A case of impetigo herpetiformis occurring in a 25-year-old multigravida woman is reported. Superficial grouped pustules on an erythematous base developed on the flexual areas of both extremities and disseminated all over the body with mild pruritus, fever and burning sensation at her 14th weeks of pregnancy. Histopathologic findings showed acanthosis and subcorneal. pogiform pustule. All lesions had gradually improved within 2 weeks after artificial abortior. Our case demonstrates the characteristic features of impetigo erpetiformis, as compared with pustular psoriasis. This, we emphasize the need to preserve it as a separate entity.
Adult ; Burns ; Extremities ; Female ; Fever ; Humans ; Impetigo* ; Pregnancy ; Pruritus ; Psoriasis ; Sensation

BACKGROUND: To preserve the natural properties of skin, its waite balance has to be maintained. Properly moisturised skin is soft, supple, luminous, elastic and tonic. Stratum corneum is the bodys main protective barrier agairist the environment along with regulation of water exchange. Pathological factors such as eczema, ichthyosis and psoriasis encourage dehydration of the stratum corneum. OBJECTIVE: The purpose of t.his study was to evaluate interrelation. hip between the hydration state of the stratum corneum and cutaneous manifestation in patients with psoriasis, diabetes and chronic renal failure undergoing hemodialysis. METHOD: Because the cutaneous conductance is an indicator of skin surface hydration state, a water sorption-desorption test of skin was performed. This test furnishes informations of the hygroscopicity and water-hoiding capacity(WHC) of the stratum cornrum in a short time. RESULTS: Hygroscopicity and WHC decreased significantly on th. scaly psoriatic lesion. Hygroscopicity increased significmtly in diabetes with pruritus. In chonic renal failure undergoing hernodialysis, the prehydration state and hygroscopicity decreased. There were no significant differences in prehydration water coritent, hygroscopicity and WHC between pruritic and nonpruritic lesions in diabetes mellitus and chronic renal failure respectively. CONCLUSION: It is suggested that disturbed hydration function oi tl e stratum corneum, such as decreased hygroscopicity and water-holding capacity on the scaly pscriatic lesion may play an important role in clinical manifestatior. Pruritus in diabetes mellitus and chromic renal failure patients doesnt seem to be the functional disturbance of hydration in stratum corneum.
Dehydration ; Diabetes Mellitus ; Eczema ; Hip ; Humans ; Ichthyosis ; Incheon ; Kidney Failure, Chronic ; Pruritus ; Psoriasis ; Renal Dialysis ; Renal Insufficiency ; Skin ; Water ; Wettability

We report a case of eczema herpeticum associated with secondry staphylococcal infection in a 19 year-old male patient with Dariers disease during tratment with etretinate. Diagnosis was made by the history, clinical feature and histologic examination with light microscope & electron microscope. This patients condition was improved by the treatment with systemic and topical antibiotics within 1 week of admission.
Acitretin* ; Anti-Bacterial Agents ; Darier Disease ; Diagnosis ; Eczema* ; Etretinate* ; Humans ; Kaposi Varicelliform Eruption* ; Male ; Staphylococcal Infections ; Young Adult

No Abstract Available.
Acne Vulgaris* ; Adolescent* ; Humans

Acute generalized exanthematous pustulosis (AGEP) has symptoms of abrupt onset of a widespread pustular eruption on an erythematous. base. Most cases appear to be related to drug reactions, mainly antibiotics, but viral infections and hypersensitivity to mercury may cause AGEP. The essential features of AGEP include. (1) numerous (several dazen) small((5mm), mostly non follicular pustules arising on a widespread erythema:purpura and target-like lesions may be associated; (2) histology showing intraepidermal or subcorneal pustules associated with one or more of the following.clermal edema, vasculitis, perivascular eosinophils, or focal necrosis of keratinocytes; (3) fever (over 38C); (4) neutrophilia, and (5) acute evolution with spontaneous resulotion of pustules within 15 days. We report a case of AGEP which presented with widespread tiny pustules on the whole body except the face, palms and soles. There were petechia, purpura, and vesiculobullous lesions on the axilla, popliteal fossa and upper abdomen. A biopsy specimen from a pustule showed subcorneal pustules with perivascular polymorphous cellular infiltration, marked dermal edema and necrotic keratinocytes. There was complete resolution of the lesions within 10 days.
Abdomen ; Acute Generalized Exanthematous Pustulosis* ; Amoxicillin ; Anti-Bacterial Agents ; Axilla ; Biopsy ; Drug Eruptions ; Edema ; Eosinophils ; Fever ; Hypersensitivity ; Keratinocytes ; Necrosis ; Purpura ; Vasculitis

A 45-year-old woman presented with a generalized fixed drug eruption due to mefenamic acid, characterized by recurring erythematous patches with central bullae on the same sites of the whole body and leaving hyperpigmentation after each attack. Patch testing of a quiescent lesion with 50% mefenamic acid in vaselin revealed an eczematous reaction after 48 hours. The disease course was mild compared to the severe clinical manifestation. We here-in report a case of generalized fixed drug eruption due to mefenamic acid which is considered a rare occurrence.
Drug Eruptions* ; Female ; Humans ; Hyperpigmentation ; Mefenamic Acid* ; Middle Aged ; Patch Tests

