migraine Disorders
;
Models, Animal
;
N-Methylaspartate
;
Neurons
;
Phosphorylation
;
Rats
;
Receptors, sigma
;
Trigeminal Nuclei
10.Differentiated Muscle-derived Stem Cells Attenuate Intimal Hyperplasia after Carotid Balloon Injury in Rat.
In Mok JUNG ; So Rhee HAN ; Keum Hee CHOI ; Yujin KWON ; Taeseung LEE ; Seung Kee MIN ; Yang Jin PARK ; Jung Kee CHUNG ; Jongwon HA ; Sang Joon KIM
Journal of the Korean Surgical Society 2010;79(Suppl 1):S7-S15
PURPOSE: Although progenitor cells may contribute to intimal hyperplasia (IH) after arterial injury, positive contribution of IH is variable with type of injury or cells. This study was designed to examine whether differentiated muscle derived stem cells (MDSC) attenuate IH in rat. METHODS: MDSCs were retrieved using preplate techniques from rat calf muscle and MDSCs (preplate 6th culture fraction, pp6) were exposed to VEGF (50 ng/ml) for endothelial differentiation prior to injection. Male rats were divided into two groups (cell treated vs. control) and underwent carotid balloon injury with 2-Fr catheter. The virus containing Green fluorescent protein (GFP) gene was transfected into cells for monitoring. Cells (5x10(6)) were indwelled into carotid artery for 30 minutes after injury and then blood flow was restored. Arteries were harvested at various intervals (1, 2 and 4 weeks) after injury. The intima to media thickness ratio (IMTR) was calculated with morphometric analysis. RESULTS: Endothelial surface markers such as VE-CADHERIN were strongly expressed on differentiated MDSCs. At 4 weeks after injury, IH was predominantly observed in control group compared to cell treated group. The intensity of GFP was strongly observed at 1 week and declined at 4 weeks in carotid artery wall at MDSC group. CD31(+) endothelial cells were observed at MDSC group compared to control. The mean IMTR in cell treated groups were significantly lower than control at 2 weeks (P=0.005) and 4 weeks (P< or =0.001). CONCLUSION: Our study demonstrates that MDSCs therapy promotes re-endothelialization and leads to attenuation of IH after balloon injury in rat.
Animals
;
Antigens, CD
;
Arteries
;
Cadherins
;
Carotid Arteries
;
Catheters
;
Endothelial Cells
;
Humans
;
Hyperplasia
;
Male
;
Muscles
;
Rats
;
Stem Cells
;
Vascular Endothelial Growth Factor A
;
Viruses