1.Maternal Cell Contamination in Chorionic Villus Sampling : An Analysis of Frequency in 1,059 Consecutive Cases.
Bo Hoon OH ; Jung Min LEE ; Gyung Hwa LEE ; Ae Young JUNG ; Moo Sik GWON
Korean Journal of Obstetrics and Gynecology 2000;43(8):1384-1388
No abstract available.
Chorion*
;
Chorionic Villi Sampling*
;
Chorionic Villi*
;
Female
;
Pregnancy
2.Effect of Acupuncture on Regional Cerebral Blood Flow at Acupoints GV 20 , GV. 26 , LI. 4 , ST. 36 , SP. 6 Evaluated by Tc-99m ECD Brain SPECT.
Ho Chun SONG ; Hee Seung BUM ; Hwa Jung KANG ; Soo Gee AN ; Sung Min KIM ; Hwan Jung JUNG ; Jee Yeol KIM
Korean Journal of Nuclear Medicine 2000;34(6):456-464
PURPOSE: To evaluate the effect of acupuncture on regional cerebral blood flow (rCBF) at acupoints suggested by oriental medicine to be related to the treatment of cerebrovascular diseases. MATERIALS AND METHODS: Rest/acupuncture-stimulation Tc-99m ECD brain SPECT using a same-dose subtraction method was performed on 54 normal volunteers (34 males, 20 females, age range from 18 to 62 years) using six paradigms: acupuncture at acupoints GV. 20, GV. 26, LI. 4, ST. 36 and SP. 6. In the control study, needle location was chosen on a non-meridian focus 1 cm posterior to the right fibular head. All images were spatially normalized, and the differences between rest and acupuncture stimulation were statistically analyzed using SPM for Windows . RESULTS: Acupuncture applied at acupoint GV. 20 increased rCBF in both the anterior frontal lobes, the right frontotemporal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at GV. 26 increased rCBF in the left prefrontal cortex. Acupuncture at LI. 4 increased rCBF in the left prefrontal and both the inferior frontal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at ST. 36 increased rCBF in the left anterior temporal lobe, the right inferior frontal lobes, and the left cerebellum. Acupuncture at SP. 6 increased rCBF in the left inferior frontal and anterior temporal lobes. In the control stimulation, no significant rCBF increase was observed. CONCLUSION: The results demonstrated a correlation between stimulation at each acupoint with increase in rCBF to the corresponding brain areas.
Acupuncture Points*
;
Acupuncture*
;
Brain*
;
Cerebellum
;
Female
;
Frontal Lobe
;
Head
;
Healthy Volunteers
;
Humans
;
Male
;
Medicine, East Asian Traditional
;
Needles
;
Prefrontal Cortex
;
Temporal Lobe
;
Tomography, Emission-Computed, Single-Photon*
3.Study on the Development of a Rapid Detection Method for Pathogenic Yersinia enterocolitica and Yersinia pseudotuberculosis by Nested Polymerase Chain Reaction.
Ho Jung OH ; Hong Ki MIN ; Yeo Won SOHN ; Seung Hwa HONG
Journal of the Korean Society for Microbiology 1999;34(2):175-187
A nested polymerase chain reaction (PCR) was applied to detect and identify pathogenic Yersinia enterocolitica and Y. pseudotuberculosis. We used photochemical postamplification procedure with 8-methoxypsoralen to control carryover contamination. Using the ail and inv gene, the sensitivity and specificity of DNA amplification by nested PCR was considerably improved. The amplified fragment sizes were 298 bp for the ail gene and 295 bp for the inv gene. Amplification was successful when the template was derived from three sources: purified DNA, aliquots of boiled bacterial suspension and aliquots of lysed bacterial suspension. The detection limits were 10 fg of DNA and 2 * 10 colony forming units (CFU) for Y. enterocolitica and 10 fg DNA and 2 CFU for Y. pseudotuberculosis.
DNA
;
Limit of Detection
;
Methoxsalen
;
Polymerase Chain Reaction*
;
Sensitivity and Specificity
;
Stem Cells
;
Yersinia enterocolitica*
;
Yersinia pseudotuberculosis*
;
Yersinia*
4.Three Cases of Iridoeorneal Endothelial Syndrome.
Tae Min BAEK ; Jang Ho KIM ; Jung Eon YONG ; Joo Hwa LEE
Journal of the Korean Ophthalmological Society 1991;32(9):747-751
Iridocorneal endothelial syndrome is a disease characterized by corneal endothelial degeneration, corneal edema, peripheral anterior synechia, iris stromal change, and secondary glaucoma. This syndrome is considered to have three major variations: Chandler's syndrome, progressive (essential) iris atrophy, and Cogan-Reese syndrome. We experienced three cases of iridocorneal endothelial syndrome with transient intraocular pressure elevation.
5.The Effect of Quinidine on Digoxin Clearance.
