2.Clinical observation of civilian colorectal injuries.
Tae Gyun KIM ; Jae Jung LEE ; Chul Jae PARK
Journal of the Korean Surgical Society 1993;44(3):406-413
No abstract available.
3.Anterior Cervical Microforaminotomy: A Minimally Invasive Anterolateral Approach for Spondylotic Lesions.
Sung Jin PARK ; Ho Gyun HA ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(1):87-94
No abstract available.
4.Effects of Multiple Exposures to Pesticides on Plasma Cholinesterase Activity and p-nitrophenol Excretion in Rats.
Bong Suk CHA ; Jung Gyun PARK ; Jong Ku PARK ; Sei Jin CHANG
Korean Journal of Preventive Medicine 1992;25(2):180-188
The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with LD50/100(mg/kg) of organophosphorous(OP), organophosphorous-organochroline(OP-OC), organophosphorous-carbamate(OP-CAB), organophosphorous-organoarsenate(OP-OA) pesticides for 4 consecutive days. In repeated administration of pesticides, plasma ChE activities were decreased, but urinary p-nitrophenol were increased after the first injection and then decreased gradually. The recovery rates of ChE activities and p-nitrophenol excretion at 48 hours after the fourth infection were delayed in comparison with the baseline value of 24 hours before the first injection. Statistical significances were found between OP and other groups except OP-OA group after the second injection in plasma ChE activities, but in urinary p-nitrophenol excretion there was statistical significance only between OP and OP-CAB.
Animals
;
Cholinesterases*
;
Pesticides*
;
Plasma*
;
Rats*
5.Endoscopic Removal of Traumatic Intracerebral Hematoma via Superolateral Keyhole.
Sung Jin PARK ; Ho Gyun HA ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(2):249-254
No abstract available.
Hematoma*
6.Endoscopic Third Ventriculostomy for Adult Aqueduct Stenosis: Double Fenestration: A Case Report and Technical Note.
Yong Jin SHIM ; Ho Gyun HA ; Ho JUNG ; Yong Seog KIM ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(8):1019-1023
No abstract available.
Adult*
;
Constriction, Pathologic*
;
Humans
;
Ventriculostomy*
7.Effect of STEL-toluene on Metabolism of Benzene in Rats.
Jaehoon ROH ; Dong Chun SHIN ; Jung Gyun PARK ; Young Hahn MOON ; Ho Keun CHUNG
Korean Journal of Preventive Medicine 1988;21(1):152-162
Benzene and toluene, which are widely used aromatic hydrocarbons in workplace, are recently proved to cause health hazards due to their toxic effects. This study investigated the influence of toluene on the urinary excretion of benzene metabolite by administering short term exposure limit(STEL) of these compounds(i.e., 13.8mg/kg of benzene and 108.8mg/kg of toluene) intraperitoneally into Sprague-Dawley rats. After administration, urinary phenol concentration of rat was measured by gas chromatography for every three hours. Data were analyzed by non-parametric statistical methods using Kruskal-Wallis multi-sample test and Mann-Whitney U test. The following results were obtained: 1. Administration of STFL-benzene increased urinary phenol concentration in rats. 2. Urinary phenol concentration was increased logarithmically according to the dosage of benzene. 3. Excretion of phenol in urine was decreased when benzene and toluene were administered simultaneously compared with administering benzene alone. In Summary, these results reveal that administration of STEL of toluene has antagonistic effect of urinary excretion of benzene metabolite in rats.
Animals
;
Benzene*
;
Chromatography, Gas
;
Hydrocarbons, Aromatic
;
Metabolism*
;
Phenol
;
Rats*
;
Rats, Sprague-Dawley
;
Threshold Limit Values
;
Toluene
8.Studies on the Morphological Changes of Neurons in Dorsal Root Ganglion and Spinal Dorsal Horn of the Rat with an Experimental Peripheral Neuropathy.
