No abstract available.
Constipation*

Controversy persists regarding the abnormality of the bone metabolism in various bone diseases. Osteocalcin, the vitamin K-dependent protein synthesized in bone, has been shown to be a specific and sensitive marker of bone turnover in metabolic bone diseases. The author measured the serum osteocalcin level using newly developed radioimmunoassay (RIA) in the patients with osteogenesis imperfecta, metastatic bone tumor, postmenopausal osteoporosis and rheumatoid arthritis, which can be the causes of osteoporosis, and ankylosing spondylitis. The aim of this paper is to demonstrate the value of the osteocalcin measurement comparing the each data of disease group with the normal control group. The results were as followings ; 1. The mean of osteocalcin in normal Korean was 4.43±1.04 ng/ml. (4.45±1.08 ng/ml in male, 4.41±1.01 ng/ml in female). The difference between male and female was not significant statistically. 2. The osteocalcin of osteogenesis imperfects was 9.14±2.21 ng/ml, which was significant statistically, And it was thought to be the result of increasing bone turnover rate and the osteocalcin was useful as biochemical marker. 3. In metastatic bone tumor, osteocalcin was under the normal level in both untreated and treated groups, which meant low bone turnover rate or low osteoblastic activity. Osteocalcin was not a useful marker for the assessment of the effect of treatment in this study, but if the radioimmunoassay was done in the same tumor group, a valuable results could be expected. 4. Osteocalcin level in the patients with postmenopausal osteoporosis and rheumatoid arthritis was not different with normal control group and osteocalcin was not useful marker for the evaluation of the degree of osteoporosis and bone turnover. 5. Osteocalcin didn't play a role in the pathologic ossification of ankylosing spondylitis. In conclusion, the osteocalcin by radioimmunoassay can be used as a biochemical marker in metabolic bone diseases and metastatic cancer for the disgnosis and the assessment of prognosis or the effect of treatment.
Arthritis, Rheumatoid ; Biomarkers ; Bone Diseases ; Bone Diseases, Metabolic ; Bone Remodeling ; Female ; Humans ; Male ; Metabolism ; Ossification, Heterotopic ; Osteoblasts ; Osteocalcin ; Osteogenesis ; Osteogenesis Imperfecta ; Osteoporosis ; Osteoporosis, Postmenopausal ; Prognosis ; Radioimmunoassay ; Spondylitis, Ankylosing ; Vitamins

No abstract available.

No abstract available.
Child* ; Femur Neck* ; Humans

No abstract available.
Femur*

Tibial Plateau fracture is relatively common injury which often produce major disability, and their treatment has been in controversy. Recent studies suggest that early knee motion and perhaps better surgical techniques have improved clinical end results. Protection from weight bearing and length of immobilization have varied among authors and variable treatment methods. Thirty-eight tibial plateau fractures treated at Kangnam Sacred Heart Hospital from March in 1984 to December in 1988 were analized and the followings were obtained. l. Of 38 patients, 29 patients were male and 9 female. 2. The most common associated injury was an ipsilateral fibular fracture. 3. Average duration of immobilization was 4 to 6 weeks in conservative treatment and 2 to 4 weeks in operative treatment. 4. We started partial weight bearing in 24 patients within 6 weeks and full weight bearing in 28 patients between 8 and 12 weeks, and good end results were obtained.
Clinical Study ; Female ; Heart ; Humans ; Immobilization ; Knee ; Male ; Weight-Bearing

In 1983, Nora et. al. reperted 35 cases of bizarre parosteal osteochodromatous proliferations of the hands and feet. All lesions occured on proximal phalanges, metatarsals, or metacarpals. The gross appearance was typically that of a small osteochondroma. Radiologically, the proliferations lacked both central continuity of the tumor with the underlying osseus medulla and flaring of the adjacent cortices. Histologically, the lesion exhibited marked proliferative activity, irregular bohy cartilaginous interface, and enlarged, bizarre, and binucleate chondrocyte. The authors experienced a case of bizarre parosteal osteochondromatous proliferation of the right foot in a 61 year-old female which arised from the proximal phalanges of second toe, hostologic and radiologic findings were consistent with the bizarre parosteal osteochondromatous proliferation. The mass was treated by excision, and neither recurrence, nor malignant change was observed up to one year follow-up period.
Chondrocytes ; Female ; Follow-Up Studies ; Foot ; Hand ; Humans ; Metacarpal Bones ; Metatarsal Bones ; Osteochondroma ; Recurrence ; Toes