Ho Soon KIM ; Hyun Oh NA ; Wan Gyun SHIN ; Min Hwa LEE ; Jung Don SEO
Korean Circulation Journal 1994;24(3):482-485
BACKGROUND: Quinidine appeared to increase serum digoxin levels when given with quinidine. Therefore elevated serum digoxin concentrations and clinical toxicity have been reported in patient receiving quinidine. Currently, Bayesian method which estimates the most probable parameters of the drug for each patient from population parameters data is useful approach for adjusting digoxin dosage. To increase the accuracy of Bayesian method, it is desirable to use population parameters of Korean. Therefore we evaluated the effect of quinidine on digoxin clearance in Korea. METHOD: Patient's records from 19 adult cardiac disease without CHF having normal renal and liver function from Seoul National University of Hospital respectively wre evaluated. Digoxin pharmacokinetic parameters, CL and Vd, were obtained from serum concentration of digoxin of single and combined therapy at each steady-state by using bayesian method. RESULTS: This study show that quinidine reduced the total body clearance of digoxin from 2.39+/-0.17 to 1.51+/-0.08ml/min/kg(p<0.05) and reduced the digoxin volume of distribution from 8.57+/-0.29 to 4.98+/-0.19L/kg(p<0.05). This results show that digoxin dosage reduced to 40-50% in Korean, if quinidine therapy is initiated.
Adult
;
Bayes Theorem
;
Digoxin*
;
Drug Interactions
;
Heart Diseases
;
Humans
;
Korea
;
Liver
;
Pharmacokinetics
;
Quinidine*
;
Seoul
6.Expression and Characterization of Chimeric Antigens of Hepatitis B and D Viruses : Implications for the Development of Divalent Vaccine.
Dong Hwa CHOI ; Jung Min PARK ; Kyu Jin PARK ; Soon Bong HWANG ; Soo Ho CHOI
Journal of Bacteriology and Virology 2001;31(4):361-367
No abstract available.
Hepatitis B*
;
Hepatitis*
7.A Case of Extramammary Paget's Disease and Candidiasis of the Vulvar Area.
Chang Min KIM ; Bo Young KIM ; Seung Hyun CHUN ; Jae Beom PARK ; Hwa Jung RYU
Korean Journal of Dermatology 2017;55(8):541-542
No abstract available.
Candidiasis*
;
Paget Disease, Extramammary*
;
Vulva
8.Cholesterol side-chain cleavage enzyme deficiency caused by a novel homozygous variant in P450 sidechain cleavage enzyme gene (CYP11A1) in a 46,XX Korean girl
Ye Ji KIM ; Sun CHO ; Hwa Young KIM ; Young Hwa JUNG ; Jung Min KO ; Chang Won CHOI ; Jaehyun KIM
Journal of Genetic Medicine 2023;20(1):25-29
The CYP11A1 gene encodes for the cholesterol side-chain cleavage enzyme (P450scc), which initiates steroid hormone biosynthesis. Defective P450scc activity results in severe glucocorticoid and mineralocorticoid deficiencies. We describe a case of P450scc deficiency due to a novel homozygous CYP11A1 variant inherited from the mother with a possibility of uniparental disomy (UPD). The patient was a female, had no family history of endocrine disease, and showed adrenal insufficiency at 13 days of age. Hormonal analysis with an adrenocorticotropic hormone stimulation test showed both glucocorticoid and mineralocorticoid deficiencies, presumed to be a defect of the early stage of steroidogenesis. Exome sequencing reported a novel homozygous frameshift variant of CYP11A1 (c.284_285del, p.Asn95Serfs*10), which was inherited from the mother.Additionally, homozygosity in 15q22.31q26.2, which included CYP11A1, was identified using a chromosomal microarray. It was suggested that the possibility of maternal UPD was involved as the cause of a P450scc deficiency by unmasking the maternally derived affected allele. To our understanding, P450scc deficiency associated with UPD encompassing CYP11A1 had not been reported in Korea before. Genetic analysis can help diagnose rare causes of primary adrenal insufficiency, including P450scc deficiency.
9.The Study of Combined Voice Therapy with Intralaryngeal Injection.
Cheol Min AHN ; Hwa Won JUNG ; Jung Eun SHIN
Journal of the Korean Society of Laryngology Phoniatrics and Logopedics 2017;28(1):25-31
BACKGROUND AND OBJECTIVES: Though voice therapy is proven to be effective in academia, treatment results and satisfaction level are inconsistent in clinics. The inconsistency may rise from diverse vocal cords misuse patterns in patient population as they suffer from different diseases or have bad phonation habits. In order to overcome the limitation, we uniformized patients' vocal cords with injection laryngoplasty prior to voice therapy. The efficacy of voice therapy and consistency in treatment results after injection laryngoplasty were assessed. MATERIALS AND METHODS: Patients diagnosed with vocal nodules were either treated with injection laryngoplasty followed by voice therapy (combined treatment group) or voice therapy only (voice therapy group). Each group consisted of 15 patients. Acoustic measures (jitter, shimmer, NHR), aerodynamic measures (MPT, Psub, MAFR), and subjective auditory conscious measures (K-VHI, K-VRQOL) between two groups were analyzed. RESULTS: After treatments, both groups improved in terms of acoustic, aerodynamic, and subjective auditory conscious measures compared to pre-treatment. Combined treatment group had statistically significantly greater improvement in shimmer, P in K-VHI, and PF in K-VRQOL compared to voice therapy group. CONCLUSION: Injection laryngoplasty treatment prior to voice therapy synergizes in treating patients compared to voice therapy only.
Acoustics
;
Humans
;
Laryngoplasty
;
Phonation
;
Vocal Cords
;
Voice*
10.Plasmapheresis in pregnancy and puerperium.
Min Hwa JUNG ; Rae Ok PARK ; Jung Il CHA ; Jong Kun LEE ; Soo Pyung KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1993;36(1):29-38
No abstract available.
Plasmapheresis*
;
Postpartum Period*
;
Pregnancy*