Won Taek LEE ; Min Gyun SON ; Gyung Seung JUNG ; Hong Suk LEE ; Gyung Ah PARK
Korean Journal of Anatomy 1997;30(5):495-510
Animal models for human chronic pain syndromes were developed and widely used for pain research. One of thsese neuropathic pain model by Kim and Chung[1992] has many advantages for operation and pain elicitation. We have examined the c-fos protein, substance P, CGRP immunoreactivity in dorsal root ganglia and dorsal horn in this neuropathic model. About 50 Sprague-Dawley rats were used for this study. L5 and L6 spinal nerve were ligated tightly to produce neuropathic pain model. After 2, 4, 8, 16, 24 hours and 1 week of surgery, rats were anesthesized and sacrificed by perfusion through the left ventricle with saline followed by 0.1M phosphate buffer[pH 7.4] containing 3% paraformaldehyde, 3% glutaraldehyde, and 0.1% picric acid. After confirmation of the roots transected by the surgery, the L5 and L6 dorsal root ganglion and spinal cord were removed and processed for immunohistochemistry. All tissue sections were immunohistochemically stained for substance P, CGRP and c-fos by using the peroxidase-antiperoxidase[PAP] method. Count the number of immunostained substance P and CGRP dorsal root ganglion cells and c-fos immunoreactive dorsal horn cells and analyzed statistically with Mann-Whitney U test. The results are as follows. 1. The number of c-fos protein immunoreactive neurons in the superficial layer of dorsal horn were increased markedly at 2 hours after operation, gradually decreased to normal level 1 week after operation. 2. The number of c-fos protein immunoreactive neurons in the deep layer of dorsal horn were gradually increased to the peak 24 hours after operation, decreased to normal level 1 week after operation. 3. The number of substance P and CGRP immunoreactive L5 and L6 dorsal root ganglion neurons were decreased markedly at 1 week after pain model operation. In conclusion, after neuropathic pain model operation, c-fos protein were immediately expressed in the superficial layer of spinal dorsal horn, thereafter c-fos protein in the deep layer of spinal dorsal horn were expressed. CGRP and substance P immunoreactive neurons were decreased markedly 1 week after neuropathic pain model operation.
Animals
;
Chronic Pain
;
Ganglia, Spinal*
;
Glutaral
;
Heart Ventricles
;
Horns*
;
Humans
;
Immunohistochemistry
;
Models, Animal
;
Neuralgia
;
Neurons*
;
Perfusion
;
Peripheral Nervous System Diseases*
;
Posterior Horn Cells
;
Rats*
;
Rats, Sprague-Dawley
;
Spinal Cord
;
Spinal Nerve Roots*
;
Spinal Nerves
;
Substance P
9.Recurrent Pulmonary Thromboembolism Treated with Urokinase.
Kyung Chang PARK ; Jee Soo KIM ; Sam KIM ; Chung Mi YOUK ; Sung Won JUNG ; Nam Ho LEE ; Dae Gyun PARK
Korean Circulation Journal 2000;30(10):1285-1290
The symptoms and signs of acute pulmonary arteries thrombosis are nonspecific. So clinical suspicion is the most important in the diagnosis. Treatment of pulmonary thromboembolism include anticoagulant, thrombolytic agent, or surgical intervention. We experienced a case of recurrent pulmonary thromboembolism without coagulation defect and any risk factor except old age and obese. Initially we treated with heparin, but clinical symptoms were aggravated. After we changed to urokinase (total 330 million IU/2 days), the pulmonary arteries obstruction were resolved and clinical symptoms were improved without any complications. So we report this clinical experience with review of articles.
Diagnosis
;
Heparin
;
Pulmonary Artery
;
Pulmonary Embolism*
;
Risk Factors
;
Thrombosis
;
Urokinase-Type Plasminogen Activator*
10.Intramedullary Hemangioblastoma of Cervicomedullary Junction with Diffuse Spinal Cord Enlargement and Cyst Formation : A Case Report.
Sung Jin PARK ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK ; Ho Gyun HA ; Ki Hwa YANG
Journal of Korean Neurosurgical Society 2000;29(6):805-809
No abstract available.
Hemangioblastoma*
;
Spinal Cord*