Longitudinal growth acceleration of the femoral shaft after fracture in children has been recognized since the late nineteenth century, Orthopaedic surgeons have attempted to compensate for the leg length discrepancy by allowing union to occur with some degree of shortening, but logitudinal overgrowth following fractures of the tibial shaft in children has been rarely studied. Thirty-one children, treated for fracture of the shaft of tibia, were studied prospectively to assess the consequent increase in longitudinal growth of the tibia. The material presented in this paper is the result of the study of thirty-one children with fractured tibia who were treated in the Department of Orthopaedic Surgery of Kangnam Sacred Heart Hospital of Hallym University, since 1986 October, the age of the child varied from 3 years to 13 years, these cases have been followed from 30 months to 40 months. We have made a radiologic study of fracture of the tibial shaft with a view to analysing the results according to a number of factors, including the sex and the type, site and degree of overriding of fracture, and method of treatment, and then the degree of overgrowth was compared with unaffected side. 1. The average tibial overgrowth following tibial shaft fracture is 7mm. 2. Growth of the femur was not affected by the tibial fracture.
Acceleration ; Child ; Femur ; Heart ; Humans ; Leg ; Methods ; Prospective Studies ; Surgeons ; Tibia ; Tibial Fractures

Anterior glenohumeral instability is mainly due to the Bankart lesion and capsular stretch. The differentiation between the Bankart lesion and capsular laxity may not be readily apparent on clinical examination. So, increasing attention has been directed toward preoperative evaluation of the labral lesion and capsular laxity. MRI and MR Arthrogram of 55 shoulders, 40 stable shoulders and 15 unstable shoulders that were confirmed by arthroscopic surgery, were reviewed to evaluate the labral and capsular shapes, especially the lesions of labroligamentous complex. To evaluate and compare the capsular laxity, we measured the anterior capsular insertion type, capsular ballooning, capsular insertion angle and anterior band of inferior glenohumeral ligament. And the following results were obtained; 1) The shape of anterior labrum was varied in the superior, middle and inferior potions in 40 stable shoulders. The anterior labral lesions were shown as torn(eight cases), displaced(six cases) and no detectable labrum(one case), in 15 unstable shoulders. Also, there were a significant di fference in the evaluation of the anteior labrum shape between MRI and MR arthrography. 2) There were not a significant difference in the type III capsular insertion type, capsular ballooning and capsular insertion angle between the stable and unstable shoulders. However, it was found that the shape of the anterior band of the inferior glenohumeral ligament had definite difference between the two groups. And so, more experience and attention should be given for the accurate preoperative evaluation of the anterior labroligamentous complex in shoulder instability.
Arthrography* ; Arthroscopy ; Ligaments ; Magnetic Resonance Imaging ; Shoulder

The cause of osteoporosis are multifactorial; these include aging, immobilization, genetic fsctor, initial bone mass, nulliparity, postmenopause, cigarette, etc. Among them the hormonal factors are very important. It is worthwhile to study the effects of various hormones on bne cells. Authors evaluated the effects of TGB-B, 17-B estradiol, insulin, and human growth hormone as a stimulatory factors, and r-interferon as a inhibitory factor on the MC3T3 osteoblast cells with measurement of cell numbers, osteocalcin and 3[H]-thymidine incorporation. 1. TGF-B was a potent stimulator on ostoblast with increased change in cell morphology (number, size, shape), osteoclacin level and 3[H]-thymidine incorporation in dose depen- dant fashion. 2. 17-B estradiol was also a potent stimulator on osteoblast activity as well as TGF-B except osteoclacin level which w#as not shown in dose dependant fashion. 3. There were little changes on osteoblast with insulin, growth hormone, and r-interferon. Through this study it is confirmed that TGF-B and 17-B estradiol showed marked stimulatory effect on osteoblast cell in vitro.
Aging ; Cell Count ; Estradiol ; Female ; Growth Hormone ; Human Growth Hormone ; Immobilization ; In Vitro Techniques ; Insulin ; Osteoblasts ; Osteocalcin ; Osteoporosis ; Parity ; Postmenopause ; Tobacco Products