1.Clinical Outcome after Pancreatectomy in Patients with Persistent Hyperinsulinemic Hypoglycemia of Infancy.
Min Ho JUNG ; Jin Soon HWANG ; Choong Ho SHIN ; Sei Won YANG ; Je G CHI
Journal of Korean Society of Pediatric Endocrinology 2000;5(2):171-181
PURPOSE: The purpose of this study was to describe the clinical outcome after pancreatcetmy and its relationship with pathological appearances and clinical features in patients with persistent hyperinsulinemic hypoglycemia of infancy(PHHI). METHODS: Medical records of 10 patients(9 males and 1 female, mean age:40.4+/-1.5 months) who were diagnosed as PHHI and underwent pancreatectomy from 1988 to 2000 were reviewed. Clincal and biochemical data were recorded. Subjects were classified arbitrarily into early-onset or late-onset group according to age of onset. Pathologic appearance of pancreas was divided into 2 forms:diffuse or focal. The former had a focal pancreatic adenomatous hyperplasia and the latter was characterized by increased number of betacells with similar distribution seen in normal neonates. RESULTS: One patient had focal, and nine had diffuse lesions. After near-total pancreatectomy, 4 patients(40.0%) showed complete response, 4(40.0%) had persistent hypoglycemia, and 2(20.0%) developed diabetes mellitus. As neurological sequelae, 6 patients(60.0%) had persistent seizures, and 6(60.0%) had delayed motor and speech development. No clinical or biochemical factors related to postoperative outcome were found. CONCLUSION: This data indicate that early diagnosis of patients who present with hypoglycemic symptoms in infancy, especially early in life, and development of more effective therapy are warranted, because there is no clinical or biochemical factor predicting final outcome after near-total pancreatectomy and only 40% of patients with PHHI remained euglycemic after surgery with possible severe neurological sequelae.
Age of Onset
;
Congenital Hyperinsulinism*
;
Diabetes Mellitus
;
Early Diagnosis
;
Female
;
Humans
;
Hyperplasia
;
Hypoglycemia
;
Infant, Newborn
;
Male
;
Medical Records
;
Pancreas
;
Pancreatectomy*
;
Seizures
2.Clinical efficacy of hysteroscopy.
Jung Soon PARK ; Je Seung LEE ; Sang Bok LEE ; Kyu Byung JUNG ; Seung Ho LEE
Korean Journal of Obstetrics and Gynecology 1991;34(2):237-244
No abstract available.
Hysteroscopy*
3.Clinical efficacy of hysteroscopy.
Jung Soon PARK ; Je Seung LEE ; Sang Bok LEE ; Kyu Byung JUNG ; Seung Ho LEE
Korean Journal of Obstetrics and Gynecology 1991;34(2):237-244
No abstract available.
Hysteroscopy*
4.Primary Lymphoma of the Uterine Cervix.
Sung Bum CHO ; Jin Ho JUNG ; Jung Rae ROH ; Chang Soo PARK ; Duk Soo BAE ; Je Ho LEE
Korean Journal of Gynecologic Oncology and Colposcopy 2000;11(2):195-199
Primary lymphoma of uterine cervix is rare disease, which usually occurs in postmenopausal periods. The usual symptoms are vaginal bleeding, postcoital bleeding. The most common pathologic feature is a diffuse cell type, B-cell line. Pap smear is not helpful in diagnosis because it is stromal origin. Biopsy confirms the diagnosis. Treatment consists of radiation therapy and/or chemotherapy. The prognosis of the disease is dependent upon Ann arbor stage and International index score rather than FIGO stage. We experienced one case of primary lymphoma of cervix and report it with a brief review of literature.
B-Lymphocytes
;
Biopsy
;
Cervix Uteri*
;
Diagnosis
;
Drug Therapy
;
Female
;
Hemorrhage
;
Lymphoma*
;
Postmenopause
;
Prognosis
;
Rare Diseases
;
Uterine Hemorrhage
5.Ovarian transposition with subsequent intrauterine pregnancy.
Suck Jung KIM ; Jung Min KANG ; Dong Je CHO ; Yoon Ho LEE ; Kook LEE ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1991;34(7):1034-1038
No abstract available.
Pregnancy*
6.Chest radiographic findings of scrub typhus: An analysis of 160 cases occurred in Ulsan area.
Ok Hwa KIM ; Dong Heon OH ; Ki Sung KIM ; Je Ho WOO ; Jung Hyeok KWON
Journal of the Korean Radiological Society 1993;29(2):205-210
Scrub typhus (Tsutsugamushi disease)is an acute febrile systemic illness caused by Rickettsia tsutsugamushi that is transmitted to humans by the bite of larval-stage trombiculid mites (chiggers). The authors analyzed chest radiographic findings of scrub typhus in 160 patients in Ulsan area. One hundred and eight (67.5%) of160 patients showed abnormal findings which included lung lesions in 108 patients (67.5%), cardiomegaly in 37 patients (23.1%), lymphadenopathy in 25 patients (15.6%) and pleural effusion in 11 patients (6.9%). Among the lung lesions, interstitial patterns were seen in 107 patients (66.9%), mostly fine or medium reticulonodular, and air-space patterns in 14 patients(8.8%) and combined interstitial and air-space patterns in 13 patients (8.1%). Sixty-four patients(40%) had combined chest radiographic findings. The typical chest radiographic findings of scrub typhus would be helpful in evaluation of the causes of acute febrile illness that occur during late fall in the endemic area.