Dupuytren's contracture is a idiopathic hypertrophy of palmar aponeurosis and consequent flexion deformity of distal palms and fingers. This patient is a 58-year-old man who has been suffering from diabetes mllitus since last 20 years. Skin lesion developed from one year ago. Skin lesion is a well defined, yellowish brown, nontender, firm, pea-sized nodule at distal palmar crease proximal to ring finger on both hands. On physical examination, he is within normal limit except skin lesion and flexion deformity on both hands. Skin biopsy on nodule revealed non-specific fibrosis. Literature was briefly reviewed.
Biopsy ; Congenital Abnormalities ; Dupuytren Contracture* ; Fibrosis ; Fingers ; Hand ; Humans ; Hypertrophy ; Middle Aged ; Physical Examination ; Skin

Hodgkin's disease, as a poly-morphous group of lymphoma, is a disease of reticuloendothelial system, skin and usually affects the lymph node and so primarily, predominantly by proliferation of lymphocyte and histiocyte. This patient is a 42 years old Housewife who was suffered from severe itching sensation on the entire body since she had illed with exfoliative decmatitis, 7 years ago. Skin lesion showed brownish colored hyperpigmentation on entire body, scattered or grouped lichenified patch with scale on extremities and hypertrophy on the palms and soles. On physical examination, she had a egg-sized, right cervical lymph node swelling and chestnut sized, left cervical lymph node swelling without pain. On laboratory findings showed within normal limits. Sternal bone marrow aspiration revealed nonspecifie findings. A chest X-Ray revealed mass shadow on right upper mediastinum. Histologically finding of the skin revealed nonspecific dermatitis picture. On diagnostic excisional biopsy of left cervical lymph node showed numerous Hodgkin's cell Liver scanning didn't show space occeuying lesion. Above as a result, by clinical manifestation, X-ray findings and histological findings of cervical lymph-node, the diagnosis of Hodgkins disease with nonspecific dermatitis was confirmed. Literature was briefly reviewed for the discussion of clinical and histological findings of this dlsease.
Adult ; Biopsy ; Bone Marrow ; Dermatitis* ; Diagnosis ; Extremities ; Histiocytes ; Hodgkin Disease* ; Humans ; Hyperpigmentation ; Hypertrophy ; Liver ; Lymph Nodes ; Lymphocytes ; Lymphoma ; Mediastinum ; Mononuclear Phagocyte System ; Physical Examination ; Pruritus ; Sensation ; Skin ; Thorax

PURPOSE: To evaluate morphologic characteristics of the microcalcifications on mammography that were confirmed pathologically. MATERIALS AND METHODS: Forty five cases of microcalcifications on mammography (fifteen cases of benign lesion, thirty cases of maiignancy) were retrospectively reviewed. RESULTS: The number of microcalcifications within 1 cm2 were more than 5 in 22 cases (73%) of 30 malignancy and less than 5 in 11 cases (73%) of 15 benignity. The heterogeneity of microcalcifications were seen in 26 cases of malignancy (87%) and the homogeneity of microcaicifications were 11 cases of benignity (73%). The morphologic characteristics of the microcalcifications were linear-V shape in 9 cases (30%), punctate shape in 8 cases (27%), fine stippled shape in 7 cases (23%), and round dot shape in 6 cases (20%) of malignancy and, round dot shape in 11 cases (73%), punctate shape in 2 cases (13%), and linear-V shape in 2 cases (13%) of benignity. CONCLUSION: Numerous irregular microcalcifications that are heterogenous in size and morphology were strong indicators of malignancy.
Mammography ; Population Characteristics ; Retrospective Studies

BACKGROUND: Recently, Q-switched lasers have been reported to be successful in treating Ota's nevus without scarring. Utilizing the principle of selective photothermolysis, the Alexandrite laser has been developed for dermal pigmented lesions and tattoos. OBJECTIVE: In this study, we evaluated the clinical, histopathological and ultrastructual effect of the Alexandrite laser in the tretment of Nevus of Ota. METHODS: Forty-seven patients with nevus of Ota were treated with energy densities ranging from 5.0 to 8.0 J/cm2 at a miriimum of 6 week intervals. Sequential skin biopsy specimens were processed for the light microscope with H&E and Fontana-Masson stains and the electron microscope. RESULTS: The average number of treatments were 2.8 per patient. After two treatment sessions, 93 % patients 26 to 75% imprivement was seen. After three treatments 50 to 95% improvement was seen. No patients had permanent textual changes or scarring. On light microscop most of the dendritic melanocytes in the upper dermis were not observed in biopsy specimens taken after clinical improvement. Electron microscopy revealed damaged melanosomes in the upper dermis immediately after irradiation. CONCLUSION: Treatment with the Alexandrite laser for nevus of Ota is considered to be a safe and effective method.
Biopsy ; Cicatrix ; Coloring Agents ; Dermis ; Humans ; Lasers, Solid-State* ; Melanocytes ; Melanosomes ; Microscopy, Electron ; Nevus of Ota* ; Skin