A pair of eyes of a 18 year-old girl with advanced congenital glaucoma was examined by light and electron microscopy. Results were as follows: 1. Trabecular meshwork and iris root showed fibrosis. 2. Schlemm's canal was absent. 3. Endothelium of the trabecular meshwork was degenerated. 4. Ciliary body was atrophied. 5. Inner layer of retina showed degeneration with the loss of nerve fiber layer and ganglion cell layer, which was replaced by Mueller cells. 6. Optic nerve showed atrophy from a loss of nerve fibers and there was proli feration of collagen tissue.
Adolescent ; Atrophy ; Ciliary Body ; Collagen ; Endothelium ; Female ; Fibrosis ; Ganglion Cysts ; Glaucoma* ; Humans ; Iris ; Microscopy, Electron ; Nerve Fibers ; Optic Nerve ; Retina ; Trabecular Meshwork

The introduction of beta-adrenergic blocking agents for the treatment of glaucoma was a major advance in the continued search for medications that effectively control the intraocular pressure with minimal side effect. Beta-adrenergic blocking agents block the aqueous pump of the ciliary epithelium resulting in decreased aqueous formation and drop in intraocular pressure. The fact that beta-adrenergic blocking agents had an affinity to intraocular tissues containing melanin granules has been reported. The purpose of this study is to know that mechanism of decrease of intraocular pressure and an affinity to melanin granules of the beta-adrenergic blocking agents. Two drops of 1% befunolol were instilled in the albino and pigmented rabbits, and the eyes were enucleated on 1, 2, 6 and 24 hours after instillation. These eyes were studied with electron microscopic examination. The results were as follows: 1. In the non-pigment epithelium of the ciliary body, mitochondria became swollen. 2. These changes appeared earlier and were more remarkable in albino rabbits than in pigmented ones. 3. In pigmented rabbits, these changes appeared slowly, but continued for longer duration and it seems to be due to affinity of beta-adrenergic blocking agents to the melanin pigment. 4. Swelling of mitochondria at the non-pigmented epithelium of the ciliary body after instillation of beta-adrenergic blocking agents seems to be the pharmacological mechanism of the drugs against aqueous formation in the ciliary body.
Adrenergic beta-Antagonists ; Ciliary Body ; Epithelium* ; Glaucoma ; Intraocular Pressure ; Melanins ; Mitochondria ; Rabbits

Retinal changes of rabbit after intraocular injection of lidocaine(group I), lidocaine-epinephrine 1:50,000 (group II), and normal saline (group III) were studied with electron microscope. The results were as follows: 1. Intracellular edema of the cells of the inner nuclear layer and the inner one third of the outer nueler layer was observed. 2. The photoreceptor outer segments showed mild fragmentation. 3. Swelling of mitochondria and several phagosomes were observed in the cytoplasm of the pigment epithelium. 4. Above changes were reversible during the observation period of one week. 5. No significant differences between the groups I, II, and III were noted.
Cytoplasm ; Edema ; Epithelium ; Injections, Intraocular* ; Lidocaine* ; Mitochondria ; Phagosomes ; Retina* ; Retinaldehyde

Medulloepithelioma(diktyoma) is a uncommon congenital tumor that is generally believed to arise from the embryonic neuroepithelium of the medullary tube. This tumor usually arises from the ciliary body epithelium. But medulloepitheliomas of the retina and optic nerve may also occur, although it is extremely rare, because the embryonal medullary epithelium that lines the optic vesicle is continuous with the epithelium lining the cavity of the optic nerve during the early embryonal period. The occurrence of medulloepithelioma of the optic nerve is exceptionally rare, with only a few cases have been previously reported. We report a first case of medulloep-ithelioma of the optic nerve head in Korea in a 5-year-old girl who presented with a poor vision and squint of the left eye.
Child, Preschool ; Ciliary Body ; Epithelium ; Female ; Humans ; Korea ; Neuroectodermal Tumors, Primitive* ; Optic Disk* ; Optic Nerve* ; Retina ; Strabismus

We built a mathematical model of the eye based on the method of Robinson and improved it. It was programmed with C language. With this model several types of paralytic strabismus including superior oblique paralysis, oculomotor nerve paralysis and double elevator paralysis were simulated. Then we performed various surgical procedures such as recession, resection of horizontal recti, transposition, myectomy. Scott's procedure on these simulated squints and analyzed the results. We tried to show the usefulness and limitation of simulation.
Elevators and Escalators ; Models, Theoretical* ; Oculomotor Nerve Diseases ; Paralysis ; Strabismus*

We built a mathematical model of the eye based on the method of Robinson and improved it. It was programmed with C language. With this model several types of paralytic strabismus including superior oblique paralysis, oculomotor nerve paralysis and double elevator paralysis were simulated. Then we performed various surgical procedures such as recession, resection of horizontal recti, transposition, myectomy. Scott's procedure on these simulated squints and analyzed the results. We tried to show the usefulness and limitation of simulation.
Elevators and Escalators ; Models, Theoretical* ; Oculomotor Nerve Diseases ; Paralysis ; Strabismus*

Generally accepted mechanisms of involutional entropion are as follows: 1. dysfunction of the inferior eyelid retractors, 2. migration of the preseptal orbicularis fibers upward, 3. reduced support of the lower lid against glove due to enophthalmos, 4. reduced horizontal support because of involutional changes in the lateral and medical canthal tendons. Sanford D. Hecht reported that the above four problems could be corrected simply and successfully by a full thickness excision of Bowlegs shape(Pentagon-shape). Five eyelids of involutional entropion were treated by the Boelegs procedure. The results were successful.
Enophthalmos ; Entropion* ; Eyelids ; Tendons

Generally accepted mechanisms of involutional entropion are as follows: 1. dysfunction of the inferior eyelid retractors, 2. migration of the preseptal orbicularis fibers upward, 3. reduced support of the lower lid against glove due to enophthalmos, 4. reduced horizontal support because of involutional changes in the lateral and medical canthal tendons. Sanford D. Hecht reported that the above four problems could be corrected simply and successfully by a full thickness excision of Bowlegs shape(Pentagon-shape). Five eyelids of involutional entropion were treated by the Boelegs procedure. The results were successful.
Enophthalmos ; Entropion* ; Eyelids ; Tendons

Canalicular occlusion with silicone plug was carried out in 11 patient, 21 eyes with dry eye syndrome and the effect and safety of the procedure were evaulated. Artificial tears were discontinued or frequency of instillation was reduced in 66.6% of eyes after occlusion of canaliculi. There were no stastiscally significant differences in the mean value of B.U.T. and Schirmer test pre-and post-canalicular occlusion. There were no cases of postoperative epophora, allergic reaction and infection.
Dry Eye Syndromes ; Humans ; Hypersensitivity ; Ophthalmic Solutions ; Silicones

We recently obsesved an unusual case of visual loss after the facial injection of autologous fat. A 42-year-old woman underwent autologous fat injection into the temple area to reduce facial wrinkles. The procedure was performed by a surgeon at local clinic. The patient immediately complained of severe right hemicranial pain and lid swelling. She vistied to the ophthalmic department of our hospital 1 week later because of total loss of vision on the right eye. We believe that the cause of blindness was multiple microembolization in the central retinal artery and posterior ciliary branches of the ophthalmic artery via lateral palpebral artery.
Adult ; Arteries ; Blindness ; Choroid* ; Female ; Humans ; Ophthalmic Artery ; Retinal Artery ; Retinaldehyde*