Cardiomegaly
;
Humans
;
Lung
;
Lymphatic Diseases
;
Orientia tsutsugamushi
;
Pleural Effusion
;
Radiography, Thoracic*
;
Scrub Typhus*
;
Thorax*
;
Trombiculidae
;
Ulsan*
7.Pressor Effect of Intracerebroventricular Diphenhydramine and Ranitidine in Rabbits.
Han Ho CHO ; Soo Han KIM ; Sam Suk KANG ; Je Hyuk LEE ; Jung Hyun WOO
Journal of Korean Neurosurgical Society 1991;20(10-11):905-910
This study was undertaken to observe the effects of centrally administred antihistamines on the blood pressure. Diphenhydramine(DPH), a H1-receptor antagonist, and ranitidine(RAN), a H2-receptor antagonist were administered intracerebroventricularly(icv) on urethane-anesthetized rabbits. 1) Both DPH and RAN administered intraccebroventricularly increased blood pressure, however the intravenous(iv) adminstration of them did not affect blood pressure. The pressor response to icv DPH was dose-dependent, but that to icv RAN was not. 2) The pressor response to icv DPH(1mg) was either markedly attenuated or reversed to depressor response by the pretreatment with icv phentolamine(250,500ug), and iv chlorisondamine(0.1, 1mg/Kg) and iv phenoxybenzamine(1mg/Kg). In cord-sectioned rabbtis, icv RAN) 1mg) did not produce pressor response. 3) The pressor responsr to icv RAN(1mg) was not affected by the pretreatment with icv phentolamine(500ug), iv chlorisondamin(1mg/Kg) and iv phenoxybenzamine(1mg/Kg), and iv phenoxybenzamine(1mg/Kg). RAN also producted pressor response in cordsectioned rabbits. These results suggest that the pressor response to icv DPH is elecited by increasing peripheral sympathetic tone via the stimulation of central alpha-adrenoreceptors and the pressor response to icv RAN is produced by releasing some humoral facotr which can increase blood pressure.
Blood Pressure
;
Diphenhydramine*
;
Histamine Antagonists
;
Rabbits*
;
Ranitidine*
9.Norepinephrine and Serotonin in the Patients with Psychogenic Impotence.
Jin Se KIM ; In Kwa JUNG ; Seung Ho RYU ; Du Geon MOON ; Je Jong KIM
Journal of the Korean Society of Biological Psychiatry 1998;5(2):278-282
Various neurotransmitters have been proposed as possible mediators of penile erection. Especially, norepinephrine and serotonin might have a important role in sexual arousal and penile erection. And it could be hypothesized that the psychogenic impotence is associated with the depletion or imbalance of norepinephrine and serotonin from evidences such as the symptomatic manifestation of depression and the antidepressant-induced sexual dysfunction. The authors investigates the association of norepienphrine and serotonin with psychogenic impotence. The psychogenic impotent group(PIG) consisted of twenty-three patients with psychogenic impotence and the controlled group(CG) consisted of twenty-seven patients without psychogenic impotence. PIG had no organic cause accounting for their erectile dysfunction. The Beck Depression Inventory(BDI) and the State-Trait Anxiety Inventory(STAI) were applied to each subject to assess mood, state anxiety(SA) and trait anxiety(TA). Plasma norepinephrine level from systemic blood and 5-hydroxyindoleacetic acid(HIAA) levels from 24-hours urine were measured in each subject. The mean score of BDI of PIG was significantly higher than that of CG(p=0.015). PIG had a tendency of higher TA compared with CG(p=0.054). And also SA was higher in PIG, bud did not show significant difference(p=0.193). The level of norepinephrine was significantly lower in patient with psychogenic impotence(p=0.000). And the level of 24-hours urine 5-HIAA was lower in PIG but did not show significant difference(p=0.494). Although the authors did not exclude depressive disorders in PIG, the present findings suggest that psychogenic impotence might have higher depressive mood and trait anxiety, and be associated with the depletion of norepinephrine in systemic blood.
Anxiety
;
Arousal
;
Depression
;
Depressive Disorder
;
Erectile Dysfunction*
;
Humans
;
Hydroxyindoleacetic Acid
;
Male
;
Neurotransmitter Agents
;
Norepinephrine*
;
Penile Erection
;
Plasma
;
Serotonin*
10.A study on the medical care expenditure of the uterine cervix carcinoma by clinical stage and treatment modality.
Hyo Ki MIN ; Doo Chae JUNG ; Soo Yong CHOI ; Je Ho LEE ; Jae Kyu LIM
Korean Journal of Epidemiology 1992;14(2):160-174
No abstract available.
Cervix Uteri*
;
Female
;
Health Expenditures*